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38,696 grants matching “als”
Immunology And Pathology Of Acute and Chronic Murine Leukemia Virus Infections
$480,128Kim Hasenkrug · National Institute Of Allergy And Infectious Diseases · ZIA · FY2021 · AI
Molecular Characterization of Breast Duct Epithelium at Risk for Breast Cancer
$480,075David Danforth · Division Of Clinical Sciences - Nci · ZIA · FY2009 · CA
Mechanisms of Tumor Cell Dormancy and Tumor Recurrence
$480,007Jeffrey E Green · Division Of Basic Sciences - Nci · ZIA · FY2012 · CA
CAS: Elucidating Trends in Earth-Abundant Metal Catalyzed Dehydrocoupling
$480,000Ryan J Trovitch · Arizona State University · · FY2022 · MPS
Collaborative Research: Quantum Mechanical Modeling of Major Mantle Materials
$480,000Renata M Wentzcovitch · University Of Minnesota-Twin Cities · · FY2003 · GEO
CAREER: Parameterizations of Langmuir Turbulence in Shallow Water
$480,000Andres E Tejada-Martinez · University Of South Florida · · FY2009 · ENG
Interplay between stable carbenes and neutral group-13 element nucleophiles, organic radicals, and strong bases
$480,000Guy Bertrand · University Of California-San Diego · · FY2014 · MPS
Developing a Regional Context for Rocky Subtidal Communities: Upwelling, Biotic Interactions and Diversity Regulation in the Galapagos Marine Reserve
$480,000Jon D Witman · Brown University · · FY2002 · GEO
Mechanisms of chromatin binding and selection by family IV bromodomains
$480,000Karen Champagne Glass · Albany College Of Pharmacy · R15 · FY2016 · GM
Dynamics of Kinesins, Dyneins, and Myosins
$479,991Paul R Selvin · University Of Illinois At Urbana-Champaign · R01 · FY2009 · AR
Using mitochondrial Ca2+ uptake as a therapeutic target for ALS
$479,964Lan Wei-Lapierre · University Of Florida · R01 · FY2023 · NS
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity Pathophysiology
$479,959Joseph T Bass · Northwestern University At Chicago · R01 · FY2021 · DK
Simultaneous dose and dose rate optimization for clinical FLASH proton radiotherapy
$479,938Hao Gao · University Of Kansas Medical Center · R01 · FY2024 · CA
The role of regulation and subcellular localization of GTP biosynthesis in melanoma invasion and metastasis
$479,923Mikhail Nikiforov · Duke University · R01 · FY2024 · CA
Genetic and Environmental Regulation of Diaphragm Development and Congenital Diaphragmatic Hernias
$479,910Gabrielle Kardon · University Of Utah · R01 · FY2022 · HD
Functional Organization of Primary Auditory Cortex
$479,908Christoph E. Schreiner · University Of California, San Francisco · R01 · FY2007 · DC
SCIENCE GOALS AND OBJECTIVES INVESTIGATIONS OF THE SOUTH ISIDIS REGION OF MARS HAVE UNCOVERED ROCKS RICH IN UNALTERED MAFIC MINERALS AS WELL AS A VARIETY OF AQUEOUS ALTERATION MATERIALS. THIS REGION OF MARS IS UNIQUE IN THAT THERE ARE EXPOSED VIEWS OF THE ANCIENT CRUSTAL ROCKS LAVA FLOWS FROM SYRTIS MAJOR ALTERATION FROM THE ISIDIS IMPACT AND MULTIPLE VALLEY NETWORKS STREAM BEDS AND DELTAS. RECENT MORPHOLOGIC AND SPECTROSCOPIC STUDIES USING COORDINATED CRISM-HRSC AND CRISM-HIRISE-CTX IMAGERY HAVE REVEALED STRATIGRAPHIC UNITS CONTAINING PHYLLOSILICATES