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17,828 grants matching “crispr”
Project 2 Symington
$352,305Lorraine S Symington · Columbia University Health Sciences · P01 · FY2022 · CA
Project 2 Symington
$352,305Lorraine S Symington · Columbia University Health Sciences · P01 · FY2023 · CA
Overcoming chemoresistance in triple negative breast cancer
$352,295Ozgur Sahin · Medical University Of South Carolina · R01 · FY2024 · CA
Mechanisms of venetoclax combination activity in acute myeloid leukemia
$352,275Jeffrey Wallace Tyner · Oregon Health & Science University · R01 · FY2021 · CA
Targeting PTPN11 dependent Hematologic Malignancies
$352,275Bill H Chang · Oregon Health & Science University · R01 · FY2020 · CA
Mechanisms of venetoclax combination activity in acute myeloid leukemia
$352,275Jeffrey Wallace Tyner · Oregon Health & Science University · R01 · FY2025 · CA
Targeting PTPN11 dependent Hematologic Malignancies
$352,275Bill H Chang · Oregon Health & Science University · R01 · FY2021 · CA
Mechanisms of immune evasion in T-cell acute lymphoblastic leukemia and its therapeutic implications
$352,270Birgit Knoechel · Utah State Higher Education System--University Of Utah · R01 · FY2025 · CA
Mechanisms and Functional Consequences of Selective miRNA transfer via extracellular vesicles
$352,264James G. Patton · Vanderbilt University · P01 · FY2020 · CA
Connecting Genomic Alterations in Liposarcomas with Drug Responses and Identification of New Therapeutic Approaches
$352,231Harold H Koeffler · Cedars-Sinai Medical Center · R01 · FY2019 · CA
Identification of Candidate Disease-Causing Variants
$352,203Steven E Brenner · University Of California, San Francisco · P01 · FY2023 · AI
Epigenetic Regulation of Osteoclastogenic Gene Expression: Factors, Targets, and Mechanisms
$352,110Woojin An · University Of Southern California · R01 · FY2024 · AR
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** A GALL IS A TUMOR-LIKE GROWTH ON A PLANT THAT IS INDUCED BY ANOTHER ORGANISM (I.E., BACTERIA, FUNGI, NEMATODE, OR INSECTS). INSECT-INDUCED PLANT GALLS REPRESENT ONE OF THE MOST AMAZING AND COMPLEX INTERSPECIFIC INTERACTIONS IN NATURE, CAPTURING THE INTEREST OF NATURALISTS, ECOLOGISTS AND EVOLUTIONARY BIOLOGISTS FOR CENTURIES. INCREASINGLY, GALL-FORMING INSECTS ALSO ACT AS ECONOMICALLY IMPORTANT AGRICULTURAL PESTS, REDUCING CROP YIELDS WORLDWIDE. SURPRISINGLY, THE GENERAL MECHANISMS BEHIND INSECT GALL INDUCTION AND GROWTH ARE UNKNOWN. THIS PROPOSAL AIMS TOUNCOVER THE EVOLUTIONARILY CONSERVED MOLECULAR MECHANISMS OF GALL FORMATIONBY HARNESSING THE GALLING SYSTEM OF CYNIPID WASPS ON LIVE OAKS, IN WHICH MANY SPECIES OF CYNIPIDS SUCCESSFULLY GALL THE SAME PLANT. THIS SYSTEM ALLOWS FOR POWERFUL NATURAL EXPERIMENTS TO TEST THE GENERALITY OF HOW GALLING ORGANISMS MANIPULATE PLANT GENOMES AND TO GENERATE NEW HYPOTHESES FOR INVESTIGATING PLANT CONTROL STRATEGIES AGAINST GALLING HERBIVORES AND OTHER PESTS THAT MANIPULATE HOST PLANT DEFENSE AND IMMUNITY. ADDITIONALLY, GALLING RESEARCH HAS GREAT POTENTIAL FOR THE ADVANCEMENT OF GENETIC ENGINEERING BECAUSE GALL-FORMATION INVOLVES THE SIMULTANEOUS MANIPULATION OF THOUSANDS OF GENES IN THE PLANT - NOT POSSIBLE WITH CURRENT TECHNOLOGIES (E.G., RNAI, CRISPR). THE EGAN LAB AT RICE UNIVERSITY WILL BE RESPONSIBLE FOR THE SAMPLING AND DISSECTION OF INSECT AND PLANT TISSUES ASSOCIATED WITH OUR RESEARCH OBJECTIVES.DURING THE COURSE OF THIS RESEARCH WE WILL CO-HOST A SEMINAR SERIES AND DEVELOP A SERIES OF LABS WITH COLLABORATORS ATTEXAS SOUTHERN UNIVERSITY, A HISTORICALLY BLACK COLLEGE (HBCU); AS WELL AS ACTIVELY PARTICIPATE IN PUBLIC ENGAGEMENT OF SCIENTIFIC RESEARCH IN THE HOUSTON AREA.
$352,099William Marsh Rice University · · FY2023 · National Institute of Food and Agriculture
Project 2: Cellular topography and function of the breast cancer tissue microenvironment
$352,077Robert Michael Angelo · Stanford University · U54 · FY2024 · CA
Tumor cell and microenvironment changes causing antiangiogenic therapy resistance
$352,024Manish Aghi · University Of California, San Francisco · R01 · FY2021 · NS
Dissecting the mechanisms that underlie mislocalization and aggregation of RNA binding proteins in neurodegenerative diseases
$352,000Ophir Shalem · Children'S Hosp Of Philadelphia · R03 · FY2019 · NS
MegaTALS: hyperspecific reagents for targeted gene modification and correction
$352,000Barry L. Stoddard · Fred Hutchinson Cancer Research Center · R01 · FY2019 · GM
MegaTALS: hyperspecific reagents for targeted gene modification and correction
$352,000Barry L. Stoddard · Fred Hutchinson Cancer Research Center · R01 · FY2021 · GM
MegaTALS: hyperspecific reagents for targeted gene modification and correction
$352,000Barry L. Stoddard · Fred Hutchinson Cancer Research Center · R01 · FY2020 · GM
Tumor cell and microenvironment changes causing antiangiogenic therapy resistance
$351,943Manish Aghi · University Of California, San Francisco · R01 · FY2020 · NS
Potentiating Checkpoint Blockade by Cross-Priming Tumor-Reactive T cells with In Situ Vaccination
$351,924Joshua D Brody · Icahn School Of Medicine At Mount Sinai · R37 · FY2025 · CA
Cellular and molecular determinants of amniote regenerative potentials.
$351,920Thomas Peter Lozito · University Of Southern California · R35 · FY2025 · GM
Project 4: Novel epigenetic treatment of IDH mutant gliomas
$351,815Harley I Kornblum · University Of California Los Angeles · P50 · FY2020 · CA
Project 3: The role of microenvironmental metabolites on metastatic progression
$351,714Kivanc Birsoy · Rockefeller University · U54 · FY2021 · CA
Project 2: Cellular topography and function of the breast cancer tissue microenvironment
$351,694Robert Michael Angelo · Stanford University · U54 · FY2025 · CA