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38,696 grants matching “als”
Determining the molecular basis of adaptive stress-triggered protein phase separation
$406,685David Allan Drummond · University Of Chicago · R01 · FY2020 · GM
Determining the molecular basis of adaptive stress-triggered protein phase separation
$406,685David Allan Drummond · University Of Chicago · R01 · FY2018 · GM
Determining the molecular basis of adaptive stress-triggered protein phase separation
$406,685David Allan Drummond · University Of Chicago · R01 · FY2019 · GM
Determining the molecular basis of adaptive stress-triggered protein phase separation
$406,685David Allan Drummond · University Of Chicago · R01 · FY2021 · GM
Exploring oncogenic translation programs in cancer
$406,648Hans-Guido Wendel · Sloan-Kettering Inst Can Research · R01 · FY2017 · CA
Exploring oncogenic translation programs in cancer
$406,648Hans-Guido Wendel · Sloan-Kettering Inst Can Research · R01 · FY2016 · CA
Exploring oncogenic translation programs in cancer
$406,648Hans-Guido Wendel · Sloan-Kettering Inst Can Research · R01 · FY2018 · CA
Carbohydrate Antigen-bearing Nanoparticles for Anti-adhesives and Tumor Vaccines
$406,632Joseph John Barchi · Division Of Basic Sciences - Nci · ZIA · FY2011 · CA
Understanding Spin Diffusion Lengths in Metals and Oxides
$406,622Christopher Leighton · University Of Minnesota-Twin Cities · · FY2018 · MPS
Cellular, kinetic, and structural mechanisms of toxicity in light chain amyloidosis
$406,558Marina Ramirez-Alvarado · Mayo Clinic Rochester · R01 · FY2021 · GM
Cellular, kinetic, and structural mechanisms of toxicity in light chain amyloidosis
$406,558Marina Ramirez-Alvarado · Mayo Clinic Rochester · R01 · FY2020 · GM
Structure and Function of CTCF: Mouse Model Studies
$406,550Fred Hutchinson Cancer Research Center · R01 · FY2005 · CA
Structure and Function of CTCF: Mouse Model Studies
$406,550Fred Hutchinson Cancer Research Center · R01 · FY2004 · CA
From Fear to Anxious Misery: Developing a Defense Circuit Dimensional Classifier
$406,502Peter J Lang · University Of Florida · R01 · FY2013 · MH
Developing novel LOX inhibitors to target chemotherapy resistant TNBC
$406,500Ozgur Sahin · Loxigen, Inc. · R42 · FY2023 · CA
A biodegradable barrier preventing anastomotic leaks after esophagectomy
$406,500Scott Kelley · Safeguard Surgical Llc · R43 · FY2025 · CA
The Physiological and Relational Bases of Persistent Posttraumatic Stress in Latino Immigrant Youth
$406,491Jeremy Bechelli · Sam Houston State University · R15 · FY2019 · MD
Neural Mechanisms of Chemotherapy-Induced Cognitive Dis
$406,478Dartmouth College · R01 · FY2004 · CA
Research Training in Child Psychiatry
$406,474David S. Shaffer · Columbia University Health Sciences · T32 · FY2008 · MH
Fair Play: Bias Literacy and Resiliency Training to Empower the Future Biomedical Workforce
