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17,828 grants matching “crispr”
Understanding the molecular mechanism of a protein-recycling complex in small cell lung cancer treatment resistance.
$295,362Benjamin H Lok · University Health Network · U01 · FY2021 · CA
Targeting STT3A and STT3B to Block Flavivirus Replication
$295,298Michael Christopher Van Zandt · New England Discovery Partners, Llc · R41 · FY2018 · AI
CRISPR-EDITING OF SWEET BASIL SUSCEPTIBILITY GENES TO IMPROVE DOWNY MILDEW RESISTANCE
$295,296Rutgers, The State University · · FY2018 · National Institute of Food and Agriculture
Characterizing Histone Deacetylases in Rhabdomyosarcoma
$295,138Eleanor Y Chen · University Of Washington · R01 · FY2016 · CA
Mechanism, specificity, and design of CRISPR RNA-mediated gene regulation
$295,065Ilya J Finkelstein · University Of Texas At Austin · R01 · FY2019 · GM
Mechanism, specificity, and design of CRISPR RNA-mediated gene regulation
$295,065Ilya J Finkelstein · University Of Texas At Austin · R01 · FY2020 · GM
Mechanism, specificity, and design of CRISPR RNA-mediated gene regulation
$295,065Ilya J Finkelstein · University Of Texas At Austin · R01 · FY2018 · GM
Automated CRISPR Enabled DNA Synthesis (CEDS)
$295,025Michael David Lynch · Duke University · R21 · FY2022 · HG
Selective Stalling of Human Translation by Small Molecules
$294,916Jamie H Cate · University Of California Berkeley · R01 · FY2021 · GM
DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells
$294,647Leonidas Bleris · University Of Texas Dallas · R01 · FY2024 · GM
Project 3: Autophagy dysfunction and neuronal activity in FTD
$294,609Ana M. Cuervo · J. David Gladstone Institutes · U54 · FY2016 · NS
The function of small RNA-based viral defense system in E. coli
$294,500Konstantin V Severinov · Rutgers, The State Univ Of N.J. · R01 · FY2015 · GM
The function of small RNA-based viral defense system in E. coli
$294,500Konstantin V Severinov · Rutgers, The State Univ Of N.J. · R01 · FY2016 · GM
The function of small RNA-based viral defense system in E. coli
$294,500Konstantin V Severinov · Rutgers, The State Univ Of N.J. · R01 · FY2014 · GM
The function of small RNA-based viral defense system in E. coli
$294,500Konstantin V Severinov · Rutgers, The State Univ Of N.J. · R01 · FY2013 · GM
Enzymatic Site-Specific Labeling of RNA for Affinity Isolation
$294,435Neal Krishna Devaraj · University Of California, San Diego · R01 · FY2017 · GM
The role of autophagy in bone remodeling
$294,196Melda Onal · Univ Of Arkansas For Med Scis · P20 · FY2023 · GM
Selective Stalling of Human Translation by Small Molecules
$294,091Jamie H Cate · University Of California Berkeley · R01 · FY2022 · GM
Delivering genetic medicines to photoreceptors with lipid nanoparticles
$294,052Adam Tuttle · Enterx Biosciences, Inc. · R43 · FY2024 · EY
Off-The-Shelf Dual Targeted NK Cells For NHL
$294,004Daniel J Weisdorf · University Of Minnesota · P01 · FY2021 · CA
NON-TECHNICAL SUMMARYCOTTON (GOSSYPIUM HIRSUTUM) IS OUR MOST IMPORTANT FIBER CROP. YIELD AND QUALITY ARE UNDERMINED BY PESTS AND PATHOGENS, INCLUDING COTTON APHIDS AND FUSARIUM FUNGAL INFECTIONS. PLANT-SYNTHESIZED OXYLIPINS, SPECIFICALLY 9-HYDROXY FATTY ACIDS RESULTING FROM 9-LIPOXYGENASE ACTIVITY (9-LOX), ARE FEEDING STIMULANTS FOR MANY PESTS, AND REDUCED LEVELS OF THESE COMPOUNDS IN CROP PLANTS CAN PROVIDE PROTECTION. ADDRESSING USDA PROGRAM AREA CRITICAL AGRICULTURAL RESEARCH AND EXTENSION (A1701), WE PROPOSE TO DEVELOP GENOME EDITING APPROACHES TO CONFER NATURAL RESISTANCE AGAINST DEVASTATING COTTON APHID AND FUSARIUM WILT BY ELUCIDATING OXYLIPIN SIGNALING AND MANIPULATING ITS DERIVATIVES. FIRST, WE WILL FUNCTIONALLY TEST GENES ENCODING 9-LOX ENZYMES USING VIRUS-INDUCED GENE SILENCING. WE PREDICT THIS WILL REDUCE 9-HYDROXY FATTY ACIDS LEVELS AND DETER APHID AND FUSARIUM INFESTATIONS. SECOND, WE WILL INTRODUCE STABLE GENETIC ALTERATIONS TO GHLOX GENES USING NEW CRISPR-MEDIATED GENE EDITING APPROACHES, AND TEST THAT THESE ARE HERITABLE AND CONFER RESISTANCE AGAINST APHIDS AND FUSARIUM. WE AIM TO ACCELERATE THESE GENE-EDITING STRATEGIES BY INCORPORATING INDUCIBLE GENES PROMOTING SOMATIC EMBRYOGENESIS AND WHOLE-PLANT REGENERATION. THIRD, BY EXPLOITING A NEW APPROACH FOR MAKING PLANT MERISTEMS MORE SUSCEPTIBLE TO GENETIC MANIPULATION, WE AIM TO DEVELOP A NOVEL, MERISTEM-BASED GENE-EDITING SYSTEM TO ACHIEVE STABLE ALTERATIONS IN GERMLINE CELLS AND BY-PASS THE NEED FOR TISSUE CULTURE. THIS HIGH-RISK OBJECTIVE MAY REVOLUTIONIZE BIOTECHNOLOGY APPROACHES TO IMPROVE COTTON AGRICULTURE. THIS PROPOSAL IS SUBMITTED AS A CO-FUNDED PRIORITY WITH THE COTTON BOARD TO DEVELOP NEW GENOME EDITING-ENABLED APPROACHES TO PROTECT COTTON FROM DAMAGING INSECT PESTS WITH THE POTENTIAL TO CONSIDERABLY REDUCE PESTICIDE USE, PRESERVE CURRENT TECHNOLOGIES, AND MAINTAIN YIELDS.
$294,000University Of North Texas · · FY2021 · National Institute of Food and Agriculture
Metabolic regulation of FOLFIRINOX acquired resistance in pancreatic cancer
$293,941Pankaj Kumar Singh · University Of Oklahoma Hlth Sciences Ctr · U54 · FY2022 · CA
Integrated Genomics Shared Resource
$293,916Martina L Veigl · Case Western Reserve University · P30 · FY2020 · CA
Surfaceome CRISPR screening for SARS-CoV-2 virulent proteins
$293,871Sanghyun Lee · Brown University · P20 · FY2025 · GM
Core E: Mass Spectrometry Core
$293,806Nevan J Krogan · Weill Medical Coll Of Cornell Univ · U54 · FY2020 · NS