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51,593 grants matching “hepatitis”
A new mechanism of hepatocyte proliferation under stress
$472,898Gen-Sheng Feng · University Of California, San Diego · R01 · FY2023 · DK
Role of CREG1 in metabolic homeostasis
$472,845Shaohua Li · Rutgers Biomedical And Health Sciences · R01 · FY2024 · DK
Mechanisms of Hepadnavirus Assembly and Replication
$472,793Jianming Hu · Pennsylvania State Univ Hershey Med Ctr · R37 · FY2025 · AI
Regulation of hepatic hepcidin expression by transferrin receptor-2
$472,790Caroline Enns · Oregon Health & Science University · R01 · FY2024 · DK
Targeted-and Image-Based Adenovirus Cancer Therapeutic Vectors
$472,780David T Curiel · Washington University · R01 · FY2012 · CA
Use of New Hepatitis C Drugs and Patients' Health Outcomes in Medicare
$472,768Jeah Jung · Pennsylvania State University, The · R01 · FY2018 · AG
IMMUNOTHERAPY
$472,747Duke University · P01 · FY2000 · CA
Mechanisms of innate immunity against HIV
$472,725Tariq M Rana · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2012 · AI
Mechanisms of innate immunity against HIV
$472,725Tariq M Rana · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2011 · AI
ALCOHOL EFFECTS ON SUBCELLULAR ORGANELLES OF THE LIVER
$472,719Thomas Jefferson University · R37 · FY2000 · AA
Molecular Epidemiology of Pancreatic Cancer
$472,715Paige M. Bracci · University Of California, San Francisco · R01 · FY2010 · CA
Mechanisms of Sex-specific Metabolic Disruption Caused by Organophosphate Flame Retardant Exposure
$472,702Cetewayo Saif Rashid · University Of Kentucky · R01 · FY2025 · ES
Cleavage Products of Dietary Carotenoids: Occurrence & Nutritional Function
$472,684Earl Howard Harrison · Ohio State University · R01 · FY2011 · HL
CELLULAR MECHANISMS OF INSULIN RESISTANCE IN HUMANS
$472,661Yale University · R01 · FY2000 · DK
RECENT STUDIES INDICATE GUT MICROBIOTA IS INVOLVED IN DEVELOPMENT OF CARDIOVASCULAR DISEASE. GUT MICROBIOTA TRANSFORM CHOLINE AND CARNITINE, COMMONLY FOUND IN MEAT OR EGG YOLK, TO TRIMETHYLAMINE (TMA), WHICH CAN THEN BE CONVERTED INTO TRIMETHYLAMINEN-OXIDE (TMAO) BY HEPATIC ENZYMES. TMAO ACCELERATES ATHEROSCLEROSIS AND IS ASSOCIATED WITH MAJOR ADVERSE CARDIAC EVENTS. THERE IS SOLID REASONING FOR INVESTIGATING ORANGE PEEL TO MODULATE GUT MICROBIOTA SUBSEQUENTLY INHIBITING TMAO FORMATION: 1) OUR PRELIMINARY STUDY SHOWED ORANGE PEEL CAN INHIBIT TMAO FORMATIONIN VIVOVIAALTERATION OF GUT MICROBIOTA AS WELL AS INHIBIT A MICROBIAL CARNITINE-SPECIFIC TMA ENZYME TO PREVENT CARNITINE TRANSFORMING INTO TMAIN VITRO. 2) APPROXIMATELY FIVE MILLION TONS OF ORANGE PEEL ARE GENERATED ANNUALLY IN THE US; 3) NATURAL ORANGE PEEL EXTRACTS ARE CONSIDERED SUBSTANCES GENERALLY RECOGNIZED AS SAFE (GRAS) BY THE FDA; 4) INCREASED USAGE OF ORANGE PEEL DIRECTED AT IMPROVING HEART HEALTH COULD POTENTIALLY PROVIDEADDITIONAL ECONOMIC RETURNS BENEFITING US AGRICULTURE AND FOOD SYSTEMS. THE HYPOTHESES OF THIS PROJECT ARE ORANGE PEEL CAN EFFECTIVELY PREVENT DEVELOPMENT OF ATHEROSCLEROSIS VIA MODIFYING GUT MICROBIOTA, AND ORANGE PEEL CONTAINS BIOACTIVE COMPONENTS THAT INTERFERE WITH ACTIVITY OF CARNITINE-SPECIFIC TMA ENZYMES. TO TEST THESE HYPOTHESES, OUR INTERDISCIPLINARY TEAM WILL COMBINE ANIMAL STUDIES AND NATURAL PRODUCTS CHEMISTRY WITHIN VITROENZYME ASSAYS TO ASSESS PATHWAYS ASSOCIATED WITH ORANGE PEEL CONSUMPTION, TMA/TMAO METABOLISM AND PREVENTION OF ATHEROSCLEROSIS AS WELL AS IDENTIFY TMA INHIBITORS, RESPECTIVELY.
$472,623University Of Florida · · FY2019 · National Institute of Food and Agriculture
Clinical Research Network in NASH
$472,508University Of California San Francisco · U01 · FY2004 · DK
ER-mitochondrial communication in calcium signaling, energy metabolism and liver disease
$472,507Gyorgy Hajnoczky · Thomas Jefferson University · R01 · FY2023 · DK
Inter- and transgenerational effects of paternal arsenic exposure
$472,448Zheng Sun · Baylor College Of Medicine · R01 · FY2025 · ES
Inter- and transgenerational effects of paternal arsenic exposure
$472,448Zheng Sun · Baylor College Of Medicine · R01 · FY2024 · ES
Inter- and transgenerational effects of paternal arsenic exposure
$472,447Zheng Sun · Baylor College Of Medicine · R01 · FY2023 · ES
Mechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLD
$472,438Madesh Muniswamy · University Of Texas Hlth Science Center · R01 · FY2025 · DK
Diagnostics for Sepsis and Community-Acquired Pneumonia
$472,430William G Weisburg · Nanogen, Inc. · U01 · FY2008 · AI
A new mechanism of hepatocyte proliferation under stress
$472,419Gen-Sheng Feng · University Of California, San Diego · R01 · FY2021 · DK
The Lipid Protein Family and Triglyceride Metabolism
$472,413Karen Reue · University Of California Los Angeles · P01 · FY2009 · HL
Expanding Treatment of Opioid Dependence Among the Privately Insured
$472,392Colleen L Barry · Yale University · R01 · FY2009 · DA