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38,696 grants matching “als”
Developmental Transitions and Risk for Alcohol Use
$471,780Gregory T. Smith · University Of Kentucky · R01 · FY2008 · AA
Development of New Therapeutics for Amyotrophic Lateral Sclerosis
$471,756Robert H Brown · Univ Of Massachusetts Med Sch Worcester · U01 · FY2008 · NS
Project 2-Abeta-Dependent and -Independent Roles of PS1
$471,755Oksana Berezovska · Brigham And Women'S Hospital · P01 · FY2021 · AG
Project 2-Abeta-Dependent and -Independent Roles of PS1
$471,754Oksana Berezovska · Brigham And Women'S Hospital · P01 · FY2022 · AG
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators
$471,754Rudolph Emile Tanzi · Brigham And Women'S Hospital · P01 · FY2021 · AG
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators
$471,754Rudolph Emile Tanzi · Brigham And Women'S Hospital · P01 · FY2022 · AG
Circadian Clock and Dietary Restriction
$471,737Roman V Kondratov · Cleveland State University · R01 · FY2022 · AG
Role of ETS factors in specifying prostate luminal cell identity and androgen receptor dependence
$471,586Charles L Sawyers · Sloan-Kettering Inst Can Research · R01 · FY2021 · CA
Role of ETS factors in specifying prostate luminal cell identity and androgen receptor dependence
$471,586Charles L Sawyers · Sloan-Kettering Inst Can Research · R01 · FY2025 · CA
The Genetics Of Obsessive Compulsive Disorder
$471,561Dennis L Murphy · National Institute Of Mental Health · Z01 · FY2007 · MH
A TEST OF CHILDREN'S ENGLISH/SPANISH SPEECH PERCEPTION IN NOISE OR SPEECH MASKERS
$471,555Lori J Leibold · Father Flanagan'S Boys' Home · R01 · FY2020 · DC
Non-Syndromic Hearing Loss -- A Collaborative Study
$471,547Richard J Smith · University Of Iowa · R01 · FY2006 · DC
INVESTIGATING SOLAR SYSTEM EVOLUTION BY IDENTIFYING AND CHARACTERIZING BINARY TROJAN AND HILDA ASTEROIDS THE PRIMARY GOAL OF THIS PROPOSAL IS TO HELP CONSTRAIN THE DYNAMICAL EVOLUTION OF THE SOLAR SYSTEM BY IDENTIFYING AND CHARACTERIZING BINARY ASTEROIDS IN THE JOVIAN TROJAN AND HILDA POPULATIONS. ONE OF THE MOST DEBATED ISSUES IN SOLAR SYSTEM FORMATION IS GIANT PLANET MIGRATION. THE OBJECTS THOUGHT TO BE MOST AFFECTED BY THIS MIGRATION ARE JOVIAN TROJAN ASTEROIDS (HEREAFTER TROJANS) WHICH LIE IN STABLE ORBITS AROUND JUPITERS L4 AND L5 LAGRANGE POINTS. GENTLE PLANETARY MIGRATION MODELS (E.G. MARZARI&SCHOLL 1998) NECESSITATE THAT TROJANS FORMED IN SITU WHILE THE NICE MODEL OF RAPID OUTWARD GIANT PLANET MIGRATION SUGGESTS THAT TROJANS FORMED IN THE OUTER SOLAR SYSTEM AND WERE SCATTERED INTO THEIR PRESENT ORBITS (E.G. MORBIDELLI ET AL. 2005). THE NICE MODEL COMBINED WITH THE GRAND TACK MODEL (E.G. WALSH ET AL. 2011) ALSO PREDICTS THAT TROJANS AND HILDA ASTEROIDS (IN 3:2 ORBITAL RESONANCE WITH JUPITER) SHARE AN ORIGIN. ONE OBSERVABLE PROPERTY THAT SETS POWERFUL CONSTRAINTS ON FORMATION LOCATION IS BULK DENSITY WHICH IS MORE LIKELY TO REFLECT EARLY SOLAR SYSTEM CONDITIONS THAN SURFACE MATERIAL ALTERED BY IRRADIATION. LOW DENSITIES ARE LINKED TO THE ICE-RICH OUTER SOLAR SYSTEM WHILE HIGH DENSITIES ARE CONSISTENT WITH THE WARMER INNER SOLAR SYSTEM ENVIRONMENT. TO HELP DETERMINE THE