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51,593 grants matching hepatitis

Thrombocytopoiesis in Diabetes: Role of Damage Associated Molecular Patterns

$496,290
Prabhakara Reddy Nagareddy · University Of Alabama At Birmingham · R01 · FY2019 · HL

Functional Dynamics of Cytochrome P4503A4

$496,257
William M Atkins · University Of Washington · R01 · FY2018 · GM

Mechanism of Proteotoxicity and Experimental Therapeutic Approaches in Porphyria

$496,238
M Bishr Omary · Rutgers Biomedical And Health Sciences · R01 · FY2023 · DK

Mechanism of Proteotoxicity and Experimental Therapeutic Approaches in Porphyria

$496,238
M Bishr Omary · Rbhs-Robert Wood Johnson Medical School · R01 · FY2022 · DK

Hepatic CYP enzymes and host-pathogen interactions

$496,223
Edward T Morgan · Emory University · R01 · FY2010 · DK

Delineating the molecular mechanisms of hepatocyte-to-cholangiocyte reprogramming

$496,215
Donghun Shin · University Of Pittsburgh At Pittsburgh · R01 · FY2024 · DK

Role of protein mediate fatty acid uptake in liver cancer

$496,197
Andreas Stahl · University Of California Berkeley · R01 · FY2022 · CA

IN 2018, OUR TEAM IDENTIFIED A NOVEL EQUINE PARVOVIRUS, NAMED EQUINE PARVOVIRUS HEPATITIS (EQPV-H). THIS VIRUS IS STRONGLY ASSOCIATED WITH THEILER'S DISEASE, A HIGHLY FATAL SYNDROME OF FULMINANT HEPATITIS IN HORSES. THIS PROJECT WILL WORK ON FURTHER IMPROVING OUR UNDERSTANDING OF THE EPIDEMIOLOGY AND PATHOGENIC MECHANISMS OF THIS NOVEL EQUINE PARVOVIRUS. THE SPECIFIC SCIENCE OBJECTIVES ARE TO PERFORM EPIDEMIOLOGIC MODELING OF NATURAL EQPV-H INFECTION KINETICS AND TRANSMISSION IN HORSES; TO CHARACTERIZE THE LIVER PATHOGENICITY OF EQPV-H TO FURTHER ESTABLISH ITS CLINICAL SIGNIFICANCE AND IMPROVE DIAGNOSTIC MEASURES; AND TO DETERMINE THE IMMUNOPATHOGENESIS OF EQPV-H. THE COMBINATION OF THIS PROPOSED WORK PROPOSED WILL LEAD TO A BETTER UNDERSTANDING OF THE EPIDEMIOLOGY AND PATHOGENICITY OF EQPV-H, WHICH IS ESSENTIAL TO IMPROVE (I) DIAGNOSTICS OF EQUINE LIVER DISEASE AND (II) MANAGEMENT STRATEGIES, INCLUDING FUTURE VACCINE DEVELOPMENT AND THERAPEUTIC INTERVENTION, ALL GEARED TOWARDS CONTROL AND PREVENTION OF DISEASE CAUSED BY EQPV-H IN THE EQUINE POPULATION.

$496,190
Cornell University · · FY2020 · National Institute of Food and Agriculture

Role of protein mediate fatty acid uptake in liver cancer

$496,153
Andreas Stahl · University Of California Berkeley · R01 · FY2019 · CA

MIRA-Regulation of drug metabolizing enzymes

$496,125
Todd C. Skaar · Indiana University Indianapolis · R35 · FY2023 · GM

MIRA-Regulation of drug metabolizing enzymes

$496,125
Todd C. Skaar · Indiana University Indianapolis · R35 · FY2022 · GM

MIRA-Regulation of drug metabolizing enzymes

$496,125
Todd C. Skaar · Indiana University Indianapolis · R35 · FY2019 · GM

MIRA-Regulation of drug metabolizing enzymes

$496,125
Todd C. Skaar · Indiana University Indianapolis · R35 · FY2020 · GM

TNF Alpha and Recovery from Alcoholic Liver Injury

$496,125
Anna Mae Elizabeth Diehl · Duke University · R01 · FY2023 · AA

MIRA-Regulation of drug metabolizing enzymes

$496,125
Todd C. Skaar · Indiana University Indianapolis · R35 · FY2021 · GM

Metabolism of islets of langerhans and hormone release

$496,114
Franz M Matschinsky · University Of Pennsylvania · R01 · FY2010 · DK

DECONSTRUCTING INFLAMMATION AND ALTERED MICROBIOTA IN METABOLIC SYNDROME

$496,103
Andrew T Gewirtz · Georgia State University · R01 · FY2023 · DK

Advancing our Understanding of Rare Pediatric Liver Diseases

$496,094
Barbara Anne Haber · Children'S Hosp Of Philadelphia · U01 · FY2009 · DK

Cardiovascular Inflammation Reduction Trial (CIRT): DCC

$496,073
Robert J Glynn · Brigham And Women'S Hospital · U01 · FY2011 · HL

(PQ8) Predicting immune-related toxicity in the adjuvant melanoma setting with checkpoint inhibition

$495,996
Iman Osman · New York University School Of Medicine · R01 · FY2021 · CA

Development of a topical malaria vaccine.

$495,962
Elizabeth H Nardin · New York University School Of Medicine · R01 · FY2014 · AI

Development of a topical malaria vaccine.

$495,942
Elizabeth H Nardin · New York University School Of Medicine · R01 · FY2015 · AI

MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases

$495,923
Peter Igarashi · Ut Southwestern Medical Center · RC1 · FY2009 · DK

Photoperiodic Control of Obesity

$495,895
Timothy Jon Bartness · Georgia State University · R37 · FY2014 · DK

Human Liver Tissue & Hepatocytes Research Resource (HLTHRR)

$495,889
David A Geller · University Of Pittsburgh At Pittsburgh · R24 · FY2024 · DK