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38,696 grants matching “als”
Implicit Attitudes and HIV Risk Behavior in Virtual Environments
$428,279Kerry L Marsh · University Of Connecticut Storrs · R01 · FY2010 · MH
The Role of Carboxypeptidase E in Cancer
$428,245Yoke Peng Loh · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2017 · HD
Pharmacoepidemiology and Pharmacogenetics of a Statin AE
$428,229Bruce M Psaty · University Of Washington · R01 · FY2008 · HL
MAINTAINING NONSMOKING
$428,227University Of California San Francisco · R01 · FY2000 · DA
Phase III Trial of Minocycline in ALS-II Data Center
$428,173California Pacific Med Ctr Res Institute · R01 · FY2005 · NS
(PQ #10) Gut-brain interactions underlying chemotherapy-induced behavioral comorbidities
$428,086Leah M Pyter · Ohio State University · R01 · FY2019 · CA
Structure and function of a novel population of regenerating ependymal cells
$427,996Arturo Alvarez-Buylla · University Of California, San Francisco · R01 · FY2020 · NS
Molecular Principles Governing Mitochondrial and Peroxisomal Remodeling as Drivers of Cell Fate and Identity
$427,950Vivian Gama · Vanderbilt University · R35 · FY2024 · GM
Molecular Principles Governing Mitochondrial and Peroxisomal Remodeling as Drivers of Cell Fate and Identity
$427,950Vivian Gama · Vanderbilt University · R35 · FY2025 · GM
Non-Invasive System for Identifying Neural Behavior
$427,941Carlo J De Luca · Altec, Inc. · R01 · FY2006 · NS
Hearing loss affects synaptic balance in auditory cortex
$427,882Dan Harvey Sanes · New York University · R01 · FY2007 · DC
Conformational Changes in Glutamate transporters
$427,779Joseph A Mindell · Neurological Disorders And Stroke · Z01 · FY2007 · NS
Influence of human gene variants on the effects of developmental MeHg exposure
$427,758Michael J Carvan · University Of Wisconsin Milwaukee · R21 · FY2009 · ES
Michigan State University VDL Vet-LIRN 2019
$427,698James Averill · Michigan State University · U18 · FY2019 · FD
Prolonged Smoking Cessation Using Prescription Step Care
$427,636University Of Tennessee Health Sci Ctr · R01 · FY2005 · CA
Inositol lipid regulation of membrane fusion and fission
$427,627Lois S Weisman · University Of Michigan At Ann Arbor · R01 · FY2014 · GM
Optimizing a Novel AAV Vector to Selectively Influence Seizure Networks In Vivo
$427,625Thomas J. McCown · Univ Of North Carolina Chapel Hill · R21 · FY2023 · NS
Inositol lipid regulation of membrane fusion and fission
$427,625Lois S Weisman · University Of Michigan At Ann Arbor · R01 · FY2012 · GM
Directly Converted Neurons as a Novel Cellular Model for ALS and FTD
$427,625Timothy M. Miller · Washington University · R21 · FY2024 · NS
A humanized mouse model for UBQLN2-associated ALS-dementia
$427,625Randal Scot Tibbetts · University Of Wisconsin-Madison · R21 · FY2023 · AG
Investigating the role of anterior lateral motor cortex in control and execution of sequenced behaviors
$427,566Susanne Elizabeth Ahmari · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · NS
Geographic Variability in Time from HIV Diagnosis to Viral Suppression in the Deep South: A Roadmap to Accelerated Treatment Initiation
$427,546Aadia Rana · University Of Alabama At Birmingham · R01 · FY2022 · AI
