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38,696 grants matching “als”
Interaction of Genotype and Level of Dietary Restriction on Lifespan and Aging
$468,723Arlan G. Richardson · University Of Oklahoma Hlth Sciences Ctr · R01 · FY2015 · AG
SPHINGOLIPIDS
$468,690Alfred Harrison Merrill · University Of California, San Diego · U54 · FY2009 · GM
Exploring the modulation of synaptic/extrasynaptic NMDAR balance as a novel therapeutic strategy in Alzheimer's disease and other neurodegenerations
$468,685Antonio Sanz-Clemente · Drexel University · R01 · FY2022 · AG
Exploring the modulation of synaptic/extrasynaptic NMDAR balance as a novel therapeutic strategy in Alzheimer's disease and other neurodegenerations
$468,685Antonio Sanz-Clemente · Drexel University · R01 · FY2024 · AG
Exploring the modulation of synaptic/extrasynaptic NMDAR balance as a novel therapeutic strategy in Alzheimer's disease and other neurodegenerations
$468,685Antonio Sanz-Clemente · Drexel University · R01 · FY2023 · AG
BACKGROUND: REMOTE COMPOSITIONAL INVESTIGATIONS IN THE THERMAL INFRARED WAVELENGTH REGION (E.G. 6-50M) HAVE LONG RELIED UPON THE ASSUMPTION OF LINEAR MIXING OF ENDMEMBER RADIANT ENERGY TO DETERMINE SURFACE MINERALOGY. VARIATIONS OF THIS TECHNIQUE HAVE BEEN SUCCESSFULLY APPLIED TO PLANETARY SURFACE INVESTIGATIONS AND IN THE LABORATORY. HOWEVER THE VALIDATION OF THIS CRITICAL ASSUMPTION HAS RELIED UPON A SURPRISINGLY SMALL NUMBER OF STUDIES [E.G. RAMSEY AND CHRISTENSEN 1998; FEELY AND CHRISTENSEN 1999; HAMILTON AND CHRISTENSEN 2000; WYATT ET AL. 2001] AND THE FULL PARAMETER SPACE UNCERTAINTIES AND ULTIMATE MINERAL ABUNDANCE RETRIEVAL ACCURACIES HAVE BEEN INSUFFICIENTLY EXPLORED. THIS IS IN LARGE PART DUE TO THE FACT THAT IT IS NOT PRACTICAL TO TEST THE LIMITS OF LINEAR MIXING PURELY IN THE LABORATORY AS MULTI-COMPONENT MIXTURES AS COMPLICATED SURFACES CANNOT BE READILY CONSTRUCTED. SIMILARLY SIMULATING SPECTRA VIA NUMERICAL MODELING OF REPRESENTATIVE (MULTI-COMPONENT LAYERED ETC.) MIXTURES HAS PROVED TO BE A SIGNIFICANT CHALLENGE DUE TO THE COMPLEX NATURE OF MODELS AND THE TYPICAL REQUIREMENT OF OPTICAL CONSTANTS AS MODEL INPUTS. TO DATE THERE HAS BEEN NO COMPREHENSIVE STUDY TO INVESTIGATE THE LIMITATIONS OF LINEAR SPECTRAL UNMIXING AND MINERAL ABUNDANCE RETRIEVALS IN TERMS OF COMPLEX MIXTURES OF MINERALS AND SIZE FRACTIONS. METHODOLOGY: IN THIS WORK WE PROPOSE TO TEST THE LIMITS OF MINERAL ABUNDANCE RETRIEVALS IN THE THERMAL INFRARED THROUGH MULTIPLE APPROACHES ENABLED BY BOTH LABORATORY STUDIES AND RADIATIVE TRANSFER MODELING. THIS ULTIMATE GOAL IS ACHIEVED BY FOUR DISTINCT TASKS: TASK 1. ACQUIRE THERMAL INFRARED EMISSION SPECTRA OF A SUITE OF MINERAL MIXTURES IN THE LABORATORY TASK 2. VALIDATE A NOVEL RADIATIVE TRANSFER MONTE CARLO EMISSION MODEL IN ORDER TO SIMULATE MINERAL MIXTURES TASK 3. EXPLORE PARTICLE SIZE LIMITATIONS OF THE RADIATIVE TRANSFER MONTE CARLO EMISSION MODEL TASK 4. GENERATE SYNTHETIC MODEL MIXTURES TO TEST MINERAL ABUNDANCE RETRIEVAL UNCERTAINTIES USING WELL-ESTABLISHED TECHNIQUES IN THE PLANETARY SCIENCE COMMUNITY RELEVANCE: THIS PROPOSAL IS DIRECTLY RELEVANT TO THE SOLAR SYSTEM WORKINGS PROGRAM AS IT SEEKS TO ENABLE OUR ABILITY TO BETTERCHARACTERIZE AND UNDERSTAND THE CHEMICAL MINERALOGICAL AND PHYSICAL FEATURES OF PLANETARY SURFACES AND MORE SPECIFICALLY DEVELOPS THETHEORETICAL AND EXPERIMENTAL BASES FOR UNDERSTANDING THESE FEATURES ON PLANETARY SURFACES. BY REFINING THE LIMITS OF THE COMMONLY USED LINEARMIXTURE MODELING WE ENABLE A RE-EVALUATION OF SPACECRAFT DATA RETURN FROM MULTIPLE PAST MISSIONS (E.G. MARS GLOBAL SURVEYOR MARS ODYSSEY LUNAR RECONNAISSANCE ORBITER) AS WELL AS FUTURE MISSIONS SUCH AS THE OSIRIS-REX AND LUCY MISSIONS. THE MODEL VALIDATED AS A PART OF THIS WORK SERVES TO FURTHER ENABLE THE REFINEMENT OF FUTURE MINERAL ABUNDANCE RETRIEVAL TECHNIQUES INCLUDING PARTIAL-LEAST SQUARES FITTING AND MAY IN FACT ITSELF BE USED TO RETRIEVE MINERAL ABUNDANCES ASSUMING THERMAL GRADIENTS ARE COMMON TO AIRLESS BODIES. WHILE THIS WORK FOCUSES ON THE LINEAR-MIXTURE MODELING TECHNIQUES THAT ARE WIDELY APPLIED TO MARS AND EARTH THE VALIDATION.
