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24,576 grants matching “microbiome”
Gut Microbiota and Effect on Immune Suppressants in Transplantation
$400,917Ajay K Israni · University Of Texas Med Br Galveston · R01 · FY2024 · AI
Agilent 7200 GC/Q-TOF for the University of Utah
$400,901James Eric Cox · University Of Utah · S10 · FY2016 · OD
Microbiome-Mediated Tumor Immunomodulation in a Pathomimetic Colorectal Cancer Chip
$400,890Hyun Jung Kim · Cleveland Clinic Lerner Com-Cwru · R33 · FY2025 · CA
Systems Biology Modeling of Severe Hospital-Acquired Pneumonia
$400,789Alan R Hauser · Northwestern University At Chicago · U19 · FY2024 · AI
Engineering microbiota to optimize inter-host transmission
$400,766Brendan Bohannan · University Of Oregon · P01 · FY2018 · GM
A Continuous Flow-Based Approach to Automated Microbial Oligosaccharide Synthesis.
$400,747Clay Samuel Bennett · Tufts University Medford · R01 · FY2022 · GM
A Continuous Flow-Based Approach to Automated Microbial Oligosaccharide Synthesis.
$400,747Clay Samuel Bennett · Tufts University Medford · R01 · FY2023 · GM
A Continuous Flow-Based Approach to Automated Microbial Oligosaccharide Synthesis.
$400,747Clay Samuel Bennett · Tufts University Medford · R01 · FY2024 · GM
The Gut Microbiome in Parkinson Disease
$400,740Natalia Palacios · University Of Massachusetts Lowell · R01 · FY2021 · NS
Tool Compounds to Probe Multispecies Biofilms in the Human Oral Microbiome
$400,683William M Wuest · Temple Univ Of The Commonwealth · R01 · FY2016 · DE
Deciphering Helicobacter pylori's glycocode: uncovering and harnessing drug targets
$400,669Danielle H. Dube · Bowdoin College · R15 · FY2021 · GM
SPACEFLIGHT HAS DEMONSTRATED CONCERNING IMPACTS TO HUMAN PHYSIOLOGY INCLUDING WELL DOCUMENTED IMMUNE SYSTEM DYSREGULATION. DIET IMMUNE FUNCTION AND THE MICROBIOME ARE INTERLINKED BUT DIET IS THE ONLY ONE OF THESE FACTORS THAT WE HAVE THE ABILITY TO EASILY AND SIGNIFICANTLY ALTER ON EARTH OR DURING FLIGHT. IT IS EXPECTED THAT AS WE UNDERSTAND DIETARY IMPACTS MORE THOROUGHLY WE MAY CONTINUE TO IMPROVE THE SPACEFLIGHT DIET IN DIRECT SUPPORT OF CREW HEALTH. WE PROPOSE HERE AN INTERDISCIPLINARY STUDY THAT WILL DETERMINE THE EFFECT OF THE CURRENT SPACEFLIGHT DIET COMPARED TO AN "ENHANCED" SPACEFLIGHT DIET (25% MORE FOODS RICH IN OMEGA-3 FATTY ACIDS LYCOPENE FLAVONOIDS FRUITS AND VEGETABLES) WITH COMPLETE DIETARY TRACKING ON IMMUNE FUNCTION GUT MICROBIOTA COMPOSITION AND NUTRITIONAL STATUS OF CREW IN GROUND-CONTROL ANALOGS AND ON ISS MISSIONS. WE HYPTHESIZE THAT BY INCREASING CONSUMPTION OF FRUITS AND VEGETABLES AND BIOACTIVE COMPOUNDS (E.G. OMEGA-3 FATTY ACIDS LYCOPENE FLAVONOIDS) AND ENHANCING OVERALL NUTRITIONAL INTAKE DURING SPACEFLIGHT (OR A GROUND-BASED ANALOG OF SPACEFLIGHT) WE WILL IMPROVE HUMAN IMMUNOLOGICAL PROFILES THE TAXONOMIC PROFILE OF THE GUT MICROBIOTA AND NUTRITIONAL STATUS BIOMARKERS. POSITIVE ASSOCIATIONS BETWEEN BENEFICIAL IMPROVEMENTS WILL PROVIDE EVIDENCE TO BETTER PREDICT THE IMPACT OF DIET ON CREW HEALTH AND ADAPTATION TO