Sort
16,300 grants matching “fatty liver disease”
Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitis
$200,135Jonathan G Stine · Pennsylvania State Univ Hershey Med Ctr · K23 · FY2024 · DK
Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitis
$200,135Jonathan G Stine · Pennsylvania State Univ Hershey Med Ctr · K23 · FY2022 · DK
Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitis
$200,135Jonathan G Stine · Pennsylvania State Univ Hershey Med Ctr · K23 · FY2023 · DK
DO HIGH DOSE B VITAMINS DELAY AGE-RELATED DECAY
$200,125Children'S Hospital &Res Ctr At Oakland · R21 · FY2004 · AT
Syk in Mitochondrial Stress Signaling and Insulin Resistance
$200,049Heide Christine Patterson · Brigham And Women'S Hospital · K08 · FY2013 · GM
A role for glycolipids and unconventional T cell subsets in alpha-gal allergy
$200,044Onyinye I Iweala · Univ Of North Carolina Chapel Hill · K08 · FY2021 · AI
University of Arizona Cancer Center - Cancer Center Support Grant [MICEO Administrative Supplement]
$200,000Juanita L Merchant · University Of Arizona · P30 · FY2024 · CA
University of Arizona Cancer Center - Cancer Center Support Grant [MICEO Administrative Supplement]
$200,000Juanita L Merchant · University Of Arizona · P30 · FY2023 · CA
TLR4 in Obesity-Driven Liver Fibrosis
$200,000Jorge Matias Caviglia · Columbia University Health Sciences · R03 · FY2014 · DK
A Multi-Center Group to Study Acute Liver Failure in Children
$200,000Robert H Squires · Children'S Hosp Pittsburgh/Upmc Hlth Sys · U01 · FY2007 · DK
Control of liver autophagy by phosphatidic acid signaling
$200,000Gilbert Di Paolo · Columbia University Health Sciences · R21 · FY2014 · AG
TLR4 in Obesity-Driven Liver Fibrosis
$200,000Jorge Matias Caviglia · Columbia University Health Sciences · R03 · FY2015 · DK
TLR4 in Obesity-Driven Liver Fibrosis
$200,000Jorge Matias Caviglia · Columbia University Health Sciences · R03 · FY2016 · DK
The role of obesity in biological responses to particulate matter in mice
$199,995Vsevolod Y Polotsky · Johns Hopkins University · P50 · FY2016 · ES
FATTY LIVER DISEASE AFFECTS HALF OF ALL DAIRY CATTLE THAT HAVE RECENTLY GIVEN BIRTH. DESPITE RESEARCH INTO THE CAUSES AND SYMPTOMS OF FATTY LIVER DISEASE IN DAIRY CATTLE, INCIDENCE RATES REMAIN HIGH (COSTING FARMERS IN EXCESS OF $60 MILLION USD ANNUALLY) INDICATING THAT ON-FARM MANAGEMENT STRATEGIES ARE NOT ENOUGH TO PREVENT FATTY LIVER DISEASE. FURTHER UNDERSTANDING OF THE BIOCHEMICAL MECHANISMS THAT LEAD TO THE DEVELOPMENT OF FATTY LIVER IS NEEDED.RODENT RESEARCH HAS INDICATED THAT A KEY COORDINATOR OF METABOLISM IN THE LIVER IS DYSREGULATED IN CASES OF FATTY LIVER. BECAUSE CONTROL OF UTILIZATION OF NUTRIENTS IS CRITICAL TO THE SURVIVAL OF AN ORGANISM, THESE PROCESSES ARE CONSERVED THROUGHOUT EVOLUTION. WE, THEREFORE, EXPECT DAIRY CATTLE TO HAVE A SIMILAR DYSFUNCTION IN CASES OF FATTY LIVER.THE OVERARCHING HYPOTHESIS FOR THIS PROJECT IS, THEREFORE, THAT THIS KEY ENZYME (PHOSPHODIESTERASE 4B (PDE4B)) IS NOT REGULATED CORRECTLY IN THE LIVER OF CATTLE WHO ARE AFFECTED BY FATTY LIVER DISEASE AFTER CALVING. TO TEST THIS HYPOTHESIS, WE WILL UTILIZE OVER-CONDITIONED (OBESE) DAIRY CATTLE AND DAIRY CATTLE OF NORMAL BODY WEIGHT. WE WILL COLLECT TISSUE SAMPLES FROM HEALTHY LIVE ANIMALS AND LIVE ANIMALS THAT ARE EXPERIENCING FATTY LIVER DISEASE. USING THESE TISSUES, WE WILL DETERMINE WHICH OF THESE KEY COORDINATORS OF ENERGY USAGE IN THE LIVER ARE DYSREGULATED. SECOND, BASED ON THE FINDINGS FROM THE ON-FARM ANIMAL EXPERIMENT, WE WILL UTILIZE THE MODEL OF FATTY LIVER DISEASE DEVELOPED IN OUR LABORATORY THAT TAKES ADVANTAGE OF TISSUE COLLECTED FROM THE SLAUGHTERHOUSE. BY USING OUR LABORATORY DISEASE MODEL, WE WILL BE ABLE TO TEST ALREADY COMMERCIALLY AVAILABLE TREATMENTS FOR EFFICACY IN ALTERING THE ACTIVITY OF THESE ENZYMES AND FIXING THE DYSREGULATION. THE ULTIMATE GOAL OF THIS RESEARCH IS PREVENTING THE DEVELOPMENT OF FATTY LIVER DISEASE. BECAUSE COMMERCIALLY AVAILABLE DRUGS EXIST, WE ANTICIPATE THAT UPON IDENTIFICATION OF THE DYSREGULATED ENZYME, WE CAN ULTIMATELY DEVELOP AN ECONOMICAL TREATMENT TO BE USED ON THE FARM FOR PREVENTION OF FATTY LIVER DISEASE, THEREBY IMPROVING ANIMAL WELFARE AND SUSTAINABILITY FOR DAIRY FARMERS.
$199,930University Of Vermont & State Agricultural College · · FY2020 · National Institute of Food and Agriculture
Protection against Arsenic-Induced Neurologic Defects by Brain DHA Enrichment
$199,875Robert M Sargis · University Of Illinois At Chicago · R21 · FY2019 · ES
Improving cognition and enriching brain DHA in APOE4 mice through dietary LPC-DHA
$199,875Leon Maing Tai · University Of Illinois At Chicago · R21 · FY2020 · AG
Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk
$199,810Bernhard Hennig · University Of Kentucky · P42 · FY2022 · ES
Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk
$199,810Yekaterina Zaytseva · University Of Kentucky · P42 · FY2023 · ES
Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk
$199,810Bernhard Hennig · University Of Kentucky · P42 · FY2021 · ES
Factors Responsible for Liver Recovery After Successful Treatment of Hepatitis C.
$199,800Winston Dunn · University Of Kansas Medical Center · K23 · FY2021 · DK
Factors Responsible for Liver Recovery After Successful Treatment of Hepatitis C.
$199,800Winston Dunn · University Of Kansas Medical Center · K23 · FY2019 · DK
Factors Responsible for Liver Recovery After Successful Treatment of Hepatitis C.
$199,800Winston Dunn · University Of Kansas Medical Center · K23 · FY2020 · DK
Factors Responsible for Liver Recovery After Successful Treatment of Hepatitis C.
$199,800Winston Dunn · University Of Kansas Medical Center · K23 · FY2018 · DK
The Growth Hormone and Insulin-like Growth Factor-1 Axis in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
$199,799Laura Elisabeth Dichtel · Massachusetts General Hospital · K23 · FY2017 · DK