$406,428Christine Maidl Pribbenow · University Of Wisconsin-Madison · R25 · FY2021 · GM
Fair Play: Bias Literacy and Resiliency Training to Empower the Future Biomedical Workforce
$406,428Christine Maidl Pribbenow · University Of Wisconsin-Madison · R25 · FY2024 · GM
Fair Play: Bias Literacy and Resiliency Training to Empower the Future Biomedical Workforce
$406,428Christine Maidl Pribbenow · University Of Wisconsin-Madison · R25 · FY2020 · GM
Fair Play: Bias Literacy and Resiliency Training to Empower the Future Biomedical Workforce
$406,428Christine Maidl Pribbenow · University Of Wisconsin-Madison · R25 · FY2023 · GM
Fair Play: Bias Literacy and Resiliency Training to Empower the Future Biomedical Workforce
$406,428Christine Maidl Pribbenow · University Of Wisconsin-Madison · R25 · FY2022 · GM
THE GOAL OF THIS PROPOSAL IS TO DETERMINE THE RELIABILITY OF A SINGLE DEUTERIUM TO HYDROGEN RATIO (D/H) MEASUREMENT IN THE COMA OF A COMET. D/H IN COMETARY WATER IS A CRITICAL TOOL FOR EVALUATING THE ORIGIN OF WATER ON EARTH AND OTHER SOLAR SYSTEM BODIES. POTENTIAL VARIATIONS WITH TIME OR SPATIALLY WITHIN THE COMA COULD HAVE A SIGNIFICANT IMPACT ON STUDIES OF THE ORIGIN AND EVOLUTION OF THE SOLAR SYSTEM. RECENT OBSERVATIONS OF COMET C/2014 Q2 (LOVEJOY) SHOW A FACTOR OF ~2 DIFFERENCE BETWEEN D/H MEASURED BEFORE AND AFTER PERIHELION. THESE DIFFERENCES COULD BE DUE TO OBSERVATION METHODS OR THEY COULD INDICATE A CHANGE IN D/H. IF D/H DID CHANGE THE VARIABILITY OBSERVED AMONG COMETS MAY BE PARTIALLY RELATED TO PROCESSES ON THE NUCLEUS AND IN THE COMA. ACCORDING TO PAGANINI ET AL. (2017): A PROPER ASSESSMENT OF POSSIBLE EVOLUTIONARY EFFECTS ON THE D/H RATIO IN A COMET WOULD REQUIRE CADENCED ASTRONOMICAL OBSERVATIONS USING THE SAME FACILITY/TECHNIQUE TO AVOID POSSIBLE SYSTEMATICS. WE DEMONSTRATE HERE THAT STATISTICALLY SIGNIFICANT VARIATION IN THE D/H WAS OBSERVED WITH THE ROSETTA ORBITER SPECTROMETER FOR ION AND NEUTRAL ANALYSIS (ROSINA) DOUBLE FOCUSING MASS SPECTROMETER (DFMS) ESTABLISHING THAT THIS IS THE IDEAL DATASET TO PROVIDE THE ASSESSMENT RECOMMENDED BY P17. IN ORDER TO ACHIEVE OUR GOAL WE WILL ANSWER FOUR SCIENCE QUESTIONS: 1. DO SUBLIMATION PROCESSES AFFECT THE D/H OBSERVED IN A COMA? 2. DOES DUST ON THE COMET SURFACE INFLUENCE THE D/H IN WATER OBSERVED IN A COMA? 3. DO ENERGETIC IONS INFLUENCE THE D/H ON SHORT TIME SCALES? 4. WHAT LEVEL OF UNCERTAINTY EXISTS FOR A SINGLE D/H MEASUREMENT FOR A COMET? THE PROPOSED WORK IS DIRECTLY RELEVANT TO THE NASA RDAP PROGRAM BECAUSE THE RESULTS WILL ENHANCE THE SCIENTIFIC RETURN OF THE ROSETTA MISSION. FURTHERMORE ALTHOUGH THE PI HAS EXTENSIVE EXPERIENCE WITH ISOTOPIC STUDIES SHE HAS NEVER BEEN FUNDED TO WORK WITH THE ROSINA DFMS DATA. THEREFORE THIS PROPOSAL WILL BROADEN THE SCIENTIFIC PARTICIPATION IN THE ANALYSIS OF ARCHIVED DATA COLLECTED FROM THE ROSETTA AND PHILAE SPACECRAFT.
$406,410The Johns Hopkins University · · FY2020 · National Aeronautics and Space Administration