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38,696 grants matching “als”
THE GALAXY EVOLUTION EXPLORER (GALEX) HAS PERFORMED SKY SURVEYS IN THE ULTRAVIOLET (UV) WITH DIFFERENT DEPTH AND COVERAGE. ITS DATABASE OF ABOUT 300 MILLION PHOTOMETRIC SOURCE MEASUREMENTS IN FAR-UV AND NEAR-UV OFFERS UNIQUE SENSITIVITY FOR IDENTIFYING AND STUDYING CLASSES OF ASTROPHYSICAL OBJECTS SUCH AS HOT STARS STAR-FORMING GALAXIES AND Z<2 QSOS. GALEX UV SOURCE CATALOGS ENABLE COMPREHENSIVE INVESTIGATIONS LONG AFTER THE MISSION IS CONCLUDED. ANOTHER UNIQUE GOLD MINE IS THE 130TB ARCHIVE OF INDIVIDUAL PHOTONS RECORDED BY GALEX'S MCP DETECTORS. UNTIL NOW ONLY INTEGRATED IMAGES AND PHOTOMETRY FROM EACH OBSERVATION WERE AVAILABLE IN THE PUBLIC ARCHIVE. NOW IT IS POSSIBLE TO SEARCH THROUGH THE PHOTON LIST AND EXTRACT PHOTOMETRY WITH CHOSEN TIME INTEGRATIONS FOR A GIVEN SOURCE. SUCH FACILITY OPENS UP UNPRECEDENTED OPPORTUNITIES FOR INVESTIGATIONS OF SHORT-TERM UV VARIABILITY SERENDIPITOUS AND UNBIASED OVER SAMPLES ORDERS-OF-MAGNITUDE LARGER THAN ANY DEDICATED VARIABILITY SEARCH COULD AFFORD AND THE ONLY ONE IN THE UV. WE WILL SEARCH FOR VARIABILITY ON ALL TIME SCALES AFFORDED BY THE DATABASE (FROM SECONDS TO THE>9 YEARS OF GALEX OPERATIONS) BUT ESPECIALLY ON THE FAST CADENCES FOR ALL HOT STELLAR SOURCES IN THE GALEX DATABASE. MOST OF THESE ARE VERY HOT WHITE DWARFS (WD) ELUSIVE AT ALL WAVELENGTHS EXCEPT THE UV OWING TO THEIR SMALL RADII AND HOT TEMPERATURES. WE HAVE IDENTIFIED ABOUT HALF A MILLION HOT WD CANDIDATES IN THE GALEX DATABASE WITH COROLLARY DATA AT LONGER WAVELENGTHS. THE GALEX-SELECTED HOT-WD SAMPLES ARE ORDERS OF MAGNITUDE LARGER THAN PREVIOUS CATALOGS AND UNBIASED THANKS TO THE UV SELECTION (E.G. BIANCHI ET AL. 2011A). OF PARTICULAR INTEREST ARE THE HOT WDS IN BINARIES WITH A COOLER (LESS EVOLVED) STAR UNIQUELY IDENTIFIED AND CHARACTERIZED FROM MATCHED UV-?? OPTICAL PHOTOMETRY. WE WILL PRODUCE A CATALOG OF FAST-CADENCE PHOTOMETRY FOR THE HOT STELLAR SOURCES SEARCH FOR VARIABILITY AND ANALYZE THE DETECTED VARIABLES. WE EXPECT THE OUTCOME TO INCLUDE SEVERAL CLASSES OF STARS WITH VARIABILITY WITHIN A GALEX OBSERVATION: CATACLYSMIC VARIABLES FLARING STARS BE STARS TRANSITING OBJECTS ORBITING WHITE DWARFS WD PULSATORS AND - MORE RARE BUT EXTREMELY RELEVANT - ECLIPSING BINARIES. DETECTION OF ECLIPSING HOT WDS WILL HAVE GREAT RELEVANCE FOR UNDERSTANDING STELLAR EVOLUTION OF INTERMEDIATE MASS STARS HELPING TO CLARIFY THE RELATION BETWEEN THE INITIAL MASS (UP TO ABOUT 8 SOLAR MASSES) TO THE FINAL WD MASS (<1 SOLAR MASS) CRITICAL FOR THE YIELD OF CHEMICAL ELEMENTS AND THE CHEMICAL EVOLUTION OF