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15,273 grants matching “antimicrobial resistance”
Catheters Designed for Decreased Clotting and Infection
$116,619Melissa M Reynolds · Mc3, Inc. · R43 · FY2007 · HL
Synthesis and Study of Medicinally Important Molecules
$116,445Mingji Dai · Emory University · R35 · FY2024 · GM
Sinorhizobium meliloti factors that affect biofilm formation and symbiosis efficiency
$116,250Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2022 · GM
Sinorhizobium meliloti factors that affect biofilm formation and symbiosis efficiency
$116,250Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2021 · GM
Sinorhizobium meliloti factors that affect biofilm formation and symbiosis efficiency
$116,250Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2023 · GM
Sinorhizobium meliloti factors that affect biofilm formation and symbiosis efficiency
$116,250Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2020 · GM
Molecular mechanism of Mincle mediated NET formation:Implications for pneumonic sepsis
$115,987Jyotika Sharma · University Of North Dakota · R01 · FY2020 · AI
HOP (HUMULUS LUPULUS) IS KNOWN FOR THE UNIQUE ARRAY OF BIOACTIVE COMPOUNDS THAT IT PRODUCES. IT HAS A LONG HISTORY OF USE IN TRADITIONAL MEDICINE. HOP PRODUCES XANTHOHUMOL, WHICH HAS ANTICANCER ACTIVITY, AND BITTER ACIDS, WHICH IMPART FLAVOR IN BREWING AND POSSESS ANTIMICROBIAL ACTIVITY. HOP IS ALSO SUSCEPTIBLE TO DISEASES INCLUDING POWDERY MILDEW (PM), WHICH REDUCES THE QUALITY AND QUANTITY OF HOP CONE YIELD. THE GENOME OF HOP IS LARGE AND COMPLEX, CHALLENGING EARLY ASSEMBLY EFFORTS. BECAUSE OF ADVANCES IN SEQUENCING AND ASSEMBLY, WE NOW HAVE A CHROMOSOME-LEVEL ASSEMBLY THAT WE CAN ANALYZE FOR GENE CONTENT AND OTHER GENOMIC FEATURES. WITH A COMPREHENSIVE ANNOTATION OF GENES, WE CAN INVESTIGATEEVOLUTIONARY PATTERNS IN HOP AND EXTENSIVELY ANALYZE GENE EXPRESSION AND FUNCTION. FIRST, LARGE-SCALE STRUCTURAL SIMILARITIES BETWEEN HOP AND CLOSELY RELATED SPECIES, INCLUDING HEMP AND MULBERRY,WILL BE IDENTIFIED BY ALIGNING GENES FROM THE HOP ASSEMBLY TO THE GENES OF THESE OTHER SPECIES. SIGNIFICANTLY SIMILAR GENE SEQUENCES WILL BE ORDERED BASED ON THEIR GENOMIC COORDINATES TO DETECT REGIONS OF CONSERVED GENE ORDER BETWEEN THE ASSEMBLIES. IN THE NEXT PHASE OF THE PROJECT, GENE EXPRESSION DURING HOP CONE DEVELOPMENT WILL BE ASSESSED. FIRST, RNA WILL BE EXTRACTED FROM CONE AND LEAF TISSUES AT FIVE DEVELOPMENTAL TIME POINTS IN CONES, FOLLOWED BY SEQUENCING AND ALIGNMENT OF RNA TO THE HOP ASSEMBLY. OVERALL, THE PURPOSE OF THIS STUDY IS TO 1) FIND GENES THAT SHOW VARIABLE EXPRESSION DURING DEVELOPMENT; 2) PREDICT THE FUNCTION OF THESE GENES BY COMPARING THEM TO GENES FROM OTHER SPECIES WITH KNOWN FUNCTION THAT HAVE A HIGHLY SIMILAR DNA SEQUENCE; 3) DETERMINE THE LOCATION OF GENES ALONG THE CHROMOSOME; AND 4) IDENTIFY OTHER GENES AND GENOMIC FEATURES SURROUNDING THESE GENES OF INTEREST.THE RESULTS OF THIS STUDY WILL HAVE AN IMPACT ON IMPROVING HOP HEALTH AND PRODUCTION. MY GOAL IS TO UNCOVER GENES THAT BOTH SHOW VARIABLE EXPRESSION DURING