$468,670Northern Arizona University · · FY2020 · National Aeronautics and Space Administration
TGFB-SMAD Signaling in Stem Cell Differentiation and Tumor Suppression
$468,594Joan Massague · Sloan-Kettering Inst Can Research · R01 · FY2018 · CA
TGFB-SMAD Signaling in Stem Cell Differentiation and Tumor Suppression
$468,594Joan Massague · Sloan-Kettering Inst Can Research · R01 · FY2016 · CA
TGFB-SMAD Signaling in Stem Cell Differentiation and Tumor Suppression
$468,594Joan Massague · Sloan-Kettering Inst Can Research · R01 · FY2015 · CA
TGFB-SMAD Signaling in Stem Cell Differentiation and Tumor Suppression
$468,594Joan Massague · Sloan-Kettering Inst Can Research · R01 · FY2017 · CA
Targeting the EPhA4 in motor neuron disease: a structure-based approach
$468,592Maurizio Pellecchia · University Of California Riverside · R01 · FY2018 · NS
Non-Syndromic Hearing Loss -- A Collaborative Study
$468,588Richard J Smith · University Of Iowa · R01 · FY2007 · DC
Reducing Disparities in Depression Care for Ethnically Diverse Older Men
$468,429Walter Ladson Hinton · University Of California At Davis · R01 · FY2011 · MH
Native Navigators and the Cancer Continuum (NNACC)
$468,374Linda Burhansstipanov · Native American Cancer Research · R24 · FY2009 · MD
Beyond SABOR: A Border Embedded Health Promotion
$468,348Elena M Bastida · University Of North Texas Hlth Sci Ctr · R24 · FY2008 · MD
Role of Rainfall on the Geochemical Evolution of Soils: The Atacama Desert of Chile
$468,343Ronald Amundson · University Of California-Berkeley · · FY2005 · GEO
HOME TELEMONITORING OF BULBAR FUNCTION BY ACOUSTIC MEASUREMENT OF SWALLOWING AND SPEECH SOUNDS IN ALS
$468,300Pennsylvania State University · · FY2021 · Defense Health Agency
Molecular regulation over the decline in long-distance corticospinal axon regenerative ability during development
$468,231Vibhu Vinodchandra Sahni · Winifred Masterson Burke Med Res Inst · R01 · FY2024 · NS
Cell and Gene Therapy, Clinical Manufacture and Monitoring Core
$468,055Antoni Ribas · California Institute Of Technology · P01 · FY2011 · CA
RASCH-BUILT OUTCOME MEASURES TO IMPROVE ALS CLINICAL TRIALS
$468,000Emory University · · FY2021 · Department of the Army
Novel gene therapy strategies for Canavan disease
$467,999Guang-Ping Gao · Univ Of Massachusetts Med Sch Worcester · R01 · FY2014 · NS
Project 1 Clinical Procedures to Support Research in Myasthenia Gravis (CAPTURE_MG)
$467,998Henry J Kaminski · George Washington University · U54 · FY2025 · NS
NRSA Training Core
$467,832Thomas D. Hurley · Indiana University Indianapolis · TL1 · FY2018 · TR
Generation of long-term B cell memory and antibody responses to viral infections
$467,775Shane P Crotty · La Jolla Institute For Immunology · R01 · FY2010 · AI
Mucus-penetrating nanoparticles for sustained microbicide delivery
$467,744Justin S. Hanes · Johns Hopkins University · R33 · FY2011 · AI