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17,054 grants matching “genome editing”
Entorhinal Transcriptome in Schizophrenia
$271,606Scott Edwards Hemby · Wake Forest University Health Sciences · R01 · FY2009 · MH
Entorhinal Transcriptome in Schizophrenia
$271,606Scott Edwards Hemby · Wake Forest University Health Sciences · R01 · FY2007 · MH
Entorhinal Transcriptome in Schizophrenia
$271,606Scott Edwards Hemby · Wake Forest University Health Sciences · R01 · FY2008 · MH
Disease Modeling Core
$271,432Holger A. Russ · University Of Colorado Denver · P30 · FY2020 · DK
Resource: Swine Somatic Cell Gene Editing Testing Center
$271,419Randall S Prather · University Of Missouri-Columbia · U42 · FY2025 · OD
CAR T cell therapy for T cell lymphoma
$271,354Malcolm K Brenner · Baylor College Of Medicine · P50 · FY2018 · CA
UC Davis Chemical Biology Program
$271,275Peter A. Beal · University Of California At Davis · T32 · FY2023 · GM
Functional Genomics and Bioinformatics Core
$271,173Haotian Zhao · Sanford Research/Usd · P20 · FY2020 · GM
Core 2: In vivo cancer modeling and screening core facility
$271,099Sidi Chen · Yale University · U54 · FY2016 · CA
Understanding how the interaction between Lag3 deficiency and hypercholesterolemia impact anti-tumor immunity and cardiovascular disease in a melanoma model
$271,004Annabelle Rodriguez · University Of Connecticut Sch Of Med/Dnt · R21 · FY2023 · CA
Mystery of the Crooked Cell 2.0: CityLab's Next Generation SocioscientificApproach to Gene Editing
$270,777Donald A Derosa · Boston University (Charles River Campus) · R25 · FY2023 · GM
Mystery of the Crooked Cell 2.0: CityLab's Next Generation SocioscientificApproach to Gene Editing
$270,776Donald A Derosa · Boston University (Charles River Campus) · R25 · FY2022 · GM
Basic Science Core I
$270,692Shohreh Amini · Temple Univ Of The Commonwealth · P30 · FY2017 · MH
Childhood Hematological Malignancies Training Program
$270,617Charles G. Mullighan · St. Jude Children'S Research Hospital · T32 · FY2023 · CA
Resource: Swine Somatic Cell Gene Editing Testing Center
$270,601Randall S Prather · University Of Missouri-Columbia · U42 · FY2024 · OD
Mystery of the Crooked Cell 2.0: CityLab's Next Generation SocioscientificApproach to Gene Editing
$270,444Donald A Derosa · Boston University (Charles River Campus) · R25 · FY2024 · GM
Cell Preparation and Analysis Core
$270,258Diane S. Krause · Yale University · U54 · FY2020 · DK
Cell Preparation and Analysis Core
$270,258Diane S. Krause · Yale University · U54 · FY2021 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HEAT INCREASINGLY THREATENS THE US AND WORLD WHEAT PRODUCTION AS CLIMATE CHANGE CONTINUES. IN THE GREAT PLAINS, HEAT IS ONE OF THE TWO TOP YIELD KILLERS, AND HEAT TOLERANT CULTIVARS ARE URGENTLY NEEDED. BREEDING HEAT TOLERANCE IN WHEAT, HOWEVER, IS HINDERED BY THE LACK OF GERMPLASM OF SATISFIED HEAT TOLERANCE AND THE COMPLICATED GENETIC MECHANISMS. OUR GOAL IS TO IMPROVE HEAT TOLERANCE OF WHEAT VIA PRECISION GENOME EDITING TECHNOLOGY.RUBISCO ACTIVASE (RCA) EMERGED RECENTLY AS A PROMISING TARGET FOR ENHANCING PLANT HEAT TOLERANCE AND PHOTOSYNTHESIS. SEVERAL CONSERVED AMINO ACID SUBSTATIONS IN WHEAT RCA2 PROTEIN SIGNIFICANTLY INCREASED TEMPERATURE OPTIMUM OF THE PROTEIN. IN THIS PROJECT, WE WILL DEVELOP NOVEL WHEAT GERMPLASM WITH ENHANCED PHOTOSYNTHETIC EFFICIENCY AND HEAT TOLERANCE BY PRECISE EDITING OF TARCA2 GENE AS PROOF OF CONCEPT WITH THREE SPECIFIC OBJECTIVES:1) CREATE NOVEL RCA2 VARIATIONS FOR ENHANCED THERMOSTABILITY.2) EVALUATE MUTATION EFFECT ON PHOTOSYNTHETIC EFFICIENCY AND HEAT TOLERANCE.3) DEVELOP BREEDING-READY GERMPLASM.THESE RESULTS ARE EXPECTED TO HAVE A POSITIVE IMPACT ON THE IMPROVEMENT OF WHEAT HEAT TOLERANCE.
$270,244South Dakota State University · · FY2024 · National Institute of Food and Agriculture
Gene Expression During Embryonic Development Of Xenopus Laevis
$270,241Igor B Dawid · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2016 · HD
Gene Editing of the Beta Globin Gene Using TAL Effector Nucleases and single stranded oligonucleotides
$270,136Dula Man · Nemours Children'S Hospital, Delaware · P20 · FY2014 · GM
PROJECT 1
$270,112Reuben S Harris · University Of Minnesota · P01 · FY2019 · CA
THE MAMMALIAN REPRODUCTIVE GENETIC DATABASE
$270,020Robert E Braun · University Of Washington · U54 · FY2010 · HD
Preclinical development of gene-edited human hematopoietic stem cells
$270,000Rodger Novak · Harvard University · U19 · FY2016 · HL
Combinatorial design of nonviral base editing systems for treating cystic fibrosis with nonsense mutations
$270,000Bowen Li · University Of Toronto · R01 · FY2025 · HL