Sort
38,696 grants matching “als”
Mechanisms of Entorhinal Cortex Function
$409,250Michael E. Hasselmo · Boston University (Charles River Campus) · R01 · FY2017 · MH
Mechanisms of Entorhinal Cortex Function
$409,250Michael E. Hasselmo · Boston University (Charles River Campus) · R01 · FY2014 · MH
Molecular Mechanisms of Homeostatic Synaptic Plasticity
$409,250Hengye Man · Boston University (Charles River Campus) · R01 · FY2014 · MH
Mechanisms of Entorhinal Cortex Function
$409,250Michael E. Hasselmo · Boston University (Charles River Campus) · R01 · FY2013 · MH
Mechanisms of Entorhinal Cortex Function
$409,250Michael E. Hasselmo · Boston University (Charles River Campus) · R01 · FY2016 · MH
Molecular Mechanisms of Homeostatic Synaptic Plasticity
$409,250Hengye Man · Boston University (Charles River Campus) · R01 · FY2016 · MH
Molecular Mechanisms of Homeostatic Synaptic Plasticity
$409,250Hengye Man · Boston University (Charles River Campus) · R01 · FY2017 · MH
Molecular Mechanisms of Homeostatic Synaptic Plasticity
$409,250Hengye Man · Boston University (Charles River Campus) · R01 · FY2015 · MH
Mechanisms of Entorhinal Cortex Function
$409,250Michael E. Hasselmo · Boston University (Charles River Campus) · R01 · FY2015 · MH
Investigation of self-nucleic acids as a trigger for neuroinflammation
$409,161Hachung Chung · Columbia University Health Sciences · R01 · FY2022 · NS
Role of Ataxin-2 polyglutamine expansion on TDP-43 transport and post-transcriptional RNA regulation in neurons
$409,111Pallavi P. Gopal · Yale University · R01 · FY2021 · NS
Targeting Oncogenic Ras-MAPK Signaling Complexes via the Scaffold KSR
$409,104Arvin Dar · Icahn School Of Medicine At Mount Sinai · R01 · FY2022 · CA
Mali International Center for Excellence in Research
$409,090Heinrich Feldmann · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
BRAIN CONNECTS: Multi-Beam Transmission Electron Microscopy of Iteratively Milled Semi-Thick Tissue Sections
$409,085Adrian Andreas Wanner · Paul Scherrer Institut Psi · U01 · FY2024 · NS
Analysis of synaptic protein dynamics
$409,077Jeremy Samuel Dittman · Weill Medical Coll Of Cornell Univ · R01 · FY2020 · NS
IL-6 involvement in alcohol-withdrawal excitability
$409,063Donna L Gruol · Scripps Research Institute, The · R01 · FY2016 · AA
CYTOLOGICAL STUDIES OF DEVELOPING AND MATURE NEURONS
$409,015Mary Bartlett Bunge · University Of Miami School Of Medicine · R01 · FY2012 · NS
Pharmacological Intervention Project
$409,003University Of Pittsburgh At Pittsburgh · R01 · FY2004 · AA
The Role of Fgf Signaling in Vertebrate Development
$408,997Mark B Lewandoski · Division Of Basic Sciences - Nci · ZIA · FY2009 · CA
Role of BMP and FGF signaling during limb development