TROJAN AND HILDA ORIGIN(S) WE WILL IDENTIFY AND CHARACTERIZE THEIR CONSTITUENT CLOSELY SEPARATED BINARY ASTEROID SYSTEMS USE THE BINARIES TO CONSTRAIN DENSITY AND COMPARE THE DENSITIES TO THOSE OF OTHER SMALL BODIES. BINARY CHARACTERIZATION OFFERS THE ONLY MEANS OF DETERMINING DENSITY APART FROM A SPACECRAFT FLY-BY. WE WILL CONDUCT THE FIRST SYSTEMATIC LARGE-SAMPLE STUDY OF TROJAN AND HILDA BINARIES. ANOTHER MAJOR RESULT FROM THIS WORK WILL BE DETERMINATION OF THE FRACTION OF TROJANS AND HILDAS IN CLOSELY SEPARATED BINARY SYSTEMS. A DIFFERENCE BETWEEN BINARY FRACTIONS OF TWO ASTEROID GROUPS IMPLIES DIFFERENT DYNAMICAL HISTORIES. FOR EXAMPLE IF ONE OF THE TROJAN CLOUDS HAS A HIGHER BINARY FRACTION THAN ANOTHER THEN THAT MIGHT SUPPORT THE JUMPING JUPITER MODEL WHICH PROPOSES THAT AN ICE GIANT TRAVERSED ONE OF THE TROJAN CLOUDS. IF THE TROJAN BINARY FRACTION IS INCONSISTENT WITH THE HILDA BINARY FRACTION THEN PERHAPS THEY DO NOT HAVE A COMMON ORIGIN AS SUGGESTED BY THE NICE MODEL. DIRECT IMAGING SURVEYS HAVE BEEN ABLE TO CONSTRAIN THE WIDELY SEPARATED TROJAN BINARY POPULATION BUT ONLY ONE SEARCH FOR CLOSE TROJAN BINARIES HAS BEEN PUBLISHED AND THIS SAMPLE WAS DOMINATED BY LARGE L5 TROJANS (>20KM; MANN ET AL. 2007). THE HILDA BINARY FRACTION HAS NEVER BEEN EXPLORED. TIGHT BINARIES WITH TYPICAL RUBBLE PILE STRUCTURES CAN SOMETIMES BE DISCOVERED BY THEIR ROTATIONAL LIGHT CURVES IF THEIR ORBITAL PLANES ARE IN LINE WITH EARTH (E.G. MANN ET AL. 2007). ALL THREE KNOWN CLOSE TROJAN BINARIES WERE DISCOVERED THIS WAY. USING DATA FROM THE WIDE-FIELD INFRARED SURVEY EXPLORER MISSION WE FOUND 80 TROJANS AND HILDAS (OUT OF ~1500 SEARCHED) WITH LARGE ENOUGH BRIGHTNESS VARIATIONS TO QUALIFY THEM AS POSSIBLE BINARIES (SONNETT ET AL. 2015). THIS SAMPLE SPANS A WIDE RANGE OF SIZES (~5-100KM) AND (FOR THE TROJANS) EQUALLY REPRESENTS BOTH L4 AND L5 CLOUDS. THREE OF THESE BINARY CANDIDATES ARE CONFIRMED THROUGH HISTORICAL DATA BUT THE REMAINDER HAVE YET TO BE CONFIRMED. IN THE PROPOSED WORK WE SEEK TO CONFIRM THEIR BINARITY BY DENSELY SAMPLING THEIR ROTATIONAL LIGHT CURVES DETERMINING THE SPIN PERIOD AND COMPARING BINARY AND SINGLE-BODY MODELS TO THE LIGHT CURVES WHILE SOLVING FOR BULK DENSITY. WE WILL THEN DEBIAS THE RESULTANT BINARY FRACTION AND COMPARE BINARY FRACTIONS TO ASSESS SIMILARITIES IN FORMATION ENVIRONMENTS AND DYNAMICAL HISTORIES. WE HAVE CONDUCTED A PILOT STUDY (9 TARGETS) AND WRITTEN MOST OF THE DEBIASING CODE AS PART OF THE PI S FELLOWSHIP ENDING IN MID-2016. WE THEREFORE SEEK ADDITIONAL SUPPORT FOR AN OBSERVING CAMPAIGN TO TARGE
$471,533Planetary Science Institute · · FY2017 · National Aeronautics and Space Administration
SCIENCE GOALS AND OBJECTIVES THE PRIMARY GOAL OF THE PROPOSED RESEARCH IS TO ACHIEVE A BETTER UNDERSTANDING OF THE DUST AGGREGATION STAGE OF PLANET FORMATION IN PROTOPLANETARY NEBULAE. A CRUCIAL STEP IN THE EARLIEST STAGES OF PLANET FORMATION IS THE GROWTH OF SOLID BODIES IN THE MILLIMETER TO METER SIZE RANGE BY THE AGGREGATION OF MILLIMETER- TO SUB-MILLIMETER-SCALE DUST GRAINS. THE PROCESS BY WHICH DUST AGGREGATED INTO PLANETESIMALS IS NOT WELL UNDERSTOOD; EXPERIMENTS WITHOUT THE EFFECTS OF GRAVITY