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38,696 grants matching “als”
Animal Models of Addiction
$456,000Carrie Ferrario · University Of Michigan At Ann Arbor · R01 · FY2023 · DA
Animal Models of Addiction
$456,000Terry E. Robinson · University Of Michigan At Ann Arbor · R01 · FY2022 · DA
THE COSMIC OPTICAL BACKGROUND (COB) IS THE SUMMED EMISSION FROM ALL SOURCES OUTSIDE OF OUR GALAXY EMITTED AT WAVELENGTHS CORRESPONDING TO THOSE VISIBLE WITH THE HUMAN EYE. THE COB IS A POWERFUL DIAGNOSTIC OF THE EMISSION FROM KNOWN ASTROPHYSICAL PROCESSES IN GALAXIES INCLUDING STELLAR NUCLEOSYNTHESIS MASS ACCRETION ONTO BLACK HOLES AND THE GRAVITATIONAL COLLAPSE OF STARS SO IS CRUCIAL IN UNDERSTANDING THE TOTAL EMISSION FROM STARS IN THE UNIVERSE. FURTHER COMPARISON OF THE COB INTENSITY TO THE SURFACE BRIGHTNESS ARISING FROM KNOWN GALAXY POPULATIONS CAN REVEAL THE PRESENCE OF DIFFUSE BACKGROUNDS PRODUCED BY MORE EXOTIC PHENOMENA SUCH AS THE DECAY OF PARTICLE SPECIES OUTSIDE THE STANDARD MODEL OR LIGHT FROM OBJECTS OUTSIDE OF GALAXIES. DESPITE A GREAT DEAL OF INTEREST DIRECT PHOTOMETRIC MEASUREMENT OF THE COB HAS PROVEN TO BE CHALLENGING. THE EARTH'S ATMOSPHERE IS SEVERAL ORDERS OF MAGNITUDE BRIGHTER THAN THE COB AND SUNLIGHT SCATTERED FROM INTERPLANETARY DUST (IPD) PARTICLES IN THE SOLAR SYSTEM PRODUCES A SIMILARLY LARGE FOREGROUND. ACCOUNTING FOR THE RELEVANT EMISSION ABSORPTION AND SCATTERING EFFECTS IN EITHER SOURCE IS A DAUNTING TASK. IT IS THUS DESIRABLE TO MEASURE THE COB FROM VANTAGE POINTS WHERE THE EARTH'S ATMOSPHERE AND THE LIGHT FROM IPD ARE NOT APPRECIABLE COMPONENTS OF THE DIFFUSE SKY BRIGHTNESS SUCH AS THE OUTER SOLAR SYSTEM.NASA'S NEW HORIZONS (NH) MISSION HAS GIVEN US AN UNPRECEDENTED VIEW OF AND FROM THE OUTER REACHES OF THE SOLAR SYSTEM. IN ADDITION TO THEIR PLANETARY IMAGING FUNCTIONS SOME OF THE NH INSTRUMENTS CAN DOUBLE AS SENSITIVE ASTRONOMICAL TELESCOPES WORKING AT OPTICAL AND NEAR-IR WAVELENGTHS. OUR TEAM HAS ALREADY ANALYZED DATA FROM THE LONG RANGE RECONNAISSANCE IMAGER (LORRI) INSTRUMENT ACQUIRED DURING NH'S CRUISE PHASE TO MEASURE THE COB IN A SINGLE WIDE BANDPASS (ZEMCOV ET AL. 2017 NATURE COMMUNICATIONS). IN THAT WORK WE PLACED A 2 SIGMA STATISTICAL UPPER LIMIT ON THE COB BRIGHTNESS OF<19 NW M^-2 SR^-1 A LEVEL ABOUT TWICE AS LARGE AS THE SUMMED LIGHT FROM GALAXIES. THE MEASUREMENT IS FROM ONLY 260S OF INTEGRATION TIME USING A DATA SET WITH CHARACTERISTICS THAT COMPLICATE ASTROPHYSICAL EXAMINATION; WE CONCLUDE THAT ADDITIONAL NH DATA COULD SIGNIFICANTLY IMPROVE THIS LIMIT. IN THIS NFDAP PROGRAM WE PROPOSE TO USE ARCHIVAL NH DATA TO MEASURE THE COSMIC OPTICAL BACKGROUND AND SEARCH FOR DIFFUSE LIGHT ASSOCIATED WITH INTERPLANETARY DUST IN BOTH THE INNER AND OUTER SOLAR SYSTEM. TO IMPROVE ON OUR PREVIOUS MEASUREMENT WE WILL USE PUBLICLY AVAILABLE DATA FROM THE LORRI NAVIGATION CAMPAIGNS AND PLUTO FLYBY AS WELL AS NEAR-IR DATA FROM THE RALPH INSTRUMENT TO EXPAND THE STUDY'S WAVELENGTH COVERAGE. THE PDS ARCHIVE CURRENTLY CONTAINS OVER 15 000 S OF EXPOSURES TAKEN DURING THESE PHASES OF THE MISSION OF WHICH WE EXPECT ~6% TO BE USEFUL FOR THIS STUDY. THIS REPRESENTS A FACTOR OF 3.5 INCREASE IN INTEGRATION TIME OVER OUR INITIAL STUDY BUT WITH DIFFERENT SYSTEMATIC ERRORS LEADING TO AT LEAST A SIGNAL TO NOISE RATIO 3 MEASUREMENT OF THE INTEGRATED LIGHT FROM GALAXIES. TO MEASURE THE COB WE WILL USE METHODS SIMILAR TO THOSE IN OUR PREVIOUS WORK WHERE ASSESSMENTS OF THE SURFACE BRIGHTNESS FROM STARS DIFFUSE GALACTIC LIGHT DARK CURRENT IN THE DETECTOR AND OTHER EMISSION SOURCES ARE