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38,696 grants matching “als”
A multi-modality approach to decode epithelial heterogeneity and function in metaplasia
$396,250Kathleen Elizabeth Delgiorno · Vanderbilt University · R35 · FY2023 · GM
Reprogramming cell fate through nucleotide metabolism
$396,250Elma Zaganjor · Vanderbilt University · R35 · FY2024 · GM
A multi-modality approach to decode epithelial heterogeneity and function in metaplasia
$396,250Kathleen Elizabeth Delgiorno · Vanderbilt University · R35 · FY2022 · GM
Anti-HIV Activity of Lung SRCR (gp-340) in Saliva
$396,250University Of Pennsylvania · R01 · FY2003 · DE
A multi-modality approach to decode epithelial heterogeneity and function in metaplasia
$396,250Kathleen Elizabeth Delgiorno · Vanderbilt University · R35 · FY2025 · GM
CHARACTERIZING THE NATURE OF SURFACE MATERIALS ON MARS IS ESSENTIAL FOR DETERMINING THE PAST AND PRESENT CLIMATE AND FOR ASSESSING FUTURE LANDING SITES. IN PARTICULAR SEDIMENTARY SURFACE MATERIALS MAY CONTAIN A RECORD OF HABITABILITY THE WATER CYCLE AND VARIABILITY ATMOSPHERIC CIRCULATION AND GEOLOGIC SURFACE PROCESSES. THE MATERIALS MAY BE INVESTIGATED BY A DIVERSE SUITE OF ORBITAL INSTRUMENTS AND A GREATER VARIETY SHOULD LEAD TO BETTER CHARACTERIZATION. CRITICAL TO THE CHARACTERIZATION OF SURFACE MATERIALS IS UNDERSTANDING THEIR MINERALOGICAL AND PHYSICAL PROPERTIES INCLUDING THEIR COMPOSITION AND DISTRIBUTION. WHEREAS MATERIALS ARE SPREAD NON-UNIFORMLY OVER THE MARTIAN SURFACE MANY DEPOSITS EXIST IN LOCATIONS THAT ARE DIFFICULT TO MEASURE WITH ONE OR MORE INSTRUMENTS IMPEDING FULL CHARACTERIZATION. IN RARE CASES MANY ORBITING INSTRUMENTS ARE ABLE TO TRAIN ON A SINGLE DEPOSIT OR MULTIPLE DEPOSITS IN THEIR ENTIRETY. WE HAVE LOCATED SEVERAL OF THESE DEPOSITS NEAR THE RIM OF VALLES MARINERIS (VM) AND NEIGHBORING CHASMATA THAT MAY BE CHARACTERIZED BY OPTICAL IMAGERY SPECTROSCOPY THERMAL BEHAVIOR AND NOW SOUNDING RADAR. OUR OBJECTIVE IS TO CONSTRAIN THE CHEMICAL AND PHYSICAL PROPERTIES OF SEDIMENTARY DEPOSITS ON THE VALLES MARINERIS RIM AND TO TEST THE VARIOUS HYPOTHESES OF THEIR ORIGIN. MULTIDISCIPLINARY APPROACHES SUCH AS THIS ARE DIFFICULT ON MARS EITHER BECAUSE SURFACE CHARACTERISTICS MAKE THE APPLICATION OF RADAR IMPOSSIBLE OR BECAUSE OF A LACK OF EXPOSURE LIMITING ACCESS WITH OTHER INSTRUMENTS. THUS THE VALLES MARINERIS PLATEAU DEPOSITS MAY SERVE AS AN IDEAL TEST LOCATION FOR UNDERSTANDING ALTERED SEDIMENTARY DEPOSITS ON MARS. CENTRAL TO OUR INVESTIGATION IS COMBINING MULTIDISCIPLINARY TECHNIQUES THAT CHARACTERIZE LAYERED DEPOSITS IN VARIOUS WAYS. IN LIGHT OF THAT WE WILL USE DATA FROM SHARAD HIRISE CTX CRISM THEMIS TES AND HRSC. AS AN ENSEMBLE THESE INSTRUMENTS PROVIDE VIEWS OF THE LLD THAT ARE MORE COMPLETE THAN IN PREVIOUS STUDIES. RECENT INCREASES IN COVERAGE WITH HIGH RESOLUTION IMAGERY DIGITAL TERRAIN MODELS (DTMS) AND SPECTRAL IMAGES WILL ENHANCE THE RETURN. IN SUPPORT OF MANY GOALS OF THE MARS DATA ANALYSIS PROGRAM (MDAP) AND THE MARS EXPLORATION PROGRAM ANALYSIS GROUP (MEPAG) WE WILL COMBINE DATASETS FROM SEVERAL INSTRUMENTS AND MISSIONS TO DETERMINE THE PHYSICAL AND COMPOSITIONAL CHARACTERISTICS OF THE LLD AND TO TEST THE OPEN HYPOTHESES OF LLD FORMATION: (1) LACUSTRINE SEDIMENTARY DEPOSITION (2) VOLCANIC DEPOSITION OR (3) AEOLIAN/ AIRFALL DEPOSITION [WEITZ ET AL. 2010 AND REFERENCES THEREIN]. FURTHERMORE WE WILL LOOK FOR EVIDENCE THAT THE LLD HAVE A COMMON SOURCE OR ALTERATION SEQUENCE AND TEST SCENARIOS OF LLD DEPOSITION OCCURRING BEFORE AND AFTER VM FORMATION AND GROWTH. PRODUCTS AND RESULTS WE WILL GENERATE TO TEST HYPOTHESES INCLUDE: MAPS OF FULL EXTENT THICKNESS AND VOLUME OF LLD OVER ENTIRE REGION WITH A FULL 3D RECONSTRUCTION; MAPS OF SPECTRAL COMPONENTS AND ALTERATION MINERALS IN A STRATIGRAPHIC CONTEXT; EXTRACTED GEOPHYSICAL AND THERMOPHYSICAL PROPERTIES FOR EACH LOCATION; CONSTRAINTS ON THE RELATIVE TIMING AND DURATION OF DEPOSITION AND ALTERATION; CONSTRAINTS ON THE HYDROLOGIC AND TECTONIC SETTINGS DURING DEPOSITION; AND CONSTRAINTS ON THE POROSITY AND DENSITY OF LLD.
$396,237Planetary Science Institute · · FY2020 · National Aeronautics and Space Administration
Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence Microscopy
$396,171Priya R. Banerjee · State University Of New York At Buffalo · R35 · FY2020 · GM
Natural history and biomarker discovery in C9orf72 Amyotrophic lateral sclerosis and frontotemporal dementia
$396,134Mary Kay Floeter · National Institute Of Neurological Disorders And Stroke · ZIA · FY2015 · NS
Astrocytic Ca2+ Signaling in the Ischemic Penumbra
$396,095Maiken Nedergaard · University Of Rochester · P01 · FY2009 · NS
Dynamic Image Analysis of Human Embryonic Stem Cells to Monitor Pluripotency
$396,054Rami Mangoubi · Charles Stark Draper Laboratory · R01 · FY2010 · EB
Spatial modeling of onchocerciasis foci in Africa by remote sensing
$396,000Thomas R Unnasch · University Of South Florida · R01 · FY2012 · TW
Origins of Diversity at Human Classical MHC Class I Genes
$396,000Peter R Parham · Stanford University · R01 · FY2011 · AI
CRCNS: Multiple Time Scale Memory Consolidation in Neural Networks
$395,986Alex D Reyes · New York University · R01 · FY2022 · MH
Randomized Trial of a Self-Management Early Intervention for Combat-Related PTSD
$395,986Juesta M Caddell · Research Triangle Institute · R01 · FY2006 · MH
Efficacy and Mechanisms of Technology-Based Behavioral Interventions
$395,952James M. Henson · Old Dominion University · R01 · FY2015 · AA
Corneal Elastography and Patient-Specific Modeling for Simulation-based Therapy
$395,938William Joseph Dupps · Cleveland Clinic Lerner Com-Cwru · R01 · FY2013 · EY
SEVERAL NEW HORIZONS (NH) OBSERVATIONS MAKE NECESSARY A NEW EXAMINATION OF UPPER ATMOSPHERIC PROPERTIES OF THE PLUTO-CHARON SYSTEM. PLUTO S UPPER ATMOSPHERE WAS COLDER THAN EXPECTED PRE-ENCOUNTER PERHAPS DUE TO TRACE SPECIES UNDERGOING RADIATIVE COOLING THE ESCAPE RATE WAS LOWER THE METHANE/NITROGEN FRACTIONATION GREATER AND THE SOLAR WIND PENETRATED CLOSER TO PLUTO. IN FACT THE SOLAR WIND INTERACTION OCCURRED INSIDE OF CHARON S ORBITAL DISTANCE. THERE WAS ALSO NO OBSERVED ATMOSPHERE ON CHARON THOUGH THERE ARE SURFACE COLORATIONS SUGGESTIVE OF INTER-BODY GAS TRANSFER AND MIGRATION OVER CHARON S SURFACE. PLUTO S SURFACE WAS OBSERVED TO SHOW RECENT POSSIBLE LIQUID FLOWS SUGGESTING PERIODS OF APPRECIABLY GREATER ATMOSPHERIC COLUMN PERHAPS DUE TO PLUTONIAN MILANKOVICH CYCLES AND IMPLYING VERY DIFFERENT ESCAPE RATES/PROCESSES IN THE PAST. THE KNOWLEDGE GAP IMPLIED BY THESE AND OTHER NH OBSERVATIONS PROVIDES THE MOTIVATION FOR THIS PROPOSAL. WE HAVE CREATED A FULLY THREE DIMENSIONAL FULLY RESOLVED DIRECT SIMULATION MONTE CARLO (DSMC) MODEL OF PLUTO S N2/CH4 UPPER ATMOSPHERE INCLUDING GAS TRANSFER TO/FROM CHARON AND ESCAPE FROM THE SYSTEM (HOEY ET AL. 2017). WE PRESENTED PRELIMINARY RESULTS FOR DIFFERENT POSSIBLE LOWER BOUNDARY CONDITIONS FOR THE PROCESS OF ATMOSPHERIC TRANSPORT FROM PLUTO TO CHARON AND ESCAPE FROM THE SYSTEM AND MATCH THE 5-TO-6 10^25 S 1 ESCAPE RATE OBSERVED BY NH (BAGENAL ET AL. 2016 GLADSTONE ET AL. 2016). IN THE COURSE OF OTHER WORK WE HAVE RECENTLY DEVELOPED MORE SOPHISTICATED MODULES FOR OUR DSMC CODE SO IT CAN NOW ACCOMMODATE MOLECULAR COLLISIONAL CHEMISTRY AND PHOTOCHEMISTRY INCLUDING CHARGED PARTICLES. WE HAVE ALSO DEVELOPED THE ABILITY TO SIMULATE LINEBY- LINE RADIATIVE TRANSPORT IN 3-D WITHIN THE DSMC CODE USING A PHOTON MONTE CARLO PROCEDURE FULLY COUPLED TO THE MOLECULAR DSMC MODELS. OUR GROUP NOW ALSO HAS THE ABILITY TO USE THE SOPHISTICATED 1-D RADIATIVE TRANSFER CODE PRESENTED IN MAHIEUX ET AL. (2015 2017). FURTHERMORE WE CAN NOW MODEL THE EFFECTS OF DIURNAL TEMPERATURE VARIATIONS IN PLUTO S