Sort
38,696 grants matching “als”
Mali International Center for Excellence in Research
$407,551Heinrich Feldmann · National Institute Of Allergy And Infectious Diseases · ZIA · FY2014 · AI
Osteoprotegerin Regulation of the Atherosclerotic Lesion Expansion
$407,528Marta Scatena · University Of Washington · R01 · FY2011 · HL
Mechanisms and Function of Myonuclear Positioning
$407,518Mary K Baylies · Sloan-Kettering Inst Can Research · R01 · FY2014 · AR
Genetic relationships between PTSD and Alcohol Use Disorder: Integrating GWAS and Deeply Phenotyped Longitudinal data.
$407,498Jacquelyn Leigh Meyers · Suny Downstate Medical Center · R01 · FY2024 · AA
THIS EFFORT WILL USE APSS PRESSURE AND WIND DATA TO NOT ONLY DETECT BUT IDENTIFY THE SIZE AND TRAJECTORY OF CONVECTIVE VORTICES SUCH AS DUST DEVILS USING METHODS PROVEN WITH TERRESTRIAL FIELD DATA (LORENZ ICARUS 271 326-337). ORBITAL DATA SHOW THAT DUST DEVILS FORM ABUNDANT TRACKS AT THE INSIGHT LANDING SITE (REISS AND LORENZ ICARUS 266 315-330). THE PROPOSER HAS DEMONSTRATED THAT THE LOW PRESSURE CORES OF SUCH VORTICES ACTING AS A NEGATIVE LOAD ON THE GROUND CREATES A PROMINENT SIGNATURE IN SURFACE TILT WHICH WILL BE DETECTABLE BY THE INSIGHT SEIS INSTRUMENT (LORENZ ET AL. BULL. SEISMOLOGICAL SOC. AM. 105 3015-3023). EVEN COARSE SEIS DATA CAN HELP RESOLVE AMBIGUITIES IN TRAJECTORY RETRIEVAL AND THE GOAL OF THIS INVESTIGATION WILL BE TO PRODUCE A CATALOG OF WELL-CHARACTERIZED VORTEX ENCOUNTERS. THIS CATALOG WILL BE MADE AVAILABLE TO ALLOW THE ESTIMATION OF GROUND ELASTIC PROPERTIES FROM THE TILT MEASUREMENT AND TO SEARCH FOR POSSIBLE SIGNATURES OF DUST DEVIL ENCOUNTER IN OTHER INSIGHT INSTRUMENTATION INCLUDING THE RADIOMETER IFG AND HP3 (E.G. LORENZ ICARUS 250 262-267). THIS PROPOSAL RESPONDS DIRECTLY TO THE SOLICITATION BY BROADENING SCIENTIFIC PARTICIPATION AND INVESTIGATING ATMOSPHERIC PHENOMENA AND SURFACE INTERACTIONS.
$407,473The Johns Hopkins University · · FY2020 · National Aeronautics and Space Administration
Regulation of deubiquitinating enzymes
$407,430Yihong Ye · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2012 · DK
Protocolized Care for Early Septic Shock (ProCESS)
$407,271Derek C Angus · University Of Pittsburgh At Pittsburgh · P50 · FY2011 · GM
Functional Activity Mapping of Brain Networks
$407,257Carol A. Barnes · University Of Arizona · RC1 · FY2009 · AG
GIVEN THE FAR-REACHING SUCCESS OF THE CASSINI MISSION IT IS CURIOUS AND DISTURBING THAT WE STILL DO NOT UNDERSTAND THE BOMBARDMENT HISTORY OF SATURN S SATELLITES. THIS IS DESPITE THE FACT WE NOW HAVE EXCEPTIONAL IMAGERY OF SATURN S MOONS AND THAT MANY GROUPS HAVE REPORTED ON THEIR CRATER HISTORIES (E.G. KIRCHOFF ET AL. 2009). AS WE SHOW IN THIS PROPOSAL THESE CRATER DATA WHEN CONSIDERED AS A SYSTEM RATHER THAN MOON BY MOON REVEAL SEVERAL INTRIGUING PROBLEMS: 1. THE WAVY CRATER SIZE FREQUENCY DISTRIBUTIONS (SFDS) FOUND ON MIMAS-SIZED BODIES FROM CALLISTO TO MIMAS-IAPETUS ARE REMARKABLY SIMILAR IN SHAPE TO ONE ANOTHER. SHOCKINGLY THIS SHAPE ALSO MATCHES THE SFD OF MAIN BELT ASTEROIDS. DYNAMICALLY ASTEROIDS ARE UNLIKELY TO BE A MAJOR SOURCE OF IMPACTORS FOR SATURN S MOONS SO WHAT DOES THIS MEAN? 2. MIMAS LOCATED DEEP INSIDE SATURN S GRAVITY WELL AT ~3 RSATURN HAS NEARLY THE SAME CRATER SIZE FREQUENCY DISTRIBUTION PER KM+2 AS DISTANT IAPETUS AT ~60 RSATURN. THIS IS SURPRISING; NEITHER SHOWS SIGNS OF RESURFACING AND GRAVITATIONAL FOCUSING OF COMETS THROUGH SATURN S SYSTEM SHOULD CREATE 17 MORE IMPACTS PER KM+2 ON MIMAS THAN IAPETUS! ACCORDINGLY CRATER DATA ON SATURN S MOONS CHALLENGES OUR SATELLITE FORMATION-EVOLUTION MODELS. UNTIL INTERPRETED WE CANNOT EASILY ATTACK KEY DECADAL SURVEY GOALS (E.G. WHEN/HOW DID SATURN S MOONS FORM WERE THEY AFFECTED BY GAS GIANT MIGRATION WHEN WERE GEOLOGIC PROCESSES ACTIVE ON SATURN S MOONS AND DID IMPACTS HEAT UP OR DELIVER ORGANICS TO SATURN S MOONS?). HERE WE PROPOSE TO ATTACK THESE PROBLEMS BY MODELING IMPACTORS STRIKING THESE SATELLITES COMPARING OUR RESULTS TO PUBLISHED CRATER AND SATELLITE GRAVITY DATA AND THEN USING THE RESULTS TO CONSTRAIN UNEXPLORED ASPECTS OF THE NICE MODEL . IN THE NICE MODEL GIANT PLANET MIGRATION SCATTERED A DISK OF PLANETESIMALS ONCE LOCATED BEYOND NEPTUNE. THIS DISK WAS COLLISIONALLY-EVOLVED LIKE THE MAIN BELT WHICH GAVE IT A WAVY MAIN BELT-LIKE SFD. THIS PROCESS NOT ONLY SENT COMET-LIKE BODIES THROUGH SATURN S SYSTEM WHERE MANY HIT SATELLITES BUT IT ALSO CAPTURED COMETS INTO ORBIT AROUND SATURN VIA SATURN-GIANT PLANET ENCOUNTERS. WHILE SOME BECAME STABLE IRREGULAR SATELLITES (NESVORNY ET AL. 2007) MANY MORE SHOULD HAVE STRUCK THE OUTERMOST REGULAR SATELLITES. WE ARGUE THESE IRREGULAR SATELLITES REPRESENT A MISSING BOMBARDMENT POPULATION THAT CAN EXPLAIN WHY MIMAS TO IAPETUS HAVE SIMILAR CRATER SFDS (I.E. ALL PROJECTILES CAME FROM SAME SOURCE) AND WHY HIGH CRATER SPATIAL DENSITIES ARE FOUND ON HYPERION/IAPETUS (I.E. IRREGULARS PREFER HITTING DISTANT MOONS). BY MODELING THIS SCENARIO WE CAN INTERPRET THE HISTORIES OF SATURN S SATELLITES AS TOLD BY THEIR CRATERS AND ALSO DATE THEIR GEOLOGIC FEATURES. OUR TASKS ARE: TASK 1. USING PUBLISHED RESULTS FROM COI NESVORNY'S LATEST VERSION OF THE NICE MODEL WE WILL USE NUMERICAL SIMULATIONS TO TRACK THE ORBITAL HISTORIES IMPACT RATES AND COLLISION VELOCITIES FOR BOTH HELIOCENTRIC PROJECTILES AND CAPTURED IRREGULAR SATELLITES STRIKING SATURN S SATELLITES. TASK 2. APPLYING AN IMPROVED ESTIMATE OF THE PRIMORDIAL DISK SFD ONCE LOCATED BEYOND NEPTUNE TO OUR TASK 1 RESULTS WE WILL INTERPRET CASSINI-DERIVED CRATER RECORDS FROM MIMAS TO PHOEBE DURING THE LATE HEAVY BOMBARDMENT AND GENERATE A NEW CHRONOLOGY FOR GEOLOGIC PROCESSES ON THESE WORLDS. WE WILL ALSO EXPLORE (I) THE LEADING/TRAILING CRATER POPULATIONS FOUND ON RHEA/IAPETUS (II) WHETHER SPECIFIC CRATER SFDS ARE SATURATED (E.G. MIMAS HYPERION) AND (III) HOW COLLISIONAL EVOLUTION AMONG CAPTURED IRREGULARS AFFECTED CRATER PRODUCTION ON PHOEBE. TASK 3. LARGE PROJECTILES CAN DELIVER SUBSTANTIAL IMPACT ENERGY AND HEAT TO SATELLITES. THIS COULD AFFECT THEIR INTERNAL STRUCTURE PRODUCING AN IRREGULAR GRAVITY FIELD OR INDUCE/PRESERVE SUBSURFACE OCEANS. USING OUR IMPACT FLUX MODELS WITH GRAVITY DATA FROM CASSINI FLYBYS WE WILL PROBE THIS ISSUE FOR TETHYS/RHEA USING AN IMPACT-TRIGGERED SATELLITE DIFFERENTIATION MODEL.
$407,152Southwest Research Institute · · FY2020 · National Aeronautics and Space Administration
Molecular Mechanism of Synaptic Plasticity
$407,138Motojiro Yoshihara · Univ Of Massachusetts Med Sch Worcester · R01 · FY2012 · MH
Molecular Mechanism of Synaptic Plasticity
$407,138Motojiro Yoshihara · Univ Of Massachusetts Med Sch Worcester · R01 · FY2011 · MH
Prevalence effects in visual search: Theoretical and practical implications
$407,138Jeremy M Wolfe · Brigham And Women'S Hospital · R01 · FY2010 · EY
Biomechanical Optimization of TE Heart Valves
$407,075Michael S Sacks · University Of Pittsburgh At Pittsburgh · R01 · FY2008 · HL
Interleukin-6 and Retinal Ganglion Cell Degeneration in Glaucoma
$407,006Rebecca M Sappington · Vanderbilt University · R01 · FY2014 · EY
Aging, Calorie Restriction and Insulin Sensitivity
$406,984Gregory D. Cartee · University Of Michigan At Ann Arbor · R01 · FY2021 · AG
Animal testing of RNA aptamers as ALS drug candidate
$406,950Li Niu · State University Of New York At Albany · R01 · FY2023 · NS
Synapse Remodeling and Neuronal MHC Class I
$406,912Carla J Shatz · Stanford University · R01 · FY2012 · MH
Genetic influences on alcoholism vulnerability in American Indians
$406,893David Goldman · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2010 · AA
Development of fast penumbral imaging in acute ischemic stroke
$406,891Phillip Zhe Sun · Emory University · R01 · FY2024 · NS
Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in Am.
$406,865David O Quissell · University Of Colorado Denver · U54 · FY2014 · DE
Enhancement of user access at the ALS
$406,850National Institute Of General Medical Sciences · Y01 · FY2009 · GM
Optimizing the Combination of Electric and Acoustic Hearing
$406,841Christopher W Turner · University Of Iowa · RC1 · FY2009 · DC
Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Bind, Placebo-Controlled Phase II to Phase III Study
$406,827Ellen Mary Lavoie Smith · University Of Michigan At Ann Arbor · R01 · FY2019 · CA
Healthy Children, Strong Families and Supportive Communities Intervention
$406,790Alexandra K Adams · University Of Wisconsin-Madison · U01 · FY2009 · HL
Reducing residual depressive symptoms with web-based Mindful Mood Balance
$406,773Zindel V Segal · University Of Toronto · R01 · FY2015 · MH