GALAXIES THE DEGENERATE MASS-RADIUS RELATION AND BINARY EVOLUTION. WE ALSO EXPECT TO DETECT TRANSITS BY PLANETS IN TIGHT ORBITS AROUND THE HOT WDS: THE PLANET/HOT-STAR FLUX CONTRAST IN THE UV AND THE SHORT (FEW MINUTES) EXPECTED DURATIONS MAKE OUR SEARCH UNIQUELY SENSITIVE TO SUCH DETECTION AND THE UNPRECEDENTEDLY LARGE SAMPLE WILL STATISTICALLY ASSESS THE EXISTENCE OF STAR-GRAZING PLANETARY BODIES. ALONG WITH OUR SCIENCE RESULTS WE WILL PUBLICLY RELEASE CATALOGS OF TIME-RESOLVED PHOTOMETRY FOR THE ENTIRE SAMPLE CATALOGS OF VARIABLES WITH ADDITIONAL COROLLARY DATA AND PRODUCTS (FFT IMAGE CUBES) AND RELATED SCIENCE TOOLS. THESE WILL SUPPORT FOLLOW-UP INVESTIGATIONS BY THE SCIENTIFIC COMMUNITY BEYOND OUR OWN GOALS. AS PART OF OUR PROJECT WE WILL ALSO CHARACTERIZE INSTRUMENTAL EFFECTS AT BRIGHT COUNT-RATES: THIS RESULT WILL BE OF GENERAL RELEVANCE TO ANY INVESTIGATION WITH GALEX DATA.
$474,471The Johns Hopkins University · · FY2017 · National Aeronautics and Space Administration
Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
$474,466Sheryl G Beck · Children'S Hosp Of Philadelphia · RC1 · FY2009 · MH
ONC201/TIC10 Anti-tumor Effect Through Regulation of the TRAIL pathway
$474,416Wafik S El-Deiry · Brown University · R01 · FY2023 · CA
ONC201/TIC10 Anti-tumor Effect Through Regulation of the TRAIL pathway
$474,416Wafik S El-Deiry · Brown University · R01 · FY2022 · CA
SEARCH AND DISCOVERY IN THE TRANS-NEPTUNIAN SOLAR SYSTEM USING THE DARK ENERGY SURVEYWITH THE RECENT SUCCESS OF THE NEW HORIZONS MISSION AND THE HYPOTHESIS OF A VERY DISTANT PLANET NINE INTEREST IN THE TRANS-NEPTUNIAN SOLAR SYSTEM IS AT AN ALL-TIME HIGH. THIS PROPOSAL DESCRIBES AN OPPORTUNITY TO LEVERAGE AN EXTRAORDINARY DATA SET TO SHED NEW LIGHT ON THIS POORLY UNDERSTOOD REGION. THE DATA COME FROM THE DARK ENERGY SURVEY (DES) WHICH HAS BEEN AWARDED 525 NIGHTS OVER 5 YEARS (2013-2018) ON THE 4-METER BLANCO TELESCOPE AT CERRO TOLOLO IN CHILE. DES CONSISTS OF TWO INTERLEAVED SURVEYS: A WIDE SURVEY THAT IS IMAGING 5000 SQ. DEG. IN FIVE COLORS TO A LIMITING R-BAND MAGNITUDE OF ~23.8 AND A SUPERNOVA SURVEY THAT OBSERVES 30 SQ. DEG. APPROXIMATELY WEEKLY FOR SIX MONTHS EACH YEAR AT A DEPTH UP TO R~24.5. THE COMBINATION OF AREA AND DEPTH THAT MAKES DES THE WORLD S FOREMOST ONGOING COSMOLOGICAL SURVEY ALSO MAKES IT IDEALLY SUITED TO DISCOVER AND STUDY HUNDREDS OF NEW TRANS-NEPTUNIAN OBJECTS (TNOS). DES S BROAD OFF-ECLIPTIC COVERAGE ALSO MAKES THIS SURVEY PARTICULARLY SENSITIVE TO THE DYNAMICALLY DISTURBED HOT TNO POPULATIONS THAT OCCUPY HIGHER-INCLINATION ORBITS. THESE OBJECTS ENCODE THE HISTORY OF THE SOLAR SYSTEM S BIRTH