Sort
1,049,261 grants matching “t cell”
Center for Integrated Cellular Analysis
$2,500,000Rahul Satija · New York Genome Center · RM1 · FY2022 · HG
Active Vaccination and Passive Antibody Strategies to Prevent Disease Caused by Multidrug-Resistant Bacterial Pathogens
$2,500,000Myron Max Levine · University Of Maryland Baltimore · U19 · FY2019 · AI
BRAIN CONNECTS: An Integrative Connectomics Coordination Center (IC3)
$2,500,000Hongkui Zeng · Allen Institute · U24 · FY2025 · NS
HIGH POWER, LOW COST SOLID OXIDE FUEL CELL STACKS FOR ROBUST AND RELIABLE DISTRIBUTED GENERATION
$2,500,000Redox Power Systems Llc · · FY2017 · Department of Energy
Case GI SPORE
$2,500,000Sanford D Markowitz · Case Western Reserve University · P50 · FY2018 · CA
Active Vaccination and Passive Antibody Strategies to Prevent Disease Caused by Multidrug-Resistant Bacterial Pathogens
$2,500,000Myron Max Levine · University Of Maryland Baltimore · U19 · FY2021 · AI
Center for Identification and Study of Individuals with Atypical Diabetes Mellitus
$2,500,000Louis H. Philipson · University Of Chicago · U54 · FY2025 · DK
Center for Integrated Cellular Analysis
$2,500,000Rahul Satija · New York Genome Center · RM1 · FY2023 · HG
Data Coordination and Integration Center for LINCS-BD2K
$2,500,000Avi Ma'ayan · Icahn School Of Medicine At Mount Sinai · U54 · FY2014 · HL
INFEWS/T2: Solar Solutions for Food, Energy and Water Systems (S2FEWS)
$2,499,999Rakesh Agrawal · Purdue University · · FY2019 · ENG
'Mosaicism in Human Tissues, from Telomere to Telomere to RFA-22-013: "Somatic Mosaicism across Human Tissues Program: Genome Characterization Centers."
$2,499,999James T Bennett · Seattle Children'S Hospital · UM1 · FY2023 · DA
MFB: Developing Next-Generation Approaches to Targeted Protein Degradation
$2,499,998Daniel K Nomura · University Of California-Berkeley · · FY2021 · MPS
A Data Coordinating Center for ENCODE
$2,499,949Joe Michael Cherry · Stanford University · U41 · FY2013 · HG
COMPREHENSIVE SICKLE CELL CENTER
$2,499,935Boston Medical Center · P60 · FY2001 · HL
4D Nucleome Network Data Coordination and Integration Center
$2,499,910Peter Park · Harvard Medical School · U01 · FY2024 · CA
Hierarchical Bayesian Modeling of Disease Dynamics: A Case Example Using Chronic Wasting Disease
$2,499,881N. Thompson Hobbs · Colorado State University · · FY2009 · BIO
Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers
$2,499,784Mary E. Choi · Weill Medical Coll Of Cornell Univ · P01 · FY2024 · HL
4D Nucleome Network Data Coordination and Integration Center
$2,499,772Peter Park · Harvard Medical School · U01 · FY2021 · CA
Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders
$2,499,658Joan L Luby · Washington University · R01 · FY2024 · MH
Expression, Structure/function, Regulation, and Roles of PDE3 Isoforms
$2,499,647Vincent Manganiello · National Heart, Lung, And Blood Institute · ZIA · FY2012 · HL
CUBICPV INC (CPV) INTENDS TO DEMONSTRATE HIGH-EFFICIENCY, HIGH-DURABILITY AND LEAD-SAFE METAL HALIDE PEROVSKITE MODULES AT LEAST 150 MM ON A SIDE EXCEEDING 4W (CELL LIGHT-TO-POWER CONVERSION EFFICIENCY =20%) IN NAME-PLATE CAPACITY FABRICATED BY SLOT-DIE COATING WITH AN EXPECTED LIFETIME EXCEEDING 20 YEARS (T97 = 1000 HRS @ 75OC, 1 SUN AND EA >0.5 EV). PSC PV MODULES WILL DEMONSTRATE MILITARY-SPECIFICATION DURABILITY (MIL-SPEC, TOP 09-2-291), IN ADDITION TO IEC 61215 DURABILITY STANDARDS AND AN ANNUAL DEGRADATION OF =1%/ANNUM IN AN OUTDOOR TEST FACILITY. WE WILL DEMONSTRATE PEROVSKITE PV MODULES THAT EXPERIENCE PB LEAKAGE INTO WATER =15 PPB (PER U.S. FEDERAL 40 CFR 141, §141.80(C)) UPON BREAKAGE AT PH 4 AND 7. IN DOING SO, WE INTEND TO DEMONSTRATE METAL HALIDE PEROVSKITE PV MODULE MANUFACTURABILITY, SCALING, DURABILITY, AND CHEMICAL SAFETY TO PRECONDITION COMMERCIAL FEASIBILITY AND BANKABILITY.
