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15,273 grants matching “antimicrobial resistance”
Contribution of IL36 Family Members to Lung Immunity
$132,053Melissa Ann Kovach · University Of Michigan At Ann Arbor · K08 · FY2014 · HL
Epidemiology and Genomics of Multidrug resistant Salmonella Typhi infections in Kenya: The role of carriage in an endemic setting
$132,013Samuel M Kariuki · Kenya Medical Research Institute (Kemri) · R01 · FY2021 · AI
Fecal Bacteriotherapy for Relapsing Clostridium difficile Infection
$131,945Colleen Renee Kelly · Miriam Hospital · R21 · FY2013 · DK
Colistimethate Dose Optimization in Infants and Children
$131,907John S Bradley · University Of California, San Diego · U54 · FY2012 · HD
Understanding the Drivers of Antibiotic use in the Treatment of Childhood Diarrhea and Relationship to Antibiotic Resistance in China
$131,904Sean Y Sylvia · Univ Of North Carolina Chapel Hill · K01 · FY2023 · AI
Understanding the Drivers of Antibiotic use in the Treatment of Childhood Diarrhea and Relationship to Antibiotic Resistance in China
$131,857Sean Y Sylvia · Univ Of North Carolina Chapel Hill · K01 · FY2022 · AI
VTEU: POPULATION PHARMACOKINETIC ANALYSES
$131,810Clarence Buddy Creech · · N01 · FY2017 · AI
Novel Ribostamycins and SAR Study of Ring III Aminosugar
$131,797Cheng-Wei T Chang · Utah State University · R01 · FY2007 · AI
Characterizing Antimicrobial Resistance in Pharyngeal Neisseria gonorrhoeae Infections and the Role of Commensal Neisseria Species
$131,757Johan Humberto Melendez · Johns Hopkins University · K01 · FY2020 · AI
Interdisciplinary Training Program--Infectious Diseases
$131,747University Of Michigan At Ann Arbor · T32 · FY2004 · AI
MICROBIAL PATHOGENS CAUSE SEVERE CROP LOSSES AND SIGNIFICANT FINANCIAL DAMAGE AROUND THE WORLD. A WARMING CLIMATE, INCREASING PESTICIDE RESISTANCE, AND ENVIRONMENTAL DAMAGE FROM PESTICIDE OVERUSE FURTHER NECESSITATES THE NEED FOR NEW PATHOGEN CONTROL STRATEGIES. SPRAY-INDUCED GENE SILENCING (SIGS), WHICH RELIES UPON RNA INTERFERENCE, IS AN EFFECTIVE AND ECO-FRIENDLY METHOD OF DISEASE CONTROL. HOWEVER, SIGS REMAINS LIMITED BY A DEPENDENCE ON PASSIVE MICROBIAL RNA UPTAKE AND THE INSTABILITY OF RNA IN THE ENVIRONMENT. BUILDING UPON HOW NANOPARTICLES CAN PROTECT AND DELIVER RNA IN VACCINES, THIS PROJECT WILL DEVELOP PLANT-DERIVED NANOVESICLES (PDNVS) AS A NEW NANOPARTICLE PLATFORM FOR DELIVERING RNA AND OTHER BIOACTIVE MOLECULES TO STUDY AND COMBAT MICROBIAL PATHOGENS. PDNVS FROM VARIOUS PLANT SOURCES WILL BE EXAMINED FOR THEIR ABILITY TO IMPROVE RNA DELIVERY TO PATHOGENS WITH VARYING INHERENT RNA UPTAKE CAPABILITIES. RNA-LOADED PDNVS WILL THEN BE USED FOR SIGS TO DETERMINE IF THEY CAN EFFECTIVELY REDUCE PATHOGENICITY AND PROVIDE PROLONGED DISEASE PROTECTION ON PLANTS. ANALYSIS OF THE DIFFERENT PDNV COMPOSITIONS WILL IDENTIFY KEY FEATURES THAT CONTROL RNA LOADING IN NANOPARTICLES AND SUBSEQUENT VESICLE UPTAKE BY MICROBES. THIS WORK WILL DEMONSTRATE HOW PDNVS, WHICH ARE ECO-FRIENDLY, ECONOMICAL, AND EASILY SCALABLE, CAN BE USED TO IMPROVE AND EXTEND SIGS TO PREVIOUSLY RECALCITRANT MICROBES. UNDERSTANDING WHAT FEATURES CONTROL NANOPARTICLE LOADING AND MICROBIAL UPTAKE WILL FACILITATE THE DESIGN OF MORE EFFECTIVE AND ROBUST ANTIMICROBIAL STRATEGIES FOR AGRICULTURE AND HUMAN HEALTH.
$131,742Regents Of The University Of California At Riverside · · FY2023 · National Institute of Food and Agriculture
Targeting non-coding RNAs as host-directed drug therapy for tuberculosis
$131,718Reto Guler · University Of Cape Town · R01 · FY2024 · AI
Targeting non-coding RNAs as host-directed drug therapy for tuberculosis
$131,642Reto Guler · University Of Cape Town · R01 · FY2023 · AI
Characterizing Antimicrobial Resistance in Pharyngeal Neisseria gonorrhoeae Infections and the Role of Commensal Neisseria Species
$131,603Johan Humberto Melendez · Johns Hopkins University · K01 · FY2021 · AI
Interdisciplinary Training Program--Infectious Diseases
$131,588University Of Michigan At Ann Arbor · T32 · FY2005 · AI
Interdisciplinary Training Program--Infectious Diseases
$131,588Betsy Foxman · University Of Michigan At Ann Arbor · T32 · FY2006 · AI
Prevention of Candidiasis in Critically III Patients
$131,490Johns Hopkins University · K23 · FY2005 · AI
Prevention of Candidiasis in Critically III Patients
$131,490Shelley L Magill · Johns Hopkins University · K23 · FY2006 · AI
Prevention of Candidiasis in Critically III Patients
$131,490Johns Hopkins University · K23 · FY2003 · AI
Prevention of Candidiasis in Critically III Patients
$131,490Shelley L Magill · Johns Hopkins University · K23 · FY2007 · AI
Prevention of Candidiasis in Critically III Patients
$131,490Johns Hopkins University · K23 · FY2004 · AI
Using Small Compounds as Probes for Studying Mechanosensitive Channel Gating
$131,437Paul L Blount · Ut Southwestern Medical Center · R01 · FY2017 · GM
Administrative Core
$131,325Suzanne L. Walker · Harvard Medical School · U19 · FY2023 · AI
Tennessee Department of Health: NARMS Cooperative Agreement Program to Enhance and Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens
$131,237John Robert Dunn · Tennessee State Department Of Health · U01 · FY2017 · FD
Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program
$131,206Lona Mody · University Of Michigan At Ann Arbor · K24 · FY2015 · AG