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38,696 grants matching “als”
Implicating the major G-quadruplex helicase, DHX36, as a novel pathogenic modifier of C9ORF72 frontal temporal dementia
$463,754Philip J Smaldino · Ball State University · R15 · FY2020 · AG
Exploring the Pathogenicity of CYLD Variants in FTD
$463,750Wei-Dong Yao · Upstate Medical University · R21 · FY2021 · NS
Induction of allograft tolerance in non-human primates
$463,699Beth Israel Deaconess Medical Center · U01 · FY2005 · AI
HIGH RESOLUTION OF THE RESOLVE INSTRUMENT ABOARD XARM WILL MAKE IT POSSIBLE THE DETECTION OF INDIVIDUAL EMISSION LINES AND THE MEASUREMENTS OF THEIR PROFILES WITH HIGH ACCURACY ALLOWING THE STUDY OF GAS DYNAMICS IN MANY EXTENDED X-RAY SOURCES INCLUDING GALAXY CLUSTERS GROUPS AND GIANT ELLIPTICAL GALAXIES. MEASURING THE VELOCITIES OF GAS MOTIONS IS ESSENTIAL FOR UNDERSTANDING THE PHYSICS OF RADIO-MODE AGN FEEDBACK THE PARTICLE (RE-)ACCELERATION AND THE ORIGIN OF ENHANCED RADIO EMISSION THE NON-THERMAL PRESSURE SUPPORT AND THE BIAS OF THE HYDROSTATIC MASS MEASUREMENTS. IN ORDER TO ANSWER THESE QUESTIONS IT IS NECESSARY TO DO COMPREHENSIVE STUDIES OF THE VELOCITY FIELD NAMELY TO MEASURE NOT ONLY THE AMPLITUDE OF GAS MOTIONS BUT ALSO THE CHARACTERISTIC SCALES ASSOCIATED WITH THE MOTIONS ANISOTROPY AND STATISTICAL PROPERTIES OF THE VELOCITY FIELD (E.G. VELOCITY POWER SPECTRUM). OUR OBSERVATIONAL PROGRAM DESCRIBED IN SECTION 3 IS TAILORED TO PERFORM SUCH DETAILED STUDIES. DURING THE PV PHASE OBSERVATIONS WE PROPOSE TO FOCUS ON TWO NEARBY GALAXY CLUSTERS: THE PERSEUS CLUSTER WHICH SHOWS STRONG AGN ACTIVITY IN THE CENTER; AND THE COMA CLUSTER - A NON-COOL-CORE CLUSTER WITH UNDERGOING MERGING ACTIVITY. AFTER THE PV PHASE THE DEVELOPED TECHNIQUES WILL BE APPLIED ON A SAMPLE OF CLUSTERS GROUPS AND MASSIVE ELLIPTICAL GALAXIES. IN ORDER TO MEASURE SPATIALLY-RESOLVED AMPLITUDE OF GAS MOTIONS (DISPERSION AND BULK VELOCITIES) WE WILL PRODUCE THE MAPS OF LINE WIDTHS AND VARIATIONS OF LINE CENTROIDS. THE HITOMI OBSERVATORY HAS ALREADY DEMOSTRATED THE FEASIBILITY OF SUCH MEASUREMENTS AND PROVIDED VELOCITY MAPS IN THE INNER _ 100 KPC REGION IN PERSEUS [1]. WE WILL ALSO MEASURE THE VELOCITIES OF GAS MOTIONS USING THE RESONANT SCATTERING EFFECT [10]. BOTH DIAGNOSTICS AS A FUNCTION OF RADIUS DEPEND DIFFERENTLY ON THE DIRECTIONALITY OF GAS MOTIONS. THEREFORE COMPARING THE RESULTS WE WILL BE ABLE TO CONSTRAIN THE ANISOTROPY OF MOTIONS [3 4]. THE FIRST HITOMI OBSERVATIONS CONFIRMED THE THEORETICAL PREDICTIONS OF FLUX SUPPRESSION IN THE STRONGEST HE-LIKE FE LINE IN THE PERSEUS CORE DUE TO THE RESONANT SCATTERING OF PHOTONS. COMPARING THE OBSERVED SUPPRESSION WITH THE RESULTS OF RADIATIVE TRANSFER SIMULATIONS THE VELOCITIES OF GAS MOTIONS HAVE BEEN MEASURED [2]. THE STATISTICAL UNCERTAINTIES ON THE MEASURED LINE FLUXES ARE CURRENTLY TOO LARGE FOR ANISOTROPY STUDIES. HOWEVER THEY CAN BE SIGNIFICANTLY IMPROVED WITH NEW XARM OBSERVATIONS. FINALLY WE PROPOSE TO PROBE VELOCITY POWER SPECTRA THAT PROVIDE INFORMATION ABOUT THE INJECTION SCALE OF MOTIONS AND VELOCITY AMPLITUDE ON EACH SPATIAL SCALE. THE METHODS THAT EXRACT THIS INFORMATION FROM THE OBSERVABLES HAVE BEEN DEVELOPED INITIALLY BY ZHURAVLEVA ET AL. [5] AND THEN FURTHER MODIFIED FOR THE COMA CLUSTER BY ZUHONE ET AL. [6]. THE APPLICATION OF THESE TECHNIQUES REQUIRES MULTIPLE VELOCITY MEASUREMENTS AT DIFFERENT RADII. COMPARISON OF THE MEASURED WITH XARM VELOCITY POWER SPECTRA AND THE INDIRECTLY MEASURED ONES FROM THE CHANDRA IMAGES [7 8] WILL CALIBRATE THE STATISTICAL RELATION BETWEEN THE AMPLITUDE OF DENSITY FLUCTUATIONS AND VELOCITY POWER SPECTRUM PROVIDING AN EFFECTIVE METHOD TO MEASURE VELOCITY POWER SPECTRA IN MANY OBJECTS. IT IS IMPORTANT TO MENTION THAT ANY DIFFERENCES BETWEEN THE DIRECT AND INDIRECT MEASUREMENTS WILL PROVIDE INFORMATION ABOUT THE ELECTRON CONDUCTION GAS VISCOSITY AND THE EFFECTS OF MAGNETIC FIELDS [12]
$463,627University Of Chicago · · FY2020 · National Aeronautics and Space Administration
Structural Studies of Prion Fibrils and Other Protein Fibrils
$463,595Robert Tycko · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
CAREER: Atomic Processes in Low Temperature Molecular Beam Epitaxy of Diluted Magnetic III/V Compound Semiconductors
$463,527Lian Li · University Of Wisconsin-Milwaukee · · FY2001 · MPS
Deep Fractions Learning: A Core Curriculum of Games, Inquiry, and Collaboration
$463,456Kara Carpenter · Teachley, Llc · R44 · FY2019 · GM
Mobile DNA in Drug Abuse
$463,414Wade H Berrettini · University Of Pennsylvania · R01 · FY2016 · DA
Neuronal and theoretical analysis of spatial orientation
$463,346Shawn R Lockery · University Of Oregon · R01 · FY2012 · MH
Design of HIV VLPs with Enhanced Immunogenicity
$463,321Richard W Compans · Emory University · R01 · FY2013 · AI
Immune Regulation of Neuronal Injury and Repair
$463,254Kathryn Jane Jones · Indiana University Indianapolis · R01 · FY2016 · NS
Environmental Metals, Excitotoxicity and ALS
$463,248William D Atchison · Michigan State University · R01 · FY2015 · ES
ALL immunobiology and the bone marrow niche
$463,229Terry Fry · Division Of Basic Sciences - Nci · ZIA · FY2017 · CA
Purging Latent HIV Reservoirs through a Combination HIV Therapeutic
$463,205Trevor P. Castor · Aphios Corporation · R43 · FY2016 · AI
Reverse genetics of mosquito systemic immunity
$463,182Alexander Simeon Raikhel · University Of California Riverside · R01 · FY2008 · AI
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
$463,165James G Fujimoto · Massachusetts Institute Of Technology · R01 · FY2024 · CA
CAREER: Transport properties and morphology associated with bursting-bubble induced jetting phenomena
$463,147James C Bird · Trustees Of Boston University · · FY2014 · ENG
Generation of long-term B cell memory and antibody responses to viral infections
$463,097Shane P Crotty · La Jolla Institute For Immunology · R01 · FY2011 · AI
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity Pathophysiology
$463,093Joseph T Bass · Northwestern University At Chicago · R01 · FY2024 · DK
Prophylactic Anthrax Toxin Vaccine
$462,918Vical, Inc. · R41 · FY2002 · AI
Variation in platelet function: human PAR4 functional genomics
$462,903Paul F. Bray · Thomas Jefferson University · R01 · FY2016 · HL
Improving substance abuse counseling adherence using web-based videoconferencing
$462,897Van L. King · Johns Hopkins University · RC1 · FY2010 · DA
Bulbar Motor Deterioration in ALS
$462,837Jordan R Green · University Of Nebraska Lincoln · R01 · FY2011 · DC
Bulbar Motor Deterioration in ALS
$462,837Jordan R Green · University Of Nebraska Lincoln · R01 · FY2012 · DC
Developmental Transitions and Risk for Alcohol Use
$462,836Gregory T. Smith · University Of Kentucky · R01 · FY2012 · AA