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38,696 grants matching “als”
Imaging Cortical Dopamine Transmission in Alcohol Dependence
$467,744Rajesh Narendran · University Of Pittsburgh At Pittsburgh · R01 · FY2009 · AA
SOCIAL SKILLS TRAINING FOR MEDICATED ADHD CHILDREN
$467,730University Of California Los Angeles · R01 · FY2004 · MH
Positive Immune-regulators During Chronic Viral Infections
$467,657Elina I Zuniga · University Of California, San Diego · R01 · FY2015 · AI
Cell and Gene Therapy, Clinical Manufacture and Monitoring Core
$467,624Antoni Ribas · California Institute Of Technology · P01 · FY2012 · CA
Architecture and function of condensates formed by ubiquitin-binding shuttle proteins and protein quality control components
$467,599Carlos Antonio Castaneda · Syracuse University · R35 · FY2025 · GM
Neurobiological signatures of perception and imitation of AV speech in children w
$467,562Julia Irwin · Southern Connecticut State University · R15 · FY2014 · DC
Clinical Research in ALS & Related Disorders for Therapeutic Development (CReATe) - Project Core #2
$467,538Joseph Paul Taylor · University Of Miami School Of Medicine · U54 · FY2019 · NS
REU Site: Applied Terrestrial Ecology of a Biodiversity Hotspot
$467,468Christopher A Lepczyk · Auburn University · · FY2025 · BIO
Development of Identified Motoneurons
$467,446Judith S Eisen · University Of Oregon · R56 · FY2007 · NS
Calorie Restriction, Mitochondrial DNA Heteroplasmy, Cardiometabolic Profiles, and Biological Aging
$467,416Jiantao Ma · Tufts University Boston · R21 · FY2024 · AG
CANDIDATE GENE STUDY OF INHERITED RETINAL DEGENERATIONS
$467,403Massachusetts Eye And Ear Infirmary · R01 · FY2005 · EY
Sensory Science and Metabolism; Molecular and Neuronal Mechanisms
$467,363Paule Joseph · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2023 · AA
Validation of Web-based Multimedia Dietary Assessment Tools
$467,204Lenore Arab · University Of California Los Angeles · R01 · FY2009 · CA
Non-Invasive Tracking of Genome-Corrected iPS cells in ALS
$467,176Jeff W Bulte · Johns Hopkins University · UH3 · FY2021 · EB
Subplate-dependent mechanisms of cortical circuit assembly
$467,121Kenneth Yu-Chung Kwan · University Of Michigan At Ann Arbor · R01 · FY2025 · NS
Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
$467,116Fuzheng Guo · University Of California At Davis · R01 · FY2021 · NS
Theme B
$467,116Anne Leighton Calof · University Of California-Irvine · P50 · FY2010 · GM
REGULATION AND EXPRESSION OF THE HSP70 GENE FAMILY
$467,115Northwestern University · R37 · FY2002 · GM
Cuentos de la Vida: Exploring Cultural Heritage through Storytelling
$467,036Melissa E. Derosier · 3-C Institute For Social Development · R44 · FY2012 · HD
Development of CM-CS1 CAR Treg to Treat Amyotrophic Lateral Sclerosis (ALS)
$466,950Joana M Murad · Celdara Medical, Llc · R44 · FY2023 · NS
ICE GIANTS LIKE URANUS REMAIN POORLY UNDERSTOOD YET WE NOW KNOW THAT THEY ARE PERHAPS THE MOST COMMON TYPE OF PLANETS BASED ON EXOPLANET DETECTIONS. A SATELLITE SYSTEM CAN BE USED TO PLACE IMPORTANT CONSTRAINTS ON THE FINAL STAGES OF A PLANET S FORMATION. HOWEVER THE ORIGIN OF THE URANIAN SATELLITES REMAINS THE LEAST WELL UNDERSTOOD OF ANY OF THE OUTER SATELLITE SYSTEMS. THE LARGE SATELLITES OF JUPITER AND SATURN LIKELY FORMED WITHIN CIRCUMPLANETARY DISKS OF GAS AND SOLIDS THAT WERE CREATED AS THOSE PLANETS ACCRETED GAS (E.G. STEVENSON ET AL. 1986). RETROGRADE TRITON WAS LIKELY CAPTURED INTACT (E.G. AGNOR&HAMILTON 2006) WHICH DESTROYED EVIDENCE OF AN ORIGINAL SATELLITE SYSTEM AT THAT ICE