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15,273 grants matching “antimicrobial resistance”
Personalized Antibiotic Therapy in the Emergency Department: PANTHER Trial
$172,687Brett Faine · University Of Iowa · R21 · FY2024 · AI
Accounting for measured and unmeasured heterogeneity in host populations
$172,616Caroline O'Flaherty Buckee · Harvard School Of Public Health · U54 · FY2016 · GM
Accounting for measured and unmeasured heterogeneity in host populations
$172,616Caroline O'Flaherty Buckee · Harvard School Of Public Health · U54 · FY2017 · GM
Accounting for measured and unmeasured heterogeneity in host populations
$172,616Caroline O'Flaherty Buckee · Harvard School Of Public Health · U54 · FY2014 · GM
Studies on bacterial populations and new therapeutics for CF lung infections
$172,610Pradeep Singh · University Of Washington · K24 · FY2010 · HL
Innate Immunity in Otitis Media Pathogenesis
$172,481David J. Lim · House Research Institute · R01 · FY2009 · DC
Modeling the Effects of HIV, Chlamydia, and Gonorrhea in Mother-Infant Pairs in Botswana.
$172,441Caitlin Dugdale · Massachusetts General Hospital · K08 · FY2022 · HD
Mouse Models of Pediatric Osteomyelitis
$172,425Deborah V Novack · Washington University · R21 · FY2019 · AR
University of Pittsburgh Training Program in Antimicrobial Resistance
$172,322Lee H. Harrison · University Of Pittsburgh At Pittsburgh · T32 · FY2020 · AI
Administrative Core
$172,321Tim Van Opijnen · Boston Children'S Hospital · U19 · FY2024 · AI
Daptomycin Resistance in Enterococcus faecium
$172,301Truc Thanh Tran · University Of Texas Hlth Sci Ctr Houston · K08 · FY2018 · AI
Daptomycin Resistance in Enterococcus faecium
$172,301Truc Thanh Tran · University Of Texas Hlth Sci Ctr Houston · K08 · FY2017 · AI
Trial to Reduce Antimicrobial Use in Nursing home residents with Alzheimer's disease and other Dementias (TRAIN-AD)
$172,300Susan L Mitchell · Hebrew Rehabilitation Center For Aged · R37 · FY2021 · AG
Vitamin D Deficiency in Glomerular Disease
$172,292Michelle Denburg · Children'S Hosp Of Philadelphia · K23 · FY2015 · DK
Vitamin D Deficiency in Glomerular Disease
$172,292Michelle Denburg · Children'S Hosp Of Philadelphia · K23 · FY2016 · DK
Modeling the Effects of HIV, Chlamydia, and Gonorrhea in Mother-Infant Pairs in Botswana.
$172,237Caitlin Dugdale · Massachusetts General Hospital · K08 · FY2021 · HD
Role of tyrosine kinases in EPEC and EHEC pathogenesis
$172,125Emory University · R01 · FY2003 · AI
The Role of Statins in Cutaneous Wound Healing
$172,125Marjana Tomic-Canic · University Of Miami School Of Medicine · R21 · FY2011 · AR
Host-pathogen interactions during osteomyelitis
$172,098James E Cassat · Vanderbilt University · K08 · FY2015 · AI
Host-pathogen interactions during osteomyelitis
$172,098James E Cassat · Vanderbilt University Medical Center · K08 · FY2016 · AI
Host-pathogen interactions during osteomyelitis
$172,098James E Cassat · Vanderbilt University · K08 · FY2014 · AI
