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17,054 grants matching “genome editing”
Endogenous retroviruses co-opted for immune defenses
$294,275Cedric Feschotte · University Of Utah · R01 · FY2016 · GM
Endogenous retroviruses co-opted for immune defenses
$294,275Cedric Feschotte · University Of Utah · R01 · FY2015 · GM
Project 1: Decoding Origin and Modeling Oncohistones in Pediatric Cancers
$294,252Nada Jabado · Rockefeller University · P01 · FY2015 · CA
Follow-Up Studies of a Genome-Wide Association Analysis in Pima Indians
$294,216Leslie J Baier · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2025 · DK
MECHANISM OF INTERFERON ACTION
$294,189University Of California Santa Barbara · R01 · FY2002 · AI
Intercellular communication and competition between migrating cells
$294,174Gillian Stanfield · University Of Utah · R01 · FY2017 · GM
Delivering genetic medicines to photoreceptors with lipid nanoparticles
$294,052Adam Tuttle · Enterx Biosciences, Inc. · R43 · FY2024 · EY
AN INVASIVE POLEROVIRUS, COTTON LEAFROLL DWARF VIRUS (CLRDV) IS AN EMERGING THREAT TO COTTON IN THE UNITED STATES. CLRDV IS TRANSMITTED BY THE COTTON APHID, APHIS GOSSYPII, AND POSSIBLY OTHER VECTOR SPECIES. THERE IS A WEALTH OF DATA ON POLEROVIRUSES AS A RESULT OF STUDIES ON POTATO LEAFROLL VIRUS AND THE YELLOW DWARF VIRUSES. OUR TEAM IS IN A STRONG POSITION TO BRING THIS KNOWLEDGE TO BEAR ON CLRDV. THE IMPACT OF CLRDV ON COTTON PRODUCTION IS CURRENTLY UNKNOWN, AND MANAGEMENT STRATEGIES ARE NONEXISTENT. NEW APPROACHES TO CONTROL THE SPREAD OF CLRDV, SUCH AS BLOCKING APHID TRANSMISSION, ARE NEEDED TO AUGMENT EXISTING MANAGEMENT STRATEGIES. IN DEPTH STUDIES ON CLRDV ARE NEEDED TO VALIDATE THAT THIS VIRUS BEHAVES SIMILARLY TO OTHER POLEROVIRUSES. IN THIS PROJECT, WE WILL SOLVE THE MACROMOLECULAR STRUCTURE OF THE CLRDV STRUCTURAL PROTEIN THAT REGULATES APHID TRANSMISSION AND DEVELOP TOOLS - TRANSGENIC COTTON AND AN ANTIBODY TEST - THAT WILL PROTECT THE CROP FROM APHID TRANSMISSION OF CLRDV. WE WILL USE PROTEOMICS TO IDENTIFY PLANT AND APHID PROTEINS THAT BIND TO CLRDV, WHICH IS THE FIRST STEP TOWARDS GENERATING GENOME-EDITED, CLRDV-RESISTANT COTTON. A MAJOR CONCERN FOR THE INDUSTRY IS THE DEVELOPMENT OF FUTURE MANAGEMENT STRATEGIES, INCLUDING TESTING AND MITIGATION, WHICH ARE THE FOCI OF OUR PROPOSAL.
