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24,576 grants matching “microbiome”
REU Site: Research Experience for Undergraduates in Genome Science and Computational Biology
$402,562Madhusudan Choudhary · Sam Houston State University · · FY2021 · BIO
Metatramscriptome of the Oral Microbiome During Periodontal Disease Progression
$402,546Jorge Frias-Lopez · Ada Forsyth Institute, Inc. · R01 · FY2011 · DE
Genes and Nutrition: Dietary Choline, the Gut Microbiota, and Atrial Fibrillation
$402,500Robert Alden Koeth · Cleveland Clinic Lerner Com-Cwru · P01 · FY2025 · HL
Genes and Nutrition: Dietary Choline, the Gut Microbiota, and Atrial Fibrillation
$402,500Robert Alden Koeth · Cleveland Clinic Lerner Com-Cwru · P01 · FY2022 · HL
Mechanisms of Experimental Crohn's Disease
$402,500Fabio Cominelli · Case Western Reserve University · R56 · FY2021 · DK
Salivary Zinc modifies Histatin 5 activity towards C. albicans survivor cells and commensalism
$402,500Mira Edgerton · State University Of New York At Buffalo · R01 · FY2025 · DE
Genes and Nutrition: Dietary Choline, the Gut Microbiota, and Atrial Fibrillation
$402,500Robert Alden Koeth · Cleveland Clinic Lerner Com-Cwru · P01 · FY2023 · HL
Designing Personalized Formulations with Machine Learning
$402,500Daniel Reker · Duke University · R35 · FY2025 · GM
Selective Inhibitors of Pro-Ferroptotic Lipoxygenases - Next Generation Radiomitigators
$402,402Valerian E Kagan · University Of Pittsburgh At Pittsburgh · U01 · FY2020 · AI
PHYTOCHEMICALS ARE VITAL COMPONENTS OF BOTH RAW AND PROCESSED FOODS AND HAVE SIGNIFICANT POTENTIAL TO IMPROVE HUMAN HEALTH. THE CHALLENGES OF STABILITY, DELIVERY INCLUDING LIMITED INTERACTIONS WITH GUT MICROBES ARE A SIGNIFICANT CONSTRAINT ON SHELF LIFE, QUALITY AND HEALTH IMPACT OF PHYTOCHEMICAL RICH RAW AND PROCESSED FOODS. TO ADDRESS THESE UNMET NEEDS, THE PROPOSED RESEARCH IS AIMED AT DEVELOPING PROGRAMMED ASSEMBLIES OF CELL BASED CARRIERS ENCAPSULATING PHYTOCHEMICALS USING CLUSTERING OF CELLS AND 3-D PRINTING. THIS PROGRAMMED ASSEMBLY IS BASED ON THE HYPOTHESIS THAT THE PRECISE CONTROL ON INTRA-TISSUE LOCALIZATION OF PHYTOCHEMICALS WILL PROVIDE A PLATFORM TO ENHANCE STABILITY, CONTROL RELEASE, IMPROVED DELIVERY AND INTERACTIONS OF PHYTOCHEMICALS WITH GUT MICROBIOME. THE OVERALL GOALS ARE TO ENGINEER: (A) CLUSTERING OF CELL-BASED CARRIERS USING PROTEIN OR NUCLEIC ACID BASED CELL-CELL BINDING AND (B) 3D APPROACHES TO DEVELOP PROGRAMMED ASSEMBLIES OF INDIVIDUAL CELL-BASED CARRIERS OR CLUSTERS. THE INFLUENCE OF THESE FOOD GRADE MATERIALS WILL BE ASSESSED BASED ON IMPROVEMENT IN STABILITY OF ENCAPSULATED PHYTOCHEMICALS, CONTROL ON RELEASE OF ENCAPSULATED COMPOUNDS DURING DIGESTION AND ENHANCEMENT IN THEIR INTERACTIONS WITH GUT MICROBES USING BOTH IN-VITRO AND IN-VIVO MODEL SYSTEMS. SUCCESS IN THIS PROJECT WILL PROVIDE A PLATFORM FOR INNOVATIONS IN 3D PRINTING OF FOOD MATERIALS WITH PRECISE CONTROL ON MICROSTRUCTURES, DISTRIBUTION OF PHYTOCHEMICALS AND BIOPOLYMER COMPOSITIONS. THESE INNOVATIONS WILL SIGNIFICANTLY ENHANCE FOOD QUALITY AND ITS HEATH IMPACTS BY IMPROVING THE SHELF LIFE OF FOOD PRODUCTS, CONTROLLING RELEASE OF BIOACTIVES DURING DIGESTION AND PROMOTING INTERACTIONS OF BIOACTIVES WITH GUT MICROBES.
$402,400University Of California, Davis · · FY2018 · National Institute of Food and Agriculture
Sample Repository for Human Genetic Research
$402,284Alissa Marie Resch · Coriell Institute For Medical Research · U41 · FY2020 · HG
Patient perceptions of bioengineered probiotics and clinical metagenomics
$402,162Richard R Sharp · Cleveland Clinic Lerner Com-Cwru · R01 · FY2009 · HG
Patient perceptions of bioengineered probiotics and clinical metagenomics
$402,162Richard R Sharp · Cleveland Clinic Lerner Com-Cwru · R01 · FY2008 · HG
Targeted genomic characterization of uncultured bacteria from the human microbiot
$402,156Mircea Podar · Ut-Battelle, Llc-Oak Ridge National Lab · R01 · FY2011 · HG
Novel analysis of association between microbiome and treatment infection in AML
$402,076Jianhua Hu · Columbia University Health Sciences · R01 · FY2020 · AI
Novel analysis of association between microbiome and treatment infection in AML
$402,064Jianhua Hu · Columbia University Health Sciences · R01 · FY2021 · AI
Novel analysis of association between microbiome and treatment infection in AML
$402,049Jianhua Hu · Columbia University Health Sciences · R01 · FY2022 · AI
Novel analysis of association between microbiome and treatment infection in AML
$402,035Jianhua Hu · Columbia University Health Sciences · R01 · FY2023 · AI
Discovery and characterization of synthetic bioinformatic natural product anticancer agents
$401,983Sean F Brady · Rockefeller University · R01 · FY2024 · CA
Microbial, immune, metabolic perturbations by antibiotics (MIME study)
$401,969Martin J Blaser · New York University School Of Medicine · U01 · FY2018 · AI
TLR5 signaling as a conserved mechanism of impaired anti-tumor immunity
$401,968Melanie R Rutkowski · University Of Virginia · R01 · FY2021 · CA
NNA: Collaborative Research: Interactions of the Microbial Iron and Methane Cycles in the Tundra Ecosystem
$401,943William B Bowden · University Of Vermont & State Agricultural College · · FY2018 · BIO
Pulmonary bacterial microbiome-epithelial cell interactions in COPD
$401,882Fernando J Martinez · University Of Michigan At Ann Arbor · R01 · FY2012 · HL
Modulation of oral microenvironment by E-cigarette aerosol mixtures
$401,876Deepak Saxena · New York University · R01 · FY2017 · DE
Oral Cavity and Brain Cross-talk in Alzheimer's Disease
$401,830Colin K Combs · University Of North Dakota · R01 · FY2025 · AG