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38,696 grants matching “als”
Glutamate Transporters in the CNS
$452,487Children'S Hospital Of Philadelphia · R01 · FY2003 · NS
PROTEINS IN MULTIPLE MYELOMA AND RELATED BLOOD DISEASES
$452,412University Of Tennessee Knoxville · R01 · FY2002 · CA
Molecular Mechanisms underlying tRNA-fragment regulation of cancer
$452,407Sohail F. Tavazoie · Rockefeller University · R01 · FY2021 · CA
High throughput ELISA chip for drug toxicity screening
$452,391Haiching Ma · Reaction Biology Corporation · R44 · FY2007 · GM
A multiplexable in vivo perturbation toolkit to identify genes affecting neurodegeneration in a model of synucleinopathy
$452,375Serge E Przedborski · Columbia University Health Sciences · R21 · FY2023 · AG
Novel Vaccine Strategies Against Ebola Virus
$452,367Richard W Compans · Emory University · R01 · FY2010 · AI
Environmental Toxicants, Race, and Cardiovascular Disease Risk in Children
$452,299Brooks B Gump · Syracuse University · R01 · FY2015 · ES
A Direct Brain to Speech Generator for use in Humans
$452,155Philip R Kennedy · Neural Signals, Inc. · R44 · FY2008 · DC
Molecular Characterization of Breast Duct Epithelium at Risk for Breast Cancer
$452,027David Danforth · Division Of Clinical Sciences - Nci · ZIA · FY2016 · CA
Assessment of whole organism vaccinations in Malian Adults
$451,901Patrick Duffy · National Institute Of Allergy And Infectious Diseases · ZIA · FY2015 · AI
Secure Base Script Knowledge: Antecedents and Sequelae
$451,838Glenn I Roisman · University Of Minnesota · R01 · FY2023 · HD
REGULATION OF CELLULAR GROWTH AND ENERGY HOMEOSTASIS
$451,818Alan R Kimmel · Diabetes, Digestive, Kidney Diseases · Z01 · FY2007 · DK
SPHINGOLIPIDS
$451,816Alfred Harrison Merrill · University Of California, San Diego · U54 · FY2011 · GM
Functionalized Congeners Of Bioactive Compounds
$451,759Kenneth Alan Jacobson · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2017 · DK
Targeting the EPhA4 in motor neuron disease: a structure-based approach
$451,694Maurizio Pellecchia · University Of California Riverside · R01 · FY2020 · NS
Prospective study of biomarkers and risk factors for ALS incidence and progressio
$451,678Alberto Ascherio · Harvard School Of Public Health · R01 · FY2015 · NS
Molecular Determinants of liver sinusoidal endothelial cells for hepatic regeneration
$451,664Shahin Rafii · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · DK
Assembly of Retroviruses and Interactions with Host Cellular Proteins
$451,624Fadila Bouamr · National Institute Of Allergy And Infectious Diseases · Z01 · FY2008 · AI
Cell Characterization and Imaging for Regenerative Therapies in Ischemic Diseases
$451,577Phillip Chung-Ming Yang · Stanford University · UM1 · FY2017 · HL
THE SPATIAL DISTRIBUTION OF PHYTOPLANKTON BIOMASS AND ITS PHOTOPHYSIOLOGICAL RESPONSES TO THE ENVIRONMENT IN THE UPPER OCEAN POTENTIALLY CAN BE INFERRED FROM SATELLITE PLATFORMS (E.G. MODIS AND HISTORICALLY MERIS) BY ANALYZING THE VARIATIONS IN SOLAR INDUCED FLUORESCENCE (SIF) ORIGINATING FROM CHLOROPHYLL A. ALTHOUGH THE SIF ALGORITHM IS POTENTIALLY MOST ADVANTAGEOUS IN CASE 2WATERS WHERE DOM AND SUSPENDED SEDIMENTS INTERFERE WITH CHLOROPHYLL ALGORITHMS BASED ON BLUE-GREEN WATER LEAVING RADIANCES THE APPLICATION OF SIF TO UNDERSTANDING EITHER PHYTOPLANKTON PHOTOPHYSIOLOGY OR CARBON FIXATION ON A GLOBAL SCALE HAS NOT YET BEEN ACHIEVED. THE VARIABILITY IN SIF QUANTUM YIELDS APPEARS TO CORRELATE WITH ENVIRONMENTAL FORCING BUT THE MECHANISMS RESPONSIBLE FOR AND THE INTERPRETATION OF