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38,696 grants matching “als”
Clinical, Immunological and Genetic Analyses of ALPS and Related Disordrs
$464,319Vemulkonda Rao · National Institute Of Allergy And Infectious Diseases · ZIA · FY2019 · AI
Target-based Assays and Screening Strategies for Chemical Probe and Therapeutic Lead Discovery
$464,311James Inglese · National Center For Advancing Translational Sciences · ZIA · FY2021 · TR
Glutamate Transporters in the CNS
$464,287Childrens Hospital Of Philadelphia · R01 · FY2004 · NS
RESEARCH METHODS CORE
$464,274Nicholas Ialongo · Johns Hopkins University · P30 · FY2012 · MH
Mammalian L1 retrotransposons as genetic characters
$464,257Anthony V. Furano · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2013 · DK
Mammalian L1 retrotransposon replication
$464,257Anthony V. Furano · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2013 · DK
Positive Immune-regulators During Chronic Viral Infections
$464,225Elina I Zuniga · University Of California, San Diego · R01 · FY2016 · AI
ABSTINENT SOCIAL SUPPORT IN OXFORD HOUSE
$464,218De Paul University · R01 · FY2003 · DA
Biomedical National Elemental Imaging Resource (BNEIR)
$464,191Brian P Jackson · Dartmouth College · R24 · FY2023 · GM
Biomedical National Elemental Imaging Resource (BNEIR)
$464,191Brian P Jackson · Dartmouth College · R24 · FY2021 · GM
Decision Making &Substance Abuse Among Inner-City Youth
$464,143University Of Alabama At Birmingham · R01 · FY2005 · DA
Silencing C9or72 with rAAV Mediated RNAi
$464,134Robert H Brown · Univ Of Massachusetts Med Sch Worcester · R01 · FY2017 · NS
Molecular Characterization of Breast Duct Epithelium at Risk for Breast Cancer
$464,117David Danforth · Division Of Clinical Sciences - Nci · ZIA · FY2014 · CA
TGFB-SMAD Signaling in Stem Cell Differentiation and Tumor Suppression
$464,097Joan Massague · Sloan-Kettering Inst Can Research · R01 · FY2019 · CA
Preclinical Diagnostic Imaging of Amyloid
$464,016Jonathan S Wall · University Of Tennessee Knoxville · R01 · FY2009 · DK
OUR GOAL IS TO FURTHER DEVELOP TECHNIQUES NEEDED TO MEASURE AND INTERPRET COSMIC-RAY-PRODUCED (COSMOGENIC) NUCLIDES IN RETURNED SAMPLES. WE HAVE BEEN ROUTINELY MEASURING COSMOGENIC BOTH GALACTIC COSMIC RAYS (GCR) AND SOLAR COSMIC RAYS (SCR) - 10BE 26AL AND 36CL IN EXTRA-TERRESTRIAL MATERIALS FOR MANY YEARS. IN THE LAST THREE YEARS WE HAVE GREATLY IMPROVED OUR MEASUREMENT SENSITIVITY FOR ALL RADIONUCLIDES BY A FACTOR OF 2-3 AND WE CAN NOW FOR THE FIRST TIME MEASURE 41CA IN EXTRATERRESTRIAL MATERIALS. THE IMPLEMENTATION OF THE GAS-FILLED-MAGNET (GFM) AT PRIME LAB HAS ENABLED THESE IMPROVEMENTS. WE ARE ALSO CONTINUING THE DEVELOPMENT OF A 53MN MEASUREMENT CAPABILITY. THE MEASUREMENT OF THESE COSMOGENIC NUCLIDES IN ASTEROIDAL AND LUNAR REGOLITH RETURNED SAMPLES PROVIDES KEY INFORMATION REGARDING THE EXPOSURE CONDITIONS AND DURATIONS OF THESE SAMPLES. BE-10 26AL 36CL 41CA AND 53MN EACH HAVE SPECIFIC PRODUCTION PATHWAYS THAT PROVIDE SPECIFIC INFORMATION: 10BE 26AL AND 53MN ARE PRODUCED BY HIGHENERGY GCR SPALLATION REACTIONS WHEREAS 41CA IS PRODUCED PRIMARILY FROM NEUTRON-CAPTURE REACTIONS ON 40CA. CL-36 IS PRODUCED BY BOTH PATHWAYS THE CL CONCENTRATION IMPACTS WHICH REACTION PATHWAY IS DOMINANT. AL-26 AND 53MN CAN ALSO BE PRODUCED IN THE UPPER CM OF ASTEROIDAL OR LUNAR SURFACE BY SCR. THE MEASUREMENT OF A SINGLE RADIONUCLIDE CANNOT BY ITSELF YIELD INFORMATION ABOUT BOTH EXPOSURE CONDITIONS I.E. DEPTH AND EXPOSURE DURATIONS BUT WITH A COMBINATION OF 3-4 NUCLIDES WE ARE ABLE TO PLACE STRONG CONSTRAINTS ON BOTH THE EXPOSURE CONDITIONS AND THE EXPOSURE DURATIONS. SINCE MOST RETURNED SAMPLES