SUBTRACTED FROM THE MEAN OF EACH IMAGE TO MEASURE THE SURFACE BRIGHTNESS RESIDUAL. WE WILL CONSTRAIN THE VARIATION IN THE BRIGHTNESS OF THE DIFFUSE GALACTIC LIGHT BY COMPARING MEASUREMENTS OF THE DIFFUSE BACKGROUND WITH THERMAL IR EMISSION AND SEARCHING FOR CORRELATIONS. FINALLY WE WILL SEARCH FOR LIGHT REFLECTED FROM THE IPD CLOUD BY SEARCHING FOR DIFFUSE BANDS OF LIGHT ALONG THE ECLIPTIC. OUR TEAM HAS A PROVEN TRACK RECORD ANALYZING THESE TYPE OF MEASUREMENTS AND WITH THE WEALTH OF NH DATA THAT IS CURRENTLY AVAILABLE WE EXPECT TO DETECT THE COB WITH WELL-UNDERSTOOD SYSTEMATIC ERRORS FOR THE FIRST TIME.
$456,000Rochester Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
MicroRNA In Diabetic Nephropathy
$455,988Farhad R. Danesh · University Of Tx Md Anderson Can Ctr · R01 · FY2022 · DK
Investigations on the integrated behavior of molecular regulatory networks that
$455,938Kurt Kohn · Basic Sciences · Z01 · FY2007 · CA
IDENTIFICATION OF MELANOMA PREDISPOSITION LOCI
$455,921University Of Utah · R01 · FY2003 · CA
Transgenic Probes of Active Circuits
$455,902Mark R Mayford · Scripps Research Institute, The · R01 · FY2011 · DA
Systems Biology
$455,901Nathan D Price · California Pacific Med Ctr Res Institute · U19 · FY2019 · AG
Research Project
$455,862K Allen Greiner · University Of Kansas Medical Center · U54 · FY2011 · CA
MECHANISMS OF MOTONEURON DEGENERATION IN TRANSGENIC
$455,850University Of Pennsylvania · R01 · FY2002 · NS
Gamma-secretase components and substrate interactions
$455,795Oksana Berezovska · Brigham And Women'S Hospital · P01 · FY2011 · AG
Regulation of glutamate transport in astrocyte subtypes and in ALS
$455,786Michael B Robinson · Children'S Hosp Of Philadelphia · R01 · FY2019 · NS
PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
$455,731University Of Minnesota Twin Cities · R01 · FY2000 · AI
Investigating addictive/compulsive feeding behavior
$455,641Michael J. Krashes · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2021 · DK
Unraveling hippocampal networks related to food memories
$455,641Michael J. Krashes · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2021 · DK
Probing neural circuits underlying satiety
$455,641Michael J. Krashes · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2021 · DK
Causal Pathways to population health impact of HIV antiretroviral treatment
$455,600Frank Courteney Tanser · University Of Kwazulu-Natal · R01 · FY2015 · HD
Genetic Epidemiology of ALS in Veterans
$455,587Silke A Schmidt · Duke University · R01 · FY2006 · ES
Outer Membrane Proteins of Francisella tularensis as Acellular Vaccines
$455,575Michael V Norgard · University Of Texas Med Br Galveston · U54 · FY2010 · AI
Protein Signatures of APOE2 and Cognitive Aging
$455,563Paola Sebastiani · Tufts Medical Center · R01 · FY2022 · AG
Molecular Glues to Target RAS-MAPK Driven Cancers
$455,542Arvin Dar · Sloan-Kettering Inst Can Research · R01 · FY2024 · CA
Non-beta-lactam GLT-1 activators: characterization in preclinical models of opioid and cocaine addiction
$455,516Scott M Rawls · Temple Univ Of The Commonwealth · R01 · FY2020 · DA
Project 2: KSHV induces tumorigenesis by harnessing differentiation in hypoxia
$455,512Erle S Robertson · University Of Pennsylvania · P01 · FY2023 · CA
Project 2: KSHV induces tumorigenesis by harnessing differentiation in hypoxia
$455,512Yan Yuan · University Of Pennsylvania · P01 · FY2024 · CA
Project 2: KSHV induces tumorigenesis by harnessing differentiation in hypoxia
$455,512Yan Yuan · University Of Pennsylvania · P01 · FY2025 · CA