Evaluating the Functional Antibody Response to Pediatric S. aureus Infections
$172,097Isaac P Thomsen · Vanderbilt University Medical Center · K23 · FY2016 · AI
Evaluating the Functional Antibody Response to Pediatric S. aureus Infections
$172,097Isaac P Thomsen · Vanderbilt University · K23 · FY2014 · AI
INFECTIOUS DISEASES CAUSE BILLION-DOLLAR LOSSES ANNUALLY TO THE AQUACULTURE INDUSTRY AND NEGATIVELY IMPACT GROWTH AND SUSTAINABILITY BOTH IN THE US AND GLOBALLY. WHILE ANTIBIOTICS ARE EFFECTIVE AGAINST MANY BACTERIAL DISEASES OF FISH, THERE ARE FEARS THAT THEIR USE IN AQUACULTURE MAY CAUSE SERIOUS ENVIRONMENTAL AND HUMAN HEALTH PROBLEMS RELATED TO THE POTENTIAL FOR FARM-TO-CLINIC ANTIBIOTIC-RESISTANCE TRANSFER. STREPTOCOCCUS INIAE (A GRAM-POSITIVE BACTERIUM) IS RECOGNIZED AS AN EMERGING PATHOGEN OF WILD AND CULTURED FISH WITH ~30 SPECIES OF SUSCEPTIBLE FISH, INCLUDING FARM-RAISED TILAPIA AND HYBRID STRIPED BASS. S. INIAE CAN RESIDE BOTH WITHIN (INTRACELLULAR) AND OUTSIDE (EXTRACELLULAR) INFECTED FISH CELLS. THERE IS A NEED FOR NOVEL (NON-ANTIBIOTIC) ANTIMICROBIALS THAT ARE REFRACTORY TO RESISTANCE DEVELOPMENT THAT CAN KILL BOTH INTRACELLULAR AND EXTRACELLULAR BACTERIA. PHAGE (BACTERIAL VIRUS) ENDOLYSINS ARE CELL WALL DEGRADING ENZYMES (PEPTIDOGLYCAN HYDROLASES, PGHS) THAT DIGEST THE MAJOR STRUCTURAL COMPONENT OF THE BACTERIAL CELL WALL (PEPTIDOGLYCAN), ALLOWING NEWLY FORMED PHAGE TO ESCAPE THE HOST CELL AND INFECT NEW HOST CELLS. IN GRAM-POSITIVE PATHOGENS (INCLUDING S. INIAE), THE PEPTIDOGLYCAN IS SURFACE EXPOSED. WHEN THE PURIFIED ENDOLYSIN IS EXPOSED EXTERNALLY, IT CAN DEGRADE THE CELL WALL AND CAUSE DEATH TO THE PATHOGEN. THIS ABILITY ALLOWS US TO USE THEM AS 'ALTERNATIVE ANTIBIOTICS'. WE HYPOTHESIZE THAT PHAGE ENDOLYSINS CAN BE IDENTIFIED FROM PUBLIC DATA SETS AND PREVENT AND/OR ERADICATE S. INIAE INFECTIONS IN FISH. COEVOLUTION OF PHAGE AND HOST ENSURES THAT THESE ENZYMES ARE HIGHLY REFRACTORY TO RESISTANCE DEVELOPMENT IN THE HOST CELL. ONCE IDENTIFIED, THE PGH PROTEINS WILL BE FUSED TO KNOWN 'PROTEIN TRANSDUCTION DOMAINS' (SHORT PROTEIN DOMAINS THAT HELP TRANSPORT PROTEINS INTO ANIMAL CELLS), ALLOWING THE ENZYME TO LYSE S. INIAE THAT RESIDES BOTH INSIDE AND OUTSIDE OF FISH CELLS. WE WILL IDENTIFY OPTIMAL (HIGH ACTIVITY) FUSION CONSTRUCTS VIA ANTI-S. INIAE ASSAYS WITH CULTURED FISH CELLS AND TEST FOR TARGET AND NON-TARGET LYTIC ACTIVITY ON MULTIPLE S. INIAE AND BACTERIAL COMMENSAL STRAINS ISOLATED FROM FARM RAISED TILAPIA. THIS PROPOSAL WILL GENERATE PGH-ANTIMICROBIALS HIGHLY SPECIFIC FOR S. INIAE FOR USE IN STRATEGIES TO PROTECT FARM-RAISED FISH FROM DISEASE.
$172,095University Of Arkansas System · · FY2021 · National Institute of Food and Agriculture
Identifying the Molecular Target of Two Novel Compounds Active Against Non-replicating Mycobacterium tuberculosis and Delineating the Role of the Putative Target, InhA, in Non-replicating States
$172,006Kohta Saito · Weill Medical Coll Of Cornell Univ · K08 · FY2022 · AI