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17,828 grants matching “crispr”
Diurnal control of memory allocation by the circadian gene Per1
$306,883Janine Lynn Kwapis · Pennsylvania State University, The · R01 · FY2025 · AG
HLA Gene Editing in the Treatment of Rheumatoid Arthritis
$306,827Brian M Freed · Rheumagen, Inc. · R41 · FY2025 · AR
Functional evolution of segmentation gene regulatory networks in insects
$306,820Leslie Pick · Univ Of Maryland, College Park · R01 · FY2022 · GM
High-content study to analyze the nutritional value of natural products for healthy aging
$306,793Sudip Mondal · Vivoverse, Llc · R43 · FY2025 · AT
Automated CRISPR Enabled DNA Synthesis (CEDS)
$306,664Michael David Lynch · Duke University · R21 · FY2023 · HG
High-precision pooled screening for quantitative molecular phenotypes
$306,623Nicholas T Ingolia · University Of California Berkeley · R01 · FY2022 · GM
EAGER: Quantifying SARS-CoV-2 antigen-antibody binding using cell-free guide RNA display
$306,500James Carothers · University Of Washington · · FY2020 · BIO
Identification and characterization of genes regulating zebrafish lens development
$306,457Mason Posner · Ashland University · R15 · FY2024 · EY
Thyroid Hormone Signaling in Human Hepatocytes
$306,431Anthony N Hollenberg · Weill Medical Coll Of Cornell Univ · R01 · FY2022 · DK
New computational tools for predicting ion effects in RNA structures
$306,383Shi-Jie Chen · University Of Missouri-Columbia · R01 · FY2019 · GM
FSHD Drug Discovery
$306,367Charles P Emerson · Univ Of Massachusetts Med Sch Worcester · P50 · FY2018 · HD
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE EMERGENCE OF LETHAL VIRUSES HAVE NEGATIVELY IMPACTED THE CULTURE OF WHITE STURGEON FOR FOOD OR RESTORATION EFFORTS IN THE PACIFIC NORTHWEST (PNW) OF NORTH AMERICA FOR DECADES. AN IRIDO-LIKE VIRUS IS THE MOST SIGNIFICANT PATHOGEN OF JUVENILE WHITE STURGEON (WHITE STURGEON IRIDOVIRUS; WSIV) RESULTING IN UP TO 95% MORTALITY UNDER INTENSIVE CULTURE. WSIV HAS ALSO BEEN DETECTED IN WILD WHITE STURGEON FROM THE LOWER COLUMBIA RIVER IN OREGON AND WASHINGTON, THE SNAKE RIVER IN SOUTHERN IDAHO, AND THE KOOTENAI RIVER IN NORTHERN IDAHO. DESPITE THE THREAT THIS VIRUS POSES, NO SURVEILLANCE PROGRAMS ARE IN PLACE DUE TO THE UNAVAILABILITY OF MOLECULAR DIAGNOSTIC ASSAYS. DEVELOPMENT OF MOLECULAR VIRAL DIAGNOSTIC ASSAYS HAS BEEN HAMPERED BY THE MINIMAL GENOMIC SEQUENCE DATA AVAILABLE FOR WSIV. TO FILL THIS INDUSTRY NEED, WE PROPOSE THE FOLLOWING RESEARCH OBJECTIVES TO: 1) SEQUENCE, ASSEMBLE, AND ANNOTATE THE GENOMES OF WSIV ISOLATES; 2) PERFORM PHYLOGENETIC ANALYSES TO UPDATE THE TAXONOMY OF WSIV; 3) DEVELOP, OPTIMIZE, AND VALIDATE THE ANALYTIC PERFORMANCE OF A QUANTITATIVE PCR (QPCR) AND RAPID CRISPR DIAGNOSTIC ASSAY FOR THE DETECTION OF WSIV; AND 4) PERFORM EXPERIMENTAL WSIV CHALLENGES TO GENERATE KNOWN POSITIVE AND NEGATIVE SAMPLES TO DETERMINE THE DIAGNOSTIC PERFORMANCE OF THE WSIV QPCR AND CRISPR ASSAYS COMPARED TO CONVENTIONAL PCR ASSAYS (GOLD STANDARD). THIS TECHNOLOGICAL LEAP FORWARD IN SCIENCE WITH THE DEVELOPMENT OF BOTH HIGH-SENSITIVITY QPCR AND RAPID ON-SITE CRISPR VIRAL DIAGNOSTICS WILL ENSURE U.S. FARMERS CAN SUSTAIN THE ICONIC WHITE STURGEON FISHERY THROUGHOUT THE PNW WHILE PROTECTING DOMESTIC/INTERNATIONAL MARKETS OF FILLETS AND CAVIAR.
$306,292Washington State University · · FY2024 · National Institute of Food and Agriculture
CRISPR-Cas9 Systems Delivered by Targeted Nanoparticles to Eradicate Herpesvirus Pathogens
$306,277Balaji Sitharaman · Theragnostic Technologies, Inc. · R43 · FY2017 · AI
High-precision pooled screening for quantitative molecular phenotypes
$306,104Nicholas T Ingolia · University Of California Berkeley · R01 · FY2023 · GM
A Novel Epigenetic Editing Platform
$306,094Brian Stanley Egan · Active Motif, Inc. · R43 · FY2025 · HG
Sequential restriction of germ line progenitors by induction
$306,048Gary M Wessel · Brown University · R01 · FY2019 · GM
A developmental engineering toolbox for large-scale tissue engineering
$306,016Alex Hughes · University Of Pennsylvania · R35 · FY2020 · GM
Role of peroxisome-mitochondrion communication in tissue aging
$306,001Hua Bai · Iowa State University · R01 · FY2024 · AG
Bone Cells and Signaling Core
$305,960Paola Pajevic Divieti · Massachusetts General Hospital · P30 · FY2016 · AR
Bone Cells and Signaling Core
$305,958Paola Pajevic Divieti · Massachusetts General Hospital · P30 · FY2014 · AR
Bone Cells and Signaling Core
$305,958Paola Pajevic Divieti · Massachusetts General Hospital · P30 · FY2017 · AR
Bone Cells and Signaling Core
$305,958Paola Pajevic Divieti · Massachusetts General Hospital · P30 · FY2015 · AR
Functional Genomics
$305,953Aniruddha J. Deshpande · Sanford Burnham Prebys Medical Discovery Institute · P30 · FY2021 · CA
Functional Genomics
$305,953Sumit K Chanda · Sanford Burnham Prebys Medical Discovery Institute · P30 · FY2023 · CA
Functional Genomics
$305,953Sumit K Chanda · Sanford Burnham Prebys Medical Discovery Institute · P30 · FY2020 · CA