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38,696 grants matching “als”
Chronic Alcohol and Brain Stress Circuit Response
$446,529Rajita Sinha · Yale University · R01 · FY2009 · AA
Non-Invasive System for Identifying Neural Behavior
$446,520Carlo J De Luca · Altec, Inc. · R01 · FY2009 · NS
The Epidemiology of Tick-borne Relapsing Fever in North America
$446,517Tom Schwan · National Institute Of Allergy And Infectious Diseases · ZIA · FY2010 · AI
DEVELOPING NEXT GENERATION TECHNIQUES FOR THE COMPREHENSIVE ANALYSIS OF ORGANICS IN RETURNED SAMPLESWE PROPOSE TO DEVELOP NEXT GENERATION TECHNIQUES FOR THE COMPREHENSIVE ANALYSIS OF ORGANICS IN RETURNED SAMPLES. WE WILL DEVELOP NOVEL EXTRACTION METHODS AND USE A COMBINATION OF STATE-OF-THE-ART HIGH RESOLUTION MASS SPECTROMETRY AND ULTRAHIGH PERFORMANCE NANOLIQUID CHROMATOGRAPHY-HIGH RESOLUTION MASS SPECTROMETRY (CALLAHAN ET AL. 2011 AND 2014) FOR TARGETED AND UNTARGETED ANALYSES OF ORGANIC COMPOUNDS. WE WILL DESIGN THESE ANALYTICAL TECHNIQUES TOWARDS THE ANALYSES OF ORGANICS IN SAMPLES THAT ARE MICRON-SIZED AND WEIGH IN THE NANOGRAM RANGE. THESE ANALYTICAL TECHNIQUES WILL BE PARTICULARLY BENEFICIAL FOR RETURNED SAMPLES WITH FINITE AMOUNTS AND EXTREMELY LIMITED SAMPLE SIZE BECAUSE THESE SAMPLES ARE HIGHLY CHALLENGING TO ANALYZE THE ORGANICS ARE USUALLY IN TRACE AMOUNTS AND FEW TECHNIQUES CAN PROVIDE ANALYSES OF ORGANICS AT THE FULL MOLECULAR LEVEL. IN ADDITION TO THE DEVELOPMENT OF ANALYTICAL METHODS AND TECHNIQUES WE WILL ANALYZE COMETARY PARTICLES AND GRAIN TRACKS IN AEROGELS FROM THE STARDUST MISSION AS ANOTHER PRIMARY GOAL. WE WILL ALSO INCORPORATE A NOVEL ANALYTICAL STRATEGY CALLED METEOROMICS WHICH INCLUDES HIGH-LEVEL DATA ANALYSES TO COMPARE ORGANICS IN COMETARY SAMPLES TO OTHER EXTRATERRESTRIAL MATERIALS SUCH AS CARBONACEOUS METEORITES. OUR STATE-OF-THE-ART ANALYSES OF COMETARY PARTICLES AND GRAIN TRACKS IN AEROGELS WOULD SIGNIFICANTLY ADVANCE OUR UNDERSTANDING OF [1] COMPLEX ORGANICS IN COMETS [2] THE DISTRIBUTION OF COMPLEX ORGANICS IN THE SOLAR SYSTEM (PARTICULARLY THE OUTER SOLAR SYSTEM) AND [3] THEIR POTENTIAL ROLE IN THE ORIGIN OF LIFE ON EARTH WHICH WOULD MAXIMIZE THE SCIENCE DERIVED FROM THE STARDUST MISSION. THE PROPOSED RESEARCH IS WITHIN THE SCOPE OF THE LARS PROGRAM BECAUSE DEVELOPING NEXT GENERATION ANALYTICAL TECHNIQUES FOR A COMPREHENSIVE MOLECULAR-LEVEL ANALYSIS OF STARDUST RETURNED SAMPLES IS DIRECTLY RELEVANT TO THE TWO ACTIVITIES SUPPORTED BY THE LARS PROGRAM NAMELY [1] DEVELOPMENT OF LABORATORY ADVANCED TECHNIQUES REQUIRED FOR THE ANALYSIS OF RETURNED SAMPLES AND [2] DIRECT ANALYSIS OF SAMPLES ALREADY RETURNED TO EARTH. THE ANALYTICAL TECHNIQUES THAT WE PROPOSE TO DEVELOP AND UTILIZE ARE NOT LIMITED TO THE STARDUST RETURNED SAMPLES ONLY. THEY WOULD BE HIGHLY VALUABLE TOWARDS THE ANALYSIS OF ORGANIC COMPOSITION IN HIGHLY SAMPLELIMITED RETURNED SAMPLES SUCH AS HAYABUSA1 AND HAYABUSA2 AND FUTURE RETURNED SAMPLES FROM OSIRIS-REX; THIS IS ESPECIALLY TRUE CONSIDERING THEIR ASTEROIDAL ORIGIN AND OUR ABILITY TO COMPARE THESE SAMPLES WITH OUR EXISTING DATABASE OF METEORITIC ORGANICS.
