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15,273 grants matching “antimicrobial resistance”
Development of a model of Gonococcal conjunctivitis for vaccine evaluations
$221,854Gerald B Pier · Brigham And Women'S Hospital · R21 · FY2024 · AI
NMR STUDIES OF BACTERIAL SIGNAL TRANSDUCTION
$221,822Brandeis University · R01 · FY2002 · GM
NMR STUDIES OF BACTERIAL SIGNAL TRANSDUCTION
$221,822Brandeis University · R01 · FY2001 · GM
NMR STUDIES OF BACTERIAL SIGNAL TRANSDUCTION
$221,822Brandeis University · R01 · FY2003 · GM
NMR STUDIES OF BACTERIAL SIGNAL TRANSDUCTION
$221,822Brandeis University · R01 · FY2004 · GM
Mechanism-guided drug repurposing for host-directed therapy of infectious diseases using interpretable and integrative ML
$221,694Arjun Krishnan · University Of Colorado Denver · R21 · FY2022 · AI
Synergistic Drug Strategies Against Pseudomonas Aeruginosa Biofilms
$221,561Jennifer Fiegel · University Of Iowa · R21 · FY2014 · AI
Mycobacterium tuberculosis: resistance to reactive oxygen and nitrogen intermedia
$221,550Marcia Ann Firmani · University Of Wisconsin Milwaukee · R15 · FY2007 · HL
Revealing Stochastic Switches in Bacteria: Theory, Modeling, and Experiments
$221,454Edo L Kussell · New York University · R01 · FY2013 · GM
Training in Pediatric Infectious Diseases
$221,447Lisa Saiman · Columbia University Health Sciences · T32 · FY2014 · AI
Using Collaborative Cross mice to develop a novel model of Mycobacterium abscesses lung infection
$221,375Martin Alfons Gengenbacher · Hackensack University Medical Center · R21 · FY2020 · AI
THE USE OF ANTIMICROBIALS IN FOOD ANIMAL PRODUCTION IS OF INCREASING SOCIETAL IMPORTANCE. IN THE BEEF CATTLE INDUSTRY, BOVINE ANAPLASMOSIS IS AN IMPORTANT, PRODUCTION-LIMITING DISEASE THAT PARTICULARLY AFFECTS THE COW-CALF SECTOR. CURRENTLY, PRODUCERS AND VETERINARIANS RELY ON THE USE OF THE ANTIBIOTIC CHLORTETRACYCLINE (CTC) TO CONTROL ACTIVE OUTBREAKS OF BOVINE ANAPLASMOSIS. CHLORTETRACYCLINE IS MOST OFTEN PROVIDED TO BEEF COWS ON PASTURE BY INCLUDING IT IN MINERAL SUPPLEMENT THAT IS OFFERED FREE-CHOICE (I.E., THE COW CAN CHOOSE TO CONSUME THE CTC-MEDICATED MINERAL OR NOT AT ANY TIME). PROBLEMS WITH THIS METHOD OF DELIVERY INCLUDE THE INABILITY OF THE PRODUCER TO ENSURE THAT EACH COW RECEIVES AN INTENDED DOSE OF CTC EACH DAY, AND IF CATTLE DO NOT CONSUME THE INTENDED DOSE, THE CTC MAY NOT HAVE ITS INTENDED EFFECT OF REDUCING ILLNESS AND DEATH DUE TO BOVINE ANAPLASMOSIS. ADDITIONALLY, IF CATTLE CONTINUOUSLY CONSUME LESS THAN THE INTENDED DOSE OF CTC IN A MEDICATED MINERAL SUPPLEMENT, BACTERIAL RESISTANCE TO CTC MAY DEVELOP OVER TIME.THIS PROJECT INTENDS TO MEASURE THE AMOUNT OF CTC-MEDICATED MINERAL THAT CATTLE ON PASTURE VOLUNTARILY CONSUME OVER TIME, AND SUBSEQUENTLY CALCULATE THE DOSE OF CTC RECEIVED. WITH THIS KNOWLEDGE, WE WILL ALSO COLLECT BLOOD SAMPLES FROM THE CATTLE, AND MEASURE THE CONCENTRATION OF CTC WITHIN THE PLASMA TO DETERMINE AVERAGE AMOUNTS OF CTC WITHIN THE BLOOD OF THE ANIMAL. FURTHER, WE WILL COLLECT FECAL SAMPLES AND NASAL SWABS TO INVESTIGATE THE DIFFERENCE IN THE MICROBIAL POPULATIONS OF THE RESPIRATORY AND GASTROINTESTINAL TRACTS OF ANIMALS BEING FED A CTC-MEDICATED MINERAL COMPARED TO THOSE FED AND NON-CTC-MEDICATED MINERAL. THE ULTIMATE GOALS OF THIS PROJECT ARE TO IMPROVE THE COLLECTIVE KNOWLEDGE OF BEST PRACTICES FOR REDUCING ILLNESS AND DEATH IN COW-CALF HERDS DUE TO BOVINE ANAPLASMOSIS, WHILE ALSO IMPROVING ANTIMICROBIAL STEWARDSHIP IN BEEF COW-CALF HERDS. OUR TEAM HOPES TO PROVIDE VETERINARIANS AND BEEF CATTLE PRODUCERS WITH INFORMATION THAT CAN BE USED WHEN DESIGNING PROGRAMS AND STRATEGIES FOR REDUCING THE RISK OF ILLNESS AND DEATH DUE TO BOVINE ANAPLASMOSIS.
$221,322Mississippi State University · · FY2025 · National Institute of Food and Agriculture
The mycobiota, bone marrow transplantation, and clinical outcomes
$221,250Tobias M Hohl · Sloan-Kettering Inst Can Research · R21 · FY2022 · AI
Identification of novel anti-virulence compounds against Pathogenic Burkholderia
$221,250Matthew M Schaefers · Boston Children'S Hospital · R21 · FY2022 · AI
Subversion of Syndecan-1 Functions in Listeriosis
$221,250Pyong Woo Park · Boston Children'S Hospital · R21 · FY2022 · AI
ENZYMOLOGY OF ANTIBIOTIC RESISTANCE
$221,177Richard N Armstrong · Vanderbilt University · R01 · FY2006 · AI
Structure/function studies of biofilm agents from Aa
$221,163Narayanan Ramasubbu · Univ Of Med/Dent Of Nj-Nj Dental School · R01 · FY2007 · DE
Characterization and Design of Histone-Derived Antimicrobial Peptides
$221,126Donald E. Elmore · Wellesley College · R15 · FY2010 · AI
Probiotic Lactobacilli and Vaginal Epithelium
$221,111Ann E Stapleton · University Of Washington · R01 · FY2006 · DK
Enhancing Neutrophil Responses to Counter MDR Gram Negative Bacterial Pneumonia
$221,060Janet S Lee · University Of Pittsburgh At Pittsburgh · R21 · FY2015 · AI
Initiation and Regulation of Immune Protease Pathways
$221,050Haobo Jiang · Oklahoma State University Stillwater · R01 · FY2011 · GM
Initiation and Regulation of Immune Protease Pathways
$221,050Haobo Jiang · Oklahoma State University Stillwater · R01 · FY2012 · GM
Administrative Core
$221,001Michael S. Gilmore · Massachusetts Eye And Ear Infirmary · P01 · FY2024 · AI
Administrative Core
$221,000Michael S. Gilmore · Massachusetts Eye And Ear Infirmary · P01 · FY2023 · AI
Biology of Infectious Diseases Training Program
$220,932Henry F Chambers · University Of California, San Francisco · T32 · FY2015 · AI