UPPER ATMOSPHERE AND ON CHARON S SURFACE. WE PROPOSE TO GREATLY EXPAND ON OUR INITIAL MODELING USING THESE MORE SOPHISTICATED MODELS NOW AVAILABLE AND CORRELATE RESULTS WITH THE NH OBSERVATIONS PARTICULARLY THOSE OF THE UV SPECTRA (ALICE) THE SOLAR WIND (SWAP) CHARON SURFACE PROPERTIES (LORRI) AND FIELDS AND PARTICLES (PEPSSI). WE WILL ALSO INDIRECTLY USE REX OBSERVATIONS OF THE LOWER ATMOSPHERE AS THEY ARE INCORPORATED INTO THE LITERATURE MODELS FROM WHICH WE DRAW OUR BOUNDARY CONDITIONS. THE PROPOSED WORK IS THUS RELEVANT TO THE NFDAP IN THAT IT INTEGRATES A VARIETY OF NH OBSERVATIONS TO MODEL THE PLUTO/CHARON ATMOSPHERE A KEY TARGET OF THE NH MISSION TO EXTEND THE SCIENTIFIC YIELD OF THE NFDAP PROGRAM. USING THESE MODELS AND NH DATA WE AIM TO GREATLY IMPROVE UNDERSTANDING OF THE UPPERMOST PORTIONS OF THE PLUTO/CHARON ATMOSPHERE PARTICULARLY AS REGARDS TO THE NATURE OF INTERBODY TRANSFER AND ESCAPE PROCESSES.
$395,878University Of Texas At Austin · · FY2021 · National Aeronautics and Space Administration
Investigation of the role of bacteria in the sarcoidosis trimolecular complex
$395,872Wonder P. Drake · Vanderbilt University · R01 · FY2006 · HL
NUTRIENT RESTRICITON AND DEVELOPMENTAL PROGRAMMING
$395,829Peter W Nathanielsz · University Of Texas Hlth Science Center · R24 · FY2006 · RR
A Novel Pharmacotherapy for Alcoholism: Evaluation of Reward, Aversion, Compulsivity, Withdrawal & Reinstatement
$395,775Abraham A Palmer · University Of California, San Diego · R01 · FY2018 · AA
Lymph node-targeted molecular vaccines for mucosal HIV immunity
$395,744Darrell J Irvine · University Of Louisiana At Lafayette · P01 · FY2020 · AI
SCIENCE GOALS/OBJECTIVES: AN OUTSTANDING OBSERVATION AT THE INTERFACE OF THE PLASMA SHEET AND THE INNER MAGNETOSPHERE IS THE PREVALENCE OF LARGE AMPLITUDE KINETIC SCALE ELECTROMAGNETIC OSCILLATIONS OF THE GEOMAGNETIC FIELD [CHASTON ET AL. 2014]. THESE FIELD VARIATIONS DRIVE EXTREME ION ENERGIZATION AND ELECTRON HEATING TO THE EXTENT THEY MAY CONTRIBUTE SIGNIFICANTLY TO INNER MAGNETOSPHERIC ENERGY DENSITY AND THE FORMATION OF AURORA. FOR THIS PROCESS TO BE SUSTAINED IN THE MANNER OBSERVED REQUIRES CONTINUOUS DRIVING AND ENERGY TRANSPORT ONTO THE FIELD-LINES WHERE THESE WAVES ARE OBSERVED. WE PROPOSE TO DETERMINE THE NATURE OF THE ENERGY TRANSPORT PROCESS THAT SUPPORTS THIS DRIVING AND IDENTIFY THE PROCESSES RESPONSIBLE FOR THE CONVERSION OF THE INCOMING ENERGY FLUX INTO THE LARGE AMPLITUDE FLUCTUATIONS OBSERVED. MISSION DATA: THIS RESEARCH WILL BE PERFORMED USING FIELDS AND PLASMA OBSERVATIONS FROM THE VAN