antimicrobial resistance — grants

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15,273 grants matching “antimicrobial resistance”

Circumventing Antibiotic Resistance with Novel Gene-Silencing Therapeutics

$199,973

David Elihu Greenberg · Ut Southwestern Medical Center · R21 · FY2015 · AI

Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA

$199,875

Ambrose L. Cheung · Dartmouth College · R21 · FY2009 · AI

Applying Ribo-Seq and RNA-Seq to identify quorum sensing pheromones and their regulons

$199,875

Michael J Federle · University Of Illinois At Chicago · R21 · FY2020 · AI

INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSIS

$199,872

Yoonjee Park · University Of Cincinnati · R21 · FY2024 · EB

Developing Non-Ototoxic Aminoglycosides

$199,871

Anthony J Ricci · Stanford University · R21 · FY2011 · DC

NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens

$199,842

Jafar Razeq · Connecticut State Dept Of Public Health · U01 · FY2025 · FD

WHETHER THROUGH FORMING SANITATION-RESISTANT BIOFILMS OR DEVELOPING ENHANCED TOLERANCE TO ANTIMICROBIALS AND SANITIZERS OR EVEN HEAT, FOODBORNE PATHOGENS ADAPT TO AND SURVIVE THE STRESSES OF FOOD PROCESSING AND SANITATION PROGRAMS, LEADING TO CONSUMER ILLNESSES. CONSEQUENTLY, UNDERSTANDING BACTERIAL PATHOGENS' STRESS TOLERANCE STRATEGIES AND CAPABILITIES FOR COLONIZING PROCESSING ENVIRONMENTS IS CRUCIAL TO DEVELOPING NEW METHODS TO FOIL THEM AND REDUCING THE BURDEN OF FOODBORNE ILLNESS. PREVIOUS RESEARCH INDICATED THAT SEVERAL ISOLATES FROM AN OUTBREAK OF SALMONELLA HEIDELBERG IN POULTRY PRODUCTS HAD INCREASED STRESS TOLERANCE AND THAT THIS WAS ASSOCIATED WITH ENHANCED STRESS TOLERANCE GENE EXPRESSION IN STATIONARY PHASE. I HYPOTHESIZE THAT ENHANCED STRESS TOLERANCE MAY PLAY A KEY ROLE IN OUTBREAKS OF SALMONELLOSIS AND THAT THIS MAY BE DETECTABLE VIA GENE EXPRESSION ANALYSIS UNDER NORMAL GROWTH CONDITIONS. KEY SEROVARS (TYPES) OF SALMONELLA IN THE U.S. INCLUDE SALMONELLA ENTERITIDIS, TYPHIMURIUM, HEIDELBERG, AND AN EMERGING SEROVAR CALLED SALMONELLA I 4,[5],12:I:-. I WILL ASSESS STRESS TOLERANCE IN ISOLATES ASSOCIATED WITH THE 2015 SALMONELLA I 4,[5],12:I:- OUTBREAK ASSOCIATED WITH PORK, THE 2011 SALMONELLA HEIDELBERG OUTBREAK ASSOCIATED WITH KOSHER BROILED CHICKEN LIVERS, AND SALMONELLA TYPHIMURIUM OUTBREAK AND ENTERITIDIS OUTBREAKS (TO BE DETERMINED). I HAVE ALSO COMPILED A LIST OF PREVIOUSLY-SEQUENCED NON-OUTBREAK ISOLATES FOR COMPARISON FOR EACH OF THESE SEROVARS. THE CHOSEN ISOLATES REPRESENT A MIX OF ANTIBIOTIC RESISTANCE CAPACITIES, ALLOWING US TO ALSO DETERMINE IF THERE IS A LINK BETWEEN ANTIBIOTIC RESISTANCE AND STRESS TOLERANCE. THESE ISOLATES WILL BE OBTAINED FROM THE USDA-ARS, WITH WHOM I HAVE A MATERIAL TRANSFER AGREEMENT.TO DETERMINE ISOLATES' STRESS TOLERANCE, WE WILL STUDY TWO KEY PROCESSING STRESSES--SANITIZERS AND HEAT. WE WILL ALSO STUDY HOW WELL THE INDIVIDUAL ISOLATES CAN FORM STRESS-TOLERANT BIOFILMS, AS THIS IS A KEY SURVIVAL MECHANISM FOR BACTERIA. WE WILL STUDY SANITIZER TOLERANCE AND BIOFILM FORMATION AT BOTH ROOM AND REFRIGERATION TEMPERATURE AND WITH HIGH AND LOW ACCESS TO NUTRIENTS, AS THESE ARE SCENARIOS COMMONLY ENCOUNTERED IN FOOD PROCESSING ENVIRONMENTS. WE WILL STUDY HEAT AT 132.8&DEG;F/56&DEG;C, AS THIS IS A LETHAL TEMPERATURE COMMONLY USED TO SCALD POULTRY. WE WILL USE THE METHODS DESCRIBED IN OUR PREVIOUS STUDY. WE PREVIOUSLY FOUND THAT STRESS TOLERANT SALMONELLA HEIDELBERG EXPRESS GENES FOR STRESS TOLERANCE AT HIGHER LEVELS, EVEN UNDER NORMAL, NON-STRESSFUL CONDITIONS. TO DETERMINE IF THIS IS TRUE FOR OTHER SALMONELLA SEROVARS, WE WILL DETERMINE THE GENE EXPRESSION PROFILES OF UP TO 3 STRESS TOLERANT AND 3 STRESS SENSITIVE ISOLATES FROM THE FIRST PART OF THE STUDY USING RNA-SEQUENCING. GENE EXPRESSION PROFILES WILL BE DETERMINED AND COMPARED USING A PREVIOUSLY DESCRIBED METHOD. WE WILL ALSO RUN THE ISOLATES' DNA SEQUENCES (PUBLICLY AVAILABLE) THROUGH THE CENTER FOR GENOMIC EPIDEMIOLOGY'S SUITE OF TOOLS TO COMPARE OVERALL GENETIC SIMILARITY, AS WELL AS PRESENCE OF PLASMIDS AND ANTIBIOTIC RESISTANCE GENES.

$199,815

University Of Vermont & State Agricultural College · · FY2020 · National Institute of Food and Agriculture

Synthetic and biological investigations of 2-aminoimidazole derived natural products.

$199,773

Ryan Edward Looper · University Of Utah · R01 · FY2016 · GM

Dermal Integration Sleeve to Reduce Exit Site Infections.

$199,765

Andrew Marshall · Healionics Corporation · R43 · FY2010 · GM

Orthopedic implant materials with bacteria-resistant and osteogenic functions

$199,710

Yuyu Sun · University Of Massachusetts Lowell · R21 · FY2013 · AR

CAREER: Self-assembling Nanofibers as Next Generation Antimicrobial Biomaterials

$199,675

He Dong · Clarkson University · · FY2017 · MPS

Cyclic di-GMP Second Messenger Signaling in the Tickborne Relapsing Fever Spirochete, Borrelia turicatae

$199,611

Jon Scott Blevins · Univ Of Arkansas For Med Scis · R21 · FY2021 · AI

Intrinsic modifiers of beta-lactam resistance in nosocomial Enterobacterales

$199,574

Jacob Eric Lazarus · Massachusetts General Hospital · K08 · FY2023 · AI

Role of Î²-lactamase encoding gene amplification in the development of non-carbapenemase producing, carbapenem-resistant Enterobacteriaceae

$199,573

Samuel A Shelburne · University Of Tx Md Anderson Can Ctr · R21 · FY2022 · AI

DECREASING BIOBURDEN TO REDUCE HEALTHCARE-ASSOCIATED INFECTIONS AND READMISSIONS

$199,535

Susan S Huang · University Of California-Irvine · UH2 · FY2013 · AT

ANTIMICROBIALS AGAINST CHLAMYDIA AND GC INFECTION: IN VITRO STUDIES

$199,510

Children'S Hospital Med Ctr (Cincinnati) · P01 · FY2000 · AI

Antimicrobial resistance in enteric pathogens from retail meat and seafood: A NARMS Retail Food Surveillance Program in Illinois

$199,500

Pratik Banerjee · University Of Illinois At Urbana-Champaign · U01 · FY2025 · FD

Circumventing Antibiotic Resistance with Novel Gene-Silencing Therapeutics

Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA

Applying Ribo-Seq and RNA-Seq to identify quorum sensing pheromones and their regulons

INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSIS

Developing Non-Ototoxic Aminoglycosides

NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens

Synthetic and biological investigations of 2-aminoimidazole derived natural products.

Dermal Integration Sleeve to Reduce Exit Site Infections.

Orthopedic implant materials with bacteria-resistant and osteogenic functions

CAREER: Self-assembling Nanofibers as Next Generation Antimicrobial Biomaterials

Cyclic di-GMP Second Messenger Signaling in the Tickborne Relapsing Fever Spirochete, Borrelia turicatae

Intrinsic modifiers of beta-lactam resistance in nosocomial Enterobacterales

Role of Î²-lactamase encoding gene amplification in the development of non-carbapenemase producing, carbapenem-resistant Enterobacteriaceae

DECREASING BIOBURDEN TO REDUCE HEALTHCARE-ASSOCIATED INFECTIONS AND READMISSIONS

ANTIMICROBIALS AGAINST CHLAMYDIA AND GC INFECTION: IN VITRO STUDIES

Antimicrobial resistance in enteric pathogens from retail meat and seafood: A NARMS Retail Food Surveillance Program in Illinois

PFI:AIR - TT: Using A. niger as a host to express recombinant endolysin

Protein-protein interaction essential for bacterial growth and virulence

Development of a diagnostic test for hypervirulent Klebsiella pneumoniae

Targeting Glycolytic Enzymes as an Antibacterial Strategy

NMR Fragment-based Design of New b-lactamase Inhibitors

Gut Microbiome and Pharmacokinetic Variability in Tuberculosis and Diabetes

Conducting Public Health Research Activities in Uzbekistan

Antimicrobial peptide resistance in Campylobacter jejuni