GIANT. IN CONTRAST BASIC PROPERTIES OF THE URANIAN SATELLITE SYSTEM ARE NOT EASILY EXPLAINED BY STANDARD ORIGIN MODELS. THE CHALLENGE IS THAT URANUS IS A RETROGRADE ROTATOR WITH AN OBLIQUITY OF 98 DEGREES AND ITS SATELLITES ORBIT IN THE SAME SENSE AS ITS RETROGRADE ROTATION. THE NEARLY CIRCULAR CO-PLANAR ORBITS OF THE MAIN URANIAN SATELLITES AND THEIR ORBITAL SPACINGS AND MASSES COMPARED TO THAT OF THE PLANET ARE SIMILAR TO JUPITER S MOONS. THIS SUGGESTS THEY MAY HAVE FORMED SIMILARLY VIA CO-ACCRETION. HOWEVER INFLOWING GAS WOULD FORM A PROGRADE DISK AROUND THE PLANET AND A SATELLITE SYSTEM ORBITING IN THE OPPOSITE SENSE TO THAT OBSERVED. ALTERNATIVELY THE SATELLITES COULD HAVE FORMED FROM A DISK PRODUCED BY A GIANT IMPACT THAT TILTED URANUS BUT THE DISKS PRODUCED BY SUCH EVENTS APPEAR TOO COMPACT AND ICE-DOMINATED TO PRODUCE THE OUTER ROCK-RICH URANIAN MOONS. A PROMISING NEW IDEA HAS BEEN PROPOSED (MORBIDELLI ET AL. 2012). THE IDEA IS THAT URANUS ORIGINALLY HAD A SMALLER OBLIQUITY AND A PROGRADE SATELLITE SYSTEM LIKE THAT AT JUPITER. THIS SYSTEM WAS DESTABILIZED BY A URANUS-TIPPING GIANT IMPACT. THE CURRENT SATELLITES THEN RE-ACCRETED IN URANUS NEW EQUATORIAL PLANE FROM DEBRIS CREATED BY DISRUPTIVE COLLISIONS BETWEEN THE ORIGINAL PROGRADE SATELLITES. A FIRST REQUIREMENT FOR THIS SCENARIO IS THAT THE IMPACT MUST PRODUCE NOT ONLY URANUS RETROGRADE OBLIQUITY BUT ALSO A MASSIVE INNER DISK CONTAINING 1% OR MORE OF THE PLANET S MASS OR ROUGHLY 100 TIMES THE MASS OF THE CURRENT SATELLITES. THE GRAVITATIONAL INFLUENCE OF THIS IMPACT-GENERATED DISK IS NEEDED SO THAT OUTER DISK DEBRIS ACCRETES INTO SATELLITES WITH LOW INCLINATIONS CONSISTENT WITH THE CURRENT LOW INCLINATION ORBITS OF TITANIA AND OBERON. A SECOND REQUIREMENT IS THAT THE MASSIVE INNER DISK MUST BE LOST SINCE NO SUCH DISK NOR COMPARABLY MASSIVE INNER MOON EXISTS AT URANUS TODAY. WHETHER SUCH CONDITIONS CAN BE ACHIEVED IS UNCLEAR. IN THIS PROPOSAL WE WILL MODEL THE FORMATION OF THE URANIAN SATELLITES IN A CO-ACCRETION + GIANT IMPACT SCENARIO. IN TASK 1 WE WILL CONDUCT SPH SIMULATIONS OF IMPACTS INTO URANUS TO DETERMINE THE TYPE OF IMPACT NEEDED TO TILT THE PLANET AND GENERATE A SUFFICIENTLY MASSIVE INNER DISK. IN TASK 2 WE WILL MODEL THE ACCRETION OF SATELLITES FROM THE POST-IMPACT SYSTEM IN TWO STAGES. FIRST WE WILL MODEL THE RE-ACCRETION OF THE OUTER REGULAR SATELLITES FROM THE DEBRIS DISK PRODUCED BY COLLISIONS AMONG THE PRIOR MOONS (TASK 2A). THEN WE WILL MODEL THE LATER EVOLUTION OF THE INNER ICE-RICH IMPACT-GENERATED DISK AS IT COOLS AND CONDENSES (TASK 2B). THE GOAL IN TASK 2 IS TO DETERMINE WHETHER THE POST-IMPACT SYSTEM CAN EVOLVE INTO A SYSTEM OF URANUS-LIKE SATELLITES WHILE THE MASSIVE IMPACT-GENERATED DISK IS NEARLY ENTIRELY LOST. TOGETHER TASKS 1 AND 2 WILL ALLOW US TO EVALUATE THE VIABILITY OF A CO-ACCRETION + GIANT IMPACT MODEL.
$466,948Southwest Research Institute · · FY2020 · National Aeronautics and Space Administration
Heterochronic Blood Exchange Inhibits α?Synucleinopathy through Modulating Plasma Protein's Mediation on Pathological α?Synuclein Spreading
$466,896Xiaobo Mao · Johns Hopkins University · R01 · FY2021 · AG
Structure/Function of Gap Junctions
$466,848Thaddeus Andrew Bargiello · Albert Einstein College Of Medicine · R01 · FY2007 · GM
Structure/Function of Gap Junctions
$466,802Thaddeus Andrew Bargiello · Albert Einstein College Of Medicine · R01 · FY2008 · GM
Characterization of a novel population of parvocellular oxytocin neurons controlling social reward learning
$466,686Gul Dolen · Johns Hopkins University · R56 · FY2019 · MH