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15,273 grants matching “antimicrobial resistance”
Synthesis of New Ligands for the Characterization of Siderophore-ExFABP Interacti
$94,997Juan R Del Valle · New Mexico State University Las Cruces · U54 · FY2007 · CA
Collaborative Research: Linking Pharmacokinetics to Epidemiological Models of Vector-Borne Diseases and Drug Resistance Prevention
$94,960Olivia Feldman · University Of Kentucky Research Foundation · · FY2018 · MPS
Bacterial Evasion of Innate Defenses at the Ocular Surface
$94,927Daria N Van Tyne · Massachusetts Eye And Ear Infirmary · K99 · FY2017 · EY
Modulation of Inflammasome Activation by Yersinia
$94,896Igor E Brodsky · University Of Pennsylvania · R01 · FY2014 · AI
Enhancing In Vitro Antimicrobial Activity of Common Antibiotics with Cyclopeptide
$94,671Maria Ngu-Schwemlein · Winston-Salem State University · SC3 · FY2009 · GM
Characterization of Francisella tularensis-specific bacteriophages
$94,669Chandra Shekhar Bakshi · New York Medical College · R03 · FY2021 · AI
BACTERIAL ANTIBIOTIC RESISTANCE IN AGRICULTURE
$94,613Manuel F Varela · New Mexico State University Las Cruces · P20 · FY2008 · RR
Genetic basis of metabolite production against clinically-derived pathogens
$94,209Hans Wildschutte · Bowling Green State University · R15 · FY2023 · GM
SIGNAL-BASED ANALYSIS OF CLINICAL MICROBIOLOGY
$93,900Vecna Technologies, Inc. · R43 · FY2000 · AI
SYNTHESIS & PHARMACOLOGICAL EVAL OF POTENTIAL ANTI-CANCER & ANTI MICROBIAL AGENT
$93,636John S. Cooperwood · Florida Agricultural And Mechanical Univ · G12 · FY2011 · RR
Novel coatings to minimize surface degradation and fracture susceptibility of dental ceramics
$93,624Josephine F. Esquivel-Upshaw · University Of Florida · R01 · FY2018 · DE
PHFE/CEIP NARMS Retail Food Surveillance Program
$93,500Duc J Vugia · Public Health Foundation Enterprises · U01 · FY2017 · FD
SGER: Inactivation of Bacillus Spores Using Antimicrobial Peptides
$93,363Terri A Camesano · Worcester Polytechnic Institute · · FY2008 · ENG
Structural studies of target recognition by large natural product antibiotics
$93,337Patrick J Loll · Drexel University · R01 · FY2009 · GM
MICROBIAL PATHOGENS CAUSE DEVASTATING CROP LOSSES AND SIGNIFICANT FINANCIAL DAMAGE AROUND THE WORLD. FURTHERMORE, A WARMING CLIMATE, PESTICIDE RESISTANCE,AND ENVIRONMENTAL DAMAGE FROM PESTICIDE OVERUSE HAVE MADE THE DEVELOPMENT OF NEW PATHOGEN CONTROL METHODS A NECESSITY. SPRAY-INDUCED GENE SILENCING (SIGS), WHICH RELIES UPON RNA INTERFERENCE, IS AN EFFECTIVE AND SUSTAINABLE METHOD OF DISEASE CONTROL. HOWEVER, SIGS REMAINS LIMITED BY THE INSTABILITY OF RNA IN THE ENVIRONMENT AND ITS DEPENDENCE ON PASSIVE MICROBIAL RNA UPTAKE. INSPIRED BY HOW NANOPARTICLES CAN BE USED TO PROTECT AND DELIVER RNA IN VACCINES, THIS PROJECT WILL DEVELOP PLANT-DERIVED NANOVESICLES (PDNVS) AS A NEW NANOPARTICLE PLATFORM FOR DELIVERING RNA AND OTHER BIOACTIVE MOLECULES TO COMBAT AND STUDY MICROBIAL PATHOGENS. PDNVS FROM DIFFERENT PLANT SOURCES WILL BE EXAMINED FOR THEIR ABILITY TO IMPROVE RNA DELIVERY TO PATHOGENS WITH VARYING INHERENT RNA UPTAKE CAPABILITIES. APPLICATION OF THE RNA-LOADED PDNVS FOR SIGS WILL DETERMINE IF THEY CAN EFFECTIVELY REDUCE PATHOGENICITY AND PROVIDE PROLONGED DISEASE PROTECTION ON PLANTS. THE COMPOSITION OF THE DIFFERENT PDNVS WILL BE ANALYZED TO DETERMINE KEY FEATURES THAT CONTROL RNA LOADING AND PDNV UPTAKE BY DIFFERENT MICROBES. THROUGH THESE EFFORTS, DESIGN RULES TO CREATE TAILORED NANOPARTICLES FOR IMPROVED DISEASE CONTROL WILL BE DEVELOPED. OVERALL, THIS WORK WILL DEMONSTRATE HOW PDNVS CAN BE USED TO EXTEND SIGS TO PREVIOUSLY UNTREATABLE MICROBES AND PROVIDE VALUABLE INFORMATION ON HOW TO DEVELOP MORE ROBUST AND EFFECTIVE ANTIMICROBIAL STRATEGIES FOR AGRICULTURE AND HUMAN HEALTH.
$93,258Michigan State University · · FY2025 · National Institute of Food and Agriculture
Vaccine and Treatment Evaluation Units: Phase IV Clinical Trial in Adults with Community Acquired Pneumonia to Assess the Effect of Early Empiric Antifungal Treatment of Coccidioidomycosis Pneumonia
$93,126Susanna Naggie · Duke University · N01 · FY2024 · AI
Pilot utility and prospective performance study of a rapid automated diagnostic f
$93,000Kristen Jennifer Kanack · Biofire Defense, Llc. · R03 · FY2014 · AI
Epidemiology of Antibiotic Resistance
$92,982Deborah Prevots · National Institute Of Allergy And Infectious Diseases · ZIA · FY2016 · AI
NARMS Cooperative Agreement Program to Enhance and Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens - South Carolina Department of Health and Environmental Control
$92,888Megan Davis · South Carolina Department Of Public Health · U01 · FY2018 · FD
Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
$92,740James P Mapes · Rules-Based Medicine, Inc. · R44 · FY2009 · GM
Central role of Caspase-8 in control of host tolerance and resistance mechanisms in pulmonary macrophage populations during severe respiratory infections
$92,583Amanda M Jamieson · Brown University · R01 · FY2025 · HL
Function and inhibition of multidrug efflux systems in Campylobacter
$92,567Qijing Zhang · Iowa State University · R01 · FY2016 · AI
Acne and group A strep: an unknown burden
$92,426David J. Margolis · University Of Pennsylvania · R01 · FY2008 · AR
Short-term biomedical research training program for veterinary students
$92,424Vilma Yuzbasiyan-Gurkan · Michigan State University · T35 · FY2019 · OD
Proof of Principle Evaluation of IV Gallium Nitrate in Patients with CF
$92,308Christopher Hooper Goss · University Of Washington · UM1 · FY2017 · HL