CARBONATE OLIVINE AND PYROXENE IN ISOLATED REGIONS (E.G. BISHOP ET AL. 2013). WE PROPOSE TO EXTEND THIS WORK ACROSS A BROADER AREA OF LIBYA MONTES AND SOUTH ACROSS TYRRHENA TERRA TOWARDS HELLAS BASIN. SPECIFIC QUESTIONS WE WILL ADDRESS INCLUDE: 1) WHEN AND HOW DID THE PHYLLOSILICATES OPAL CARBONATE ZEOLITE AND PERHAPS SULFATES FORM? 2) HOW WERE THE SURFACE ROCKS ALTERED BY THE SYRTIS FLOW AND THE ISIDIS IMPACT? (AND HOW SIMILAR WERE THE GEOLOGIC PROCESSES AT LIBYA MONTES NILI FOSSAE AND TYRRHENA TERRA?) 3) WHAT WERE THE EFFECTS OF THE AQUEOUS CHANNELS AND DELTAS ON THE SURFACE ROCKS? 4) HOW DID SMALLER CRATERS SUCH AS DULOVO HASHIR BRADBURY LIPANY JERRY-DESLOGES AUKI AND LOPEZ AFFECT THE SURFACE ROCKS? 5) HOW DOES THE SURFACE MINERALOGY ACROSS THE STUDY REGION COMPARE WITH ELEMENTAL ABUNDANCES FROM GRS? AND 6) WHAT EXTENT DOES IMPACT ALTERATION PLAY IN FORMATION OR TRANSFORMATION OF THE MINERALOGY? MORE SPECIFICALLY ARE THE BEIDELLITE AND CHLORITE FORMED THROUGH LOW-TEMPERATURE ALTERATION FROM IMPACTS OR FROM BURIAL DIAGENESIS? METHODOLOGY TASK 1A) WE WILL CONDUCT REGIONAL ANALYSES OF THE SPECTRAL PROPERTIES USING TES THEMIS AND CRISM MULTISPECTRAL IMAGES AND COMPARE THESE WITH TRENDS IN CHEMISTRY FROM GRS AND GRAIN SIZE INDURATION ETC. FROM THERMAL INERTIA DERIVED FROM TES AND THEMIS. TASK 1B) WE WILL ANALYZE ALL TARGETED CRISM IMAGES ACROSS THE LIBYA MONTES AND TYRRHENA TERRA REGIONS FOR DETAILED LOCAL INVESTIGATION OF THE MINERALOGY AND CORRELATION WITH FLUVIAL IMPACT VOLCANIC AND AEOLIAN FEATURES. TASK 2) WE WILL PERFORM AGE DATING AND SURFACE ANALYSES IN ORDER TO GENERATE MAPS OF GEOLOGIC TERRAINS ACROSS THE REGION. TASK 3) WE WILL PREPARE STRATIGRAPHIC VIEWS OF COMPOSITIONAL UNITS USING CRISM OVER CTX/HRSC DTMS WITH ARCSCENE FOR TENS TO 100S OF KM VIEWS CRISM OVER MOLA WITH ENVI FOR 5-10 KM VIEWS AND CRISM OVER HIRISE DTMS FOR THE HIGHEST RESOLUTION AT<3 KM VIEWS. TASK 4) WE WILL SYNTHESIZE THE RESULTS FROM ALL 3 TASKS IN CONTEXT OF WORK BY OTHERS IN THE REGION IN ORDER TO UNDERSTAND THE EFFECTS OF VOLCANIC FLUVIAL AND AEOLIAN PROCESSES AND IMPACT CRATERS ON THE MINERALOGY AND SURFACE MORPHOLOGY. THROUGH JOINT ANALYSES OF MULTIPLE DATASETS WE EXPECT TO GAIN A DETAILED UNDERSTANDING OF THE DOMINANT PROCESSES AFFECTING THE REGION PROVIDE A FULLER PICTURE OF THE AQUEOUS GEOCHEMICAL ENVIRONMENT THROUGH TIME DOCUMENT SITES OF LIKELY IMPORTANCE FOR HABITABILITY AND CHARACTERIZE SITES UNDER CONSIDERATION FOR FUTURE LANDING SITES. RELEVANCE OF PROJECT TO MDAP THE PROPOSED STUDY IS RELEVANT TO UNDERSTANDING THE AQUEOUS GEOCHEMISTRY OF MARS INCLUDING WATER-RELATED ALTERATION IN MULTIPLE SITES. THIS INVESTIGATION WILL UTILIZE MULTIPLE DATA SETS TAKEN OF MARS ESPECIALLY FROM THE MARS RECONNAISSANCE ORBITER (MRO) MARS EXPRESS MARS GLOBAL SURVEYOR (MGS) AND MARS ODYSSEY WHICH MAKES THE PROPOSED STUDY RELEVANT TO THE MDAP PROGRAM. BECAUSE THE LIBYA MONTES REGION HAS BEEN PROPOSED AS A LANDING SITE INVESTIGATING THIS SITE ALSO SUPPORTS MDAP OBJECTIVES. THE CONTEXT OF THE RESULTS PROVIDED BY THIS STUDY WILL ALSO BE RELEVANT TO THE NUMEROUS LANDING SITES PROPOSED IN THE VICINITY OF THE NILI FOSSAE REGION.
