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17,054 grants matching “genome editing”
The neuronal sodium channel gene SCN8A
$298,213University Of Michigan At Ann Arbor · R01 · FY2002 · NS
Engineering iPSC-RBCs for Transfusion
$298,116John D Roback · Emory University · R01 · FY2020 · HL
EAGER: Targeted and specific elimination of plant chromosomes
$298,102Luca Comai · University Of California-Davis · · FY2023 · BIO
Expression genetics of CYP3A drug metabolizing enzymes
$297,894Danxin Wang · Ohio State University · R01 · FY2017 · GM
Biological Core
$297,854Carolyn Ann Worby · University Of Kentucky · P01 · FY2019 · NS
STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
$297,539Wistar Institute · R01 · FY2003 · GM
Molecular mechanisms of Eph receptor signaling
$297,513Vladislav Belyy · Ohio State University · R35 · FY2024 · GM
THE WESTERN FLOWER THRIPS, FRANKLINIELLA OCCIDENTALIS, IS GLOBAL PEST AND A VECTOR OF TOMATO SPOTTED WILT VIRUS (TSWV) AND RELATED ORTHOTOSPOVIRUSES THAT CAUSE SIGNIFICANT YIELD LOSSES IN CROPS. OUR LONG-RANGE GOAL IS TO DEVELOP GENOME-EDITING TECHNOLOGIES FOR POPULATION SUPPRESSION AND/OR POPULATION REPLACEMENT OF F. OCCIDENTALIS AS A MEANS OF REDUCING RELIANCE ON CONVENTIONAL CHEMICAL MANAGEMENT STRATEGIES AND MITIGATING ORTHOTOSPOVIRUS TRANSMISSION BY THIS SUPERVECTOR. GENOME-EDITING HAS NOT YET BEEN APPLIED TO THRIPS AND APPLICATION OF THESE TECHNOLOGIES WILL ALSO ENABLE BASIC STUDIES OF GENE FUNCTION IN THRIPS, INCLUDING VIRUS-VECTOR INTERACTIONS. THE AIM OF THIS PROPOSAL IS TO DEVELOP AND OPTIMIZE A PROOF-OF-PRINCIPLE CRISPR/CAS9 GENE-KNOCKOUT SYSTEM FOR F. OCCIDENTALIS USING TRADITIONAL AND NEW METHODOLOGIES OF DELIVERY OF CAS9 AND GUIDE RNAS. WE WILL TARGET GENES WITH EASILY SCORED VISIBLE PHENOTYPES WHICH WILL ENABLE DIRECT FEEDBACK THEREBY HASTENING PROGRESS AND CLEARLY SIGNALING SUCCESS. THE SPECIFIC RESEARCH OBJECTIVES ARE TO:OBJECTIVE 1. DEVELOP METHODS FOR MICROINJECTING PRECELLULAR F. OCCIDENTALIS EMBRYOS.OBJECTIVE 2. USE THE CRISPR/CAS9 SYSTEM TO KNOCKOUT F. OCCIDENTALIS EYE-COLOR GENES.OUR RESEARCH ADDRESSES THE USDA-NIFA CHALLENGE OF DEVELOPING MORE SUSTAINABLE, PRODUCTIVE AND ECONOMICALLY-VIABLE PLANT PRODUCTION SYSTEMS. SPECIFICALLY, WE WILL EXPAND THE USE OF GENE EDITING TECHNOLOGY TO VECTORS OF PLANT VIRUSES FOR PEST AND DISEASE CONTROL.
