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1,049,261 grants matching “t cell”
Mechanisms of Energy Balance and Cancer Prevention
$2,463,212Anne M McTiernan · Fred Hutchinson Cancer Research Center · U54 · FY2007 · CA
Center for Genomic Regulation
$2,463,036Willard M Freeman · Oklahoma Medical Research Foundation · P20 · FY2025 · GM
Host-Pathogen Interaction in Leptospirosis
$2,463,023David A Haake · University Of California Los Angeles · P01 · FY2023 · AI
Vascular Cell Signaling and Atherogenesis
$2,462,964Weill Medical College Of Cornell Univ · P01 · FY2003 · HL
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES
$2,462,957Timothy A Springer · Immune Disease Institute, Inc. · P01 · FY2011 · HL
Defining regulators of immunity to acute infection using CRISPR screens
$2,462,939Arlene H Sharpe · Harvard Medical School · U19 · FY2017 · AI
Capacitative Calcium Entry
$2,462,878James W Putney · National Institute Of Environmental Health Sciences · ZIA · FY2014 · ES
Vaccine Induced Immunity in the Young and Aged
$2,462,810Rafi Ahmed · Emory University · U19 · FY2009 · AI
New Approaches to Inducing Cardiac Allograft Tolerance
$2,462,802Joren C Madsen · Massachusetts General Hospital · P01 · FY2021 · HL
Barrett's Esophagus: Predictors of Progression
$2,462,800Brian J Reid · Fred Hutchinson Cancer Research Center · P01 · FY2015 · CA
Biochemistry Of Lymphocyte Activation
$2,462,667John J. O'Shea · Arthritis, Musculoskeletal, Skin Dis · Z01 · FY2007 · AR
Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics
$2,462,651Joseph D Dougherty · Washington University · RM1 · FY2025 · MH
Genetic Analysis of Resistance to Viral Infection
$2,462,415Bruce A Beutler · Scripps Research Institute, The · P01 · FY2008 · AI
GENERAL CLINICAL RESEARCH CENTER
$2,462,305University Of Chicago · M01 · FY2000 · RR
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort Study
$2,462,168Dana Dabelea · University Of Colorado Denver · UH3 · FY2021 · OD
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort Study
$2,462,168Dana Dabelea · University Of Colorado Denver · UH3 · FY2020 · OD
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort Study
$2,462,168Dana Dabelea · University Of Colorado Denver · UH3 · FY2022 · OD
Genes and signals controlling mammalian hematopoiesis.
$2,462,161Paul E Love · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2021 · HD
Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIV
$2,461,914Manolis Kellis · Broad Institute, Inc. · U01 · FY2021 · DA
A Compartmental Analysis of HIV Reservoirs and Immune Reconstitution
$2,461,908Timothy W Schacker · University Of Minnesota · P01 · FY2008 · AI
Scripps Research Institute Molecular Screen Center(RMI)
$2,461,844Scripps Research Institute · U54 · FY2005 · MH
