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38,696 grants matching “als”
A role for extracellular vesicles in neuroinflammation associated to frontotemporal dementia
$429,000Davide Trotti · Thomas Jefferson University · R21 · FY2022 · NS
Dystrophin signaling and the epigenetic landscape of human iPSC-derived muscles
$429,000Pier Lorenzo Puri · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2017 · AR
Dystrophin signaling and the epigenetic landscape of human iPSC-derived muscles
$429,000Pier Lorenzo Puri · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2015 · AR
The role of viral and cellular proteins in early events of HIV-1 replication
$428,976Vinayaka R Prasad · Albert Einstein College Of Medicine · R37 · FY2013 · AI
Transgenic Probes of Active Circuits
$428,912Mark R Mayford · Scripps Research Institute, The · R01 · FY2013 · DA
Neisserial porins and antigen presenting cells
$428,807Lee Mark Wetzler · Boston Medical Center · R56 · FY2015 · AI
Blood vessel assembly from multipotent hemangioma-derived stem cells
$428,750Joyce E. Bischoff · Boston Children'S Hospital · R01 · FY2010 · HL
Statistical Methods for Medical Tests and Biomarkers
$428,749Margaret S. Pepe · Fred Hutchinson Cancer Research Center · R01 · FY2010 · GM
Age Associated Changes In Structural And Functional Cardio-Vascular Properties
$428,723Edward Lakatta · National Institute On Aging · ZIA · FY2015 · AG
SCIENCE TOPIC AND OBJECTIVES: LARGE NEUTRAL DENSITY ENHANCEMENTS ASSOCIATED WITH UPWELLING IN THE CUSP REGION OF THE EARTH'S IONOSPHERE ARE A CONSISTENT FEATURE OF F-REGION SATELLITE MEASUREMENTS IN THE MAGNETIC NOON MERIDIAN AND HAVE RECEIVED CONSIDERABLE ATTENTION. VARIOUS MECHANISMS HAVE BEEN PROPOSED TO EXPLAIN THE OBSERVATIONS BUT THE MOST LIKELY DRIVER NOW APPEARS TO BE JOULE HEATING. IN PARTICULAR SMALL-SCALE STRUCTURING OF THE FIELD-ALIGNED CURRENTS (FAC) IN THE REGION HAS IMPLIED SIGNIFICANTLY ENHANCED JOULE HEATING DUE TO THE ASSOCIATED SMALL-SCALE ELECTRIC FIELD FLUCTUATIONS THAT IS THEREFORE THE MAJOR CONTRIBUTING FACTOR RESPONSIBLE FOR THE OBSERVED UPWELLING. RECENT HIGH-RESOLUTION MODELING STUDIES (BRINKMAN ET AL. JGR 2016) HAVE SHOWN THAT FEATURES GENERALLY CONSISTENT WITH THE OBSERVED NEUTRAL UPWELLING CAN BE REPRODUCED BY THE MODEL WHEN DRIVEN WITH REASONABLY-CHOSEN ELECTRODYNAMIC FORCING PARAMETERS. THERE HAVE BEEN FEW DIRECT MEASUREMENTS HOWEVER OF THE SMALL-SCALE ELECTRODYNAMIC FORCING AND HEATING IN THE CUSP IN SPITE OF THE CRITICAL ROLE OF THE REGION IN THE COUPLING BETWEEN THE MAGNETOSPHERE IONOSPHERE AND THERMOSPHERE AT HIGH LATITUDES. SPECIFIC GOALS FOR THE EXPERIMENT ARE 1) TO OBTAIN HIGH-RESOLUTIONS MEASUREMENTS OF THE FLUCTUATING PLASMA DRIFTS AND ESTIMATES OF THE ASSOCIATED JOULE HEATING OVER A HORIZONTAL REGION OF SEVERAL HUNDRED KILOMETERS WITHIN THE CUSP REGION 2) TO MEASURE THE HORIZONTAL AND VERTICAL NEUTRAL FLOW VELOCITIES OVER THE SAME REGION AND 3) TO USE THE MEASURED PLASMA DRIFTS TO DEFINE THE FORCING FOR A HIGH-RESOLUTION MODEL AND TO COMPARE THE MODEL HORIZONTAL AND VERTICAL NEUTRAL VELOCITIES WITH THE OBSERVED NEUTRAL FLOW FIELD IN ORDER TO TEST OUR UNDERSTANDING OF THE COUPLING PROCESSES. METHODOLOGY WE PROPOSE TO LAUNCH A ROCKET FROM THE NY- LESUND ROCKET RANGE ON SVALBARD INTO THE CUSP REGION. THE ROCKET WILL CARRY EIGHT BARIUM/ STRONTIUM CANISTERS TO DEPLOY A SERIES OF TRACER CLOUDS ACROSS THE TRAJECTORY AT F-REGION HEIGHTS. THE BARIUM IONIZES QUICKLY WHEN EXPOSED TO SUNLIGHT AND PROVIDES A VISIBLE TRACER OF THE ION FLOW. THE BARIUM CLOUDS CAN BE TRACKED FOR UP TO 30 MINUTES IN THESE CONDITIONS AND THUS PROVIDE A LAGRANGIAN MEASUREMENT OF THE ELECTRIC FIELD FLUCTUATIONS