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17,828 grants matching “crispr”
Investigating mechanisms of bladder tumorigenesis and therapeutic resistance
$1,300,700Abdul Banday · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Hereditary Muscle Disease Unit
$1,300,552Ami Mankodi · National Institute Of Neurological Disorders And Stroke · ZIA · FY2017 · NS
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE DECODE THE SALMONID GENOME PROJECT IS A MAJOR RESEARCH EFFORT AIMED AT BETTER UNDERSTANDING HOW CHANGES IN THE GENETIC CODE IN ANIMALS CAN INFLUENCE BIOLOGICAL TRAITS. THIS KNOWLEDGE WILL IMPOROVE THE SELECTION OF HIGHER PRODUCING AGRICULTURAL ANIMALS THAT CAN PRODUCE MORE FOOD ON LESS FEED AND WITH LESS IMPACT ON THE ENVIRONMENT. INSIGHT IN TO HOW THE GENOME FUNCTIONS COULD ALSO IMPROVE OUR UNDERSTANDING OF ANIMAL AND HUMAN HEALTH AS WELL AS HOW TO BETTER PROTECT OUR PRECIOUS NATURAL SPECIES FROM BIOLOGICAL OR ENVIRONMENTAL THREATS. UNFORTUNATELY, OUR ABILITY TO CHARACTERIZE GENOME FUNCTION IN ANIMALS IS CURRENTLY LIMITED BY THE TIME AND RESOURCES REQUIRED TO MAKE CHANGES TO THE GENETIC CODE AND THEN MEASURE THEIR EFFECT ON THE WHOLE ORGANISM. TO OVERCOME THIS LIMITATION, THE DECODE THE SALMONID GENOME PROJECT WILL USE ADVANCES IN CRISPR GENOME EDITING TECHNOLOGY AND A UNIQUE AGRICULTURAL MODEL SYSTEM, THE RAINBOW TROUT, TO PERFORM THE FIRST LARGE-SCALE PROFILING OF THE GENOME INAN AGRICULTURAL SPECIES. THE RESEARCH AIMS TO EVALUATE THE FUNCTION OF OVER 1000 LOCATIONS IN THE TROUT GENOME TO GAIN INSIGHT INTO REGIONS THAT ARE IMPORTANT FOR THE GROWTH OF ANIMALS AND THEIR ABILITY TO TOLERATE HIGH TEMPERATURES AND LOW OXYGEN LEVELS. TO ACCOMPLISH THIS, TROUT FAMILIES WILL BE ENGINEERED WITH CRISPR GENOME EDITING TECHNOLOGY TO HAVE MULTIPLE GENETIC MODIFICATIONS (4-12). NUMEROUS FAMILIES WILL BE PRODUCED TO CREATE A MIXED POPULATION WITH OVER 1000 GENETICALLY MODIFIED LOCATIONS. HIGH AND LOW PERFORMING FAMILIES WILL THEN BE IDENTIFIED USING A HIGH-THROUGHPUT SCREENING PROCESS THAT ASSESSES THE GROWTH, THERMAL TOLERANCE AND HYPOXIA TOLERANCE OF EACH FAMILY. THIS WILL ALLOW US TO RAPIDLY IDENTIFY GENETIC CHANGES THAT INFLUENCE THESE KEY BIOLOGICAL TRAITS OF INTEREST.THROUGH THIS EFFORT, A NATIONAL RESOURCE OF GENE EDITED FISH WILL BE PRODUCED THAT CONTAIN UNIQUE GENETIC CHANGES WHICH CAN BE STUDIED BY FUTURE INTERESTED RESEARCH GROUPS. THE GENE EDITED LINES WILL FORM THE FOUNDATION FOR MORE ADVANCED STUDIES INVESTIGATING THE INTERACTION OF THESE GENETIC CHANGES ON COMPLEX BIOLOGICAL TRAITS, SOMETHING THAT IS DIFFICULT OR IMPOSSIBLE TO PERFORM USING CURRENT METHODS. THE MODEL SYSTEMS PRODUCED IN THIS RESEARCH WILL ALSO LIKELY CONTAIN MANY NOVEL PRODUCTION TRAITS THAT CAN BE IDENTIFIED AND SELECTED FOR TO IMPROVE THE GENETICS OF US CULTURED SALMON AND TROUT SPECIES. TAKEN TOGETHER THE RESEARCH WILL FUNDAMENTALLY ADVANCE OUR UNDERSTANDING OF SALMON AND TROUT BIOLOGY AND THE GENETICS UNDERLYING IMPORTANT AQUACULTURE TRAITS WHILE ALSO PROVIDING KNOWLEDGE OF CONSERVED BIOLOGICAL MECHANISMS THAT COULD HAVE BROADER IMPACTS ON OTHER AGRICULTURAL SECTORS OR EVEN HUMAN HEALTH.