HIGH PERFORMANCE HYDROCARBON MEMBRANE ELECTRODE ASSEMBLY THE OBJECTIVES OF THIS PROJECT ARE TO RAISE THE PERFORMANCE AND DURABILITY OF ALL-HYDROCARBON MEMBRANE-ELECTRODE ASSEMBLIES (HC-MEAS) FOR POLYMER-ELECTROLYTE FUEL CELL (PEFC) POWERED MEDIUM- AND HEAVY-DUTY VEHICLES (M/HDVS). THE PROJECT TEAM WILL FOCUS ON THREE TANGIBLE ELEMENTS: MAKING HYDROCARBON MEMBRANES (HCMS) WITH HIGH PERFORMANCE AND DURABILITY, FINDING COMBINATIONS OF HYDROCARBON IONOMERS (HCIS), PROCESSING CONDITIONS, AND CATALYSTS (PLATINUM-GROUP METAL (PGM) NANOPARTICLES ON CARBON) THAT YIELD GOOD CATALYST LAYERS (CLS), AND INVESTIGATING HOW REPLACING SOLID PLATES (SPS) WITH POROUS WATER-TRANSPORT PLATES (WTPS) AFFECTS THE VALUE PROPOSITION FOR HC-MEAS. FOCUSING ON THESE THREE AREAS SHOULD ENABLE THE TEAM TO DEMONSTRATE POWER DENSITIES WITH HC-MEAS THAT ARE COMPETITIVE WITH STATE-OF-ART (SOA) PERFLUOROSULFONIC ACIDS MEAS (PFSA-MEAS) AT THE SAME PGM LOADING AT THE END OF 36 MONTHS. THE DURABILITY OF HYDROCARBON MEMBRANES IS WORSE THAN PFSAS. THE TEAM WILL DEPLOY A VARIETY OF STRATEGIES TO CLOSE THIS GAP INCLUDING FLUORINE-FREE REINFORCEMENTS, ORGANIC AND INORGANIC RADICAL SCAVENGERS, AND WTPS. THIS PROJECT SHOULD PROVIDE IMPORTANT NEW INFORMATION ABOUT THE EFFECTIVENESS OF THESE APPROACHES. THE PROJECT IS DIVIDED INTO TWO 18-MONTH BUDGET PERIODS, BP1 AND BP2, SEPARATED BY A QUANTITATIVE GO/NO-GO GATE REVIEW. THE HIGH-LEVEL GOAL OF BP1 IS TO DEMONSTRATE A HC-MEA WITH PERFORMANCE AND DURABILITY THAT IS COMPETITIVE WITH SOA HC-MEAS IN BOTH WTPS AND SPS, AND TO ARTICULATE A CLEAR PATH TO AN HC-MEA THAT REACHES DOE’S 2030 TARGETS. THE TEAM WILL PURSUE PERFORMANCE TARGETS AT REALISTIC TEMPERATURES, PRESSURES, AND FLOWS. REACHING THE CHALLENGING BP1 AND BP2 GOALS WILL REQUIRE THE TEAM TO DEVELOP HCMS WITH LOW RESISTANCE AND LOW H2 AND O2 PERMEABILITY. CATALYST LAYERS REQUIRE HCIS WITH HIGH CONDUCTIVITY AND H2 AND O2 PERMEABILITY. HCIS AFFORD MORE SYNTHETIC OPTIONS TO SIMULTANEOUSLY ACHIEVE LOW GAS PERMEABILITIES IN IONOMERS FOR MEMBRANES AND HIGH GAS PERMEABILITIES IN IONOMERS FOR CATALYST LAYERS THAN CONVENTIONAL PFSAS. IONOMERS THAT SWELL EXCESSIVELY IMPEDE GAS TRANSPORT IN THE MACROPORES BETWEEN AGGLOMERATES. THE TRADE BETWEEN GAS TRANSPORT IN THE MACROPORES AND THROUGH THE IONOMER NEEDS TO BE CAREFULLY BALANCED. HCIS NEED TO BE DISPERSED IN ALCOHOL/WATER MIXTURES TO FACILITATE PROCESSING AND FABRICATION, AND THE TEAM SHALL STUDY HOW SOLVENT COMPOSITION AFFECTS CL STRUCTURE AND PERFORMANCE. PFSA AND HYDROCARBON IONOMERS COAT CARBON SUPPORTS DIFFERENTLY, AND COMPREHENSIVE STUDIES SHALL BE CONDUCTED TO DETERMINE BEST CARBON/IONOMER COMBINATIONS, AS WELL AS BEST IONOMER-TO-CARBON (I/C) AND PLATINUM-TO-CARBON (PT/C) RATIOS. THE GOAL AT THE END OF THE PROJECT (BP2) IS TO REACH DOE’S TARGETS OF DEMONSTRATING 2.5 KW/GPGM POWER OUTPUT (750 MW/CM2 AT 0.7 V). A STRETCH GOAL IN LINE WITH DOE’S 2030 TARGETS IS TO ACHIEVE THIS PERFORMANCE AFTER RUNNING A HEAVY-DUTY ACCELERATED STRESS TEST (AST) EQUIVALENT TO 25,000 HOURS.
$2,461,837Rtx Corporation · · FY2025 · Department of Energy
Optimizing Human B and T Cell Vaccines Against HIV Using Humanized BLT Mice
$2,461,800Todd M Allen · Massachusetts General Hospital · P01 · FY2015 · AI
GLASS-AD: Global Latinos Sequencing Study for Alzheimer's Disease
$2,461,689Giuseppe Tosto · Columbia University Health Sciences · U01 · FY2025 · AG
OPTIMIZED LYOPHILIZATION AND RECONSTITUTION OF ERYTHROMER, A BIO-INSPIRED, ARTIFICIAL RED BLOOD CELL
$2,461,670Kalocyte Inc · · FY2025 · Defense Health Agency