$408,997Mark B Lewandoski · Division Of Basic Sciences - Nci · ZIA · FY2009 · CA
COMET 103P/HARTLEY 2 IS A FASCINATING OBJECT. IT IS THE SMALLEST OF THE COMETS VISITED BY SPACECRAFT BUT HAD VERY WELL DEVELOPED AND PRODUCTIVE COMA. IT IS ONE OF THE SO-CALLED "HYPERACTIVE" COMETS THAT INCLUDE SHORT-PERIOD COMETS 46P/WIRTANEN AND 73P/SCHWASSMAN- WACHMANN 3 AS WELL AS SOME LONG-PERIOD (OORT CLOUD) COMETS. THE GAS PRODUCTION RATES OF THESE COMETS EXCEED THE RATE THAT WOULD BE EXPECTED IF 100% OF THE SURFACE WERE COVERED IN PURE WATER ICE. HARTLEY 2 WAS VISITED BY THE DEEP IMPACT SPACECRAFT AS PART OF THE EXTENDED EPOXI MISSION ON 4 NOVEMBER 2010. THIS WAS A PARTICULARLY FAVORABLE APPARITION OF THIS COMET WHICH PASSED WITHIN 0.15 AU FROM THE EARTH AND WAS WIDELY OBSERVED FROM GROUND BASED AND SPACE BASED FACILITIES. ONE OF THE SURPRISING ASPECTS OF THE EPOXI MISSION IN COMBINATION WITH REMOTE OBSERVATIONS WAS THAT ITS HYPERACTIVITY WAS DUE TO DIRECT SUBLIMATION OF MAJOR REGIONS OF THE NUCLEUS HAVING BEEN DOMINATED BY CO2 WHICH LIBERATED MANY WATER ICE GRAINS AND CHUNKS THAT SUBSEQUENTLY SUBLIMATED IN THE COMA. A STUDY BY OUR GROUP (FOUGERE ET AL. 2013 ICARUS 225 688) SUGGESTED THAT SIMILAR AMOUNTS OF H2O AND CO2 WERE SUBLIMATING FROM THE NUCLEUS DIRECTLY BUT MOST OF THE WATER PRODUCTION RESULTED FROM THE SUBLIMATION OF THE EXTENDED ICY GRAIN/CHUNK HALO RELEASED BY CO2 ACTIVITY. THIS PICTURE WAS QUANTITATIVELY SPECIFIED ONLY FOR THE SNAPSHOT THAT REPRESENTED THE TIME PERIOD OF THE FLYBY AND USED A 2D-AXISYMMETRIC APPROXIMATION FOR THE NUCLEUS SHAPE AND ACTIVITY. WE PROPOSE HERE TO EXTEND OUR ANALYSIS TO THE LARGER SET OF EPOXI SPECTRAL IMAGES TAKEN DURING THE ENTIRE PERIOD AROUND CLOSE APPROACH USING OUR 3D ANALYSIS AND MODELING TOOLS DEVELOPED SINCE 2013 IN CONNECTION WITH THE ROSETTA MISSION (FOUGERE ET AL. 2016 A&A 588 A134) AND CASSINI DATA ANALYSIS (TENISHEV ET AL. 2010 JGR 115 A092302; AND 2014 JGR 119 2658). EPOXI SPECTRA (A'HEARN ET AL. 2011 SCIENCE 332 1396) TAKEN OVER SEVERAL DAYS INDICATED A VARIATION IN THE RELATIVE PRODUCTION OF H2O AND CO2 AS THE BI-LOBED NUCLEUS ROTATED EVERY 18 HOURS CHANGING ILLUMINATION BY THE SUN FROM ONE LOBE TO THE OTHER. WE WILL MODIFY OUR SPHERICAL HARMONIC BASED SURFACE ACTIVITY INVERSION TECHNIQUE TO USE IMAGE DATA. WE HAVE ALREADY DONE THIS FOR A SIMILAR INVERSION METHOD APPLIED TO BOTH CASSINI INMS IN SITU DENSITIES AND CASSINI UVS STELLAR OCCULTATION COLUMN DENSITIES. WE WILL THEN USE THE SPHERICAL HARMONICS INVERSION OF THE H2O AND CO2 POTENTIAL ACTIVITY TOGETHER WITH OUR COMET ADAPTIVE MESH SIMULATION (C-AMPS) DIRECT SIMULATION MONTE CARLO MODEL THAT NOW CAN RUN FULLY IN 3D WITH AN IRREGULAR NUCLEUS AND ANY SOLAR ILLUMINATION GEOMETRY TO DETERMINE THE FULL ACTIVITY DISTRIBUTION OF THE NUCLEUS AS IT CHANGES IN TIME. IN ADDITION TO C-AMPS WE HAVE A NEWLY DEVELOPED MULTINEUTRAL- GAS-DUST-FLUID MODEL THAT IS BASED ON THE U. MICHIGAN BATSRUS FLUID MODEL FOR FORWARD MODELING OF EXPLICIT TIME DEPENDENCE OF THE ROTATING NUCLEUS TO COMPARE EPOXI SPECTRAL IMAGES WITH OTHER REMOTE EARTH AND NEAR-EARTH BASED OBSERVATIONS. THE PROPOSED INVESTIGATION COMBINES EXPERTISE WITH THE EPOXI MEASUREMENTS AND DATA AT THE UNIVERSITY OF MARYLAND AND SOPHISTICATED PHYSICAL MODEL ANALYSIS AT THE UNIVERSITY OF MICHIGAN AND APPLIES THEM DIRECTLY TO SEVERAL OF THE FUNDAMENTAL GOALS OF THE DISCOVERY DATA ANALYSIS PROGRAM. DATA ARE AVAILABLE IN THE PDS SMALL BODIES NODE (SBN) AND IN FACT SCIENTISTS THAT ARE PART OF THE SBN AND WERE MEMBERS OF THE ORIGINAL EPOXI TEAM ARE INVESTIGATORS ON THIS PROPOSAL. THE RESULTS TO BE OBTAINED BY THIS PROPOSED WORK WOULD REPRESENT A SIGNIFICANT INTEREST TO THE DDAP AND TO NASA AND ITS PLANETARY PROGRAMS.
$408,911Regents Of The University Of Michigan · · FY2020 · National Aeronautics and Space Administration
THE CENTRAL VALLEY (CV) IN CALIFORNIA COVERS APPROXIMATELY 20 000 SQUARE MILES AND IS ONE OF THE MOST PRODUCTIVE AGRICULTURAL REGIONS IN THE WORLD WITH AN ESTIMATED VALUE OF $17 BILLION PER YEAR IN CROPS GROWN. THE REGIONAL POPULATION ALMOST DOUBLED BETWEEN 1980 AND TODAY AND IS PROJECTED TO INCREASE TO 6 MILLION BY 2020. POPULATION GROWTH INCREASED AGRICULTURE PRODUCTION AND MULTI-YEAR DROUGHTS HAVE CREATED AN EXTREME DEMAND FOR WATER. AS A RESULT ~20% OF GROUNDWATER PUMPING IN THE UNITED STATES OCCURS IN THE CV AQUIFER SYSTEM AND SINCE 1960 THE GROUNDWATER STORAGE HAS BEEN DEPLETED BY OVER 70 GIGATONS. THEREFORE IT IS OF CRITICAL IMPORTANCE TO DEVELOP TOOLS AND DATASETS THAT COULD BE USED BY WATER AGENCIES TO MANAGE THE CV AQUIFER SYSTEM WATER RESOURCES AS A WHOLE. ADDITIONALLY THE CV IS IN CLOSE PROXIMITY TO ACTIVE TECTONIC FAULTS: THE SAN ANDREAS FAULT SYSTEM TO THE WEST LESS THAN 30 KM FROM THE VALLEY SIDE THE GARLOCK FAULT ZONE TO THE SOUTH ~10 KM AWAY AND THE EASTERN CALIFORNIA SHEAR ZONE TO THE EAST. RECENT WORKS HAVE DEMONSTRATED THAT LOAD CHANGES ASSOCIATED WITH LOSS OF SURFACE WATER DURING THE 2012-2015 CALIFORNIA DROUGHT LED TO CHANGES IN SEISMICITY ON THE SAN ANDREAS FAULT SYSTEM (AMOS ET AL. 2014) BUT TO THIS DAY NO WORK HAS INVESTIGATED THE LONG-TERM EFFECT FROM THE MULTI DECADAL GROUNDWATER WITHDRAWAL FROM THE AQUIFER SYSTEM HAS HAD IN TERMS OF STRESS CHANGE ON THESE FAULTS. THE PROPOSED PROJECT AIMS TO QUANTIFY THE EFFECT OF THE LAST 25 YEARS OF GROUNDWATER EXTRACTION ON THE STRESS AND SEISMICITY ON THE NEARBY FAULTS AT THE SCALE OF THE CV. THE DRIVING HYPOTHESIS OF THE PROPOSED PROJECT IS THAT THE EFFECTIVE LOAD CHANGES ASSOCIATED WITH LONG-TERM GROUNDWATER WITHDRAWAL ARE LARGE ENOUGH TO INDUCE STRESS CHANGES ON NEARBY FAULTS THAT COULD ALTER THE SEISMIC ACTIVITY. THE GOALS OF THE PROPOSED PROJECT ARE TO 1) CHARACTERIZE 25 YEARS OF SURFACE DEFORMATION ASSOCIATED WITH GROUNDWATER WITHDRAWAL (TWICE AS LONG AS THE CURRENT GPS RECORDS USED TO DESCRIBE REGIONAL DEFORMATION) USING INSAR DATA FROM MULTIPLE SATELLITE PLATFORMS COMBINED WITH EXISTING GPS DATA AND AT THE SCALE OF THE CV; 2) GEODETICALLY CHARACTERIZE THE TIME-DEPENDENT HYDRAULIC PROPERTIES OF THE CV AQUIFER SYSTEM BASED ON THE RELATIONSHIP BETWEEN DEFORMATION AND WATER LEVEL CHANGES; 3) QUANTIFY THE EFFECTIVE LOAD CHANGES DUE TO GROUNDWATER WITHDRAWAL THROUGH DEVELOPMENT OF AN HYDROLOGIC MODEL EXPLAINING THE 25 YEARS OF SUBSIDENCE DATA AND DRAWDOWN OBSERVATIONS AND ACCOUNTING FOR THE TIME-DEPENDENT NON-ELASTIC PROPERTIES; 4) ESTIMATE THE RESULTING STRESS CHANGES ON NEIGHBORING FAULTS; AND 5) EVALUATE THE INFLUENCE OF WATER WITHDRAWAL ON THE SEISMICITY THROUGH ANALYSIS OF THE LONG-TERM SEISMIC CATALOG. THE PROPOSED GEODETIC-HYDROLOGIC APPROACH WILL LEAD TO THE DEVELOPMENT OF TOOLS AND DATASETS THAT CAN BE USED BY WATER MANAGERS TO UNDERSTAND HOW WATER MOVES THROUGH THE AQUIFER SYSTEM AND ADDRESS ISSUES OF SUSTAINABILITY AND WATER COMPETITION. ADDITIONALLY THIS PROJECT WILL ANSWER THE QUESTION OF HOW LONG TERM GROUNDWATER EXTRACTION MAY AFFECT THE STATE OF STRESS ON FAULTS AND THE RESULTING SEISMICITY. THIS PROJECT FOCUSES ON NATURAL HAZARDS AND HUMAN IMPACT TWO OF THE OVERARCHING TOPICS IDENTIFIED IN THE NASA CHALLENGES AND OPPORTUNITIES FOR RESEARCH IN ESI REPORT. IT WILL ADVANCE THE UNDERSTANDING OF THE SOLID EARTH BY CHARACTERIZING HOW GROUNDWATER EXTRACTION MAY INFLUENCE THE EARTHQUAKE CYCLE AND WILL EXPLORES HOW THE SOLID EARTH IS LINKED AND INTERACTS WITH THE BROADER EARTH SYSTEM BY EXAMINING SOLID EARTH AND HYDROLOGIC PROCESSES JOINTLY. FINALLY THIS PROJECT IS RELEVANT TO THE NISAR MISSION AS IT WILL DEMONSTRATE THAT INSAR CAN BE USED TO MONITOR GROUNDWATER RESOURCES AND DEVELOP SUSTAINABILITY PLANS.
$408,907University Of Oregon · · FY2020 · National Aeronautics and Space Administration
Investigating Toxic Elements and Nanoparticles in ALS Etiology: A Geospatial and Toxicological Evaluation of Massachusetts ALS Registry Patients
$408,881Elijah W Stommel · Dartmouth-Hitchcock Clinic · R01 · FY2023 · ES
Neurophysiology of robust speech perception in human superior temporal gyrus
$408,878Nima Mesgarani · Columbia Univ New York Morningside · R01 · FY2015 · DC
Metabolic Mechanisms for Programmed Cell Death
$408,864James M Phang · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA