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38,696 grants matching “als”
Glutamate Transporters in the CNS
$458,533Children'S Hospital Of Philadelphia · R01 · FY2002 · NS
Development of a novel fluorescent tracer for detection of retinal TDP43 in ALS and FTD
$458,527Stella Sarraf · Amydis Diagnostics, Inc. · R43 · FY2022 · AG
NOVEL THERAPEUTICS TARGETING STRESS GRANULES FOR C9ORF72-MEDIATED ALS
$458,516Mayo Clinic Jacksonville (A Nonprofit Corporation) · · FY2021 · Defense Health Agency
Reducing Youth Violence and Racism/Discrimination: The Efficacy of Comprehensive Prevention Strategies (CPS)
$458,451Sara McDaniel · University Of Alabama In Tuscaloosa · R01 · FY2024 · MD
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
$458,412Fuzheng Guo · University Of California At Davis · R01 · FY2024 · NS
Coordinated regulation of signaling events for insulin biosynthesis and secretion
$458,400Gen-Sheng Feng · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2009 · DK
Rapid-Response Crystallography
$458,361Marc Allaire · University Of Calif-Lawrenc Berkeley Lab · P30 · FY2022 · GM
Safety of Anti-CGRP Migraine Therapeutics in Ischemic Stroke
$458,347Cenk Ayata · Massachusetts General Hospital · R01 · FY2023 · NS
Role of p38alpha signaling in mutant SOD1-linked motor neuron disease
$458,329Gerardo Andres Morfini · University Of Illinois At Chicago · R21 · FY2020 · NS
High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
$458,313Wilfried Rossoll · Mayo Clinic Jacksonville · R33 · FY2020 · NS
Mechanistic analysis of axonal transport defects in neurodegenerative disease
$458,300Erika L Holzbaur · University Of Pennsylvania · R37 · FY2018 · NS
Mechanistic analysis of axonal transport defects in neurodegenerative disease
$458,300Erika L Holzbaur · University Of Pennsylvania · R37 · FY2019 · NS
Mechanistic analysis of axonal transport defects in neurodegenerative disease
$458,300Erika L Holzbaur · University Of Pennsylvania · R37 · FY2020 · NS
Theme B
$458,282Anne Leighton Calof · University Of California-Irvine · P50 · FY2009 · GM
State-dependent modulation of retinothalamic axonal boutons
$458,250Mark L Andermann · Beth Israel Deaconess Medical Center · R01 · FY2021 · EY
Morphogenesis Biophysics and Genetics of Dorsal Closure
$458,242Duke University · R01 · FY2004 · GM
The genetic basis for age-related hearing loss in outbred mice
$458,156Rick A. Friedman · University Of California, San Diego · R01 · FY2021 · DC
Calorie restriction and aging
$458,127Rafael De Cabo · National Institute On Aging · Z01 · FY2008 · AG
MOUNTING EVIDENCE SUGGESTS THAT MANY SUPERNOVA (SN) PROGENITORS EXHIBIT OUTBURSTS AND/OR ENHANCED MASS LOSS IN THE YEARS PRECEDING THE SN. SUCH MASS LOSS COULD DRASTICALLY ALTER THE APPEARANCE OF BOTH THE PROGENITOR AND THE SUBSEQUENT SN WITH SIGNIFICANT IMPACT ON THE INTERPRETATION OF DATA COLLECTED BY SEVERAL NASA MISSIONS. PRE-SN PROGENITOR VARIABILITY CAN ALTER THE APPEARANCE OF PROGENITORS IMAGED BY HST IMPACTING THE INFERRED PROGENITOR PROPERTIES. ADDITIONALLY MASS LOSS PRECEDING THE SN CAN COMPLETELY CHANGE THE SHOCK BREAKOUT SIGNATURE IN UV/X-RAY BANDS GREATLY AFFECTING SHOCK BREAKOUTS DETECTED BY GALEX/SWIFT. THIRD MASS LOSS IN THE FINAL YEARS OF STELLAR EVOLUTION SIGNIFICANTLY IMPACTS EARLY SN LIGHT CURVES SUCH AS THOSE BEING MEASURED BY KEPLER/K2 AND (IN THE NEAR FUTURE) TESS/WFIRST. A COMPELLING MECHANISM FOR PRE-SN OUTBURSTS IS ENERGY TRANSPORT VIA GRAVITY/ACOUSTIC WAVES WITHIN MASSIVE STAR SN PROGENITORS. PRELIMINARY INVESTIGATIONS (QUATAERT ET AL. 2012 2016 FULLER 2017) HAVE SHOWN THAT WAVES EXCITED BY CORE CONVECTION DURING LATE-STAGE NUCLEAR BURNING CAN CARRY LARGE AMOUNTS OF ENERGY INTO THE ENVELOPES OF PROGENITOR STARS EXPELLING SOME MASS AND CAUSING PRE-SN PROGENITOR VARIABILITY. WHILE ENCOURAGING THESE INVESTIGATIONS HAVE EMPLOYED MANY SIMPLIFICATIONS THAT MUST BE IMPROVED FOR ROBUST PREDICTIONS OF PRE-SN OUTBURSTS. ADDITIONALLY THESE WORKS HAVE ONLY INVESTIGATED A VERY SMALL SUB-SAMPLE OF SN PROGENITORS AND THEY MUST BE EXTENDED TO THE DIVERSE POPULATION OF STARS APPROACHING CORE-COLLAPSE (E.G. HYDROGEN-POOR STARS VERY MASSIVE STARS MERGER PRODUCTS TIGHT BINARIES ELECTRON-CAPTURE SN PROGENITORS ETC.) IN ORDER TO UNDERSTAND WAVE HEATING EFFECTS FOR DIFFERENT TYPES OF SNE. WE PROPOSE TO QUANTIFY THE OBSERVABLE EFFECTS OF WAVE-DRIVEN OUTBURSTS AND MASS LOSS USING MESA STELLAR EVOLUTION CALCULATIONS INCORPORATING WAVE ENERGY TRANSPORT AND HYDRODYNAMICS. THESE MODELS WILL PREDICT THE EVOLUTION OF STELLAR STRUCTURES SURFACE TEMPERATURES LUMINOSITIES MASS LOSS RATES WIND SPEEDS AND CSM DENSITY PROFILES. WE WILL THUS PREDICT PROGENITOR TEMPERATURE/ LUMINOSITY AS A FUNCTION OF STELLAR MASS AND TIME BEFORE EXPLOSION WHICH WE WILL COMPARE TO HST PROGENITOR DATA. WE WILL THEN USE OUR CIRCUMSTELLAR DENSITY PROFILES TO PREDICT SHOCK BREAKOUT SIGNALS FOR COMPARISON WITH GALEX/SWIFT DATA. NEXT USING OUR MODEL STELLAR STRUCTURES AND WIND DENSITY PROFILES WE WILL MODEL SN LIGHT CURVES FOR COMPARISON WITH KEPLER/TESS DATA. AS THE NUMBER OF WELL OBSERVED SN GROWS DURING UPCOMING SURVEYS OUR THEORETICAL WORK WILL BE VITAL FOR INTERPRETATION OF THIS DATA ALLOWING US TO DETERMINE WHICH AFFECTS CAN (OR CANNOT) BE ASCRIBED TO WAVE ENERGY TRANSPORT WITHIN THE PROGENITOR. THIS WILL BE CRUCIAL TO UNDERSTANDING THE LATE PHASES OF MASSIVE STAR EVOLUTION AND THE CONNECTION BETWEEN THE DIVERSE POPULATION OF CORE-COLLAPSE SNE AND THEIR STELLAR PROGENITORS.
$458,103California Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
Development of a Patient-Specific Surgical Planning Tool for Type I Laryngoplasty
$458,041Bernard Rousseau · University Of Pittsburgh At Pittsburgh · R01 · FY2021 · DC
The Genetic Basis of Human DNA Replication Timing
$458,040Amnon Koren · Roswell Park Cancer Institute Corp · R35 · FY2024 · GM
The Genetic Basis of Human DNA Replication Timing
$458,040Amnon Koren · Roswell Park Cancer Institute Corp · R35 · FY2025 · GM
Prevention of Relapse in Recurrent Depression with MBCT
$458,025Centre For Addiction And Mental Health · R01 · FY2005 · MH
Community Outreach and Engagement
$457,959Timiya S Nolan · University Of Alabama At Birmingham · P30 · FY2025 · CA
Using Mitochondrial Ca2+ Uptake as a Therapeutic Target for ALS
$457,949Lan Wei-Lapierre · University Of Florida · R01 · FY2025 · NS