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17,828 grants matching “crispr”
EAGER: Enabling Efficient Genome Editing for Advanced Biomanufacturing Applications
$300,000Kelvin H Lee · University Of Delaware · · FY2015 · BIO
Enzymatic Synthesis of RNA
$300,000Steven A Benner · Foundation For Applied Molecular Evolutn · R01 · FY2023 · HG
In vivo Sickle Cell Disease Gene Therapy Using a Novel Virus Like Particle
$300,000David Scott Johnson · Gigamune, Inc. · R43 · FY2024 · HL
RoL: FELS: EAGER: Exploring the adaptive possibilities of 'redundancy' in a plant defense hormone signaling pathway
$300,000Eric Klavins · University Of Washington · · FY2018 · BIO
EAGER: Engineered, Smart, Nucleic Acid-Binding, Intrinsically Disordered Proteins to Enable Ubiquitous Detection of Viral Pathogens and Diagnosis
$300,000Gabriel P Lopez · University Of New Mexico · · FY2020 · ENG
BTT EAGER: Mitotic Recombination between Homologous Chromosomes
$300,000Anne B Britt · University Of California-Davis · · FY2019 · BIO
EAGER: A Genome Wide HDR Enhancement Screen in Maize
$300,000Kenneth D Birnbaum · New York University · · FY2024 · BIO
Regulation of cell death and disease by a novel membrane protein MADMAN.
$300,000Zhigao Wang · University Of South Florida · R01 · FY2023 · GM
Cpf1-mediated inactivation of an AAV transgene
$300,000Michael David Alpert · Emmune, Inc · R43 · FY2018 · AI
Developing generalized engineering tools to create enhanced phage therapy for the clinic and commercialization
$300,000Robert McBride · Felix Biotechnology, Inc. · R41 · FY2022 · AI
AIM 1: EXAMINE THE RESPONSE OF WILD-TYPE AND CX43-DEFICIENT (VIA CRISPR GENE EDITING) MURINE OSTEOCYTES (OCY454) TO SIMULATED MICROGRAVITY IN VITRO USING A HIGH ASPECT RATIO VESSEL (HARV). AIM 2: EXAMINE THE EFFECT OF SIMULATED MICROGRAVITY IN VIVO ON BONES FROM OSTEOCYTE-SPECIFIC CX43-DEFICIENT MICE. CX43 WILL BE SELECTIVELY DELETED FROM MICE USING A CRE RECOMBINASE APPROACH SIMILAR TO WHAT WE PREVIOUSLY USED TO DELETE CX43 FROM OSTEOBLASTS AND OSTEOCYTES. USING WELL-ESTABLISHED EXPERIMENTAL PARADIGMS LIKE THE HARV APPARATUS AND HLS GREATLY INCREASES THE PROBABILITY OF SUCCESSFULLY COMPLETING OUR AIMS AND ATTAINING IMPORTANT NOVEL FINDINGS. COLLECTIVELY OUR INFRASTRUCTURE AND EXPERTISE IN COMBINATION WITH MULTIPLE UNIQUE REAGENTS PLACE US IN AN UNPARALLELED POSITION TO RAPIDLY AND SIGNIFICANTLY ADVANCE KNOWLEDGE PERTAINING TO THE MECHANISMS UNDERLYING MICROGRAVITY-INDUCED BONE LOSS. THESE AIMS AND THE EXPERIMENTS DESIGNED THEREIN REPRESENT A SUBSTANTIVE DEPARTURE FROM OUR CURRENT UNDERSTANDING AND WILL REVEAL NOVEL TARGETS FOR COUNTERMEASURES.
$300,000Virginia Commonwealth University · · FY2020 · National Aeronautics and Space Administration
Defining a molecular mechanism for paralogous compensation
$300,000Richard Cripps · University Of New Mexico · · FY2017 · BIO
EAGER: Developing High-Throughput CRISPR/Single-cell RNA-seq Screening in Maize
$300,000Kenneth D Birnbaum · New York University · · FY2018 · BIO
Conditional male lethal Anopheles stephensi line for the efficient manufacture of malaria vaccines
$300,000Peter F. Billingsley · Sanaria, Inc. · R43 · FY2023 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GETTING SICK FROM EATING CONTAMINATED FOOD IS A RISK WE ALL FACE. ILLNESSES CAUSED BY BACTERIA IN OUR FOOD ARE BECOMING A BIG HEALTH AND ECONOMIC PROBLEM IN THE UNITED STATES. AS THESE BACTERIA BECOME RESISTANT TO ANTIBIOTICS, DETECTING AND TREATING THE ILLNESSES THEY CAUSE ARE GETTING EVEN HARDER. CURRENTLY, THE BEST WAYS TO DETECT THESE ANTIBIOTIC-RESISTANT BACTERIA IN FOOD ARE THROUGH SLOW METHODS LIKE CULTURING AND PCR (POLYMERASE CHAIN REACTION). WHILE ACCURATE, THESE METHODS TAKE A LONG TIME AND REQUIRE TRAINED EXPERTS TO OPERATE. THIS PROJECT AIMS TO CREATE A SMALL, PORTABLE DEVICE CALLED THE NANOPHOTONIC-CRISPR CHIP (NPC-CHIP) THAT CAN QUICKLY AND ACCURATELY DETECT ANTIBIOTIC-RESISTANT BACTERIA IN FOOD. NO EXPERT OR LAB IS NEEDED. THE NPC-CHIP COMBINES LIGHT AND CRISPR TECHNOLOGIES INTO ONE TINY CHIP. NON-EXPERT USERS CAN EASILY CARRY AND USE IT TO IDENTIFY THE CONTAMINATION IN FOOD. IN THIS PROJECT, THE CHIP PERFORMANCE WILL BE TESTED IN MILK SAMPLES. IF SUCCESSFUL, THIS FAST, SENSITIVE, AND PORTABLE NPC-CHIP CAN HELP CONTROL THE SPREAD OF DISEASE-CAUSING BACTERIA IN OUR FOOD SUPPLY CHAIN AND REDUCE THE OVERUSE OF ANTIBIOTICS, CRUCIAL FOR FOOD SAFETY AND PUBLIC HEALTH.?
$300,000Arizona State University · · FY2024 · National Institute of Food and Agriculture
Development of STAR Editors (CRISPR-Cas9/lgRNA-ssDNA) for the cure of chronic hepatitis B
$300,000Minghong Zhong · Genelancet Biosciences Inc · R43 · FY2022 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CALIFORNIA'S AVOCADO INDUSTRY, A $400 MILLION CORNERSTONE OF THE STATE'S AGRICULTURAL SECTOR, FACES A SIGNIFICANT CHALLENGE - AVOCADO SUNBLOTCH VIROID DISEASE (ASBVD). THIS INSIDIOUS PATHOGENSILENTLY INFECT AVOCADO TREES, OFTEN WITHOUT OUTWARD SYMPTOMS. THE ECONOMIC CONSEQUENCES ARE DEVASTATING, WITH INFECTED TREES EXPERIENCING SUBSTANTIAL YIELD REDUCTION. CURRENT METHODS FOR DETECTING ASBVD ARE IMPEDED BY THEIR COMPLEXITY AND TIME-CONSUMING NATURE, RENDERING THEM IMPRACTICAL FOR LARGE-SCALE MONITORING EFFORTS. THIS PROPOSAL SEEKS TO DEVELOP A TRANSFORMATIVE TECHNOLOGY THAT LEVERAGES A UNIQUE COMBINATION OF CUTTING-EDGE TOOLS, INCLUDING ULTRA-SENSITIVE NANOPROBES, THE REVOLUTIONARY CRISPR GENE-EDITING TECHNIQUE, AND HIGH-THROUGHPUT LAB-ON-A-CHIP DEVICES. THIS INNOVATIVE SYSTEM HAS THE REMARKABLE POTENTIAL TO SIMULTANEOUSLY ANALYZE HUNDREDS OF AVOCADO SAMPLES WITHIN MINUTES, DETECTING ASBVD AT INCREDIBLY LOW CONCENTRATIONS. THE BENEFITS OF THIS INNOVATIVE TECHNOLOGYEXTEND FAR BEYOND THE SAFEGUARDING OF CALIFORNIA'S AVOCADO INDUSTRY. ITHAS THE POTENTIAL TO SERVE AS A MODEL FOR THE DEVELOPMENT OF RAPID, RELIABLE, AND COST-EFFECTIVE DETECTION METHODS FOR A WIDE RANGE OF PLANT AND ANIMAL DISEASES, CONTRIBUTING SIGNIFICANTLY TO THE ADVANCEMENT OF AGRICULTURAL DISEASE MANAGEMENT PRACTICES.
$300,000Regents Of The University Of California At Riverside · · FY2024 · National Institute of Food and Agriculture
Enhancement of gametocytogenesis in Plasmodium falciparum by genetic engineering for improved PfSPZ Vaccine Manufacture
$300,000Stephen Lev Hoffman · Sanaria, Inc. · R43 · FY2020 · AI
Alterations and Renovations
$300,000Robert E Friesel · Mainehealth · U54 · FY2022 · GM
RoL: FELS: EAGER Rules of lifespan determination and buffering from lifelong spatiotemporal activity of key aging pathways.
$299,999Adriana San Miguel · North Carolina State University · · FY2018 · BIO
Parametric design software for nanostructured CRISPR payloads
$299,999Steven L Armentrout · Parabon Nanolabs, Inc. · R43 · FY2023 · GM
Design, Implementation, and Evaluation of a Gene Editing Technology Toolkit for Undergraduate Education
$299,996Hooi Lynn Kee · Stetson University · · FY2021 · EDU
Enhancement of gametocytogenesis in Plasmodium falciparum by genetic engineering for improved PfSPZ Vaccine Manufacture
$299,994Stephen Lev Hoffman · Sanaria, Inc. · R43 · FY2021 · AI
ReDDDoT Phase 1: Planning Grant: Piloting an impact accelerator model for cultivating equity and ethics in genetics innovation
$299,993Marnie E Gelbart · Harvard University · · FY2024 · TIP
RoL: EAGER: DESYN-C3: Programmable control of metabolism in synthetic cells using intrinsically disordered proteins
$299,986Nick J Carroll · University Of New Mexico · · FY2018 · ENG