SPACEFLIGHT AND TO DESIGN TARGETED MORE-EFFICIENT DIETARY INTERVENTIONS. SPECIFICALLY WE PROPOSE TO 1) IMPLEMENT A PILOT GROUND-CONTROL STUDY WITH ANALOG CREW RANDOMIZED BETWEEN TWO SPACEFLIGHT DIETS AND DETERMINE DIET EFFECTS ON IMMUNE DYSREGULATION INCLUDING LEUKOCYTE DISTRIBUTION INFLAMMATORY CYTOKINE PROFILES T CELL FUNCTION AND OTHER RELEVANT IMMUNOLOGICAL MARKERS THE TAXONOMIC AND METATRANSCRIPTOMIC PROFILE OF THE GUT MICROBIOME AND NUTRITIONAL BIOMARKERS AND METABOLITES AT SELECTED INTERVALS AND STATISTICALLY EVALUATE TO ASSOCIATE SHIFTS ACROSS EACH MEASURE AND IN RELATION TO NUTRIENT INTAKE; AND 2) DETERMINE EFFECTS OF DIET ON IMMUNE DYSREGULATION INCLUDING LEUKOCYTE DISTRIBUTION INFLAMMATORY CYTOKINE PROFILES T CELL FUNCTION AND OTHER RELEVANT IMMUNOLOGICAL MARKERS THE TAXONOMIC AND METATRANSCRIPTOMIC PROFILE OF THE GUT MICROBIOME AND NUTRITIONAL BIOMARKERS AND METABOLITES AT SELECTED INTERVALS IN SPACEFLIGHT AND STATISTICALLY EVALUATE TO ASSOCIATE SHIFTS ACROSS EACH MEASURE AND IN RELATION TO GROUND-CONTROL DATA. THIS STUDY SPECIFICALLY ADDRESSES THE B.4 RESEARCH EMPHASIS 3 - UNDERSTANDING HOW COMPLEX ORGANISMS ADAPT TO SPACEFLIGHT BY PROVIDING DETAILED COMPREHENSIVE ANALYSIS OF THE EFFECT OF DIET ON THE HUMAN IMMUNE SYSTEM GUT MICROBIOTA AND NUTRITIONAL STATUS DURING HUMAN ADAPTATION TO SPACEFLIGHT.
$400,616J. Craig Venter Institute, Inc. · · FY2020 · National Aeronautics and Space Administration
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)
$400,597Paule Joseph · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2023 · AA
Core I: Immunology
$400,572Stephen C De Rosa · University Of Washington · P30 · FY2020 · AI
Biomarker Core
$400,564Tony Wyss-Coray · Stanford University · P30 · FY2022 · AG
Modulation of Viral Antigen Presentation in the Lung
$400,545Anna Karolina Palucka · Jackson Laboratory · U19 · FY2020 · AI
Novel Re-engineered L DOPA Probiotic Therapy for Parkinson's Disease
$400,457Anumantha Gounder Kanthasamy · University Of Georgia · R33 · FY2022 · NS
Admin Core - Britton
$400,445Robert A Britton · Baylor College Of Medicine · U19 · FY2022 · AI
Nasal Microbial Consortia Combat Antibiotic-Resistant Bacteria
$400,444Katherine Paige Lemon · Baylor College Of Medicine · U19 · FY2022 · AI
Defined microbial communities to prevent and eradicate infection by AMR pathogens
$400,444Robert A Britton · Baylor College Of Medicine · U19 · FY2022 · AI
Mechanistic insights into bacteriophage properties required for enhanced therapeutic potential at mucosal surfaces
$400,444Anthony W Maresso · Baylor College Of Medicine · U19 · FY2022 · AI
Organoid Cultivation Core
$400,444Sarah E Blutt · Baylor College Of Medicine · U19 · FY2022 · AI
Microbial and Phage Cultivation Core
$400,444Robert A Britton · Baylor College Of Medicine · U19 · FY2022 · AI
Gut Dysbiosis and Cerebral Small Vessel Disease
$400,298Robert M Bryan · Baylor College Of Medicine · R01 · FY2018 · NS
Gut Dysbiosis and Cerebral Small Vessel Disease
$400,298Robert M Bryan · Baylor College Of Medicine · R01 · FY2019 · NS