$479,900Seti Institute · · FY2020 · National Aeronautics and Space Administration
Functional Organization of Primary Auditory Cortex
$479,845Christoph E. Schreiner · University Of California, San Francisco · R01 · FY2006 · DC
BASED ON RECENT MODELING DISSOLVED NITROGEN APPEARS TO SIGNIFICANTLY REDUCE THE EVAPORATION RATE OF LIQUID METHANE ON THE SURFACE OF TITAN. WE HAVE DEVELOPED A NEW METHOD FOR CALCULATING THE EVAPORATION RATE OF LIQUID METHANE SATURATED WITH NITROGEN UNDER TITAN S 1.5 BAR ATMOSPHERE. THE NEWLY DERIVED EVAPORATION RATES WERE COMPARED TO EVAPORATION RATES CALCULATED FOR PURE METHANE AS A FUNCTION OF BOTH TEMPERATURE AND RELATIVE HUMIDITY. WE FIND THAT THE PURE METHANE ASSUMPTION SIGNIFICANTLY OVERESTIMATES THE METHANE EVAPORATION RATE FROM SURFACE POOLS ON TITAN. FOR EXAMPLE AT 94 K AND 60% HUMIDITY THE PURE METHANE ASSUMPTION OVERESTIMATES THE METHANE EVAPORATION RATE BY MORE THAN 40%. THIS PREVIOUS OVERESTIMATION OF EVAPORATION RATES LIKELY HAS A PROFOUND IMPACT ON PREVIOUS INTERPRETATIONS OF CASSINI VIMS OBSERVATIONS OF TITAN S SURFACE AND OF CLOUDS IN TITAN S ATMOSPHERE. FOR EXAMPLE RECENT OBSERVATIONS OF NORTHERN SUMMER CLOUDS IN TITAN S TROPOSPHERE HAVE BEEN SPARSER AND LESS FREQUENT THAN PREDICTED BY GENERAL CIRCULATION MODELS (GCMS). AN OVERESTIMATION OF METHANE EVAPORATION FROM TITAN S LAKES AND SEAS COULD EXPLAIN THIS DISCREPANCY BETWEEN OBSERVATIONS AND EXISTING PREDICTIONS. THE SEASONAL EVOLUTION OF THE METHANE AND ETHANE SEAS DEPEND ON NOT JUST THE EVAPORATION OF METHANE SATURATED WITH NITROGEN BUT ALSO ON THE EVAPORATIVE PROCESSES ASSOCIATED WITH NITROGEN-METHANE-ETHANE MIXTURES. WE PROPOSE TO MODEL THE EVAPORATIVE PROCESSES OF BINARY MIXTURES OF NITROGEN-METHANE AND TERNARY MIXTURES OF NITROGEN-METHANEETHANE AND TO THEN INCORPORATE THESE RESULTS INTO A GENERAL CIRCULATION MODEL (GCM) OF TITAN. WE WILL COMPARE THE GCM PREDICTIONS OF CLOUD FORMATION DERIVED USING THE NEW EVAPORATIVE RELATIONSHIPS TO CASSINI VIMS OBSERVATIONS OF CLOUDS (E.G. BROWN ET AL. 2009 AP.J 706; RODRIGUEZ ET AL. 2011 ICARUS 216; TURTLE ET AL. 2011 GRL 38). OUR PROPOSAL IS RELEVANT TO THE CDAP PROGRAM. IN PARTICULAR CDAP SOLICITS RESEARCH PROPOSALS TO CONDUCT SCIENTIFIC INVESTIGATIONS UTILIZING OR ENHANCING THE UTILIZATION OF DATA OBTAINED BY THE CASSINI MISSION. TASKS RESPONSIVE TO THIS CALL INCLUDE . . . 