ALLEN PROBES SPACECRAFT. DURING ACTIVE TIMES THESE SPACECRAFT ROUTINELY TRAVERSE THE REGION WHERE THE HOT PLASMAS OF THE PLASMASHEET MEET THE COOLER HIGHLY MAGNETIZED PLASMAS OF THE INNER MAGNETOSPHERE AND THE LARGE AMPLITUDE ELECTRIC FIELD FLUCTUATIONS DESCRIBED ABOVE ARE FOUND. THE MEASUREMENTS FROM THE VAN ALLEN PROBES SPACECRAFT ALLOW A FULL CHARACTERIZATION OF THE PLASMA AND LOCAL WAVE PROPERTIES IN THE SPACECRAFT FRAME THROUGH THIS REGION. DATA ANALYSIS METHODOLOGY: USING THESE MEASUREMENTS WE WILL QUANTIFY THE ENERGY INPUT INTO THIS REGION AND DETERMINE THE RATE AT WHICH THIS INCOMING ENERGY IS CONVERTED INTO THE KINETIC FIELD VARIATIONS OBSERVED. THIS WILL BE ACHIEVED USING THE METRICS OF WAVE AND PARTICLE ENERGY FLUX IN COMBINATION WITH THE APPLICATION OF A SPECTRAL APPROACH FOR LOW FREQUENCY MODE DECOMPOSITION DEVELOPED BY THE PI. THE CHARACTERIZATION OF THE LOCAL PLASMA ENVIRONMENT IN COMBINATION WITH THE MODE DECOMPOSITION WILL ALLOW THE IDENTIFICATION OF MODE CONVERSION AND THE ASSOCIATED COUPLING OF INJECTED ENERGY TO SHEAR AND COMPRESSIONAL OSCILLATIONS IN THE GEOMAGNETIC FIELDS. WE NOTE THAT THESE PROCESSES ARE TYPICALLY INVOKED AS THE MEANS FOR DRIVING THE GENERATION OF SHEAR ALFVEN WAVES AND FIELD-ALIGNED CURRENTS AT THE INNER EDGE OF THE PLASMA SHEET YET TO OUR KNOWLEDGE THERE ARE NO DIRECT MEASUREMENTS OF THE ACTION OF THESE PROCESS IN THIS ENVIRONMENT. RELEVANCE: THIS RESEARCH GOES BEYOND THE MISSION GOALS OF THE VAN ALLEN PROBES TO ADDRESS THE GOALS OF THE HELIOPHYSICS DECADAL SURVEY TO DETERMINE THE DYNAMICS AND COUPLING OF EARTH S MAGNETOSPHERE IONOSPHERE AND ATMOSPHERE AND THEIR RESPONSE TO SOLAR AND TERRESTRIAL INPUTS AND TO DISCOVER AND CHARACTERIZE FUNDAMENTAL PROCESSES THAT OCCUR BOTH WITHIN THE HELIOSPHERE AND THROUGHOUT THE UNIVERSE. THE ENERGY CONVERSION AND TRANSPORT PROCESSES WE SEEK TO EXPLORE COUPLE THE IONOSPHERE TO THE MAGNETOSPHERE VIA PROCESSES FUNDAMENTAL TO THE PLASMA ENVIRONMENT OF THE SPACE. REFERENCE: CHASTON C. C. ET AL. (2014) OBSERVATIONS OF KINETIC SCALE FIELD LINE RESONANCES GEOPHYS. RES. LETT. DOI: 10.1002/2013GL058507.
$395,732Regents Of The University Of California, The · · FY2017 · National Aeronautics and Space Administration
Core C-- Metabolism Core
$395,731William C Stanley · University Of Maryland Baltimore · P01 · FY2007 · HL
Molecular Basis of Sensory Transduction in C. elegans
$395,718Miriam B Goodman · Stanford University · R01 · FY2012 · NS
Hyper-surveillance and suicides among Black youth in the U.S.
$395,615Parvati Singh · Ohio State University · R01 · FY2025 · MH