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78,016 grants matching “breast cancer”
The role of the tumor biofilm in determining tissue tropism
$630,835Kandice Tanner · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Long-term health consequences of birth by cesarean section
$630,815Jorge Eduardo Chavarro · Harvard School Of Public Health · R01 · FY2021 · HD
Inflammation, Macrophage Differentiation, and Cancer
$630,814Zheng-Gang Liu · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
The pro-metastatic role of androgen receptor in estrogen receptor mutated breast cancer
$630,810Min Yu · University Of Maryland Baltimore · R01 · FY2025 · CA
Increasing Colorectal and Breast Cancer Screnning in Women
$630,760Victoria L Champion · Indiana University Indianapolis · R01 · FY2010 · CA
Couple Communication in Cancer: A Multi-Method Examination
$630,735Shelby Langer · Arizona State University-Tempe Campus · R01 · FY2019 · CA
UNIVERSITY OF PENNSYLVANIA CANCER GENETICS NETWORK
$630,733University Of Pennsylvania · U24 · FY2001 · CA
Kansas City Clinical Oncology Program CCOP
$630,725Rakesh Gaur · Nci Community Oncology Research Program · U10 · FY2008 · CA
(PQ#9)Targeting leaky ryanodine receptor (RyR2) to treat and prevent chemotherapy-associated cognitive dysfunction in patients with breast cancer.
$630,724Theresa A Guise · Indiana University Indianapolis · R01 · FY2018 · CA
Targeting Slc16a/Mct Lactate Transporters in Cancer Therapeutics
$630,698John L. Cleveland · H. Lee Moffitt Cancer Ctr & Res Inst · R01 · FY2015 · CA
Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis
$630,676Rebecca A Shelby · Duke University · R01 · FY2021 · CA
Novel regulatory networks driving human ribosome biogenesis
$630,652Susan J Baserga · Yale University · R35 · FY2021 · GM
Novel regulatory networks driving human ribosome biogenesis
$630,652Susan J Baserga · Yale University · R35 · FY2022 · GM
Nanoimmunoliposome-Complexed SPIO: Tumor-Specific Detection of Early Lung Cancer
$630,627Esther H Chang · Georgetown University · R01 · FY2010 · CA
Immune Enhancement and Therapy of Cancer
$630,621University Of California San Francisco · U01 · FY2005 · CA
Aerobic Capacity, Depression, & Inflammatory Responsivity in Cancer Survivors
$630,581Janice K Kiecolt-Glaser · Ohio State University · R01 · FY2018 · CA
Development of high throughput screening technologies in breast cancer
$630,575Konstantinos Konstantopoulos · Johns Hopkins University · R01 · FY2019 · CA
Risk factors for breast cancer molecular subtypes
$630,556Celine M Vachon · Mayo Clinic Rochester · R01 · FY2010 · CA
Rapid Automated High-Throughput Radiation Biodosimetry
$630,543David Jonathan Brenner · Columbia University Health Sciences · U19 · FY2012 · AI
Role of Genetic Susceptibility in Therapy-related Subsequent Malignancies
$630,540Smita Bhatia · Beckman Research Institute/City Of Hope · R01 · FY2011 · CA
Project 1
$630,523Bruce W Stillman · Cold Spring Harbor Laboratory · P01 · FY2016 · CA
Leadership, Planning and Evaluation
$630,506Michael Barry Kastan · Duke University · P30 · FY2024 · CA