$446,412Boise State University · · FY2017 · National Aeronautics and Space Administration
Causal Pathways to population health impact of HIV antiretroviral treatment
$446,321Frank Courteney Tanser · Kwazulu-Natal Research Institute Tb-Hiv · R01 · FY2016 · HD
ARTICULATORY KINEMATICS IN NEUROGENIC SPEECH DISORDERS
$446,259University Of Wisconsin Madison · R01 · FY2002 · DC
New compounds to study neurological disorders related to autophagic dysfunction
$446,233Travis T. Denton · Washington State University · R15 · FY2016 · NS
Nanometric Fluorescence Imaging of Single Motor Proteins
$446,222University Of Illinois Urbana-Champaign · R01 · FY2004 · GM
Pathological role of c-Abl in alpha-synucleinoapathy
$446,132Michael K Lee · University Of Minnesota · R01 · FY2018 · NS
Developing and implementing community based participatory health research with young adults with Down syndrome
$446,096Marie Moore Channell · University Of Illinois At Urbana-Champaign · R21 · FY2025 · HD
Triple Quadrupole Mass Spectrometer for Metabolomics Analysis
$446,015Susan T Weintraub · University Of Texas Hlth Science Center · S10 · FY2011 · RR
Center for Adaptive Leadership in Symptom Science
$446,003Sharron L Docherty · Duke University · P30 · FY2015 · NR
The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma
$445,962Olivier Elemento · Weill Medical Coll Of Cornell Univ · R01 · FY2019 · CA
Controlling an Ontogenic Masterswitch to Maximize Thrombopoiesis
$445,926Adam N. Goldfarb · University Of Virginia · R01 · FY2016 · HL
Controlling an Ontogenic Masterswitch to Maximize Thrombopoiesis
$445,926Adam N. Goldfarb · University Of Virginia · R01 · FY2017 · HL
Defining Immune Cell Heterogeneity in Human ALS and Mouse Model of the Disease
$445,897Serge E Przedborski · Columbia University Health Sciences · R01 · FY2023 · NS
Defining immune cell heterogeneity in human ALS and mouse model of the disease
$445,897Serge E Przedborski · Columbia University Health Sciences · R01 · FY2022 · NS
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
$445,861Matteo Ligorio · Ut Southwestern Medical Center · R37 · FY2024 · CA
FUNDAMENTAL INVESTIGATION OF THE MICROSTRUCTURAL PARAMETERS TO IMPROVE DYNAMIC RESPONSE IN AL-CU MODEL SYSTEM
$445,854Illinois Institute Of Technology · · FY2010 · Department of Defense
CORNEAL HSV-1: A NOVEL VIRULENCE/REACTIVATION GENE
$445,800University Of California Irvine · R01 · FY2002 · EY
Multichannel Microstimulation of Primary Afferent Neurons to Restore Propriocepti
$445,790Michael L Boninger · University Of Pittsburgh At Pittsburgh · R01 · FY2013 · NS
Identification of vascular inductive signals in liver regeneration
$445,665Shahin Rafii · Weill Medical Coll Of Cornell Univ · R01 · FY2016 · DK
Identification of vascular inductive signals in liver regeneration
$445,665Shahin Rafii · Weill Medical Coll Of Cornell Univ · R01 · FY2015 · DK
Identification of vascular inductive signals in liver regeneration
$445,665Shahin Rafii · Weill Medical Coll Of Cornell Univ · R01 · FY2014 · DK
Outer Membrane Proteins of Francisella tularensis as Acellular Vaccines
$445,663Michael V Norgard · University Of Texas Med Br Galveston · U54 · FY2013 · AI