EXCEPT MANNED APOLLO SAMPLES ARE COLLECTED FROM UNKNOWN DEPTHS ON THE SURFACE OF A PLANETARY BODY IDENTIFYING THE SAMPLING DEPTH IS EXTREMELY IMPORTANT NOT ONLY FOR COSMOGENIC NUCLIDE STUDIES BUT ALSO SPACE WEATHERING BIOLOGICAL AND RADIATION HISTORIES. THE COMBINATION OF THESE NUCLIDES IS CRITICAL IN IDENTIFYING MATERIAL THAT WAS EXPOSED UNDER DIFFERENT CONDITIONS FROM WHICH IT WAS COLLECTED THAT IS MATERIAL THAT IS NOW ON THE SURFACE BUT WAS EXPOSED TO COSMIC RAYS FOR MUCH OF ITS HISTORY AT A DEEPER LOCATION. IT HAS BEEN PROPOSED THAT ASTEROID AND LUNAR REGOLITH ARE DYNAMIC; COSMOGENIC NUCLIDES WOULD BE KEY IN EVALUATING THIS HYPOTHESIS. OUR ULTIMATE GOAL IS THE FURTHER SOPHISTICATION OF AMS MEASUREMENT TECHNIQUES ALLOWING HIGH SENSITIVE AND PRECISE MEASUREMENTS OF SAMPLES RETURNED BY HAYABUSA1 TO 25143 ITOKAWA BY THE OSIRIS-REX MISSION TO 101955-BENNU AND BY THE HYAYBUSA2 MISSION TO 162173 RYUGU AS WELL AS COMET AND LUNAR SAMPLE RETURN MISSIONS. ALTHOUGH WE HAVE BEEN USING THE GFM FOR SEVERAL YEARS NOW AND WE HAVE IMPROVED THE DETECTION SENSITIVITY THERE IS YET OPPORTUNITY FOR FURTHER ADVANCES IN SENSITIVITY. FURTHER DEVELOPMENTS ARE: IMPROVEMENTS IN THE DETECTION SYSTEM; IMPROVED STRIPPING EFFICIENCIES IN THE TERMINAL OF THE ACCELERATOR; AND INVESTIGATION OF ALTERNATIVE CHEMICAL FORMS OF THE CATHODE MATERIAL LEADING TO BETTER NEGATIVE ION YIELDS IN THE ION SOURCE. TO BE BETTER PREPARED FOR RETURN SAMPLES FROM ASTEROID AND LUNAR SURFACES WE WILL UNDERTAKE MEASUREMENTS IN SMALL REGOLITH SAMPLES FROM LUNAR SAMPLES. MEASUREMENTS OF RADIONUCLIDES IN THESE ANALOG SAMPLES WILL ENABLE US TO IDENTIFY BOTH MEASUREMENT AND INTERPRETATION ISSUES THAT NEED IMPROVING BEFORE SAMPLES ARRIVE. THE DEVELOPMENT TECHNIQUES AND METHODS WILL BE APPLIED TO FUTURE SAMPLE RETURN MISSIONS SUCH AS OSIRIS-REX HAYABUSA2 FUTURE COMET AND LUNAR SAMPLES MEASUREMENTS OF COSMOGENIC NUCLIDES IN IDP S AND GENESIS SAMPLES. THE DESCRIBED RESEARCH IS DIRECTLY RELEVANT TO NASA LABORATORY ANALYSIS OF RETURNED SAMPLES (LARS) PROGRAM IN ROSES-2018 INCLUDING DEVELOP NEW ANALYTICAL INSTRUMENTATION OR COMBINATIONS OF ANALYTICAL INSTRUMENTS OR NEW COMPONENTS OF ANALYTICAL INSTRUMENTS LEADING TO SIGNIFICANT IMPROVEMENTS IN THE PRECISION AND TO ENABLE NEW TYPES OF MEASUREMENTS.
$464,000Purdue University · · FY2020 · National Aeronautics and Space Administration
Mechanism of Therapy in high-risk AML
$463,996Mohammad Azam · Cincinnati Childrens Hosp Med Ctr · R01 · FY2024 · CA
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
$463,983James G Fujimoto · Massachusetts Institute Of Technology · R01 · FY2023 · CA
Binaural Hearing
$463,983Harry Steven Colburn · Boston University (Charles River Campus) · R01 · FY2016 · DC
Function and mechanism of the HCV p7 channel and its therapeutic potential
$463,975James J Chou · Harvard Medical School · R01 · FY2017 · GM
Dopamine Transporter Binding by PET in Adult ADHD
$463,941Thomas J Spencer · Massachusetts General Hospital · R01 · FY2007 · MH
Exploring exosomes in neurodevelopmental and neuropsychiatric diseases using brain organoids
$463,931Dilek Colak · Weill Medical Coll Of Cornell Univ · R21 · FY2023 · MH
Predicting Late-Emerging RD: Neurobiological and Cognitive Factors
$463,901Laurie E Cutting · Vanderbilt University · R01 · FY2014 · HD
Transcriptional regulation over neurogenesis of cortical output neuron segmental identity and diversity
$463,843Vibhu Vinodchandra Sahni · Winifred Masterson Burke Med Res Inst · R01 · FY2023 · NS
Conditioned social fear, the prefrontal cortex, and bed nucleus of the stria terminalis
$463,838Sondra T Bland · University Of Colorado Denver · R15 · FY2020 · HD