$2,499,603Cubicpv Inc. · · FY2022 · Department of Energy
INFECTION AND DISEASE ADVERSELY IMPACT PERFORMANCE, GROWTH, MORBIDITY AND MORTALITY IN PRODUCTION ANIMALS AND HAS MAJOR ECONOMIC IMPACTS ON COMMERCIAL POULTRY PRODUCTION. THIS IS EXACERBATED BY CONSUMER WORRIES ABOUT ANTIBIOTIC USE, WHICH PRESSURES PRODUCERS TO USE ALTERNATIVE STRATEGIES TO PREVENT INFECTION. AN ILLUSTRATING EXAMPLE IS THE AVIAN INFLUENZA OUTBREAK OF 2015, WHICH HAS BEEN DESCRIBED AS THE WORST IN US HISTORY WITH THE LOSS OF OVER 48 MILLION BIRDS (CHICKEN AND TURKEY). THIS EVENT UNDERSCORES THE NEED TO FUNCTIONALLY ANNOTATING THE CHICKEN GENOME TO UNDERSTAND COMPLEX GENETIC TRAITS SUCH AS DISEASE RESISTANCE, WHICH IN TURN COULD SERVE AS A POWERFUL TOOL TO ENSURE SUSTAINABLE AGRICULTURAL SYSTEMS. FURTHERMORE, IN POULTRY PRODUCTION, ADDITIONAL FACTORS AFFECTING COMMERCIAL AND ECONOMIC PERFORMANCE NEED TO BE CONSIDERED IN BREEDING. FACTORS INCLUDING INTESTINAL HEALTH, EGG LAYING PERFORMANCE OR GROWTH EFFICIENCY IN BROILERS CERTAINLY ARE OF PARTICULAR ECONOMIC SIGNIFICANCE.TO IMPROVE OUR UNDERSTANDING OF THE UNDERLYING MECHANISMS CONTROLLING THESE AND OTHER TRAITS, IDENTIFICATION OF CIS-REGULATORY ELEMENTS ON THE GENOME IS WARRANTED. THESE REGULATORY ELEMENTS CONTROL THE EXPRESSION OF GENES AND CONSEQUENTLY PHENOTYPE; HOWEVER, THE TARGETED TISSUES AND CELLS FOR ANALYSIS NEED TO BE DETERMINED FOR EACH TRAIT OF INTEREST, AS THESE REGULATORY ELEMENTS ARE TISSUE SPECIFIC, AND EVEN DIFFER FROM CELL TO CELL WITHIN A GIVEN TISSUE. ADDITIONALLY, ENVIRONMENTAL FACTORS SUCH AS NUTRITION INTERACT WITH EPIGENETIC MODIFIERS WORKING AT THESE REGULATORY ELEMENTS, THUS MAKING IT POSSIBLE TO PROMOTE THE EXPRESSION OF DESIRABLE PRODUCTIVE TRAITS BY MANAGEMENT.IN THE PAST, SELECTIVE BREEDING OF POULTRY HAS RESULTED IN IMPROVED FEED CONVERSION RATIOS IN BROILERS, ALBEIT AT THE COST OF DECREASED IMMUNE COMPETENCE AND GREATER SUSCEPTIBILITY TO DISEASE. IN CONTRAST, SOME LINES OF BIRDS ARE KNOWN TO BE MORE RESISTANT TO A VARIETY OF PATHOGENS.THE EMERGENCE OF ANTIMICROBIAL RESISTANCE SUGGESTS THAT GENETIC RESISTANCE TO DISEASE WOULD PROVIDE AN ADVANTAGE OVER THE USE OF ANTIMICROBIALS. WHILE PARAMETERS OF IMMUNE COMPETENCE, SUCH AS ANTIBODY PRODUCTION, PHAGOCYTIC ACTIVITY AND CYTOKINE PRODUCTION OF THE HOST ARE KNOWN, THE GENETIC AND MOLECULAR BASIS FOR DISEASE RESISTANCE IS STILL NOT WELL UNDERSTOOD. IT HAS BECOME APPARENT THAT PATHOGENS INTERACT WITH EPIGENETIC REGULATORS OF THE HOST, AIDING IMMUNE EVASION AND REPLICATION OF THE PATHOGEN.IDENTIFICATION OF REGULATORY ELEMENTS AND THEIR INFLUENCE ON TARGET GENES DIRECTLY RESPONSIBLE FOR ENHANCED IMMUNITY IN POULTRY IS CRUCIAL IN ORDER TO SELECT FOR TRAITS THAT IMPROVE DISEASE RESISTANCE FOR BREEDING PURPOSES AND FLOCK HEALTH.
$2,499,551Western University Of Health Sciences · · FY2018 · National Institute of Food and Agriculture
Modulation Of Neuronal Channels and Receptors in the Brain
$2,499,546Jerrel L Yakel · National Institute Of Environmental Health Sciences · ZIA · FY2020 · ES
Longitudinal Multiomics Microbial Profiling in Healthy and Disease Individuals
$2,499,529Michael P Snyder · Stanford University · U54 · FY2014 · DK
OTHER FUNCTIONS SBIR PHASE II TOPIC 275, "DEVELOPMENT OF GENERIC TRASTUZUMAB FOR
$2,499,488Magdalena Leszczyniecka · Stc Biologics, Inc · N44 · FY2012 · CA