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166,118 grants matching “stem cells”
Sex-specific trajectories in epigenomic regulation of brain patterning
$940,117Flora M Vaccarino · Yale University · R01 · FY2022 · MH
Integrated Cell-type Specific Biological Annotation of Genomic Variants in Alzheimer Disease
$940,114Suman Jayadev · University Of Washington · R56 · FY2017 · AG
Yale Center of Excellence in Molecular Hematology
$940,020Diane S. Krause · Yale University · P30 · FY2007 · DK
Cancer and Context
$939,920Ian G Macara · Vanderbilt University · R35 · FY2020 · CA
Identifying Genes for Type 2 Diabetes: FUSION
$939,832Michael Boehnke · University Of Michigan At Ann Arbor · U01 · FY2013 · DK
CCR FACS Core Laboratory
$939,713Karen Wolcott · Division Of Basic Sciences - Nci · ZIC · FY2013 · CA
The yellow fever vaccine saga: Defining the viral and host determinants responsible for success versus failure
$939,659Charles M. Rice · Rockefeller University · R01 · FY2019 · AI
Hormonal and Paracrine Regulation of Spermatogenesis
$939,564Barry R Zirkin · Johns Hopkins University · U54 · FY2009 · HD
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
$939,520Aaron D. Gitler · Stanford University · R35 · FY2017 · NS
RP3: Targeting ATG gene-dependent immunity for novel anti-infective therapeutics
$939,459Seungmin Hwang · Ut Southwestern Medical Center · U19 · FY2023 · AI
BioRad Galactomannan EIA for Diagnosis of Aspergillosis
$939,437Fred Hutchinson Cancer Research Center · U01 · FY2003 · AI
Liver Pathobiology and Gene Therapy Research Core Center
$939,375Allan W Wolkoff · Albert Einstein College Of Medicine, Inc · P30 · FY2015 · DK
Genetic Determinants of Antidepressant Response
$939,370Francis J McMahon · National Institute Of Mental Health · ZIA · FY2022 · MH
The consequences of repeat expansion in the Fragile X-related disorders
$939,288Karen P. Usdin · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2017 · DK
Transgenic Core
$939,275Toren Finkel · National Heart, Lung, And Blood Institute · ZIC · FY2012 · HL
Targeted disruption the enzymes of O-GlcNAc cycling: Animal models of Disease
$939,098John A. Hanover · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2013 · DK
Calmodulin-driven Nuclear Trafficking linked to diabetes and insulin signaling
$939,098John A. Hanover · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2013 · DK
Defining and Controlling Airway Disease
$939,000Michael Jay Holtzman · Washington University · R35 · FY2019 · HL
Durable HIV Vaccine Targeting Mucosal Epithelium
$939,000Marie-Claire Elisabeth Gauduin · Texas Biomedical Research Institute · R01 · FY2023 · AI
Advanced Mass Spectrometry Facility
$938,947David Anderson · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIC · FY2009 · DK
Molecular strategies for early detection and targeting of cancer
$938,926Tannishtha Reya · Columbia University Health Sciences · R35 · FY2024 · CA
Endocytic Mechanisms in the Hereditary Spastic Paraplegias
$938,821Craig Blackstone · National Institute Of Neurological Disorders And Stroke · ZIA · FY2016 · NS
Identification of non-coding RNAs to therapeutically target undruggable pathways in metastatic lung adenocarcinoma and squamous cell carcinoma
$938,802Elsa R Flores · H. Lee Moffitt Cancer Ctr & Res Inst · R35 · FY2021 · CA
Cardiac lineage determination and nuclear architecture
$938,793Jonathan A Epstein · University Of Pennsylvania · R35 · FY2024 · HL
WE PROPOSE TO INVESTIGATE THE EFFECT OF GRAVITY ON FUNDAMENTAL PROPERTIES OF MAMMALIAN STEM CELLS DURING DIFFERENTIATION OF 3-D CULTURES OF INDUCED PLURIPOTENT STEM (IPS) CELLS. EXPERIMENTS ABOARD THE ISS STS AND GROUND-BASED SIMULATIONS HAVE DEMONSTRATED THAT MICROGRAVITY INFLUENCES GENE EXPRESSION CELL PROLIFERATION AND DIFFERENTIATION IN STEM CELLS. HOWEVER THE MECHANISM BEHIND THESE OBSERVATIONS IS NOT CLEARLY UNDERSTOOD. IN THIS STUDY WE WILL INVESTIGATE HOW EXPOSURE TO MICROGRAVITY FUNDAMENTALLY ALTERS THE REGULATION OF OCT4 A TRANSCRIPTION FACTOR NECESSARY TO MAINTAIN PLURIPOTENCY AND HOW THESE CHANGES CAN AFFECT THE TIMING PROGRESSION AND OUTCOMES OF CELL DIFFERENTIATION. OUR LABORATORY HAS CREATED AN OCT4:CREER MTMG TRANSGENIC MOUSE THAT FOR THE FIRST TIME ALLOWS LINEAGE TRACING OF OCT4 EXPRESSION IN STEM CELLS AND THEIR PROGENY. WE WILL USE IPS CELLS DERIVED FROM THIS MODEL TO DETERMINE THE INFLUENCE OF MICROGRAVITY ON THE LOSS OF PLURIPOTENCY AND DIFFERENTIATION.
$938,671Regents Of The University Of Minnesota · · FY2015 · National Aeronautics and Space Administration