SCIENCE GOALS AND OBJECTIVES DURING GEOMAGNETIC STORMS THE OUTER RADIATION BELT BECOMES INCREASINGLY DYNAMIC AND THE FLUX OF ELECTRONS CAN RAPIDLY VARY OVER FIVE ORDERS OF MAGNITUDE INCREASING OR DECREASING DEPENDING ON THE BALANCE BETWEEN ELECTRON LOSS AND ACCELERATION. THESE DYNAMICS ARE PARTLY CONTROLLED BY WAVE-PARTICLE INTERACTIONS MEDIATED BY VERY LOW FREQUENCY AND ULTRA LOW FREQUENCY WAVES WHICH CAN DRIVE BOTH ELECTRON LOSS AND ACCELERATION. THESE WAVE-PARTICLE INTERACTIONS ARE HIGHLY DEPENDENT ON THE AMPLITUDE AND SPATIAL AND TEMPORAL DISTRIBUTIONS OF THE WAVES. RECENT WORK HAS DEMONSTRATED THAT THE STORM-TIME DISTRIBUTION OF THESE WAVES ULF AND VLF IS EXTREMELY DIFFERENT THEN TYPICAL DISTRIBUTIONS DERIVED FROM BOTH QUIET AND ACTIVE GEOMAGNETIC CONDITIONS. THE SCIENTIFIC GOAL OF THIS PROPOSAL IS USE THE VAN ALLEN PROBES MMS THEMIS AND AEROCUBE6 (AC6) TO CHARACTERISE THE SPATIAL TEMPORAL AND AMPLITUDE DISTRIBUTIONS AND DETERMINE THE SOLAR WIND AND MAGNETOSPHERIC DRIVERS OF BOTH ULF AND VLF WAVES DURING GEOMAGNETIC STORMS. THIS WILL BE ACCOMPLISHED THROUGH THREE SCIENTIFIC OBJECTIVES: (1) DETERMINE WHICH PHYSICAL PROCESSES DRIVE STORM-TIME VLF WAVES AND CHARACTERIZE THE STORM-TIME DISTRIBUTIONS OF VLF WAVE POWER AND SPATIAL AND TEMPORAL DISTRIBUTIONS. (2) DETERMINE WHICH PHYSICAL PROCESSES DRIVE STORM-TIME ULF WAVES AND CHARACTERIZE THE STORM-TIME DISTRIBUTIONS OF VLF WAVE POWER AND SPATIAL AND TEMPORAL DISTRIBUTIONS. (3) DETERMINE THE SPATIAL AND TEMPORAL SCALES OF MICROBURSTS DURING GEOMAGNETIC STORMS. MISSION DATA AND AUXILIARY DATA SETS THIS PROPOSAL WILL UTILIZE DATA FROM THE NASA VAN ALLEN PROBES THEMIS AND MMS MISSIONS AND AEROSPACE AC6. THESE DATA ARE FREELY AVAILABLE.. THE NASA OMNIWEB DATA SET USING COMBINED MISSION DATA FROM ACE AND WIND WILL BE USED TO CHARACTERIZE SOLAR WIND DYNAMICS. FINALLY GROUND-BASED MAGNETOMETER DATA FROM THEMIS CARISSA IMAGE AND SUPERMAG WILL BE USED AS AN AUXILIARY DATA SET. ALL THESE DATA SETS ARE FREELY AVAILABLE ON THE WEB. DATA ANALYSIS AND METHODOLOGY THIS PROPOSAL BUILDS ON THE STATISTICAL ANALYSIS DETAILED IN MURPHY ET AL. [2016] AND WATT ET AL. [2017] WHICH HAS DEMONSTRATED LARGE VARIATION IN ULF AND VLF WAVE POWER DURING GEOMAGNETICALLY ACTIVE TIMES. THIS ANALYSIS WILL BE EXTENDED TO DETERMINE THE SPATIAL TEMPORAL AND AMPLITUDE DISTRIBUTIONS OF THESE WAVES DURING STORMS AND THE DOMINANT DRIVERS OF THESE WAVES. DURING THE VAN ALLEN PROBE ERA THERE HAVE BEEN OVER 150 GEOMAGNETIC STORMS (2012-2017) THROUGH THE EXTENDED PHASE (2019) WE EXPECT TO SEE SIMILAR NUMBER YIELDING OVER 200 STORMS TO STUDY MAGNETOSPHERIC DYNAMICS DURING THE GEOMAGNETIC STORMS. OBSERVATIONS FROM THE VAN ALLEN PROBES THEMIS AND MMS WILL BE USED TO CHARACTERISE ULF AND VLF WAVE POWER. THIS DATA WILL BE FURTHER SUPPLEMENTED WITH GROUND-BASED MAGNETOMETER DATA. OBSERVATIONS FROM AC6 WILL BE USED TO IDENTIFY STORM-TIME MICROBURST AND CHARACTERIZE BOTH THEIR LIFETIMES AND SPATIAL EXTENTS. EXTENDING THIS ANALYSIS TO SOLAR WIND DRIVERS DURING STORMS WILL FURTHER ALLOW STORM-TIME SOLAR WINDMAGNETOSPHERE COUPLING TO BE DIAGNOSED. MISSION AND DECADAL SURVEY RELEVANCE THE SCIENTIFIC GOAL AND OBJECTIVES PROPOSAL IS EXTREMELY TIMELY ADDRESSING THE MAIN SCIENCE GOALS OF THE VAN ALLEN PROBES INCLUDING DISCOVER WHICH PROCESSES SINGLY OR IN COMBINATION ACCELERATE AND TRANSPORT RADIATION BELT ELECTRONS AND IONS AND UNDER WHAT CONDITIONS AND UNDERSTAND AND QUANTIFY THE LOSS OF RADIATION BELT ELECTRONS AND DETERMINE THE BALANCE BETWEEN COMPETING ACCELERATION AND LOSS PROCESSES . THIS PROPOSAL ALSO ADDRESSES TWO OF THE FOUR HIGH-LEVEL SCIENCE GOALS IN THE HELIOPHYSICS DECADAL SURVEY DETERMINE THE DYNAMICS AND COUPLING OF EARTH S MAGNETOSPHERE IONOSPHERE AND ATMOSPHERE AND THEIR RESPONSE TO SOLAR AND TERRESTRIAL INPUTS AND DISCOVER AND CHARACTERIZE FUNDAMENTAL PROCESSES THAT OCCUR BOTH WITHIN THE HELIOSPHERE AND THROUGHOUT THE UNIVERSE.
$427,519University Of Maryland, College Park · · FY2020 · National Aeronautics and Space Administration
Identifying the Polygenic Basis of the Human Brain and Psychiatric Disorders
$427,463Chi-Hua Chen · University Of California, San Diego · R01 · FY2013 · MH
Mechanisms governing metastatic reactivation of breast cancer.
$427,427Filippo G Giancotti · Sloan-Kettering Inst Can Research · R01 · FY2014 · CA