ARE NEEDED TO INVESTIGATE IT. THE PRIMARY SCIENCE OBJECTIVES OF THE PROPOSED WORK ARE AS FOLLOWS: TO DETERMINING THE EFFECTS OF: (1) PARTICLE SIZE; (2) NUMBER DENSITY; AND (3) COMPOSITION ON THE AGGREGATION (ACCRETION) OF DUST-SCALE GRAINS IN MICROGRAVITY CONDITIONS. METHODOLOGY THE INVESTIGATION WOULD BUILD ON OUR PREVIOUS RECORD OF SUCCESSFUL MICROGRAVITY EXPERIMENTS WITH GRANULAR MATERIALS (LOVE ET AL. 2014) TO EXTEND THESE RESULTS TO ADDITIONAL MATERIALS AND PARTICLE CONTAINERS USING MORE ADVANCED METHODS AND ANALYSES. THE PROPOSED WORK FOCUSES THE BULK OF ITS EXPERIMENTAL INVESTIGATION ON GRANULAR MEDIA RELEVANT TO PROTOPLANETARY ENVIRONMENTS SUCH AS VARIOUS SILICATE MINERALS AND POWDERED ORDINARY AND CARBONACEOUS CHONDRITE MATERIALS. THE RESULTS OF THE PROPOSED WORK WOULD GREATLY CONSTRAIN PARTICLE AGGREGATION AND CLUSTER GROWTH IN THE EARLY PROTOPLANETARY DISK. RELEVANCE TO CALL THE SCOPE OF PROGRAM FOR EMERGING WORLDS INCLUDES "INVESTIGATIONS RELATED TO UNDERSTANDING THE FORMATION AND EARLY EVOLUTION OF OUR SOLAR SYSTEM". THIS PROPOSAL IS FOCUSED ON RESEARCH DIRECTED AT "PROTOPLANETARY DISK FORMATION AND EVOLUTION PHYSICAL PROCESSING OF DUST AND THE FORMATION AND ACCRETION OF SOLAR SYSTEM BODIES" BY CONDUCTING MICROGRAVITY EXPERIMENTS ON THE AGGREGATION OF MILLIMETER- TO SUB-MILLIMETER-SCALE GRAINS UNDER CONDITIONS RELEVANT TO THOSE IN THE EARLY PROTOPLANETARY NEBULA. THE PROPOSAL ALSO EXPLICITLY INVOLVES THE SUBSEQUENT ANALYSES AND PUBLICATION OF THESE EXPERIMENTAL DATA.
$471,447Southwest Research Institute · · FY2020 · National Aeronautics and Space Administration
Dissecting the role of striatal cell types in abnormal repetitive behaviors and treatment response
$471,436Susanne Elizabeth Ahmari · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · MH
Neuroprotective role of GLP-1 receptor agonists
$471,425Nigel H. Greig · National Institute On Aging · ZIA · FY2011 · AG
Project 2-Abeta-Dependent and -Independent Roles of PS1
$471,415Oksana Berezovska · Brigham And Women'S Hospital · P01 · FY2020 · AG
Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators
$471,414Rudolph Emile Tanzi · Brigham And Women'S Hospital · P01 · FY2020 · AG
Educational Framework of Genomic Data Science for Regional Populations; Hakim et al
$471,410Shazia Tabassum Hakim · Dine' College · UE5 · FY2025 · CA
Testing a Promising Treatment for Youth Substance Abuse in a Community Setting
$471,384Phillippe Belton Cunningham · Medical University Of South Carolina · R01 · FY2017 · DA
Parent-Child Communication About Cancer
$471,277Bruce E Compas · Vanderbilt University · R01 · FY2007 · CA
Optimization of ultrasound-facilitated blood-brain barrier opening
$471,242Elisa E Konofagou · Columbia Univ New York Morningside · R01 · FY2012 · EB
Genetic and Environmental Regulation of Diaphragm Development and Congenital Diaphragmatic Hernias
$471,238Gabrielle Kardon · University Of Utah · R01 · FY2024 · HD
Alzheimer's ABeta, Apolipoproteins &Blood-Brain Barrier
$471,199University Of Rochester · R01 · FY2001 · NS
Structural and mechanistic studies of V(D)J recombination
$471,192Wei Yang · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK