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17,054 grants matching “genome editing”
Apelin Signaling in Muscle Regeneration
$299,672Romain Madelaine · University Of Maine Orono · P20 · FY2024 · GM
Apelin Signaling in Muscle Regeneration
$299,662Romain Madelaine · University Of Maine Orono · P20 · FY2025 · GM
IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome
$299,626Gregory A Wray · Duke University · · FY2019 · O/D
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FRUIT PHOTOSYNTHESIS CONTRIBUTES TO YIELD AND FRUIT NUTRIENT QUALITY AS DEMONSTRATED IN A WIDE RANGE OF FLESHY FRUITS, EARS OF CEREALS, OIL SEEDS, LEGUMES ETC. TOMATO IS ONE OF THE WORLD'S MOST CONSUMED VEGETABLES WITH $1.78 BILLION ECONOMIC VALUE IN THE US IN 2022 (USDA-NASS). TOMATO SERVES AS A GREAT MODEL TO STUDY FLESHY FRUIT DEVELOPMENT, INCLUDING CHLOROPLAST DEVELOPMENT AND CHLOROPHYLL ACCUMULATION IN FRUITS. ALTHOUGH LEAVES ARE THE PRIMARY PHOTOSYNTHETIC ORGANS, UP TO 20% OF THE CARBON IN TOMATO FRUIT IS DERIVED FROM FRUIT PHOTOSYNTHESIS ITSELF, IMPACTING YIELD, NUTRIENT CONTENT, FLAVOR, AND OVERALL FRUIT QUALITY. THIS HAS BEEN VALIDATED IN THE UNIFORM RIPENING (U) MUTATION IN TOMATO, WHERE THE TRANSCRIPTION FACTOR (TF) GOLDEN 2-LIKE (SLGLK2) IS DISABLED. SLGLK2 DETERMINES CHLOROPLAST DEVELOPMENT, AND CHLOROPHYLL ACCUMULATION IN A DEVELOPING FRUIT THEREBY CONTRIBUTING TO IMPROVED FRUIT QUALITY. THE SELECTION OF 'U' IN MODERN TOMATO VARIETIES INADVERTENTLY COMPROMISED RIPE FRUIT QUALITY FOR DESIRABLE PRODUCTION TRAITS. PD'S RESEARCH IDENTIFIED ANOTHER TF, TKN4 IN TOMATO, A CLASS I KNOTTED-LIKE HOMEOBOX (KNOX) GENE THAT ALSO INFLUENCES CHLOROPLAST DEVELOPMENT AND CHLOROPHYLL ACCUMULATION IN FRUIT THROUGH REGULATION OF SLGLK2 EXPRESSION. THE IDENTIFICATION OF KNOX REGULATORY MODULE HIGHLIGHTS AN ENTIRELY NOVEL ROLE FOR KNOX TFS IN FRUIT DEVELOPMENT, WHICH NEEDS TO BE DECIPHERED. BY UTILIZING A TOMATO DIVERSITY PANEL, WE WILL IDENTIFY GENOME-WIDE LOCI UNDERLYING FRUIT CHLOROPHYLL ACCUMULATION BYGENOME-WIDE ASSOCIATION STUDIES (GWAS). WE WILL PERFORM TARGETED TRANSCRIPTOME ANALYSES OF KNOX MUTANTS AND INTEGRATE WITH GWAS RESULTS TO CONSTRUCT GENE REGULATORY NETWORKS GOVERNING FRUIT CHLOROPHYLL ACCUMULATION. WE WILL IDENTIFY GENOME-WIDE BINDING SITES FOR KNOX AND OTHER KEY TFS INVOLVED IN FRUIT CHLOROPLAST DEVELOPMENT. MOLECULAR BASIS OF CHLOROPLAST DEVELOPMENT AND CHLOROPHYLL ACCUMULATION IN FRUITS IDENTIFIED THROUGH THIS PROJECT CAN POTENTIALLY TRANSLATE INTO CROP VARIETIES WITH IMPROVED YIELD AND FRUIT QUALITY THROUGH BREEDING/ GENE-EDITING. PROGRESS IN THIS AREA HAS THE LONG-RUN POTENTIAL TO FAVORABLY ENGINEER PHOTOSYNTHESIS CONTRIBUTING TO YIELD AND QUALITY OF FOOD CROPS.
$299,622University Of Florida · · FY2024 · National Institute of Food and Agriculture
BTT EAGER: Plant genome editing and engineering via novel nanotechnology-based systems
$299,521Heidi F Kaeppler · University Of Wisconsin-Madison · · FY2019 · BIO
DNA Processing Enzymes with [4Fe4S] Clusters for DNA Signaling
$299,412Jacqueline K Barton · California Institute Of Technology · R01 · FY2017 · GM
DNA Processing Enzymes with [4Fe4S] Clusters for DNA Signaling
$299,412Jacqueline K Barton · California Institute Of Technology · R01 · FY2016 · GM
Integrating epigenomic maps to predict regulatory functions of genetic variants
$299,400Chunyu Liu · University Of Illinois At Chicago · R01 · FY2015 · ES
Role of peroxisome-mitochondrion communication in tissue aging
$299,252Hua Bai · Iowa State University · R01 · FY2025 · AG
CAR T cell therapy for T cell lymphoma
$299,192Malcolm K Brenner · Baylor College Of Medicine · P50 · FY2020 · CA
A genetic model for metazoan programmed DNA elimination
$299,125Jianbin Wang · University Of Tennessee Knoxville · R01 · FY2023 · GM
EAGER: Biochemical and Genetic Tools for Analysis of Paralogous Polymerase Subunits in Grasses
$299,092Rebecca A Mosher · University Of Arizona · · FY2019 · BIO
EAGER: Clonal propagation of tomato through seeds
$299,071Venkatesan Sundaresan · University Of California-Davis · · FY2019 · BIO
A genetic model for metazoan programmed DNA elimination
$298,988Jianbin Wang · University Of Tennessee Knoxville · R01 · FY2024 · GM
Developing a Platform for Multiplexed Large Payload Delivery
$298,853Elizabeth Schramm · Opencell Technologies, Inc. · R43 · FY2019 · CA
A genetic model for metazoan programmed DNA elimination
$298,847Jianbin Wang · University Of Tennessee Knoxville · R01 · FY2025 · GM
Dissection of the transcriptional network of human primordial germ cells
$298,800Renee A Reijo Pera · Montana State University - Bozeman · R01 · FY2018 · HD
Unraveling the molecular connections that link circadian rhythms and lipid metabolism
$298,764Xuemin Wang · University Of Missouri-St. Louis · R01 · FY2022 · GM
Roles of SWI/SNF complexes in posttranscriptional processing of RNA
$298,737Xiuren Zhang · Texas A&M Agrilife Research · R01 · FY2021 · GM
Epigenetic regulation of hormone action in Tribolium and Aedes
$298,700Subba R Palli · University Of Kentucky · R01 · FY2023 · GM
Epigenetic regulation of hormone action in Tribolium and Aedes
$298,700Subba R Palli · University Of Kentucky · R01 · FY2021 · GM
Epigenetic regulation of hormone action in Tribolium and Aedes
$298,700Subba R Palli · University Of Kentucky · R01 · FY2024 · GM
Epigenetic regulation of hormone action in Tribolium and Aedes
$298,700Subba R Palli · University Of Kentucky · R01 · FY2022 · GM
Epigenetic editor therapeutics
$298,530Alexey V Fedulov · Epigenter, Llc · R41 · FY2025 · GM
Roles of SWI/SNF complexes in posttranscriptional processing of RNA
$298,525Xiuren Zhang · Texas A&M Agrilife Research · R01 · FY2022 · GM