$294,000Agricultural Research Service · · FY2021 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** INSECT PESTS POSE A MAJOR THREAT TO UNITED STATES AGRICULTURE AND MANY PEST MANAGEMENT TOOLS, SUCH AS PESTICIDES ARE LOSING THEIR EFFECTIVENESS AS PESTS BECOME RESISTANT. THIS CONTRIBUTES TO LOST AGRICULTURAL PRODUCTIVITY, FINANCIAL BURDENS FOR GROWERS AND CONSUMERS, AND ENVIRONMENTAL BURDENS THROUGH INCREASED PESTICIDE INPUTS. A MAJOR GOAL OF THIS PROJECT IS TO DEVELOP NEW TARGETED AGRICULTURAL PEST MANAGEMENT TECHNOLOGIES THAT REDUCE CROP LOSSES AND PRODUCTION COSTS, WHILE IMPROVING ENVIRONMENTAL SAFETY.WE WILL USE CUTTING-EDGE GENOME-EDITING TECHNOLOGY TO CREATE COTTON PLANTS WITH MODIFIED PRODUCTION OF ECOLOGICALLY IMPORTANT DEFENSE COMPOUNDS CALLED TERPENOIDS. TERPENOIDS PLAY IMPORTANT ROLES IN PLANT DEFENSE AGAINST INSECTS AND PATHOGENS AND BY ALTERING PLANT PRODUCTION OF THESE COMPOUNDS, WE EXPECT TO BOOST PLANT RESISTANCE TO KEY INSECT PESTS. WE WILL CHARACTERIZE THE DEFENSE CHEMISTRY OF GENOME-EDITED COTTON PLANTS AND EVALUATE THEIR RESISTANCE AGAINST A SUITE OF KEY PEST SPECIES, INCLUDING COTTON APHIDS AND BOLLWORM CATERPILLARS. THE FINDINGS FROM THIS RESEARCH WILL INCREASE OUR KNOWLEDGE ABOUT TERPENOID BIOSYNTHESIS IN COTTON PLANTS AND THE ROLE OF TERPENOID COMPOUNDS IN COTTON RESISTANCE AGAINST INSECT PESTS, WHICH WILL ADVANCE THE FIELDS OF BIOCHEMISTRY, CHEMICAL ECOLOGY, AND PLANT BIOLOGY. THIS RESEARCH WILL ALSO CONTRIBUTE TO IMPROVING SUSTAINABLE AND EFFECTIVE PEST MANAGEMENT STRATEGIES BY IDENTIFYING NEW TECHNOLOGIES THAT CAN REDUCE PESTICIDE INPUTS AND IMPROVE PRODUCTIVITY.
$294,000Texas A&M Agrilife Research · · FY2022 · National Institute of Food and Agriculture
NON-TECHNICAL SUMMARYCOTTON (GOSSYPIUM HIRSUTUM) IS OUR MOST IMPORTANT FIBER CROP. YIELD AND QUALITY ARE UNDERMINED BY PESTS AND PATHOGENS, INCLUDING COTTON APHIDS AND FUSARIUM FUNGAL INFECTIONS. PLANT-SYNTHESIZED OXYLIPINS, SPECIFICALLY 9-HYDROXY FATTY ACIDS RESULTING FROM 9-LIPOXYGENASE ACTIVITY (9-LOX), ARE FEEDING STIMULANTS FOR MANY PESTS, AND REDUCED LEVELS OF THESE COMPOUNDS IN CROP PLANTS CAN PROVIDE PROTECTION. ADDRESSING USDA PROGRAM AREA CRITICAL AGRICULTURAL RESEARCH AND EXTENSION (A1701), WE PROPOSE TO DEVELOP GENOME EDITING APPROACHES TO CONFER NATURAL RESISTANCE AGAINST DEVASTATING COTTON APHID AND FUSARIUM WILT BY ELUCIDATING OXYLIPIN SIGNALING AND MANIPULATING ITS DERIVATIVES. FIRST, WE WILL FUNCTIONALLY TEST GENES ENCODING 9-LOX ENZYMES USING VIRUS-INDUCED GENE SILENCING. WE PREDICT THIS WILL REDUCE 9-HYDROXY FATTY ACIDS LEVELS AND DETER APHID AND FUSARIUM INFESTATIONS. SECOND, WE WILL INTRODUCE STABLE GENETIC ALTERATIONS TO GHLOX GENES USING NEW CRISPR-MEDIATED GENE EDITING APPROACHES, AND TEST THAT THESE ARE HERITABLE AND CONFER RESISTANCE AGAINST APHIDS AND FUSARIUM. WE AIM TO ACCELERATE THESE GENE-EDITING STRATEGIES BY INCORPORATING INDUCIBLE GENES PROMOTING SOMATIC EMBRYOGENESIS AND WHOLE-PLANT