3) NONDATAANALYSIS TASKS THAT SIGNIFICANTLY ENHANCE THE USE OR FACILITATE THE INTERPRETATION OF MISSION DATA. OUR INVESTIGATION WILL ENHANCE THE USE OF CASSINI DATA AND FACILITATE THE INTERPRETATION OF CASSINI DATA. SPECIFICALLY OUR INVESTIGATION WILL PROVIDE NEW INSIGHT INTO CASSINI VIMS OBSERVATIONS OF TROPOSPHERIC CLOUDS. WE WILL IMPROVE THE INTERPRETATION OF THIS DATA THROUGH THE USE OF NEW STATE-OF-THE-ART MODELING OF THE EVAPORATIVE PHYSICS OF BINARY AND TERNARY MIXTURES IN THE LAKES/SEAS AND ON THE SURFACE OF TITAN. BECAUSE OUR PROPOSED WORK INCLUDES THE REINTERPRETATION OF CASSINI VIMS OBSERVATIONS AND IS SO CLOSELY TIED TO AND CONSTRAINED BY CASSINI OBSERVATIONS IT IS NOT WITHIN THE SCOPE OF OTHER NASA PROGRAMS INCLUDING SOLAR SYSTEM WORKINGS OR EMERGING WORLDS.
$479,831Southwest Research Institute · · FY2020 · National Aeronautics and Space Administration
GOALS AND OBJECTIVES: RECENT JUNO OBSERVATIONS HAVE ILLUSTRATED THAT THE CHARACTERISTICS OF THE ELECTRON PRECIPITATION IN THE JUPITER AURORA IS LARGELY BROADBAND (E.G. MAUK ET AL. 2017A 2017B ALLEGRINI ET AL. 2017). AS IN THE TERRESTRIAL CONTEXT THE BROADBAND NATURE OF THE PRECIPITATION IS SUGGESTIVE OF ENERGIZATION IN DISPERSIVE SCALE ALFVEN WAVES (INERTIAL OR KINETIC). HOWEVER A DIRECT CAUSAL LINK FOR JUPITER HAS YET TO BE ESTABLISHED AND THE DETAILS OF THE ENERGIZATION PROCESS YET TO BE UNDERSTOOD. WITH THESE MOTIVATIONS IN MIND WE PLAN TO INVESTIGATE: (1) CAN PERTURBATIONS OF ALFVEN WAVE ENERGY IN THE JUPITER MAGNETODISC ACCOUNT FOR THE OBSERVED BROADBAND ELECTRON SPECTRA AT HIGH LATITUDES? (2) WHERE IS THE PRIMARY ELECTRON ENERGIZATION HAPPENING AND WHAT ARE THE RELATIVE CONTRIBUTIONS OF INERTIAL AND KINETIC ALFVEN WAVES TO THE OBSERVED BROADBAND ELECTRON SPECTRUM? AND (3) TO WHAT EXTENT DO ELECTRONS ENERGIZED IN DISPERSIVE SCALE ALFVEN WAVES CONTRIBUTE TO THE GENERATION OF THE SUPRATHERMAL ELECTRON POPULATION?
$479,816University Of Alaska Fairbanks · · FY2020 · National Aeronautics and Space Administration
General Purpose Brain-Computer Interface (BCI) System
$479,742Jonathan Rickel Wolpaw · Wadsworth Center · R01 · FY2010 · EB
Vocational Outcomes for Youth With Substance Abuse Problems and High HIV Risk
$479,661Scott W Henggeler · Medical University Of South Carolina · R01 · FY2010 · DA
TLR Immunotherapy to Eradicate Anatomic SIV Reservoirs
$479,653James Burton Whitney · Beth Israel Deaconess Medical Center · R01 · FY2020 · AI
Regulation of metastatic progression by an endothelial-derived factor
$479,624Sohail F. Tavazoie · Rockefeller University · R01 · FY2020 · CA
Electrical Signaling in a Circadian Pacemaker Circuit
$479,595Todd C Holmes · University Of California-Irvine · R01 · FY2010 · NS