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17,054 grants matching “genome editing”
GROWING ENOUGH FOOD MAY SOON BECOME MUCH MORE DIFFICULT. INCREASING CLIMATE EXTREMES WILL CAUSE MORE CROP FAILURES AND THE POPULATION WILL GROW TO 9.8 BILLION IN ONLY 30 YEARS. THESE CHALLENGES CAN BE ADDRESSED BY BREEDING MORE RESILIENCE INTO OUR HIGH PRODUCING CROP VARIETIES, BUT DOING THIS BY TRADITIONAL BREEDING TAKES UP TO 7 YEARS. THIS CAN BE REDUCED TO JUST 1 YEAR BY A KIND OF GENOME EDITING (THE ABILITY TO MAKE CHANGES TO GENES) THAT CAN DIRECTLY CHANGE AN INEFFICIENT GENE IN A HIGH PRODUCING CROP INTO A MUCH MORE EFFICIENT VERSION OF THE SAME GENE FOUND IN OTHER CROP VARIETIES. THIS KIND OF GENOME EDITING REQUIRES A DNA REPAIR PROCESS PRESENT IN ALL CELLS KNOWN AS HOMOLOGY DIRECTED REPAIR OR HDR. HOWEVER, HDR DOES NOT OCCUR VERY OFTEN IN PLANT CELLS, AND THEREFORE GENOME EDITING USING HDR ARE TOO INEFFICIENT FOR BREEDING. THUS, THE GOAL OF THIS PROJECT IS TO EXPLORE STRATEGIES TO MAKE HDR MORE ACTIVE IN PLANT CELLS AND BROADEN OUR ABILITIES TO IMPROVE GENES IN CROPS TO BE BOTH RESILIENT AND HIGH PRODUCING. TO MAKE HDR MORE ACTIVE IN PLANT CELLS, I WILL EITHER APPLY DIFFERENT CHEMICALS THAT ARE THEORETICALLY EXPECTED TO IMPROVE HDR ACTIVITY OR ADJUSTING THE ACTIVITY OF DIFFERENT GENES THAT IMPROVE HDR. THESE TWO KINDS OF TREATMENTS WILL BE TESTED IN AN EXPERIMENT DESIGNED TO RAPIDLY SCORE HDR ACTIVITY. LEAVES OF TOBACCO (N. TABACUM) HAVE A BROKEN SIGNAL GENE WILL BE INJECTED WITH GENOME EDITING DNA AND A WORKING SIGNAL GENE. IN EACH CELL THAT RECEIVES THE INJECTION, HDR MAY OCCUR AND SWAP THE BROKEN SIGNAL GENE WITH THE WORKING VERSION WHICH CAN THEN BE MEASURED. THIS WILL BE PERFORMED WITH EACH TREATMENT,THE CHEMICALS AND HDR ACTIVATING GENE ADJUSTMENTS, WITH THE EXPECTATION THAT SOME MAY INCREASE HDR VS WITHOUT USING THEM. THE PROJECT WILL RESULT IN SCIENTIFIC PUBLICATIONS DETAILING EACH TREATMENT'S EFFICACY ON IMPROVING HDR ACTIVITY. OTHER PLANT GENETICISTS AND BREEDERS WILL USE THIS INFORMATION AND INCORPORATE ONE OF THESE TREATMENTS FOR A MORE EFFICIENT GENOME EDITING STRATEGY TO IMPROVE GENES IN VARIOUS MAJOR FIELD CROPS SUCH AS WHEAT OR RICE. NOT ONLY DOES THIS ENSURE FOOD SECURITY BUT IMPROVES AGRICULTURE'S IMPACT ON BOTH ECONOMIES, IN THE FORM OF REDUCED LOSSES OF CROPS SOLD TO MARKETS, AND THE ENVIRONMENT, AS MORE RESILIENT CROPS REDUCE THE NEED AND USAGE OF WATER, PESTICIDES, AND FERTILIZERS.
$179,014The Pennsylvania State University · · FY2020 · National Institute of Food and Agriculture
Why don't lizards regenerate perfect tails like salamanders?
$178,852Thomas Peter Lozito · University Of Southern California · R01 · FY2019 · GM
Genetically Mediated Hair Cell Degeneration in 3D Inner Ear Organoids
$178,830Rick F Nelson · Indiana University Indianapolis · K08 · FY2020 · DC
Genetically Mediated Hair Cell Degeneration in 3D Inner Ear Organoids
$178,830Rick F Nelson · Indiana University Indianapolis · K08 · FY2019 · DC
Genetically Mediated Hair Cell Degeneration in 3D Inner Ear Organoids
$178,830Rick F Nelson · Indiana University Indianapolis · K08 · FY2021 · DC
Genetically Mediated Hair Cell Degeneration in 3D Inner Ear Organoids
$178,830Rick F Nelson · Indiana University Indianapolis · K08 · FY2018 · DC
Genetically Mediated Hair Cell Degeneration in 3D Inner Ear Organoids
$178,830Rick F Nelson · Indiana University Indianapolis · K08 · FY2017 · DC
Trageting mTOR Dependent Mechanism in Clear Cell Renal Carcinoma
$178,707David McDermott · Beth Israel Deaconess Medical Center · P50 · FY2019 · CA
Collaborative Research: ORCC: Harnessing Adaptive Variation in Drought Resistance Strategies to Manage Populations Under Climate Change
$178,638Nicholas J Kooyers · University Of Louisiana At Lafayette · · FY2022 · BIO
Role of Dopamine Neuron-Specific Gene Enhancers in Cocaine Relapse
$178,637Luis Miguel Tuesta · University Of Miami School Of Medicine · K01 · FY2019 · DA
The Graduate Program in Tropical Infectious Diseases (GPiTID)
$178,549Dyann F Wirth · Harvard School Of Public Health · T32 · FY2019 · AI
CORE--MOLECULAR DIVERSITY
$178,448University Of Washington · P30 · FY2000 · AI
Functional Landscape of Glycosylation in Skin Cancer
$178,427Matthew Robert Kudelka · Rockefeller University · K99 · FY2024 · CA
Exploring Transcriptional Adaptation: Therapeutic Potential and Impact on Human Genetics
$178,416Mohamed El-Brolosy · Whitehead Institute For Biomedical Res · K99 · FY2025 · HG
Cell Models Core
$178,295Stephen A Duncan · Medical University Of South Carolina · P30 · FY2025 · DK
Disease Modeling Core
$178,231Peter J Dempsey · University Of Colorado Denver · P30 · FY2022 · DK
The Role of Non-Coding RNA Editing in MET Signaling in NSCLC
$178,171Mario Acunzo · Virginia Commonwealth University · R21 · FY2024 · CA
Ultrasound-programmable gene editing in kidneys
$178,122Scott Hammond Medina · Pennsylvania State University, The · R21 · FY2021 · DK
Mechanoregulatory mechanisms of von Willebrand disease and thrombosis
$178,092Hongxia Fu · University Of Washington · K25 · FY2020 · HL
Mechanoregulatory mechanisms of von Willebrand disease and thrombosis
$178,092Hongxia Fu · University Of Washington · K25 · FY2018 · HL
Mechanoregulatory mechanisms of von Willebrand disease and thrombosis
$178,092Hongxia Fu · University Of Washington · K25 · FY2021 · HL
Mechanoregulatory mechanisms of von Willebrand disease and thrombosis
$178,092Hongxia Fu · University Of Washington · K25 · FY2019 · HL
Mechanoregulatory mechanisms of von Willebrand disease and thrombosis
$178,092Hongxia Fu · University Of Washington · K25 · FY2017 · HL
Localization and function of SLC24A5 in skin pigmentation
$178,000Michael S Marks · Children'S Hosp Of Philadelphia · R03 · FY2025 · TR
The identification of endocardial regulatory elements in cardiac regeneration
$177,987Roland S Wu · University Of California, San Francisco · K08 · FY2019 · HL