Magnetic Resonance Fingerprinting of Tumor Vascular Perfusion and Acidosis
$630,474Christopher A Flask · Case Western Reserve University · R01 · FY2024 · CA
THE EARLY YEARS OF LIFE--FROM CHILDHOOD THROUGH ADOLESCENCE--ARE A CRITICAL TIME FOR SETTING THE FOUNDATION FOR LIFELONG HEALTH. WHILE MANY STUDIES HAVE LOOKED AT NUTRITION AFFECTS DURING GESTATION AND LACTATION, THERE'S MUCH LESS RESEARCH ON HOW WHAT CHILDREN AND TEENS EAT IMPACTS THEIR HEALTH AS ADULTS. THIS IS ESPECIALLY CONCERNING, BECAUSE NATIONAL DIETARY DATA SHOWS THAT MOST CHILDREN AND TEENS IN THE U.S. HAVE POOR DIETS--SCORING BELOW 55 OUT OF 100 ON THE HEALTHY EATING INDEX. BREAST CANCER IS THE MOST COMMON CANCER AMONG FEMALES IN THE UNITED STATES, WITH OVER 310,000 NEW CASES EXPECTED IN 2024 ALONE. IT ALSO REMAINS THE SECOND LEADING CAUSE OF CANCER-RELATED DEATHS IN FEMALES. WHILE ADVANCES IN SCREENING AND TREATMENT HAVE HELPED REDUCE DEATH RATES SINCE 1990, THE NUMBER OF NEW BREAST CANCER CASES CONTINUES TO RISE--ESPECIALLY AMONG YOUNGER FEMALES. ALARMINGLY, ABOUT HALF OF FEMALE WHO DIE FROM BREAST CANCER IN THE U.S. TODAY ARE UNDER THE AGE OF 45. ONE KEY GAP IN OUR UNDERSTANDING IS WHY BREAST CANCER IN YOUNGER FEMALE HAS BEEN INCREASING OVER THE PAST 50 YEARS. OUR PROJECT AIMS TO EXPLORE WHETHER POOR WESTERN-STYLE DIET (WSD) DURING CHILDHOOD AND ADOLESCENCE PLAYS A ROLE IN THIS TREND--AND IF IMPROVING EARLY-LIFE NUTRITION COULD HELP PREVENT BREAST CANCER LATER ON. IN OUR EARLY STUDIES USING ANIMAL MODELS, WE FOUND THAT EATING A HIGH-FAT DIET DURING YOUTH LED TO LONG-LASTING CHANGES IN THE GUT MICROBIOME AND IN BREAST TISSUE--CHANGES THAT MAY INCREASE THE RISK OF DEVELOPING BREAST CANCER LATER IN LIFE. THESE FINDINGS SUGGEST THAT THE RISE IN BREAST CANCER AMONG YOUNG FEMALE MAY BE LINKED, AT LEAST IN PART, TO THE INCREASING POPULARITY OF WESTERN-STYLE DIETS, WHICH ARE OFTEN HIGH IN FAT AND LOW IN FIBER AND ESSENTIAL NUTRIENTS. BEANS ARE A POWERFUL, NUTRIENT-RICH FOOD THAT CAN HELP IMPROVE THE QUALITY OF WSD. THEY CONTAIN FIBER, PROTEIN, AND OTHER IMPORTANT NUTRIENTS THAT MANY PEOPLE IN WESTERN COUNTRIES DON'T GET ENOUGH OF. HOWEVER, WE STILL DON'T KNOW ENOUGH HOW EFFECTIVE TO INCORPORATE BEANS INTO WSD FOR CHILDREN AND ADOLESCENTS AND THEREBY TO PROMOTE BREAST HEALTH, REDUCING THE RISK OF EARLY-ONSET BREAST CANCER. THIS PROJECT WILL FOCUS ON THREE MAIN GOALS: 1) TO EXAMINE HOW ADDING BEANS TO A WESTERN-STYLE DIET DURING CHILDHOOD AFFECTS THE GUT AND BREAST HEALTH LATER IN LIFE; 2) TO INVESTIGATE WHETHER THIS DIETARY CHANGE CAN REDUCE THE RISK OF DEVELOPING BREAST CANCER IN ADULTHOOD; AND 3) TO UNDERSTAND THE ROLE OF THE GUT MICROBIOME IN CONNECTING EARLY-LIFE DIET TO BREAST HEALTH OUTCOMES. BY EXPLORING THESE QUESTIONS, WE HOPE TO DEVELOP PRACTICAL, SCIENCE-BASED DIETARY STRATEGIES TO HELP REDUCE THE RISK OF BREAST CANCER--STARTING WITH BETTER NUTRITION IN THE EARLY YEARS OF LIFE.
$630,393University Of Massachusetts · · FY2025 · National Institute of Food and Agriculture
Creation of in vivo active chemical probes for CAMKK2 to treat cancer
$630,383David Harold Drewry · Univ Of North Carolina Chapel Hill · R01 · FY2019 · CA