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24,576 grants matching “microbiome”
The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer
$350,675Richard Bernard Hayes · New York University School Of Medicine · R01 · FY2012 · CA
The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer
$350,675Richard Bernard Hayes · New York University School Of Medicine · R01 · FY2015 · CA
The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer
$350,675Richard Bernard Hayes · New York University School Of Medicine · R01 · FY2011 · CA
NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
$350,656Michael D Gershon · Columbia University Health Sciences · R01 · FY2009 · NS
Clinical Core
$350,605Bruce D Greenwald · University Of Maryland Baltimore · U19 · FY2015 · AI
Compressive Genomics for Large Omics Data Sets: Algorithms, Applications and Tools
$350,550Bonnie Berger · Massachusetts Institute Of Technology · R01 · FY2019 · GM
Research Training Program in Environmental Toxicology
$350,448Susan L Schantz · University Of Illinois At Urbana-Champaign · T32 · FY2016 · ES
Macrophage small RNA export to HDL protects against inflammation and atherosclerosis
$350,325Kasey C Vickers · Vanderbilt University Medical Center · P01 · FY2024 · HL
Developing Advanced Algorithms to Address Major Computational Challenges in Current Microbiome Research
$350,321Yijun Sun · State University Of New York At Buffalo · R01 · FY2018 · AI
Bioanalytical Core
$350,307Narendra P Singh · University Of South Carolina At Columbia · P20 · FY2022 · GM
Compressive Genomics for Large Omics Data Sets: Algorithms, Applications and Tools
$350,181Bonnie Berger · Massachusetts Institute Of Technology · R01 · FY2018 · GM
Interdisciplinary Immunology Training Program
$350,163David G. Schatz · Yale University · T32 · FY2020 · AI
Novel PET Radiotracers for Imaging Infection
$350,142Peter J Tonge · State University New York Stony Brook · R01 · FY2020 · EB
Novel PET Radiotracers for Imaging Infection
$350,142Peter J Tonge · State University New York Stony Brook · R01 · FY2019 · EB
Novel PET Radiotracers for Imaging Infection
$350,142Peter J Tonge · State University New York Stony Brook · R01 · FY2018 · EB
Project 3
$350,055Peter Belenky · Miriam Hospital · P20 · FY2018 · GM
Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center
$350,000James A Tonascia · Johns Hopkins University · U24 · FY2020 · DK
Impact of the Microbiome on the Efficacy of Radiation Therapy
$350,000Stephen L. Shiao · Cedars-Sinai Medical Center · R01 · FY2020 · CA
Impact of the Microbiome on the Efficacy of Radiation Therapy
$350,000Stephen L. Shiao · Cedars-Sinai Medical Center · R01 · FY2017 · CA
Understanding the genomic basis and evolutionary history of lactase persistence, and the dynamics of the associated gut microbiome, in pastoralist populations
$350,000Michael C Campbell · University Of Southern California · · FY2021 · SBE
Collaborative Research: Novel Statistical Tools for Metagenomics and Metabolomics Data
$350,000Jun Liu · Harvard University · · FY2019 · MPS
NECROTIC ENTERITIS (NE) CAUSED BY CLOSTRIDIUM PERFRINGENS INFECTION HAS REEMERGED AS A PREVALENT POULTRY DISEASE WORLDWIDE BECAUSE OF RESTRICTING USAGE OF PROPHYLACTIC ANTIBIOTICS UNDER CONSUMER PREFERENCES AND REGULATORY PRESSURES. IT IS ESTIMATED THAT NE COSTS POULTRY INDUSTRY $6 BILLION EVERY YEAR WORLDWIDE. FEW EFFECTIVE ANTIMICROBIAL ALTERNATIVES ARE AVAILABLE TO PREVENT AND TREAT NE. THE LONG TERM GOAL OF THIS PROPOSAL IS TO IDENTIFY SPECIFIC MICROBIOME AND ITS DOWNSTREAM TARGETS AS EFFECTIVE AND SUSTAINABLE ANTIMICROBIAL ALTERNATIVES TO REDUCE NECROTIC ENTERITIS. OUR PRELIMINARY DATA SHOWED THAT MICROBIOTA METABOLIC PRODUCT DEOXYCHOLIC ACID (DCA) PREVENTED EIMERIA MAXIMA AND C. PERFRINGENS-INDUCED NE, PRODUCTIVITY LOSS, SEVERE INTESTINAL INFLAMMATION, AND CELL DEATH. FOLLOWING MECHANISM STUDIES REVEALED THAT C. PERFRINGENS SPORULATION AND INFLAMMATORY COX SIGNALING DROVE NE DEVELOPMENT AND DCA REDUCED THEM. BASING ON THESE DATA AND CURRENT STATE OF KNOWLEDGE, WE HYPOTHESIZE THAT MICROBIOTA METABOLIC PRODUCT DCA ATTENUATES NE THROUGH REDUCING INFLAMMATORY RESPONSE AND C. PERFRINGENS SPORULATION. IN CURRENT PROPOSAL, WE WILL INVESTIGATE MECHANISM ON HOW INFLAMMATORY SIGNALING PATHWAYS AND C. PERFRINGENS VIRULENCE MODULATE NE OUTCOME AT MOLECULAR LEVELS AND IN CHICKENS. MORE SPECIFICALLY, WE AIM TO IMPLEMENT THE FOLLOWING OBJECTIVES.OBJECTIVE 1: EVALUATE THE CONTRIBUTION OF DCA-ATTENUATED INFLAMMATORY COX-2 SIGNALING ON NE. OBJECTIVE 2: DETERMINE THE ROLE OF DCA-REDUCED C. PERFRINGENS SPORULATION ON NE.UPON COMPLETION, THIS PROJECT COULD SIGNIFICANTLY IMPROVE POULTRY PRODUCTIVITY AND PROVIDE EFFECTIVE AND NEW APPROACHES FOR ANTIMICROBIAL FREE FEEDING REGIMENTS.
$350,000Division Of Agriculture Of The University Of Arkansas · · FY2020 · National Institute of Food and Agriculture
Understanding the genomic basis and evolutionary history of lactase persistence, and the dynamics of the associated gut microbiome, in pastoralist populations
$350,000Michael C Campbell · Howard University · · FY2020 · SBE
Impact of the Microbiome on the Efficacy of Radiation Therapy
$350,000Stephen L. Shiao · Cedars-Sinai Medical Center · R01 · FY2021 · CA
Impact of the Microbiome on the Efficacy of Radiation Therapy
$350,000Stephen L. Shiao · Cedars-Sinai Medical Center · R01 · FY2018 · CA