EXPERIENCED BY THE PLASMA FLOW AS IT TRAVERSES THE REGION. THE STRONTIUM REMAINS NEUTRAL AND PROVIDES A VISIBLE TRACER OF THE NEUTRAL FLOW FIELD INCLUDING BOTH THE HORIZONTAL AND VERTICAL FLOW COMPONENTS. THE IN-SITU DATA WILL BE COMBINED WITH RADAR DATA FROM THE EISCAT SVALBARD RADAR (ESR) AND GROUNDBASED OPTICAL DATA TO ESTIMATE THE SMALL-SCALE FLUCTUATING FIELD CONTRIBUTION TO THE JOULE HEATING ACROSS THE CUSP REGION. THE PROPOSED STUDY IS AN INTERNATIONAL COLLABORATIVE EFFORT BETWEEN CLEMSON AND JAXA THE JAPANESE SPACE AGENCY IN WHICH NASA WILL PROVIDE THE LAUNCH VEHICLES AND JAXA WILL PROVIDE THE RELEASE CANISTERS FOR THE PAYLOAD. GROUND-BASED OBSERVATIONS WILL BE A SHARED EFFORT BETWEEN CLEMSON AND PARTICIPANTS FROM SEVERAL OTHER JAPANESE INSTITUTIONS. THE HIGH-RESOLUTION MODELING WILL BE CARRIED OUT BY THE AEROSPACE CORPORATION. DATA ANALYSIS WILL BE A JOINT EFFORT BY ALL THE INVESTIGATORS. THE LAUNCHES ARE PROPOSED FOR NOVEMBER 2019 AS PART OF THE GRAND CHALLENGE INITIATIVE CAMPAIGN SCHEDULED FOR THAT PERIOD FROM AND YA AND SVALBARD IN NORWAY. RELEVANCE TWO OF THE OVERARCHING GOALS IN THE 2014 NASA SCIENCE PLAN ARE TO "EXPLORE THE PHYSICAL PROCESSES IN THE SPACE ENVIRONMENT FROM THE SUN TO THE EARTH..." AND TO "ADVANCE OUR UNDERSTANDING OF THE CONNECTIONS THAT LINK THE SUN THE EARTH PLANETARY SPACE ENVIRONMENTS..." THE INTERACTION BETWEEN THE MAGNETOSPHERE IONOSPHERE AND THERMOSPHERE IN THE EARTH'S CUSP REGION IS A CRITICAL LINK THAT CONNECTS THE SPACE ENVIRONMENT TO THE EARTH'S ATMOSPHERE. UNDERSTANDING THE PHYSICS OF THE FORCING IN THAT REGION AND THE RESPONSE OF THE NEUTRAL ATMOSPHERE IS ESSENTIAL TO OUR UNDERSTANDING OF THE COUPLING PROCESSES.
$428,715Clemson University · · FY2020 · National Aeronautics and Space Administration
MECHANISMS FOR ABERRANT GLUTAMATE TRANSPORT IN ALS
$428,647Johns Hopkins University · R01 · FY2003 · NS
CANDIDATE GENE STUDY OF INHERITED RETINAL DEGENERATIONS
$428,593Massachusetts Eye And Ear Infirmary · R01 · FY2002 · EY
Developing ASO Therapy for Repeat Expanded C9orf72 ALS-FTD
$428,588John Ravits · University Of California, San Diego · R01 · FY2015 · NS
Developing ASO Therapy for Repeat Expanded C9orf72 ALS-FTD
$428,588John Ravits · University Of California, San Diego · R01 · FY2016 · NS
Developing ASO Therapy for Repeat Expanded C9orf72 ALS-FTD
$428,588John Ravits · University Of California, San Diego · R01 · FY2017 · NS
Developing ASO Therapy for Repeat Expanded C9orf72 ALS-FTD
$428,588John Ravits · University Of California, San Diego · R01 · FY2018 · NS
Examining the Influence of Soc. Determinants of Health on Gestational WeightGain
$428,571Monica L. Baskin · University Of Alabama At Birmingham · U54 · FY2014 · MD
Cochlear Detoxification System
$428,557Shinichi Someya · University Of Florida · R01 · FY2019 · DC
ORAL AND SKELETAL BONE LOSS IN OLDER MEN
$428,550Eric S. Orwoll · Oregon Health & Science University · R01 · FY2006 · DE
Flow Cytometric Analysis of Genotoxicity
$428,469Cytomation Gtx, Inc. · R44 · FY2002 · CA
MRI/MRSI Studies of Bipolar Treatment Response
$428,418Perry Franklin Renshaw · Mclean Hospital · R01 · FY2007 · MH
Chicago Endothelial Function Study
$428,383Louise C. Hawkley · University Of Chicago · R01 · FY2010 · AG
Area at Risk, Myocardial Infarction, and Myocardial Salvage
$428,321Andrew Arai · National Heart, Lung, And Blood Institute · ZIA · FY2019 · HL
AN ENDOCANNABINOID MECHANISM FOR STRESS-INDUCED ANALGESIA
$428,315Andrea Grace Hohmann · University Of Georgia · R01 · FY2007 · DA
Genetic Metabolic Myopathy - Acid Maltase Deficiency
$428,288Vittorio Sartorelli · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2013 · AR