DEVELOPMENT AND CONTRIBUTE TO THE PRESENTATION OF DESIRED TRAITS, INCLUDING DISEASE RESISTANCE AND SYNTHESIS OF BIOACTIVE COMPOUNDS. MAPPING SIMILARITIES BETWEEN THE GENOMES OF HOP AND CLOSELY RELATED SPECIESWILL IMPROVE OUR UNDERSTANDING ABOUT THE EVOLUTIONARY HISTORY OF HOP. IT WILL ALSO PROVIDE INSIGHT ABOUT WHETHER GENES INVOLVED IN TRAITS OF INTEREST ARE CONSERVED BETWEEN SPECIES OR SHOW EVIDENCE OF SELECTIVE PRESSURE AND DUPLICATION. THE RESULTS OF THIS STUDY WILL INFORM THE DEVELOPMENT OF DISEASE-RESISTANT HOP CULTIVARS CONTAINING A DESIRED PROFILE OF BIOACTIVE COMPOUNDS THROUGH IMPROVED GENOMICS-ASSISTED BREEDING STRATEGIES. TAKEN TOGETHER, THE CHROMOSOME-LEVEL ASSEMBLY OF HOP WILL TRANSFORM HOP GENOMICS.
$115,556Oregon State University · · FY2020 · National Institute of Food and Agriculture
SC3: Regulation of polar adhesion during Sinorhizobium meliloti infection
$115,500Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2018 · GM
Alcorn Pilot
$115,500John F Alcorn · University Of Pittsburgh At Pittsburgh · P30 · FY2016 · DK
Regulatory network of a conserved polar factor in Sinorhizobium meliloti
$115,500Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2015 · GM
SC3: Regulation of polar adhesion during Sinorhizobium meliloti infection
$115,500Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2019 · GM
Alcorn Pilot
$115,500John F Alcorn · University Of Pittsburgh At Pittsburgh · P30 · FY2017 · DK
SC3: Regulation of polar adhesion during Sinorhizobium meliloti infection
$115,500Joseph Chiung-Chu Chen · San Francisco State University · SC3 · FY2017 · GM
Alcorn Pilot
$115,499John F Alcorn · University Of Pittsburgh At Pittsburgh · P30 · FY2015 · DK
INTRACELLULAR INFECTION OF HUMAN ALVEOLAR MACROPHAGES
$115,425University Of Washington · K08 · FY2000 · HL
INTRACELLULAR INFECTION OF HUMAN ALVEOLAR MACROPHAGES
$115,425University Of Washington · K08 · FY2001 · HL
POPULATION BIOLOGY AND GENETICS OF ANTIMICROBIAL ACTION
$115,388Emory University · R29 · FY2000 · GM
Reducing Infection in Indwelling Medical Devices
$115,294Ast Products, Inc. · R43 · FY2001 · AI
Hospital-Acquired Infections in the Elderly
$115,272Keith S Kaye · Wayne State University · K23 · FY2008 · AG
Inside out: Revealing strategies for intracellular S. aureus persister eradication
$115,123Kuan-Yi Lu · Univ Of North Carolina Chapel Hill · K99 · FY2025 · AI
Antimicrobial Nanocoating
$115,087R. Giles Dillingham · Brighton Technologies Group, Inc. · R44 · FY2008 · AI
Task C08: Manufacturing of a colon-delivery formulation platform of metronidazole for treating Clostridium difficile infection
$115,067Jon Mirsalis · Sri International · N01 · FY2021 · AI
NARMS Cooperative Agreement Program to Enhance and Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens - South Carolina Department of Health and Environmental Control
$115,000Megan Davis · South Carolina Department Of Public Health · U01 · FY2017 · FD
National Antimicrobial Resistance Monitoring System for Louisiana
$115,000Raoult Ratard · Louisiana State Office Of Public Health · U01 · FY2017 · FD