$1,300,000Washington State University · · FY2023 · National Institute of Food and Agriculture
Center for Integrated Multi-modal and Multi-scale Nucleome Research
$1,300,000Bing Ren · University Of California, San Diego · UM1 · FY2023 · HG
Center for Integrated Multi-modal and Multi-scale Nucleome Research
$1,300,000Bing Ren · University Of California, San Diego · UM1 · FY2020 · HG
Center for Integrated Multi-modal and Multi-scale Nucleome Research
$1,300,000Bing Ren · University Of California, San Diego · UM1 · FY2022 · HG
Center for Integrated Multi-modal and Multi-scale Nucleome Research
$1,300,000Bing Ren · University Of California, San Diego · UM1 · FY2021 · HG
Center for Integrated Multi-modal and Multi-scale Nucleome Research
$1,300,000Bing Ren · University Of California, San Diego · UM1 · FY2024 · HG
Sphingolipids in Cancer Biology and Therapy
$1,299,443Yusuf Awni Hannun · State University New York Stony Brook · P01 · FY2020 · CA
Sphingolipids in Cancer Biology and Therapy
$1,299,443Yusuf Awni Hannun · State University New York Stony Brook · P01 · FY2021 · CA
Sphingolipids in Cancer Biology and Therapy
$1,299,443Yusuf Awni Hannun · State University New York Stony Brook · P01 · FY2023 · CA
Sphingolipids in Cancer Biology and Therapy
$1,299,443Yusuf Awni Hannun · State University New York Stony Brook · P01 · FY2019 · CA
Drosophila Functional Genomics
$1,297,019Brian Oliver · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2022 · DK
Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease
$1,296,090Manolis Kellis · Massachusetts Institute Of Technology · R01 · FY2019 · AG
Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease
$1,295,549Manolis Kellis · Massachusetts Institute Of Technology · R01 · FY2020 · AG
Targeting FGFR4, RAS, and PAX3-FOXO1 gene in Rhabdomyosarcoma
$1,295,181Javed Khan · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease
$1,294,990Manolis Kellis · Massachusetts Institute Of Technology · R01 · FY2021 · AG
ER Network Shaping Mechanisms in the Hereditary Spastic Paraplegias
$1,294,415Craig Blackstone · National Institute Of Neurological Disorders And Stroke · ZIA · FY2021 · NS
Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease
$1,294,415Manolis Kellis · Massachusetts Institute Of Technology · R01 · FY2022 · AG
Identification of genomic regulatory elements in pancreas cells
$1,293,505Hatice Arda · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Project 2
$1,291,540Alan D Frankel · University Of California, San Francisco · U54 · FY2024 · AI
ER Network Shaping Mechanisms in the Hereditary Spastic Paraplegias
$1,290,879Craig Blackstone · National Institute Of Neurological Disorders And Stroke · ZIA · FY2016 · NS
Risk Genes and Environmental Interactions in Neural Tube Defects
$1,287,230Margaret Elizabeth Ross · Weill Medical Coll Of Cornell Univ · P01 · FY2020 · HD
Functional genomics of bipolar disorder
$1,287,148Francis J McMahon · National Institute Of Mental Health · ZIA · FY2014 · MH
Functionally Assessing Transcriptional Enhancers In Vivo
$1,286,578Len Alexander Pennacchio · University Of Calif-Lawrenc Berkeley Lab · R01 · FY2018 · HG