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17,828 grants matching “crispr”
Impact of hemodynamics on efferocytosis in endothelial cells
$351,000Zufeng Ding · Georgia State University · R01 · FY2025 · HL
Impact of hemodynamics on efferocytosis in endothelial cells
$351,000Zufeng Ding · Georgia State University · R01 · FY2024 · HL
Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
$350,935Shiaw-Yih Lin · University Of Tx Md Anderson Can Ctr · R01 · FY2024 · CA
Computational modeling of DNA methylation-mediated gene regulation
$350,896John R. Edwards · Washington University · R01 · FY2020 · LM
Defining the Function of Age-Related Epimutation in Intestinal Tumorigenesis
$350,851Lanlan Shen · Baylor College Of Medicine · R01 · FY2022 · CA
Defining the Function of Age-Related Epimutation in Intestinal Tumorigenesis
$350,851Lanlan Shen · Baylor College Of Medicine · R01 · FY2023 · CA
Genetics of long non-coding RNAs in zebrafish
$350,675Alexander F Schier · Harvard University · R01 · FY2018 · HD
Genetics of long non-coding RNAs in zebrafish
$350,675Alexander F Schier · Harvard University · R01 · FY2017 · HD
Genetics of long non-coding RNAs in zebrafish
$350,675Alexander F Schier · Harvard University · R01 · FY2014 · HD
Modeling and targeting tumor-immune signaling interactions in tumor microenvironment
$350,626Fuhai Li · Washington University · R01 · FY2023 · LM
Enhancing Genome Editing Technology with Natural Cas9 Inhibitors
$350,593Erik J Sontheimer · Univ Of Massachusetts Med Sch Worcester · R01 · FY2021 · GM
Enhancing Genome Editing Technology with Natural Cas9 Inhibitors
$350,593Erik J Sontheimer · Univ Of Massachusetts Med Sch Worcester · R01 · FY2020 · GM
Molecular mechanisms underlying the preservation of neural stem cell quiescence during aging
$350,591Ashley E Webb · Brown University · RF1 · FY2022 · AG
Core C. Bioinformatics and data sharing.
$350,426Sabine Ehrt · Weill Medical Coll Of Cornell Univ · P01 · FY2020 · AI
Identifying genetic vulnerabilities in neuroendocrine prostate cancer
$350,381Kathleen Kelly · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Project 1: Novel mechanisms driving mucin secretion and mucus plugging in type 2-high asthma
$350,270David J Erle · University Of California, San Francisco · U19 · FY2025 · AI
THIS RESEARCH ALIGNS WITH AREA 5E OF THE BRAG RFA, MODELING APPROACHES TO UNDERSTAND THE IMPACT OF GENETIC ENGINEERING FOR POPULATION SUPPRESSION OR ALTERATION (GENE DRIVE, RELEASE OF INSECT CARRY DOMINANT LETHAL, ETC.) ON TARGET POPULATIONS OR NON-TARGET SPECIES THAT INTERACT WITH THE TARGETED SPECIES, ESPECIALLY WHEN INCORPORATING BIOLOGICALLY REALISTIC PARAMETERS (E.G. OF RESISTANCE EVOLUTION, NUMBERS OF INDIVIDUALS RELEASED, ETC.)OUR GOALS ARE (1) TO ASSESS THE RISKS OF GENOME EDITING TECHNOLOGIES, SUCH AS CRISPR-CAS9, WHEN USED TO MAKE GENE DRIVES TO SUPPRESS POPULATIONS OF CROP PESTS; (2) TO ASSESS THE EFFECT OF GENETIC BACKGROUND ON THE SPREAD OF GENE DRIVES; AND, TO IDENTIFY AND CHARACTERIZE DRIVE RESISTANT MUTATIONS PRE-EXISTING IN WILD POPULATIONS OR CREATED BY FEATURES OF CRISPR/CAS 9 ITSELF ; AND, (3) TO INCORPORATE OUR EXPERIMENTAL FINDINGS INTO MODELS OF GENE DRIVE.WE PROPOSE TO CONSTRUCT GENE DRIVES AND INTRODUCE THEM INTO POPULATIONS OF THE FLOUR BEETLE TRIBOLIUM CASTANEUM, A STORAGE GRAIN PEST. WE WILL IDENTIFY KEY FACTORS GOVERNING THE SPREAD OF GENE DRIVES IN WILD POPULATIONS AND IN GENETICALLY SUBDIVIDED POPULATIONS COMPARABLE TO REGIONAL AGRICULTURAL FIELDS. WE WILL DEVELOP GENE DRIVES ON GENETIC BACKGROUNDS SIMILAR TO AND DIVERGENT FROM THE LABORATORY STRAINS AND CHARACTERIZE THE GENETIC FEATURES OF POPULATIONS THAT REDUCE DRIVE EFFICIENCY. OUR RESULTS AND METHODS WILL INFORM THE DEVELOPMENT OF GUIDELINES FOR REGULATORY AGENCIES CHARGED WITH EVALUATING THE LIKELIHOOD OF SUCCESS OF PROPOSED DRIVE RELEASES.WE PROPOSE TO ASSESS THE BIOLOGICAL RISKS ASSOCIATED WITH THE PROPOSED USE OF GENE DRIVES BASED ON CRISPR-CAS9 GENOME EDITING TECHNOLOGY TO CONTROL CROP PESTS. MOREOVER, WE PROPOSE TO CONSTRUCT AND EVALUATE THE EFFICACY OF DRIVE REVERSAL SAFEGUARDS FOR CONTROLLING OR STOPPING THE SPREAD OF ARTIFICIAL GENE DRIVES AND PREVENTING FUTURE SPREAD OF A DRIVE TARGETING THE SAME REGION WITHIN A GENE OF INTEREST.
$350,270Trustees Of Indiana University · · FY2019 · National Institute of Food and Agriculture
A Resource Center for Tetrahymena Thermophila
$350,240Theodore G Clark · Cornell University · P40 · FY2020 · OD
Establishing a Novel Instrumental Model for Elucidating Mitochondrial DNA-Associated Dysfunction and Pathogenicity
$350,210Zengyi Shao · Iowa State University · R35 · FY2021 · GM
Mechanisms of Neural Stem Cell Mechanoregulation
$350,206David V Schaffer · University Of California Berkeley · R01 · FY2017 · NS
Mechanisms of Neural Stem Cell Mechanoregulation
$350,206David V Schaffer · University Of California Berkeley · R01 · FY2018 · NS
Mechanisms of Neural Stem Cell Mechanoregulation
$350,206David V Schaffer · University Of California Berkeley · R01 · FY2019 · NS
Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes
$350,050Victor S Batista · Yale University · R01 · FY2024 · GM
Epigenetic entrainment of striatal engram-like neurons across the time course of LID development
$350,036Karen Jaunarajs · University Of Alabama At Birmingham · R01 · FY2025 · NS
Optimizing Antibody Production in CHO Cells Using Epi-MAX Technology to Increase Heavy and Light Chain Expression
$350,000Shane Byrne · Codomax Inc. · R41 · FY2024 · TR