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64,565 grants matching “drug discovery”
Biocontainment Research support services core
$650,619Farhang Alem · George Mason University · UC7 · FY2025 · AI
Mechanisms of the Development and Maintenance of Salmonella Gallbladder Carriage
$650,502John S Gunn · Research Inst Nationwide Children'S Hosp · R01 · FY2022 · AI
Regulation of resistance to CDK4/6 inhibitor in breast cancer
$650,485Wenge Zhu · George Washington University · R01 · FY2023 · CA
Cpdm: Cloning a Gene that Regulates Eosinophil Function
$650,364John Paul Sundberg · Jackson Laboratory · R01 · FY2014 · AR
Novel molecular imaging approaches to monitor gene and cell-based therapies
$650,363Caius Gabriel Radu · University Of California Los Angeles · R01 · FY2011 · CA
Basic Dopamine Transporter Mechanisms Of Cocaine
$650,333Jonathan L Katz · National Institute On Drug Abuse · ZIA · FY2012 · DA
NOVEL GROUP A STREPTOCOCCUS HUMAN VACCINE CANDIDATES
$650,270Baylor College Of Medicine · U01 · FY2005 · AI
Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach
$650,259Qi Zhou · Purdue University · R01 · FY2017 · AI
Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction
$650,198Douglas A Marchuk · Duke University · R01 · FY2018 · NS
Fluorescence System for Sensing Biospecific Interactions
$650,121Bioelectrospec, Inc. · R44 · FY2003 · RR
Expansion of an efficient drug repurposing platform for rare genetic diseases.
$650,041Christopher Gibson · Recursion Pharmaceuticals, Llc · R44 · FY2016 · TR
Discovery and Assessment of Genetic Determinants of HCV and HIV Control
$650,016Raymond T Chung · Massachusetts General Hospital · R01 · FY2014 · DA
A Multipronged Interrogation of Large-Scale Omics Data to Reveal COVID-19 Pathways
$650,002Carlos Cruchaga · Washington University · RF1 · FY2020 · AG
CAREER: Stereoselective Carbene Cascade Cyclizations
$650,000Indrajeet Sharma · University Of Oklahoma Norman Campus · · FY2018 · MPS
KETOSIS IS A COMMON HEALTH ISSUE IN DAIRY COWS AFTER GIVING BIRTH, RESULTING FROM A LACK OF ENERGY. IT AFFECTS HOW FAT TISSUE FUNCTIONS, ESPECIALLY THE FAT AROUND VISCERA, WHICH IS CRITICAL FOR OVERALL HEALTH. KETOSISLEADS TO MAJOR ECONOMIC LOSSES DUE TO LOWER MILK PRODUCTION, POOR REPRODUCTIVE PERFORMANCE, AND HIGH TREATMENT COSTS. YET, WE STILL DON'T FULLY UNDERSTAND HOW KETOSIS CHANGES THIS FAT COMPARED TO FAT UNDER THE SKIN AND HOW IT RELATES TO THE DEVELOPMENT OF KETOSIS. WE HYPOTHESIZE THAT KETOSIS DISRUPTS FAT CELLS' FUNCTION AND HOW THEY INTERACT WITH THE TISSUE STRUCTURES THAT SUPPORT THEM, AND THESE CHANGES ARE DEPENDENT ON THELOCATION OF THE FAT IN THE BODY.THIS PROJECT AIMS TO (1) STUDY HOW KETOSIS CHANGES THE GENETICS OF FAT CELLS IN DIFFERENT AREAS OF THE BODY, (2) INVESTIGATE HOW IT ALTERS THE STRUCTURE OF FAT TISSUE (CALLED THE EXTRACELLULAR MATRIX), AND (3) DEFINE HOW THESE CHANGES AFFECT COMMUNICATION BETWEEN CELLS AND THE EXTRACELLULAR MATRIX. USING ADVANCED TOOLS TO STUDY GENES AND PROTEINS, WE AIM TO UNCOVER SPECIFIC CHANGES IN FAT TISSUE THAT OCCUR DURING A KETOTIC STATE. BY COMPARING HEALTHY DAIRY COWS TO THOSE AFFECTED BY KETOSIS, WE EXPECT TO IDENTIFY CELL TYPES, GENES, AND PROTEINS THAT ARE DISRUPTED BY THIS DISORDER. THIS INFORMATION COULD LEAD TO THE DEVELOPMENT OF NEW STRATEGIES, ESPECIALLY NUTRITIONAL AND DRUG-BASED APPROACHES, TO TARGET THE FAT TISSUE MORE EFFECTIVELY. ULTIMATELY, THIS RESEARCH WILL HELP SCIENTISTS AND FARMERS FIND BETTER WAYS TO MANAGE COW HEALTH, LOWER THE RISK OF DISEASES LINKED TO POOR FAT METABOLISM, AND REDUCE THE NUMBER OF COWS LOST TO SEVERE ILLNESS. OVER TIME, THESE DISCOVERIES COULD IMPROVE ANIMAL WELL-BEING, REDUCE VETERINARY COSTS, AND INCREASE PROFITABILITY IN THE DAIRY INDUSTRY.
$650,000Texas Tech University System · · FY2025 · National Institute of Food and Agriculture
Phenotype MicroArrays for Drug Toxicity Screening
$650,000Biolog, Inc. · R44 · FY2004 · MH
GOALI: An Industrial-Academic Collaboration for Sustainable Catalysis with Earth Abundant Metals
$650,000Paul J Chirik · Princeton University · · FY2023 · MPS
Molecular Mechanisms of Cell-Cell Attachment
$650,000Tina Izard · The Scripps Research Institute · · FY2020 · BIO
CAREER: Riemannian Reformulation of Collective Variable Based Free Energy Calculation Methods
$650,000Mahmoud Moradi · University Of Arkansas · · FY2020 · MPS
DartCF: The Dartmouth Cystic Fibrosis Research Center
$650,000Dean R Madden · Dartmouth College · P30 · FY2024 · DK
CAREER: Carbonylation Methodologies and Strategies for Complex Natural Product Synthesis
$650,000Mingji Dai · Purdue University · · FY2016 · MPS
Validating targets in p. aeruginosa type III secretion using chemical probes
$649,975Donald T Moir · Microbiotix, Inc · R01 · FY2015 · AI
The Conundrum of Absentee Receptors: Efficacy Potentiation Through Drug-Receptor Modulation
$649,942Mark W Grinstaff · Boston University (Charles River Campus) · R01 · FY2022 · AR
HIGH-THROUGHPUT SCREENING
$649,927Hakim Djaballah · Sloan-Kettering Inst Can Research · P30 · FY2010 · CA
Development of soluble epoxide hydrolase inhibitors for the treatment of Alzheimer's disease
$649,899Kin Sing Stephen Lee · Michigan State University · R01 · FY2023 · AG