REGENERATION. THIRD, BY EXPLOITING A NEW APPROACH FOR MAKING PLANT MERISTEMS MORE SUSCEPTIBLE TO GENETIC MANIPULATION, WE AIM TO DEVELOP A NOVEL, MERISTEM-BASED GENE-EDITING SYSTEM TO ACHIEVE STABLE ALTERATIONS IN GERMLINE CELLS AND BY-PASS THE NEED FOR TISSUE CULTURE. THIS HIGH-RISK OBJECTIVE MAY REVOLUTIONIZE BIOTECHNOLOGY APPROACHES TO IMPROVE COTTON AGRICULTURE. THIS PROPOSAL IS SUBMITTED AS A CO-FUNDED PRIORITY WITH THE COTTON BOARD TO DEVELOP NEW GENOME EDITING-ENABLED APPROACHES TO PROTECT COTTON FROM DAMAGING INSECT PESTS WITH THE POTENTIAL TO CONSIDERABLY REDUCE PESTICIDE USE, PRESERVE CURRENT TECHNOLOGIES, AND MAINTAIN YIELDS.
$294,000University Of North Texas · · FY2021 · National Institute of Food and Agriculture
Exonizaton of Alu Insertion Polymorphisms
$293,948Kathleen H Burns · Dana-Farber Cancer Inst · R01 · FY2020 · GM
Project 1 High-order assembly of MegaTrans complexes for hormone-independent enhancer activation
$293,849Zhijie "jason" Liu · University Of Texas Hlth Science Center · U54 · FY2021 · CA
Project 3 Topological mapping of chromatin architectures for hormone-independent gene transcription
$293,849Victor Jin · University Of Texas Hlth Science Center · U54 · FY2021 · CA
Outreach Core
$293,849Nameer Kirma · University Of Texas Hlth Science Center · U54 · FY2021 · CA
A Modular Framework for Accurate, Efficient, and Reproducible Analysis of RNA-Seq Data
$293,841Robert Patro · Univ Of Maryland, College Park · R01 · FY2020 · HG
TRANSFER OF ORGANELLE GENES TO THE NUCLEUS
$293,696Indiana University Bloomington · R01 · FY2000 · GM
High-throughput identification of causal variants underlying quantitative traits in yeast
$293,688Leonid Kruglyak · University Of California Los Angeles · R01 · FY2020 · GM
High-throughput identification of causal variants underlying quantitative traits in yeast
$293,688Leonid Kruglyak · University Of California Los Angeles · R01 · FY2019 · GM
Computational Methods for Mapping Genetic Interactions in Human Cells
$293,583Chad L Myers · University Of Minnesota · R01 · FY2020 · HG
MRI: Acquisition of an Advanced Multi-Functional Wide-Wavelength-Range Fourier Transform Infrared Spectrometer for Multi-Materials Characterization
$293,560Steve W Martin · Iowa State University · · FY2021 · MPS
Establishing Acomys as a genetic platform for regeneration research
$293,550Kathleen Joyce Millen · Seattle Children'S Hospital · R21 · FY2024 · OD
Developing novel Type 1 CRISPR tools for gene editing therapy
$293,319Zhonggang Hou · Genetobe Inc. · R41 · FY2024 · GM
Core B: Genetically Engineered Mouse Core
$293,311Gregory M Barton · University Of California Berkeley · P01 · FY2016 · AI
Molecular genetics and population studies of the KIR and HLA gene complexes
$293,184Mary N. Carrington · Division Of Basic Sciences - Nci · ZIA · FY2017 · CA
Chemical enhancement of CRISPR/Cas9 mediated site-specific genome engineering
$293,005Katherine Pawelczak · Nerx Biosciences, Inc. · R43 · FY2016 · GM