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17,054 grants matching “genome editing”
Investigation of energetics of sharp DNA bending
$296,818Harold D Kim · Georgia Institute Of Technology · R01 · FY2023 · GM
SCGE Disease Models Studies Supplement: Allele-specific Genome Editing in Two Mouse Models of Charcot-Marie-Tooth Disease
$296,595Stephen A Murray · Jackson Laboratory · U42 · FY2022 · OD
MECHANISM OF INTERFERON ACTION
$296,558University Of California Santa Barbara · R01 · FY2003 · AI
CRISPR/CAS9-MEDIATED GENOME EDITION (GE) IN FOOD-ANIMALS CAN BENEFIT BOTH THE SCIENTIFIC COMMUNITY AND THE FUTURE AGRICULTURAL INDUSTRY. THE CURRENT METHOD FOR GE IN CHICKENS REQUIRES HIGHLY SKILLED EXPERTISE FOR: 1) ISOLATION, CULTURE, AND GE OF PRIMORDIAL GERM CELLS (PGCS) IN VITRO, 2) TRANSFER OF GENOME-EDITED PGCS INTO RECIPIENT EMBRYOS, AND 3) GENERATION OF GERMLINE CHIMERAS AND ITS OFFSPRING WITH GE. IN ADDITION, THE CURRENT PGC-MEDIATED METHOD HAS NOT BEEN SUCCESSFUL FOR OTHER AVIAN SPECIES. THEREFORE, IT IS NECESSARY TO DEVELOP AN EASY AND EFFICIENT METHOD WITHOUT MEDIATING PGCS IN CULTURE. TO IMPROVE EFFICIENCY AND OVERCOME THESE TECHNICAL BARRIERS, WE DEVELOPED AN OPTIMIZED CRISPR/CAS9 VECTOR AND GENERATED GENOME-EDITED POULTRY USING ADENOVIRUS AS A DELIVERY SYSTEM OF THE OPTIMIZED CRISPR/CAS9 INTO BLASTODERMS WITHOUT MEDIATING PGC IN CULTURE. THE EFFICIENCY OF TARGETED GENOME MODIFICATION IN POULTRY DEPENDS ON THE RATE OF GENOME MODIFICATION IN THE GERM CELL POPULATION. THEREFORE, THIS PROPOSAL IS FOCUSING ON THE DEVELOPMENT OF A STRATEGY TO DIRECTLY TARGET MORE GERM CELLS BY INJECTING THE CRISPR/CAS9 ADENOVIRUS INTO THE EMBRYO. WITH FOUR OBJECTIVES, WE WILL INJECT THE CRISPR/CAS9 ADENOVIRUS INTO FOUR DIFFERENT LOCATIONS WHERE PGCS ARE DISPERSED, CIRCULATING OR CONGREGATED DURING EARLY EMBRYO DEVELOPMENTAL PROCESSES TO PROVIDE THE MOST EFFICIENT NEXT-GENERATION METHOD FOR GE IN POULTRY. SUCCESSFUL DEVELOPMENT OF THE PROPOSED NEXT GENERATION METHOD OF GE IN POULTRY IS EXPECTED TO ADVANCE AVIAN RESEARCH AND DEVELOP MORE PRODUCTIVE GENOMIC LINES OF POULTRY FOR INFECTIOUS DISEASE RESISTANCE, HIGHER GROWTH AND FEED EFFICIENCY, AND INCREASED MUSCLE WITH REDUCED FAT.
$296,400Ohio State University, The · · FY2020 · National Institute of Food and Agriculture
Cancer transcriptome characterization using massively parallel DNA sequencing
$296,351Marco Antonio Marra · British Columbia Cancer Agency · U24 · FY2014 · CA
Rat Resource and Research Center
$296,276Elizabeth C Bryda · University Of Missouri-Columbia · P40 · FY2024 · OD
Statistical Methods for Transcriptome Profiling Using RNA Sequencing
$296,142Mingyao Li · University Of Pennsylvania · R01 · FY2014 · GM
Genetic Analysis of Germ Cell Immortality
$296,022Shawn Cameron Ahmed · Univ Of North Carolina Chapel Hill · R01 · FY2016 · GM
Genetic Analysis of Germ Cell Immortality
$296,022Shawn Cameron Ahmed · Univ Of North Carolina Chapel Hill · R01 · FY2017 · GM
EDITING OF APOLIPOPROTEIN-B mRNA
$296,000Cleveland Clinic Foundation · R01 · FY2003 · HL
EDITING OF APOLIPOPROTEIN-B mRNA
$296,000Cleveland Clinic Foundation · R01 · FY2002 · HL
EDITING OF APOLIPOPROTEIN-B mRNA
$296,000Cleveland Clinic Foundation · R01 · FY2001 · HL
Genetic Analysis and Manipulation Core (GAEC)
$295,957Clifford J Woolf · Boston Children'S Hospital · P50 · FY2021 · HD
Studying Pentalogy of Cantrell in Humans and Mice
$295,925Robert Adelstein · National Heart, Lung, And Blood Institute · ZIA · FY2018 · HL
AF: Medium: Collaborative Research: The Role of Order in Search
$295,912Gad M Landau · New York University · · FY2009 · CSE
Functional impact, mechanistic role, and targetability of ROS1 aberrations in cancer
$295,911Monika A Davare · Oregon Health & Science University · R01 · FY2020 · CA
Functional impact, mechanistic role, and targetability of ROS1 aberrations in cancer
$295,911Monika A Davare · Oregon Health & Science University · R01 · FY2021 · CA
Statistical Methods for Transcriptome Profiling Using RNA Sequencing
$295,907Mingyao Li · University Of Pennsylvania · R01 · FY2015 · GM
Project 4: Prognostic Significance and Therapeutic Potential of DROSHA Mutations in Wilms Tumor
$295,763James F Amatruda · Ut Southwestern Medical Center · P50 · FY2019 · CA
Transgenic zebrafish for neurobiology
$295,750Florian Engert · Harvard University · R24 · FY2017 · NS
Transgenic zebrafish for neurobiology
$295,750Florian Engert · Harvard University · R24 · FY2015 · NS
Transgenic zebrafish for neurobiology
$295,750Florian Engert · Harvard University · R24 · FY2016 · NS
Unraveling the molecular connections that link circadian rhythms and lipid metabolism
$295,695Xuemin Wang · University Of Missouri-St. Louis · R01 · FY2024 · GM
Enabling Plant Natural Product Biosynthesis by Debugging Heterologous Protein Expression in Yeast
$295,675Mark Alan Blenner · Clemson University · R35 · FY2019 · GM
Statistical Methods for Transcriptome Profiling Using RNA Sequencing
$295,664Mingyao Li · University Of Pennsylvania · R01 · FY2016 · GM