ENVIRONMENT AND THE FORMATION AND MIGRATION HISTORIES OF THE GIANT PLANETS. THE MOST DISTANT TNOS DISPLAY AN ALIGNMENT IN ORBITAL AND PHYSICAL SPACE THAT MAY POINT TO THE EXISTENCE OF A DISTANT SUPER-EARTH SUCH AS THE PLANET NINE (P9) RECENTLY PROPOSED BY BATYGIN&BROWN (2016). THIS HYPOTHESIS CAN BE DECISIVELY TESTED WITH OUR DATA. WE WILL DO SO BOTH THROUGH A DIRECT SEARCH FOR P9 AND THROUGH THE DISCOVERY OR EXCLUSION OF DYNAMICALLY RELATED OBJECTS PREDICTED BY THE THEORY SUCH AS A POPULATION OF HIGH INCLINATION CENTAURS AND ADDITIONAL DISTANT ALIGNED OBJECTS. OUR DIRECT SEARCH WILL COMPLEMENT THE RECENT ANALYSIS BY FIENGA ET AL. (2016) WHICH USED THE PRECISE MEASUREMENTS OF THE DISTANCE TO SATURN OBTAINED BY NASA S CASSINI SATELLITE OVER THE PAST DECADE. THEIR ANALYSIS EXCLUDES A BROAD RANGE OF POSSIBLE P9 POSITIONS NEAR PERIHELION BUT SHOWS THAT A SMALL REGION CORRESPONDING TO A P9 TRUE ANOMALY NEAR 120 DEGREES IS FAVORED OVER THE NULL HYPOTHESIS. THIS FAVORED REGION LIES IN THE MIDDLE OF THE DES SURVEY FOOTPRINT. THE PI LEADS THE TRANSIENTS AND MOVING OBJECTS SCIENCE WORKING GROUP WITHIN DES AND HAS DISCOVERED ALL ~50 OF THE TRANS-NEPTUNIAN OBJECTS FOUND BY DES TO DATE. AMONG THESE OBJECTS IS ONE OF THE SIX OBJECTS MOST DISTANT TNOS WHOSE ALIGNED ORBITS MOTIVATED THE P9 HYPOTHESIS. THIS SEARCH BEGAN IN THE DES SUPERNOVA SURVEY FIELDS WHOSE REGULAR TEMPORAL CADENCE SIMPLIFIES THE PROBLEM OF CONNECTING OBSERVATIONS OF FROM DIFFERENT EPOCHS. WE HAVE BEGUN TO EXTEND THE SEARCH TO THE WIDE SURVEY WHOSE SPARSER TEMPORAL CADENCE LEADS TO A MORE CHALLENGING COMBINATORIC PROBLEM. A PROTOTYPE SEARCH USING ONLY 100 SQ. DEG. OF DATA (2% OF THE FULL SURVEY AREA) FROM THE 2013-14 SEASON RESULTED IN OVER A DOZEN NEW TNOS AND GIVES US CONFIDENCE THAT THE STRATEGY WE INTEND TO DEPLOY AT SCALE FOR THE FULL 5000 SQ. DEG. FIVE-YEAR WIDE SURVEY WILL BE SUCCESSFUL. THIS PROPOSAL WILL RESULT IN MULTIPLE-OPPOSITION ORBITS FOR SEVERAL HUNDRED NEW PRIMARILY HIGH-INCLINATION TNOS COMPLETE WITH MULTICOLOR PHOTOMETRY AND A WELL-CHARACTERIZED SELECTION FUNCTION. THESE DATA WILL PROVIDE US WITH AN OPPORTUNITY TO REASSESS THE DYNAMICAL HISTORY OF THE SOLAR SYSTEM. THIS PROJECT WILL INCLUDE A THEORETICAL ANALYSIS TO PROVIDE A DYNAMICAL INTERPRETATION OF THE DATA WITH A FOCUS ON EVOLUTIONARY SCENARIOS THAT PRODUCE THE OBSERVED POPULATIONS OF TNOS. WE ALSO OUTLINE A PROGRAM TO ALLOW CITIZEN SCIENTISTS TO SEARCH FOR TNOS IN PUBLIC DES DATA. THIS PROPOSAL REQUIRES NO MODIFICATIONS TO DES S TIME ALLOCATION SURVEY STRATEGY OR DATA REDUCTION PIPELINES BUT WILL GREATLY AMPLIFY THE SCIENTIFIC RETURN ON THIS DATA SET.
$474,336Regents Of The University Of Michigan · · FY2017 · National Aeronautics and Space Administration
CyanoMap: Mapping inland lake quality and Amyotrophic lateral sclerosis risk fact
$474,294Nathan Torbick · Applied Geosolutions, Llc · R44 · FY2014 · ES
A Computational Psychiatry Investigation of the effects of Mood on Reward Learning and Attention
$474,291Yael Niv · Princeton University · R01 · FY2021 · MH
Systems Biology
$474,147Nathan D Price · California Pacific Med Ctr Res Institute · U19 · FY2021 · AG
(PQ #10) Gut-brain interactions underlying chemotherapy-induced behavioral comorbidities
$474,121Leah M Pyter · Ohio State University · R01 · FY2021 · CA
Regulatory immune cells in immune suppression: The role of tBregs
$474,095Bira Arya · National Institute On Aging · ZIA · FY2015 · AG
Excessive Alcohol Drinking Associated with GABA Alpha 2-Regulated TLR4 Expression
$473,880Marjorie C Gondre-Lewis · Howard University · R01 · FY2017 · AA
Excessive Alcohol Drinking Associated with GABA Alpha 2-Regulated TLR4 Expression
$473,880Marjorie C Gondre-Lewis · Howard University · R01 · FY2016 · AA
DIPHTHERIA TOX REPRESSOR: GENETIC &STRUCTURAL ANALYSIS
$473,840Boston Medical Center · R01 · FY2004 · AI
CLINICIAN MANAGED INTERPERSONAL PSYCHOTHERAPY
$473,761University Of Iowa · R01 · FY2004 · MH
Inducing antigen specific B cell tolerance
$473,750James C. Paulson · Scripps Research Institute, The · R01 · FY2012 · AI
Inducing antigen specific B cell tolerance
$473,750James C. Paulson · Scripps Research Institute, The · R01 · FY2016 · AI
Inducing antigen specific B cell tolerance
$473,750James C. Paulson · Scripps Research Institute, The · R01 · FY2015 · AI
X-ray Diffraction Analysis of Human Adenovirus
$473,750Vijay S Reddy · Scripps Research Institute, The · R01 · FY2009 · AI
X-ray Diffraction Analysis of Human Adenovirus
$473,750Vijay S Reddy · Scripps Research Institute, The · R01 · FY2008 · AI
Inducing antigen specific B cell tolerance
$473,750James C. Paulson · Scripps Research Institute, The · R01 · FY2014 · AI
Prevent IgM MGUS Progression by Targeting the Driver Mutation
$473,744Xinfang Yu · Baylor College Of Medicine · U54 · FY2024 · CA
The development and validation of a novel tool for the assessment of bulbar dysfunction in ALS
$473,743Yana Yunusova · Sunnybrook Research Institute · R01 · FY2019 · DC
Circadian Clock and Dietary Restriction
$473,578Roman V Kondratov · Cleveland State University · R01 · FY2025 · AG
Genetic Modifiers of Cancer Risk
$473,552Sharon A. Savage · Division Of Cancer Epidemiology And Genetics · ZIA · FY2019 · CA
Epigenetic Editing of Mutant C9orf72
$473,444Edward Byung-Ha Lee · University Of Pennsylvania · R01 · FY2020 · NS