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38,696 grants matching “als”
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ACROSS THE GLOBE, AGRICULTURAL FOOD SECURITY IS CRITICALLY THREATENED BY COMPLEX AND RECALCITRANT ISSUES INCLUDING A BURGEONING POPULATION, A CHANGING CLIMATE, SHIFTS IN PESTS AND PATHOGENS AND THE EROSION OF SOIL HEALTH (HEEB ET AL. 2019; JONES ET AL. 2013; SAVARY ET AL. 2019). TOGETHER THESE ISSUES DEMAND MORE EFFICIENT AND COST-EFFECTIVE USE OF RESOURCES IN AGRICULTURAL PRODUCTION SYSTEMS. AT THE SAME TIME, INTENSIVE CROP PRODUCTION HAS BECOME DATA RICH AS MULTIDISCIPLINARY RESEARCH PROVIDES OPPORTUNITIES TO TRANSFORM TRADITIONAL FARMING APPROACHES TO ADDRESS GLOBAL FOOD SECURITY. EFFECTIVELY HARNESSING THESE DATA THROUGH PRECISION TECHNOLOGIES HAS CLEARLY DEMONSTRATED POTENTIAL TO ENHANCE PRODUCTIVITY, EFFICIENCY AND ENVIRONMENTAL OUTCOMES ACROSS PRIMARY PRODUCTION (HEDLEY 2015). OVERCOMING THESE CHALLENGES DEMANDS A HIGH LEVEL OF AGRICULTURAL LITERACY AMONG EDUCATORS, STUDENTS, AND FUTURE LEADERS, HOWEVER, STUDIES INDICATE THAT, IMPROVEMENTS IN AGRICULTURAL LITERACY ARE STILL NECESSARY (KOVAR AND BALL 2013).OUR LONG-TERM GOAL IS TO ADDRESS A CRITICAL WORKFORCE DEFICIENCY IN AGRICULTURAL PLANT SCIENCES THAT WILL BE IMMERSED IN THE DIGITAL ERA. THESE PROFESSIONS USE RESEARCH-BASED KNOWLEDGE TO DEVELOP AND EXTEND INNOVATIVE SOLUTIONS TO SERIOUS PROBLEMS FACING US AGRICULTURE. THIS PROJECT WILL ENABLE THE CAPACITY OF FUTURE GENERATIONS, INCLUDING STUDENTS FROM UNDERREPRESENTED MINORITIES, TO EFFECTIVELY CAPTURE THE RAPID ADVANCES IN DIGITAL AND PRECISION AGRICULTURE FOR SUSTAINABLE, AGRICULTURAL ECONOMIC GROWTH. TRAINING IN THIS AREA WILL HENCE RESULT IN IMPROVED USE OF PRECISION AGRICULTURE TOOLS TO ENHANCE AGRICULTURAL PRODUCTION AND REDUCE ECONOMIC, ENVIRONMENTAL, SOCIAL AND CULTURAL FACTORS THAT HAVE TRADITIONALLY BEEN BARRIERS TO INTEGRATING THESE TOOLS INTO PRACTICAL DECISION MAKING BY PRODUCERS.
$495,704Cornell University · · FY2021 · National Institute of Food and Agriculture
LIM Gene Control of Motor Neuron Development
$495,591Salk Institute For Biological Studies · R01 · FY2005 · NS
LIM Gene Control of Motor Neuron Development
$495,591Salk Institute For Biological Studies · R01 · FY2003 · NS
LIM Gene Control of Motor Neuron Development
$495,591Salk Institute For Biological Studies · R01 · FY2002 · NS
Immune Regulation of Neuronal Injury and Repair
$495,471Kathryn Jane Jones · Indiana University Indianapolis · R01 · FY2013 · NS
Fabrication, perfusion and imaging of pre-vascularized tissue scaffolds
$495,368Mary E Dickinson · Baylor College Of Medicine · R01 · FY2010 · HL
ANTI-INFLAMMATORY THERAPIES NEUROTOXICALLY INDUCED PD
$495,344Mc Lean Hospital (Belmont, Ma) · R01 · FY2002 · NS
COVID-19 Instrumentation in the RTB
$495,304Iyadh Douagi · National Institute Of Allergy And Infectious Diseases · ZIC · FY2022 · AI
The National Dental PBRN Administrative and Resource Center
$495,298Gregg H Gilbert · University Of Alabama At Birmingham · U19 · FY2020 · DE
Electrical impedance tomography for the improved assessment of pulmonary function in neuromuscular disease
$495,274Seward B Rutkove · Beth Israel Deaconess Medical Center · R21 · FY2020 · NS
Electrical and mechanical properties of motor units in a mouse model of ALS
$495,212Charles Heckman · Northwestern University At Chicago · R01 · FY2013 · NS
Linking Plasticity of Hippocampal Representation across the Single Neuron and Circuit Levels
$495,144Jayeeta Basu · New York University School Of Medicine · R01 · FY2019 · NS
Specification of Dorsal Lbx1-Derived Interneurons
$495,140Martyn D Goulding · Salk Institute For Biological Studies · R01 · FY2007 · NS
Alcohol Use Disorder and Cannabis: Testing Novel Harm Reduction Strategies
$495,131Kent E Hutchison · University Of Colorado Denver · R01 · FY2025 · AA
Metabolic Mechanisms for Programmed Cell Death
$495,101James M Phang · Division Of Basic Sciences - Nci · ZIA · FY2010 · CA
Specification of Dorsal Lbx1-Derived Interneurons
$495,072Martyn D Goulding · Salk Institute For Biological Studies · R01 · FY2006 · NS
High-Throughput Genomic Approaches to Identify ALS Genes
$495,019Robert H Brown · Massachusetts General Hospital · R01 · FY2008 · NS
Novel DNA Polymerase Inhibitors as Gram-Positive Antibacterial Agents
$495,012Thale Cross Jarvis · Crestone, Inc. · R43 · FY2010 · AI
High-Throughput Genomic Approaches to Identify ALS Genes
$495,008Robert H Brown · Massachusetts General Hospital · R01 · FY2007 · NS
Neurofilaments, SOD1 and Motor Neuron Diseases
$495,006Ludwig Institute For Cancer Research · R01 · FY2002 · NS
Optimization of ultrasound-facilitated blood-brain barrier opening
$495,000Elisa E Konofagou · Columbia Univ New York Morningside · R01 · FY2011 · EB
The Singlet Diradical Character of Multiple Bonded Compounds of the Heavier Group 13 and 14 Elements
$495,000Philip P Power · University Of California-Davis · · FY2007 · MPS
Social Aggression: Growth and Outcomes
$495,000Marion K. Underwood · University Of Texas Dallas · R56 · FY2008 · MH
UNEXPECTED OBSERVATIONS BY THE MMS/FEEPS SENSORS OF MULTIPLE DISPERSIVE ENERGETIC ELECTRON SIGNATURES [FENNELL ET AL. 2016] HIGHLIGHTED THE EXISTENCE OF "MICROINJECTIONS". THAT IS ELECTRONS ORGANIZED INTO CLUSTERS OF TEMPORAL ELEMENTS WHERE THE HIGHEST ENERGY ELECTRONS ARE OBSERVED FIRST FOLLOWED BY EVER LOWER ENERGY ELECTRONS UNTIL THEY MAP OUT ENERGY VERSUS TIME PROFILES REMINISCENT OF CLASSIC SUBSTORM INJECTIONS BUT ON A MUCH SHORTER TIME SCALE AND USUALLY REPETITIVE. THEY OCCURRED IN THE MIDNIGHT TO DUSK LOCAL TIME SECTOR ABOVE ~8 RE GEOCENTRIC. AN INTRIGUING FEATURE WAS THAT THE MICROINJECTION ELECTRONS WERE DOMINANTLY FIELD ALIGNED. THE DISPERSIVE NATURE OF THE ELECTRONS LED FENNELL ET AL. [2016] TO ARGUE THAT THEIR INJECTION HAD OCCURRED FAR FROM THE OBSERVATION POINT AND THAT THEY GRADIENT-CURVATURE DRIFTED TO THE MMS FLEET. DRIFT TRACINGS INDICATED THAT THEY WERE GENERATED NEAR THE MAGNETOPAUSE BOUNDARY SUNWARD OF DUSK AND MIGHT BE ASSOCIATED WITH KELVIN-HELMHOLTZ INSTABILITIES ULF WAVES OR FLUX TRANSFER EVENTS. IT WAS ALSO SPECULATED THAT THESE MICROINJECTIONS MIGHT PLAY A ROLE IN THE DEVELOPMENT OF THE SEED ELECTRON POPULATION THAT IS ULTIMATELY ACCELERATED TO HIGHER ENERGIES TO MAKE UP THE OUTER ZONE RADIATION BELT. FROM THOSE INITIAL OBSERVATIONS ONE COULD NOT DETERMINE KEY FEATURES OF THE PROCESS NAMELY: HOW THE ELECTRON MICROINJECTIONS WERE GENERATED WHERE THEY WERE GENERATED AND WHY THEY WERE FIELD ALIGNED. MICROINJECTIONS HAVE A VARIABLE RANGE OF ENERGY-TIME SIGNATURES. WITHIN MICROINJECTION CLUSTERS ONE OFTEN OBSERVES THAT THEIR TEMPORAL PROFILES CAN CROSS EACH OTHER INDICATING THEY DRIFTED DIFFERENT DISTANCES. THIS IMPLIES THERE CAN BE MORE THAN ONE SOURCE REGION ACTIVE AT THE SAME TIME OR THAT THE SOURCE REGION ITSELF IS MOVING AS IT "THROWS OFF" MULTIPLE ELECTRON INJECTIONS. SOME MICROINJECTIONS HAVE A DOUBLE PEAKED SPECTRUM WHICH DISPERSES IN TIME. THESE MIGHT BE OVERLAPPING INJECTIONS OR INJECTIONS OF A SOURCE POPULATION THAT ALREADY HAD A SPECTRAL PEAK. IN ADDITION THE REPETITION RATE OF MICROINJECTIONS IN A CLUSTER DOES NOT APPEAR TO BE CONSTANT. THE OBSERVATIONS SUGGEST THERE ARE INTERVALS WHERE THE TIME BETWEEN MICROINJECTIONS IS SHORTER OR LONGER WITH THE SLOWER REPETITION RATE BEING UP TO TWICE AS LONG AS THE AVERAGE FOR A CLUSTER. ALL SUCH FEATURES MUST BE RELATED TO THE GENERATION PROCESS. THUS WE PROPOSE THE FOLLOWING INVESTIGATIONS. 1. WE WILL ANALYZE THE COMPLETE SET OF MICROINJECTIONS OBTAINED BY MMS FROM JULY 2015 THROUGH NOV. 2017. WE WILL CHARACTERIZE THEIR SPATIAL-TEMPORAL FEATURES AND THE CONDITIONS IN THE INTERPLANETARY MEDIUM AND INSIDE THE MAGNETOSPHERE WHEN THEY OCCURRED. 2. WE WILL USE DRIFT CALCULATIONS IN FIELD MODELS TO INFER WHERE THESE MICROINJECTION POPULATIONS CAME FROM AND WHERE THEY GO AFTER PASSING THE MMS SATELLITES. WE CAN THEN CHECK OTHER OBSERVATIONS LIKE THOSE FROM VAN ALLEN PROBES GOES GEOTAIL AND THEMIS TO HELP DEFINE THE SOURCE POPULATION AND HELP DETERMINE IF THE MICROINJECTIONS MAINTAIN THEIR IDENTITY AS THEY DRIFT BEYOND MMS. 3. WE WILL USE THE INFORMATION GAINED TO UNRAVEL THE GENERATION PROCESS OR PROCESSES USING MODELS TO INVESTIGATE THE PHYSICS AND TO PINPOINT THEIR SOURCE REGION(S). FOR EXAMPLE WE WILL TRACE PARTICLES THROUGH THE FIELDS FROM GLOBAL MHD AND RCME MODELS TO INFER THE ENERGY CHANGES AND PARTICLE ORGANIZATION BY THE KELVIN-HELMHOLTZ ACTIVITY ULF WAVES AND FLUX TRANSFER EVENTS THEY PREDICT. THESE STUDIES DIRECTLY SUPPORT THE MMS GOAL OF UNDERSTANDING THE ROLE RECONNECTION AND BOUNDARY PROCESSES PLAY IN THE TRANSPORT AND ENERGIZATION OF THE PLASMA ACROSS THE MAGNETOPAUSE AND WITHIN THE OUTER MAGNETOSPHERE. IN ADDITION THE STUDIES CONTRIBUTE DIRECTLY TO THE DECADAL SURVEY'S GOALS OF DETERMINING THE DYNAMICS AND COUPLING OF THE EARTH'S MAGNETOSPHERE AND IONOSPHERE IN RELATION TO THE SOLAR TERRESTRIAL INPUTS AND CHARACTERIZING WHAT MAY BE A UBIQUITOUS PROCESS THAT OCCURS THROUGHOUT THE UNIVERSE AT MAGNETIZED PLANETS.
$495,000The Aerospace Corporation · · FY2020 · National Aeronautics and Space Administration
Cancer Therapy Clinical Trials Using Novel Recombinant Vaccines
$494,990James L. Gulley · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA