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1,049,261 grants matching “t cell”
A Comprehensive Spatial Picture of Transcription in the Nucleus
$2,400,000Arjun Raj · University Of Pennsylvania · DP2 · FY2011 · OD
Non-coding RNA engineers antibody diversity
$2,400,000Uttiya Basu · Columbia University Health Sciences · DP2 · FY2011 · OD
Engineering 3D in vitro niches to reveal fundamentals of cellular biomechanics
$2,400,000Sarah C Heilshorn · Stanford University · DP2 · FY2009 · OD
Molecular mechanisms and pathways of novel genomic loci regulating plasma lipids
$2,400,000Daniel James Rader · University Of Pennsylvania · RC2 · FY2009 · HL
BIO-AI: RESEARCH-PGR: Harnessing Multi-Omics and AI/ML to Unveil Nutrient Recycling Mechanisms in Maize Senescence
$2,400,000Rajandeep S Sekhon · Clemson University · · FY2025 · BIO
Breast Cancer Family Registry Cohort
$2,399,998Mary Beth Terry · Columbia University Health Sciences · U01 · FY2020 · CA
Discovery of Chemical Probes and Therapeutic Leads, Phase II
$2,399,995Joseph M Fox · University Of Delaware · P20 · FY2023 · GM
Discovery of Chemical Probes and Therapeutic Leads, Phase II
$2,399,995Joseph M Fox · University Of Delaware · P20 · FY2024 · GM
Cytoskeletal Regulation of Lung Endothelial Pathobiology
$2,399,985Joe G. N. Garcia · University Of Chicago · P01 · FY2008 · HL
Cancer Center Support Grant
$2,399,981Roy A. Jensen · University Of Kansas Medical Center · P30 · FY2018 · CA
Defining the Pathogenesis of Immune Deficiency in Chronic HIV Infection
$2,399,969Michael Marcel Lederman · Case Western Reserve University · P01 · FY2010 · AI
Development of new photo-releasable neuropeptide nano-vesicles for studying modulation in the brain
$2,399,777Zhenpeng Qin · University Of Texas Dallas · RF1 · FY2019 · NS
Alzheimer's disease-specific extracellular vesicles: from pathology to novel biomarker discovery
$2,399,582Vasiliki Machairaki · Johns Hopkins University · RF1 · FY2023 · AG
Macrophage Plasticity in Inflammatory Lung Injury
$2,399,579Asrar B. Malik · University Of Illinois At Chicago · P01 · FY2022 · HL
Establishing the anatomical and functional mechanisms of white matter deep brain stimulation
$2,399,556Peter Rudebeck · Icahn School Of Medicine At Mount Sinai · RF1 · FY2025 · MH
Building the Chromosome Segregation Machinery from Scratch
$2,399,496Sabine Petry · Princeton University · DP2 · FY2016 · GM
CURRENT PREDICTIONS OF THE RISK OF RADIATION EXPOSURE INDUCED DEATH HAVE LARGE UNCERTAINTIES IN PART THIS IS BECAUSE OF POOR UNDERSTANDING OF FACTORS THAT INFLUENCE RISK IN THE LOW DOSE RANGE CORRESPONDING TO ANTICIPATED HUMAN EXPOSURE. MODELING SUGGESTS THAT THE DOSE RESPONSE MAY BE STRONGLY NONLINEAR WITH AN INCREASE IN RISK AT LOW DOSES ATTRIBUTABLE TO NON-TARGETED EFFECTS (NTES) IN CELLS NOT DIRECTLY TRAVERSED BY A RADIATION TRACK. A MODEL INCORPORATING NTES FITTED TO MOUSE HARDERIAN GLAND CARCINOGENESIS DATA PREDICTS THAT MARS MISSION CANCER RISK MAY BE TWO-FOLD GREATER THAN THAT ATTRIBUTABLE TO TARGETED EFFECTS ALONE . THESE FINDINGS HIGHLIGHT THE NEED FOR A BETTER UNDERSTANDING OF THE MECHANISMS UNDERLYING THE HIGH RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) OF GCR FOR CARCINOGENESIS INCLUDING ITS ABILITY TO ELICIT NTES. THE PRINCIPAL HYPOTHESIS FOR THIS PROPOSAL IS THAT EXPOSURE TO GCR AND PARTICULARLY ITS HIGH CHARGE AND ENERGY (HZE) PARTICLE COMPONENTS IS ASSOCIATED WITH CHRONIC DNA DAMAGE SIGNALING LEADING TO DECLINE IN THE FUNCTIONAL STATUS OF THE DNA REPAIR MACHINERY AND THAT THIS IS A KEY CONTRIBUTOR TO GCR CARCINOGENESIS. PRIOR STUDIES ESTABLISH THE SCIENTIFIC PREMISE FOR THIS HYPOTHESIS AND IDENTIFY POTENTIAL UNDERLYING MECHANISMS ONE OF WHICH IS DEPLETION OF CELLULAR NAD+ POOLS AS A CONSEQUENCE OF PERSISTENT DNA DAMAGE RESULTING IN REDUCED ACTIVITY OF IMPORTANT NAD+-DEPENDENT ENZYMES. THESE INCLUDE THE DNA DAMAGE SENSING AND REPAIR FACTOR PARP1 AND PROTEIN DEACYLASES KNOWN AS SIRTUINS. EXPERIMENTS WILL INVESTIGATE THE ROLE OF THE NAD+/PARP1/SIRTUIN AXIS IN EXPERIMENTS USING BOTH HUMAN BRONCHIAL EPITHELIAL CELLS AND WILD-TYPE C57BL/6 MICE. THE WORK WILL FOCUS ON LUNG CANCER RISK AS AN ENDPOINT. SPECIFIC AIMS ARE: AIM 1. TO INVESTIGATE THE SCOPE AND MECHANISTIC BASIS FOR A GCR EXPOSURE-RELATED DECLINE IN THE FUNCTIONAL STATUS OF THE REPAIR MACHINERY USING A BRONCHIAL EPITHELIAL CELL MODEL. AIM 2.TO TEST THE HYPOTHESIS THAT GCR EXPOSURE LEADS TO A CHRONIC DNA DAMAGE RESPONSE IN MOUSE LUNG AND WHETHER THIS CAN BE ABATED WITH A DIETARY COUNTERMEASURE. WE WILL INVESTIGATE GENDER DOSE AND RADIATION QUALITY EFFECTS. AIM 3. TO DETERMINE WHETHER RADIOGENIC TUMORS DISPLAY A MUTATIONAL SIGNATURE INDICATIVE OF A DECLINE IN THE FUNCTIONAL STATUS OF THE DNA REPAIR MACHINERY AS REFLECTED IN THEIR MUTATIONAL SIGNATURE THUS ESTABLISHING A FUNCTIONAL LINK TO TUMORIGENESIS. ANTICIPATED DELIVERABLES INCLUDE RESEARCH RESULTS TO IMPROVE EVALUATION OF SEX DEPENDENCE OF RADIOGENIC LUNG CANCER; TO ALLOW FOR CALCULATION OF RBES INCLUDING MIXED FIELD RBES FOR MALES AND FEMALES PARTICULARLY AT LOW DOSES AND IN WILD TYPE BACKGROUNDS WHERE DIRECT MEASUREMENTS OF RBE FOR RADIATION-INDUCED CANCERS IS INFEASIBLE OR SUBJECT TO LARGE EXPERIMENTAL UNCERTAINTIES AND TO PERFORM AN INITIAL EVALUATION OF A POTENTIAL COUNTERMEASURE.
$2,399,359Emory University · · FY2020 · National Aeronautics and Space Administration
Molecular Basis For The Morphogenesis Of The Inner Ear
$2,399,351Doris Wu · National Institute On Deafness And Other Communication Disorders · ZIA · FY2024 · DC
4D Nucleome Network Data Coordination and Integration Center
$2,399,341Peter Park · Harvard Medical School · U01 · FY2018 · CA
Genetic Epidemiology
$2,399,238Alisa Goldstein · Division Of Cancer Epidemiology And Genetics · ZIA · FY2022 · CA
PATHOPHYSIOLOGY OF THE ENDOTHELIUM
$2,399,202Brigham And Women'S Hospital · P01 · FY2003 · HL
Integrating Mechanistic Insights from Diverse Models to Prevent CMV Reactivation following Transplantation
$2,399,125Mary A Hummel · Northwestern University At Chicago · P01 · FY2019 · AI
NORTHERN CALIFORNIA COMPREHENSIVE SICKLE CELL CENTERS
$2,398,888Elliott P Vichinksy · Children'S Hospital & Res Ctr At Oakland · U54 · FY2006 · HL
Brain capillary endothelial cell energetics and neurovascular uncoupling in dementia
$2,398,590Fabrice Dabertrand · University Of Colorado Denver · RF1 · FY2024 · NS
Genetic and Signaling Pathways in Epithelial Thyroid Cancer
$2,398,547Matthew D Ringel · Ohio State University · P01 · FY2009 · CA