THIS VARIABILITY ARE FUNDAMENTALLY NOT KNOWN DUE TO VERY LIMITED FIELD STUDIES OF BIOPHYSICALLY RELATED PROCESSES. WITHIN THE FRAMEWORK OF THE NASA OBB FUNDED PROJECT ON "THE APPLICATION OF LIFETIME ANALYSES IN THE UPPER OCEAN TO THE INTERPRETATION OF SATELLITE-BASED SOLAR INDUCED CHLOROPHYLL FLUORESCENCE SIGNALS" (NNX08AC24G) WE DESIGNED AND CONSTRUCTED A SEA-GOING INSTRUMENT PACKAGE TO DIRECTLY AND SIMULTANEOUSLY MEASURE LIFETIMES AND QUANTUM YIELDS OF PHYTOPLANKTON CHLOROPHYLLA FLUORESCENCE IN THE OCEAN. THE QUANTUM YIELDS ARE ACCURATELY CALCULATED FROM PICOSECOND-RESOLVED MEASUREMENTS OF FLUORESCENCE LIFETIMES AND ALLOWED FOR THE FIRST VALIDATION AND CALIBRATION OF THE SATELLITE-BASED RETRIEVALS OF SIF QUANTUM YIELDS. THIS NOVEL TECHNOLOGY WAS DEPLOYED ON TEN CRUISES IN THE ATLANTIC PACIFIC ARCTIC AND SOUTHERN OCEANS SPANNING FIVE YEARS TO INFER THE VARIABILITY IN PHYTOPLANKTON PHYSIOLOGY AND SIF SIGNALS IN MAJOR BIOGEOCHEMICAL PROVINCES OF THE OCEAN. THE COMBINATION OF AMPLITUDE-BASED VARIABLE FLUORESCENCE AND LIFETIME MEASUREMENTS ALLOWED US TO DEDUCE THE GLOBAL BUDGETS OF FATE OF SOLAR RADIATION ABSORBED BYPHYTOPLANKTON FOR THE FIRST TIME. THE RESULTS OF THIS RESEARCH ARE SUMMARIZED IN A PAPER IN SCIENCE (LIN ET AL. 2016).HERE WE PROPOSE TO EXPAND THESE ROBUST AND HIGHLY SENSITIVE TECHNOLOGIES TO ELUCIDATE THE PATTERNS OF GLOBAL DISTRIBUTIONS OF QUANTUM YIELDS OF CHLOROPHYLL FLUORESCENCE IN THE OCEAN. THIS EFFORT IS ESSENTIAL TO INTERPRETING THE VARIABILITY OF SATELLITE-BASED RETRIEVALS OF SIF QUANTUM YIELDS IN RELATION TO PHYTOPLANKTON PHOTOPHYSIOLOGICAL RESPONSES TO ENVIRONMENTAL FORCING; E.G. NUTRIENT AVAILABILITY ON BASIN MESO-SCALE AND SMALLER SPATIAL SCALES. SPECIFICALLY WE PROPOSE TO CONSTRUCT AND DEPLOY A NETWORK OF FIVE PAIRED CALIBRATED INSTRUMENTS TO BE USED BY THE OCEANOGRAPHIC COMMUNITY THROUGHOUT THE WORLD. THE RESULTING DATA WILL BE ANALYZED AND ARCHIVED AT RUTGERS UNIVERSITY AND DISTRIBUTED TO THE COMMUNITY VIA COLLABORATION WITH THE OCEAN COLOR PROGRAM AT GSFC.WE ENVISION THAT THIS PROJECT WILL PROVIDE THE SCIENTIFIC BACKGROUND FOR THE INTERPRETATION OF THE VARIABILITY IN SOLAR INDUCED FLUORESCENCE SIGNALS IN THE OCEAN HELP TO IMPROVE MODIS CHLOROPHYLL BASED BIOMASS ALGORITHMS (AND POTENTIALLY FOLLOW-ON SENSORS ON OTHER SATELLITES) AND PROVIDE CRUCIAL PHYSIOLOGICAL INFORMATION NEEDED FOR BETTER ESTIMATES OF PRIMARY PRODUCTION FROM REMOTE SENSING OF THE OCEAN COLOR AND SOLAR INDUCED FLUORESCENCE. WE SUGGEST THAT RELATING THE SPACE-BASED ESTIMATES TO IN SITU MEASUREMENTSOF CHLOROPHYLL FLUORESCENCE LIFETIMES WILL PROVIDE A PATHWAY TO ROBUSTLY OBSERVE HOW PHOTOBIOLOGICAL ENERGY UTILIZATION AND DISSIPATION PROCESSES IN THE GLOBAL OCEAN POTENTIALLY CHANGE IN THE FUTURE.
$451,526Rutgers, The State University · · FY2016 · National Aeronautics and Space Administration
Probing Coupled Electronic and Vibrational Motions in Ultrafast Proton Transfer Processes with Mixed-Frequency Multidimensional Vibronic and Soft X-ray Spectroscopies
$451,500Munira Khalil · University Of Washington · · FY2019 · MPS
Preclinical Diagnostic Imaging of Amyloid
$451,374Jonathan S Wall · University Of Tennessee Knoxville · R01 · FY2010 · DK
Role of CREBBP missense mutations in lymphomagenesis
$451,334Laura Pasqualucci · Columbia University Health Sciences · R01 · FY2024 · CA
Immune Regulation In Toxoplasmosis
$451,318Alan Sher · National Institute Of Allergy And Infectious Diseases · ZIA · FY2021 · AI
DIPHTHERIA TOX REPRESSOR: GENETIC &STRUCTURAL ANALYSIS
$451,258Boston Medical Center · R01 · FY2000 · AI