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17,828 grants matching “crispr”
Precision controllers of mammalian gene expression
$298,760Roger Brent · Fred Hutchinson Cancer Research Center · R21 · FY2019 · CA
Targeting STT3A and STT3B to Block Flavivirus Replication
$298,652Michael Christopher Van Zandt · New England Discovery Partners, Llc · R41 · FY2017 · AI
Project 3: The role of microenvironmental metabolites on metastatic progression
$298,581Kivanc Birsoy · Rockefeller University · U54 · FY2025 · CA
Discovery and characterization of a novel acylcarnitine transporter in brown adipocytes
$298,560Judith Anne Simcox · University Of Wisconsin-Madison · R01 · FY2024 · DK
Predicting 3D physical gene-enhancer interactions through integration of GTEx and 4DN data
$298,222Jie Liang · University Of Illinois At Chicago · R03 · FY2023 · OD
Genetics regulators of vascular smooth muscle thermogenic differentiation
$298,222Matthew D Lynes · Mainehealth · P20 · FY2023 · GM
Novel therapeutic target to combat cutaneous lupus
$298,132Fanny Astruc Diaz · Dermaxon, Llc · R41 · FY2021 · TR
EAGER: Targeted and specific elimination of plant chromosomes
$298,102Luca Comai · University Of California-Davis · · FY2023 · BIO
Engineering the C. Elegans Genome
$298,000Erik M Jorgensen · University Of Utah · R01 · FY2018 · GM
Engineering the C. Elegans Genome
$298,000Erik M Jorgensen · University Of Utah · R01 · FY2016 · GM
SPOT-CHECK: capture of site-specific complexes in vivo
$297,975Cynthia Therese McMurray · University Of Calif-Lawrenc Berkeley Lab · R21 · FY2018 · NS
Expression genetics of CYP3A drug metabolizing enzymes
$297,894Danxin Wang · Ohio State University · R01 · FY2017 · GM
Biological Core
$297,854Carolyn Ann Worby · University Of Kentucky · P01 · FY2019 · NS
An instrument-free malaria diagnostic
$297,761Gregory John Tobin · Biological Mimetics, Inc. · R43 · FY2024 · AI
Identification of Candidate Disease-Causing Variants
$297,559Steven E Brenner · University Of California, San Francisco · P01 · FY2024 · AI
Investigation of energetics of sharp DNA bending
$297,388Harold D Kim · Georgia Institute Of Technology · R01 · FY2022 · GM
A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineage
$297,248Angela M. Belcher · Massachusetts Institute Of Technology · R21 · FY2022 · CA
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2021 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2017 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2019 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2020 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2018 · GM
PAPAYA (CARICA PAPAYA L.) IS AN ECONOMICALLY IMPORTANT NUTRITIOUS FRUIT CROP, WIDELY GROWN IN THE TROPICS AND SUBTROPICS. BESIDES ITS USE AS FOOD, THE FRUIT IS ALSO USED IN THE COSMETICS, PHARMACEUTICAL AND FOOD PROCESSING INDUSTRIES. PAPAYA PLANTS OCCUR IN THREE SEX TYPES, BUT ITS SEX DETERMINING GENE (S) HAVE YET TO BE DEFINED. A RANGE OF VIRAL, FUNGAL AND OOMYCETE PATHOGENS SEVERELY THREATEN PAPAYA PRODUCTION. TO BETTER UTILIZE PAPAYA PRODUCTS AND REDUCE THE COST IN PRODUCTION ASSOCIATED WITH DISEASE CONTROLAND IDENTIFICATION OF HERMAPHRODITE PLANTS, FUNCTIONAL UNDERSTANDING OF PAPAYA GENES IS A PREREQUISITE,BUT HINDERED BY THE LACK OF AN EFFECTIVE GENE KNOCKOUT SYSTEM IN PAPAYA.CRISPR-MEDIATED GENE EDITING TECHNOLOGY HAS REVOLUTIONIZED FUNCTIONAL GENOMICS OF MANY ORGANISMS, AND IS A POWERFUL TOOL TO BREED TRANSGENE-FREE NEW VARIETIES WITH NUMEROUS DESIRABLE TRAITS. HOWEVER, A GENE EDITING SYSTEM HAS NOT BEEN ESTABLISHED IN PAPAYA. THIS PROJECT IS TO ESTABLISH METHODSFOR EFFECTIVEGENOME EDITING OF PAPAYA TO MEET THE DIVERSE NEEDS OF GENE FUNCTIONAL ANALYSES AND BREEDING.TO MAXIMIZE THE SUCCESS, WE WILL UTILIZE TWO CRISPR SYSTEMS (CAS9 AND CAS12) AND COMPLEMENTARY APPROACHES. SPECIFICALLY, WE WILL: 1) ESTABLISH AN EFFECTIVE AND ROUTINE PAPAYA GENE EDITING SYSTEM VIA AGROBACTERIUM-MEDIATED TRANSFORMATION, AND 2) DEVELOP DNA-FREE GENOME EDITING OF PAPAYA WITH PREASSEMBLED CRISPR-NUCLEASE RIBONUCLEOPROTEIN COMPLEXES.
$296,942University Of Hawaii · · FY2020 · National Institute of Food and Agriculture
Acoustic microvortices instrumentation for dosage controlled, high efficiency cell engineering
$296,930Abraham P Lee · University Of California-Irvine · R01 · FY2023 · GM
Investigation of energetics of sharp DNA bending
$296,818Harold D Kim · Georgia Institute Of Technology · R01 · FY2023 · GM