$297,417North Carolina State University · · FY2021 · National Institute of Food and Agriculture
Investigation of energetics of sharp DNA bending
$297,388Harold D Kim · Georgia Institute Of Technology · R01 · FY2022 · GM
Training in Developmental Hematology
$297,379Donald B Kohn · University Of California Los Angeles · T32 · FY2018 · HL
Reformulating NT-Z001 and its delivery route to treat rheumatoid arthritis
$297,327Yanmei Qi · Navega Therapeutics, Inc. · R43 · FY2025 · AR
RNA EDITING IN PLANT ORGANELLES
$297,260Cornell University Ithaca · R01 · FY2001 · GM
A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineage
$297,248Angela M. Belcher · Massachusetts Institute Of Technology · R21 · FY2022 · CA
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2019 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2017 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2021 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2020 · GM
Interaction of the TMEM127 tumor suppressor with the mTORC1 lysosomal activating complex
$297,221Patricia Leal Dahia · University Of Texas Hlth Science Center · R01 · FY2018 · GM
Histone H2A.X signaling and chromatin remodeling in late erythropoiesis
$297,200Michael D Bulger · University Of Rochester · R01 · FY2021 · HL
Elucidating Mechanisms of Recognition and Excision of Damaged Bases by NEIL glycosylases
$297,119Sheila Sue David · University Of California At Davis · R01 · FY2023 · GM
High-throughput identification of causal variants underlying quantitative traits in yeast
$297,030Leonid Kruglyak · University Of California Los Angeles · R01 · FY2022 · GM
High-throughput identification of causal variants underlying quantitative traits in yeast
$297,030Leonid Kruglyak · University Of California Los Angeles · R01 · FY2021 · GM
Unraveling the molecular connections that link circadian rhythms and lipid metabolism
$297,001Xuemin Wang · University Of Missouri-St. Louis · R01 · FY2023 · GM
PAPAYA (CARICA PAPAYA L.) IS AN ECONOMICALLY IMPORTANT NUTRITIOUS FRUIT CROP, WIDELY GROWN IN THE TROPICS AND SUBTROPICS. BESIDES ITS USE AS FOOD, THE FRUIT IS ALSO USED IN THE COSMETICS, PHARMACEUTICAL AND FOOD PROCESSING INDUSTRIES. PAPAYA PLANTS OCCUR IN THREE SEX TYPES, BUT ITS SEX DETERMINING GENE (S) HAVE YET TO BE DEFINED. A RANGE OF VIRAL, FUNGAL AND OOMYCETE PATHOGENS SEVERELY THREATEN PAPAYA PRODUCTION. TO BETTER UTILIZE PAPAYA PRODUCTS AND REDUCE THE COST IN PRODUCTION ASSOCIATED WITH DISEASE CONTROLAND IDENTIFICATION OF HERMAPHRODITE PLANTS, FUNCTIONAL UNDERSTANDING OF PAPAYA GENES IS A PREREQUISITE,BUT HINDERED BY THE LACK OF AN EFFECTIVE GENE KNOCKOUT SYSTEM IN PAPAYA.CRISPR-MEDIATED GENE EDITING TECHNOLOGY HAS REVOLUTIONIZED FUNCTIONAL GENOMICS OF MANY ORGANISMS, AND IS A POWERFUL TOOL TO BREED TRANSGENE-FREE NEW VARIETIES WITH NUMEROUS DESIRABLE TRAITS. HOWEVER, A GENE EDITING SYSTEM HAS NOT BEEN ESTABLISHED IN PAPAYA. THIS PROJECT IS TO ESTABLISH METHODSFOR EFFECTIVEGENOME EDITING OF PAPAYA TO MEET THE DIVERSE NEEDS OF GENE FUNCTIONAL ANALYSES AND BREEDING.TO MAXIMIZE THE SUCCESS, WE WILL UTILIZE TWO CRISPR SYSTEMS (CAS9 AND CAS12) AND COMPLEMENTARY APPROACHES. SPECIFICALLY, WE WILL: 1) ESTABLISH AN EFFECTIVE AND ROUTINE PAPAYA GENE EDITING SYSTEM VIA AGROBACTERIUM-MEDIATED TRANSFORMATION, AND 2) DEVELOP DNA-FREE GENOME EDITING OF PAPAYA WITH PREASSEMBLED CRISPR-NUCLEASE RIBONUCLEOPROTEIN COMPLEXES.
$296,942University Of Hawaii · · FY2020 · National Institute of Food and Agriculture
Gene Delivery Core
$296,891Mikhail F. Alexeyev · University Of South Alabama · P01 · FY2020 · HL