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17,054 grants matching “genome editing”
Core C: Genome Engineering Core
$283,535Bruce R Conklin · J. David Gladstone Institutes · P01 · FY2023 · HL
Targeted Delivery of Cas9 to Lung Epithelial Cells using Enveloped Delivery Vehicles
$283,500Jennifer A Doudna · J. David Gladstone Institutes · R21 · FY2025 · HL
Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9
$283,255Giulia Palermo · University Of California Riverside · R01 · FY2021 · GM
Project 1: Decoding Origin and Modeling Oncohistones in Pediatric Cancers
$282,942Nada Jabado · Rockefeller University · P01 · FY2017 · CA
Project 1: Decoding Origin and Modeling Oncohistones in Pediatric Cancers
$282,942Nada Jabado · Rockefeller University · P01 · FY2016 · CA
Project 1: Decoding Origin and Modeling Oncohistones in Pediatric Cancers
$282,942Nada Jabado · Rockefeller University · P01 · FY2018 · CA
Molecular Mechanism and Biological Function of 3'-5' Nucleotide Addition
$282,905Jane Elizabeth Jackman · Ohio State University · R01 · FY2011 · GM
Endonuclease-mediated disruption of latent HSV as curative therapy
$282,779Keith R Jerome · Fred Hutchinson Cancer Research Center · R01 · FY2021 · AI
Building transgenic tools in Acomys cahirinus, an emerging model for mammalian regenerative biology and healthy aging
$282,750Kathleen Joyce Millen · Seattle Children'S Hospital · R21 · FY2021 · OD
New tools for the characterization of gene predictions in prokaryote genomes: app
$282,734Luciano Brocchieri · University Of Florida · R01 · FY2010 · GM
Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9
$282,639Giulia Palermo · University Of California Riverside · R01 · FY2022 · GM
UC Davis Chemical Biology Program
$282,570Peter A. Beal · University Of California At Davis · T32 · FY2024 · GM
Expression Genetics of CYP3A Drug Metabolizing Enzymes
$282,564Danxin Wang · University Of Florida · R01 · FY2018 · GM
Exploring the Genetics of FASD in Complementary Mouse and Fish Models
$282,530Scott Parnell · Univ Of North Carolina Chapel Hill · U01 · FY2021 · AA
CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics
$282,110Michael S Kay · University Of Utah · U54 · FY2023 · AI
A new tool for the cell-specific identification of RNA binding protein targets
$282,094Michael Rosbash · Brandeis University · R01 · FY2014 · DA
Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9
$281,994Giulia Palermo · University Of California Riverside · R01 · FY2023 · GM
IUCRC Phase III University of Florida: Center for Arthropod Management Technologies (CAMTech)
$281,994Bryony C Bonning · University Of Florida · · FY2023 · ENG
Collaborative Research: REU Site: Summer Undergraduate Research Program in RNA and Genome Biology (REU-RGB)
$281,994Aaron M Johnson · University Of Colorado At Denver · · FY2024 · BIO
PLANT PARASITIC NEMATODES ARE HIGHLY EVOLVED OBLIGATE PARASITES THAT THREATEN GLOBAL FOOD SECURITY. THESE NEMATODES HAVE A REMARKABLE ABILITY TO MODIFY HOST CELLS THAT SERVE AS THEIR ONLY SOURCE OF NUTRIENTS THROUGHOUT THEIR LIFE CYCLE. WHILE THESE PESTS HAVE BEEN INVESTIGATED MAINLY BECAUSE THEY ARE MAJOR CONSTRAINTS ON FOOD PRODUCTION GLOBALLY, THEY ALSO PROVIDE AN EXCELLENT SYSTEM TO INVESTIGATE SPECIFIC PROBLEMS IN PLANT AND ANIMAL DEVELOPMENT. HOWEVER, NO METHOD CURRENTLY EXISTS TO EDIT A PLANT-PARASITIC NEMATODE GENE OF INTEREST, CHANGE ITS EXPRESSION LEVEL, OR INCORPORATE NEW GENES. STUDIES ON PLANT-NEMATODE INTERACTIONS THEREFORE LAG THOSE FOR OTHER PATHOSYSTEMS. THE SPECIFIC AIM OF THIS PROPOSAL IS TO DEVELOP FUNCTIONAL GENOMIC TOOLS FOR AN AGRICULTURALLY IMPORTANT PLANT-PARASITIC NEMATODE. BUILDING ON OUR PRELIMINARY RESULTS, WE PROPOSE TO DELIVER A TOOL-KIT FOR THE GENERATION AND IDENTIFICATION OF HERITABLE GENOME EDITING EVENTS IN PLANT-PARASITIC NEMATODES. WE WILL: I) OPTIMIZE TRANSIENT EXPRESSION OF INTRODUCED GENES IN SOMATIC CELLS OF ROOT-KNOT NEMATODES, II) DEVELOP A STRATEGY FOR GENOME EDITING IN MALE GONADS AND IDENTIFY HERITABLE EDITING EVENTS, AND 3) DISSEMINATE THE INFORMATION TO THE SCIENTIFIC COMMUNITY AND THE PUBLIC. ACHIEVEMENT OF THESE GOALS WOULD BE A TRANSFORMATIVE TECHNICAL ADVANCE FOR THE FIELD OF PLANT-NEMATODE INTERACTIONS AND WOULD FACILITATE THE DEVELOPMENT OF MUCH-NEEDED ENVIRONMENTALLY SAFE STRATEGIES TO CONTROL THESE HIGHLY DAMAGING PLANT PATHOGENS. THE GOAL OF PROPOSED RESEARCH IS DIRECTLY RELEVANT TO THE AFRI PROGRAM AREA AGRICULTURAL INNOVATION THROUGH GENE EDITING (A1191), WHICH SUPPORTS THE EXPANSION OF TRANSFORMATION AND GENE-EDITING TECHNOLOGIES FOR USE IN AGRICULTURALLY IMPORTANT MICROORGANISMS.
$281,953University Of California, Davis · · FY2021 · National Institute of Food and Agriculture
Pharmacological Control Of Human Hemoglobin Gene Expression
$281,940Alan Schechter · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2018 · DK
3/3 Multidimensional investigation of the etiology of autism spectrum disorder
$281,886Nenad Sestan · Yale University · R01 · FY2017 · MH
Molecular Neuroscience of Alcohol and Drug Abuse Research Training
$281,832Dipak Kumar Sarkar · Rutgers, The State Univ Of N.J. · T32 · FY2022 · AA
Nucleic Acid-Based Anti-CRISPR Inhibitors of Cas9
$281,595Keith Thomas Gagnon · Southern Illinois University Carbondale · R01 · FY2020 · GM
A new tool for the cell-specific identification of RNA binding protein targets
$281,231Michael Rosbash · Brandeis University · R01 · FY2013 · DA